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THE DEVELOPMENT OF A LIQUID LITHIUM NEUTRON GENERATING TARGET FOR ACCELERATOR BASED NEUTRON CAPTURE THERAPY

Research Project

Project/Area Number 20240054
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical systems
Research InstitutionKyoto University

Principal Investigator

KOBAYASHI Tooru  Kyoto University, 京都大学・原子炉実験所, 准教授 (90089136)

Co-Investigator(Kenkyū-buntansha) ARITOMI Masanori  東京工業大学, 原子炉工学研究所, 教授 (60101002)
TAKAHASHI Minoru  東京工業大学, 原子炉工学研究所, 準教授 (90171529)
HAYASHIZAKI Noriyosu  東京工業大学, 原子炉工学研究所, 準教授 (50334537)
KATABUCHI Tatsuya  東京工業大学, 原子炉工学研究所, 助教 (40312798)
NAKAGAWA Masamichi  東京工業大学, 原子炉工学研究所, 助教 (10172280)
TANAKA Kenichi  札幌医科大学, 医学部, 講師 (70363075)
GERARD Bengua  北海道大学, 大学病院, 特任助教 (50402954)
Co-Investigator(Renkei-kenkyūsha) HATTORI Toshiyuki  東京工業大学, 原子炉工学研究所, 教授 (50402954)
IGASHIR Masayuki  東京工業大学, 原子炉工学研究所, 教授 (10114852)
YAMAMOTO Tetsuya  筑波大学, 人間総合科学研究科, 講師 (30375505)
NAKAMURA Hiroo  九州大学, 大学院・総合理工学研究院, 学術研究員 (20354665)
Research Collaborator ASAKAWA Hiroyoshi  ノズルネットワーク株式会社, 社長
ISHIHARA Shinji  エンジニアリングメイト, 代表
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥50,050,000 (Direct Cost: ¥38,500,000、Indirect Cost: ¥11,550,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2009: ¥25,090,000 (Direct Cost: ¥19,300,000、Indirect Cost: ¥5,790,000)
Fiscal Year 2008: ¥22,360,000 (Direct Cost: ¥17,200,000、Indirect Cost: ¥5,160,000)
Keywords中性子捕捉療法 / 液体リチウムターゲット / 加速器 / 低侵襲治療システム / 放射線工学 / 熱流動 / 薄膜 / ビーム応用 / BNCT照射システム / 液膜流 / 液体リチウム / 中性子工学
Research Abstract

The prospect of realizing a stable and long-lived neutron-generating target using liquid lithium was investigated for an accelerator-based system which can be used for the selective treatment of cancer via boron-neutron capture therapy. Using an incident proton beam energy of 2MeV at a current of 20mA and a beam diameter of 3cm to generate neutrons from the ^7Li(p,n)^7Be reaction, it was confirmed that a stable liquid lithium flow (i.e., flow rate of 30m/s, 50mm in width, 50mm in length, thickness of 0.5mm) which can remove 40kW of heat, can be achieved along the inside surface of a cylindrical curved plate. From the experiments performed, the parameters necessary for the fabrication of the liquid lithium neutron generating target were determined

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (42 results)

All 2011 2010 2009 2008

All Presentation (42 results)

  • [Presentation] Study on High Speed Lithium Jet for Neutron Source of Boron Neutron Capture Therapy (BNCT)2011

    • Author(s)
      M.Takahashi, T.Kobayashi, M.Zhang, M.Mak, J.Stefanica, V.Dostal, W.Zhao
    • Organizer
      ICONE19-43192
    • Place of Presentation
      Chiba, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] 加速器中性子捕捉療法用液体リチウム液膜流ターゲットの開発 (2)リチウム平面噴流試験2011

    • Author(s)
      高橋実, 古林徹, 張明光, Michael MAK, Jiri STEFANICA, 日野彰, 長澤雄真, 石原信二
    • Organizer
      原子力学会2011春の年会
    • Place of Presentation
      福井
    • Related Report
      2010 Final Research Report
  • [Presentation] 加速器中性子捕捉療法用液体リチウム液膜流ターゲットの開発 (1)中性子捕捉療法用中性子発生ターゲットの概要2011

    • Author(s)
      古林徹、高橋実、有冨正憲、中川順達、林崎規託、片渕竜也、Bengua Gerard、田中憲一、服部俊幸、井頭政之、山本哲哉、中村博雄
    • Organizer
      原子力学会2011春の年会
    • Place of Presentation
      福井
    • Related Report
      2010 Final Research Report
  • [Presentation] 加速器中性子捕捉療法用液体リチウム液膜流ターゲットの開発(1)中性子捕捉療法用中性子発生ターゲットの概要2011

