|Budget Amount *help
¥28,860,000 (Direct Cost: ¥22,200,000、Indirect Cost: ¥6,660,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2009: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2008: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
We evaluated the effect of a stress management program using the work-environment improvement approach on psychological distress with a controlled trial design, and the effect of an Internet-based cognitive behavioral therapy (CBT) program on depression with a randomized controlled trial design among workers. We also investigated the effect of a CBT on activity (blood flow) of frontal brain measured by brain imaging technique, and the differential effect by serotonin transporter polymorphism. The stress management program using the work-environment improvement approach failed to show a significant intervention effect on psychological distress. The Internet-based CBT program showed a significant intervention effect on depression at six-month follow-up and significantly lower incidence of major depression at 12-month follow-up in the intervention group than the control group. The CBT program showed a non-significant, but slightly increased activity of frontal brain of the participants. No clear differential effect of the CBT program by serotonin transporter polymorphism was found.