    • Author(s)
      古林徹、高橋実、有冨正憲、中川順達、林崎規託、片渕竜也、Bengua Gerard、田中憲一、服部俊幸、井頭政之、山本哲哉、中村博雄
    • Organizer
      日本原子力学会2011春の年会
    • Place of Presentation
      福井
    • Related Report
      2010 Annual Research Report
  • [Presentation] 加速器中性子捕捉療法用液体リチウム液膜流ターゲットの開発(2)リチウム平面噴流試験2011

    • Author(s)
      高橋実, 古林徹, 張明光, Michael MAK, Jiri STEFANICA, 日野彰, 長澤雄真, 石原信二
    • Organizer
      日本原子力学会2011春の年会
    • Place of Presentation
      福井
    • Related Report
      2010 Annual Research Report
  • [Presentation] 発生中性子エネルギーに依存する加速器BNCT照射システムの特性と将来性2010

    • Author(s)
      古林徹
    • Organizer
      第7回日本中性捕捉療法学会
    • Place of Presentation
      東京
    • Year and Date
      2010-08-05
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 加速器BNCT ターゲット兼冷却材用リチウム液幕噴流・液膜流の熱水力学的限界仕様2010

    • Author(s)
      中川順達、古林徹、高橋実、有富正憲
    • Organizer
      日本混相流学会2010年会
    • Place of Presentation
      浜松
    • Year and Date
      2010-07-18
    • Related Report
      2010 Final Research Report
  • [Presentation] 加速器BNCTターゲット兼冷却材用リチウム液幕噴流・液膜流の熱水力学的限界仕様2010

    • Author(s)
      中川順達, 古林徹, 高橋実, 有富正憲
    • Organizer
      日本混相流学会2010年会
    • Place of Presentation
      浜松
    • Year and Date
      2010-07-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小型線形加速器によるBNCT照射システムの開発2010

    • Author(s)
      林崎規託、服部俊幸、松本義久、片渕竜也、塚原剛彦、古林徹、山本哲哉
    • Organizer
      原子力学会2010年会
    • Place of Presentation
      茨城
    • Year and Date
      2010-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] 小型線形加速器によるBNCT照射システムの開発2010

    • Author(s)
      林崎規託、服部俊幸、松本義久、片渕竜也、塚原剛彦、古林徹、山本哲哉
    • Organizer
      原子力学会2010春の年会
    • Place of Presentation
      茨城
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Medical Physics for BNCT with a Dream2010

    • Author(s)
      古林徹
    • Organizer
      Hatanaka Memorial Lecture 2010, 14^<th> ICNCT
    • Place of Presentation
      Buenos Aires
    • Related Report
      2010 Final Research Report
  • [Presentation] Development of a BNCT Irradiation System using ^7Li(p,n)^7Be Near Threshold Neutrons2010

    • Author(s)
      T.Kobayashi, G.Bengua, K.Tanaka, N.Hayashizaki, T.Katabuchi, T.Hattori, M.Aritomi
    • Organizer
      14th ICNCT
    • Place of Presentation
      Buenos Aires
    • Related Report
      2010 Final Research Report
  • [Presentation] A novel BNCT Irradiation System with an On-line Monitor using ^7Li(p,n)^7Be Near Threshold Neutrons2010

    • Author(s)
      T.Kobayashi, G.Bengua, K.Tanaka, N.Hayashizaki, T.Katabuchi, T.Hattori, M.Aritomi
    • Organizer
      SSD-16
    • Place of Presentation
      Sydney
    • Related Report
      2010 Final Research Report
  • [Presentation] Study on Liquid Lithium Target System for Boron Neutron Capture Therapy (BNCT)2010

    • Author(s)
      M.Takahashi, T.Kobayashi, M.Nakatsuka, T.Ardiansyah, M.Kulhanek, A.Vojacek, V.Dostal, S.Uchida, M.Zhang
    • Organizer
      ICONE18-29516
    • Place of Presentation
      Xi'an, CHINA
    • Related Report
      2010 Final Research Report
  • [Presentation] 加速器BNCT ターゲット兼冷却材用リチウム液膜噴流・液膜流の運動量欠損2010

    • Author(s)
      中川順達、古林徹、高橋実、有富正憲
    • Organizer
      日本機械学会流体工学部門講演会
    • Place of Presentation
      米沢
    • Related Report
      2010 Final Research Report
  • [Presentation] 小型線形加速器を用いたBNCT照射システムの開発2010

    • Author(s)
      林崎規託、服部俊幸、松本義久、片渕竜也、塚原剛彦、古林徹、山本哲哉、熊田博明
    • Organizer
      原子力学会2010秋の大会
    • Place of Presentation
      札幌
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] BNCT用陽子線形加速器の研究2010

    • Author(s)
      高村雅希、林崎規託、服部俊幸、古林徹
    • Organizer
      原子力学会2010秋の大会
    • Place of Presentation
      札幌
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 加速器BNCTターゲット兼冷却材用リチウム液幕噴流・液膜流の安定性問題2010

    • Author(s)
      中川順達、古林徹、高橋実、有富正憲
    • Organizer
      100906-08機械学会年次大会2010
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report
  • [Presentation] Medical Physics for BNCT with a Dream2010

    • Author(s)
      T.Kobayashi
    • Organizer
      14th Int.Conf.on Neutron Capture Therapy
    • Place of Presentation
      Buenos Aires
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development of a BNCT Irradiation System using ^7Li(p,n)^7 Be Near Threshold Neutrons2010

    • Author(s)
      T.Kobayashi, G.Bengua, K.Tanaka, N.Hayashizaki, T.Katabuchi, T.Hattori, M.Aritomi
    • Organizer
      14th Int.Conf.on Neutron Capture Therapy
    • Place of Presentation
      Buenos Aires
    • Related Report
      2010 Annual Research Report
  • [Presentation] A novel BNCT Irradiation System with an On-line Monitor using ^7Li(p,n)^7 Be Near Threshold Neutrons2010

    • Author(s)
      T.Kobayashi, G.Bengua, K.Tanaka, N.Hayashizaki, T.Katabuchi, T.Hattori, M.Aritomi
    • Organizer
      16th Solid State Dosimetry
    • Place of Presentation
      Sydney
    • Related Report
      2010 Annual Research Report
  • [Presentation] Study On Liquid Lithium Target System For Boron Neutron Capture Therapy (BNCT)2010

    • Author(s)
      M.Takahashi, T.Kobayashi, M.Nakatsuka, T.Ardiansyah, M.Kulhanek, A.Vojacek, V.Dostal, S.Uchida, M.Zhang
    • Organizer
      ICONE18-29516
    • Place of Presentation
      Xi'an, CHINA
    • Related Report
      2010 Annual Research Report
  • [Presentation] 加速器BNCTターゲット兼冷却材用リチウム液膜噴流・液膜流の運動量欠損2010

    • Author(s)
      中川順達, 古林徹, 高橋実, 有富正憲
    • Organizer
      日本機械学会流体工学部門講演会
    • Place of Presentation
      米沢
    • Related Report
      2010 Annual Research Report
  • [Presentation] 加速器BNCTターゲット兼冷却材用リチウム液幕噴流・液膜流の安定性問題2010

    • Author(s)
      中川順達, 古林徹, 高橋実, 有富正憲
    • Organizer
      機械学会年次大会2010
    • Place of Presentation
      名古屋
    • Related Report
      2010 Annual Research Report
  • [Presentation] 加速器BNCTターゲット兼冷却材用リチウムの凹曲板流下液膜の遠心力不安定2009

    • Author(s)
      中川順達、古林徹、高橋実、有富正憲
    • Organizer
      日本機械学会 流体工学部門
    • Place of Presentation
      名古屋
    • Year and Date
      2009-11-07
    • Related Report
      2010 Final Research Report
  • [Presentation] 加速器BNCTターゲット兼冷却材用リチウムの平板流下液膜内の境界層構造2009

    • Author(s)
      中川順達、古林徹、高橋実、有富正憲
    • Organizer
      日本機械学会流体工学部門
    • Place of Presentation
      名古屋
    • Year and Date
      2009-11-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] 加速器BNCTターゲット兼冷却材用リチウムの凹曲板流下液膜の遠心力不安定2009

    • Author(s)
      中川順達、古林徹、高橋実、有富正憲
    • Organizer
      日本機械学会流体工学部門
    • Place of Presentation
      名古屋
    • Year and Date
      2009-11-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] The Status on the Development of an Accelerator-based BNCT System in Japan2009

    • Author(s)
      古林徹
    • Organizer
      Neutrons for therapy sat. meeting of NEUDOS-11
    • Place of Presentation
      Cape Town
    • Year and Date
      2009-10-12
    • Related Report
      2010 Final Research Report
  • [Presentation] 加速器BNCT照射システム開発の経緯と今後2009

    • Author(s)
      古林徹
    • Organizer
      第6回日本中性捕捉療法学会
    • Place of Presentation
      京都
    • Year and Date
      2009-09-20
    • Related Report
      2010 Final Research Report
  • [Presentation] 加速器中性子捕捉療法用液体リチウム液膜流ターゲットの開発(1) 水液膜流模擬試験2009

    • Author(s)
      中塚雅士、Teddy Ardiansyah、高橋実、中川順達、古林徹
    • Organizer
      原子力学会2009分科会
    • Place of Presentation
      仙台
    • Year and Date
      2009-09-17
    • Related Report
      2010 Final Research Report
  • [Presentation] 陽子線加速器中性子によるホウ素中性子捕捉療法(BNCT)2009

    • Author(s)
      古林徹、田中憲一、ジェラード・ベングア、服部俊幸、林崎規託、高橋実、片淵竜也
    • Organizer
      原子力学会・加速器・ビーム利用部会企画セッション
    • Place of Presentation
      仙台
    • Year and Date
      2009-09-17
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 加速器中性子捕捉療法用液体リチウム液膜流ターゲットの開発(1)水液膜流模擬試験2009

    • Author(s)
      中塚雅士、Teddy Ardiansyah、高橋実、中川順達、古林徹
    • Organizer
      原子力学会2009秋の分科会
    • Place of Presentation
      仙台
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 加速器BNCTターゲット兼冷却材用リチウム液幕噴流の基本的安定性2009

    • Author(s)
      中川順達、古林徹、高橋実、有富正憲
    • Organizer
      日本機械学会2009年会
    • Place of Presentation
      岩手
    • Year and Date
      2009-09-14
    • Related Report
      2010 Final Research Report
  • [Presentation] 加速器BNCTターゲット兼冷却材用リチウム液幕噴流の基本的安定性2009

    • Author(s)
      中川順達、古林徹、高橋実、有富正憲
    • Organizer
      日本機械学会
    • Place of Presentation
      岩手
    • Year and Date
      2009-09-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] 加速器BNCTターゲット兼冷却材用液体リチウムの流動様式2009

    • Author(s)
      中川順達、古林徹、高橋実、有富正憲
    • Organizer
      日本混相流学会2009年会
    • Place of Presentation
      熊本
    • Year and Date
      2009-08-09
    • Related Report
      2010 Final Research Report
  • [Presentation] 加速器BNCTターゲット兼冷却材用液体リチウムの流動様式2009

    • Author(s)
      中川順達、古林徹、高橋実、有富正憲
    • Organizer
      混相流学会年会
    • Place of Presentation
      熊本
    • Year and Date
      2009-08-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] BNCT using the Near Threthold ^7Li(p,n)^7Be with Thick Li-Target2009

    • Author(s)
      T.Kobayashi, G.Bengua, K.Tanaka
    • Organizer
      NEUDOS-11
    • Place of Presentation
      Cape Town
    • Related Report
      2010 Final Research Report
  • [Presentation] Neutrons for BNCT from the Near Threshold 7Li (p, n) 7Be on a Thick Li-target2008

    • Author(s)
      T. Kobayashi, G. Bengua, K. Tanaka
    • Organizer
      13th International Conference on Neutron Capture Therapy
    • Place of Presentation
      Florence (Italy)
    • Year and Date
      2008-11-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] Beam shaping assembly with thick liquid lithium target for neutron production in BNCT2008

    • Author(s)
      G. Bengua, T. Kobayashi, K. Tanaka, M. Ishikawa
    • Organizer
      13th International Conference on Neutron Capture Therapy
    • Place of Presentation
      Florence (Italy)
    • Year and Date
      2008-11-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] 加速器BNCT照射システムの現状と見通し2008

    • Author(s)
      古林徹
    • Organizer
      第5回日本中性捕捉療法学会
    • Place of Presentation
      倉敷
    • Year and Date
      2008-07-25
    • Related Report
      2010 Final Research Report
  • [Presentation] Beam Shaping Assembly with Thick Liquid Lithium Target for Neutron Production in BNCT2008

    • Author(s)
      G.Bengua, T.Kobayashi, K.Tanaka, M.Ishikawa
    • Organizer
      13th ICNCT
    • Place of Presentation
      Florence
    • Related Report
      2010 Final Research Report
  • [Presentation] Neutrons for BNCT from the Near Threshold ^7Li(p,n)^7Be on a Thick Li-target2008

    • Author(s)
      T.Kobayashi, G.Bengua, K.Tanaka
    • Organizer
      13th ICNCT
    • Place of Presentation
      Florence
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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