放射線、化学物質の継世代的(遺伝的)影響-マイクロサテライト突然変異誘発と疾病

• Project/Area Number: 20241014
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: National Institute of Biomedical Innovation
• Principal Investigator: NOMURA Taisei National Institute of Biomedical Innovation, 難病・疾患資源研究所, プロジェクトリーダー (90089871)
• Co-Investigator(Kenkyū-buntansha): RYO Haruko 独立行政法人医薬基盤研究所, プロジェクトサブリーダー (90301267) ; ADACHI Shigeki 独立行政法人医薬基盤研究所, 特任研究員 (60379261) ; FUJIKAWA Kazuo 近畿大学, 理工学部, 教授 (90247958) ; HONGYO Tadashi 大阪大学, 大学院・医学系研究科, 准教授 (90271569) ; NAKAJIMA Hiroo 大阪大学, 大学院・医学系研究科, 助教 (20237275) ; OKUMURA Meinosin 大阪大学, 大学院・医学系研究科, 教授 (40252647)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥50,050,000 (Direct Cost: ¥38,500,000、Indirect Cost: ¥11,550,000); Fiscal Year 2010: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000); Fiscal Year 2009: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000); Fiscal Year 2008: ¥23,270,000 (Direct Cost: ¥17,900,000、Indirect Cost: ¥5,370,000)
• Keywords: 放射線・化学物質 / 継世代影響 / マイクロサテライト / 疾病 / 遺伝子発現 / 中性子線 / 白血病 / N5マウス / 環境 / 継世代的影響 / 疾患 / 突然変異 / 遺伝的不安定性 / マウス

Research Abstract

Microsatellite mutations increased almost linearly in the F1 offspring of adult N5 males exposed to nuclear radiations (neutron 0.2Gy/h + γ-rays 0.2Gy/h) at spermatogonia stages. Mutation was inherited as if Menderian inheritance. Its rate was 3.5 x 10^<-2>/Gy/locus and RBE was about 16. Leukemia and changes in gene expression were also inherited in the offspring.

Research Products

• [Journal Article] A rapid and easy method for the qualitative detection of intracellular 2 deposition of inhaled nanoparticles Nanomedicine (2011)
  • Author(s): H.Nakajima, K.Ozaki, T.Hongyo, I.Narama, T.Todo
  • Journal Title: E.Pub.
  • Peer Reviewed
• [Journal Article] Measurement of relative biological effectiveness of protons in human cancer cells using a laser-driven quasimonoenergetic proton beamline. (2011)
  • Author(s): Yogo A.(1番目), Nomura T.(17番目), Kondo K.(19番目)(19名)
  • Journal Title: APPLIED PHYSICS LETTERS 98 Pages: 53701-53701
  • Peer Reviewed
• [Journal Article] Biological Consequence and Health Concern from Low Dose and Low Dose Rate Radiations in Mice and Humans. (2011)
  • Author(s): Taisei Nomura.
  • Journal Title: Health Physics. 100 Pages: 266-268
  • Peer Reviewed
• [Journal Article] Excretion into feces of asialo GM1 in the murine digestive tract and Lactobacillus johnsonii exhibiting binding ability toward asialo GM1. A possible role of epithelial glycolipids in the discharge of intestinal bacteria. (2011)
  • Author(s): Iwamori M, Iwamori Y, Adachi S, Nomura T.
  • Journal Title: Glycoconj. J. 28 Pages: 21-30
  • Peer Reviewed
• [Journal Article] Excretion into feces of asialo GM1 in the murine digestive tract and Lactobacillus johnsonii exhibiting binding ability toward asialo GM1.A possible role of epithelial glycolipids in the discharge of intestinal bacteria. (2011)
  • Author(s): Iwamori M
  • Journal Title: Glycoconj.J. Volume: 28 Pages: 21-30
  • Peer Reviewed
• [Journal Article] Biological Consequence and Health Concern from Low Dose and Low Dose Rate Radiations in Mice and Humans. (2011)
  • Author(s): Taisei Nomura
  • Journal Title: Health Physics. Volume: 100 Pages: 266-268
  • Peer Reviewed
• [Journal Article] 宇宙環境の人体影響評価と防護に関する研究 (2011)
  • Author(s): 野村大成
  • Journal Title: Space Util.Res. Volume: 27 Pages: 107-110
  • NAID: 120006830344
  • Peer Reviewed
• [Journal Article] Measurement of relative biological effectiveness of protons in human cancer cells using a laser-driven quasimonoergetic proton beamline (2011)
  • Author(s): A.Yogo
  • Journal Title: APPLIED PHYSICS LETTERS Volume: 98 Pages: 53701-53701
  • Peer Reviewed
• [Journal Article] A rapid and easy method for the qualitative detection of intracellular deposition of inhaled nanoparticles. (2011)
  • Author(s): Nakajima H
  • Journal Title: Nanomedicine Volume: 6(in press)
  • Peer Reviewed
• [Journal Article] Effects of Fission Neutrons on Human Thyroid Tissues Maintained in SCID Mice. (2010)
  • Author(s): S.Adachi, H.Ryo, T.Hongyo, H.Nakajima, R.Tsuboi-Kikuya, Y.Tokita, F.Matsuzuka, K.Hiramatsu, K.Fujikawa, T.Itoh, T.Nomura
  • Journal Title: Mutat Res. 696 Pages: 107-113
  • Peer Reviewed
• [Journal Article] No evidence of increased mutation rates at microsatellite loci in offspring of A-bomb survivors. (2010)
  • Author(s): M.Kodaira, H.Ryo, N.Kamada, K.Furukawa, N.Takahashi, H.Nakajima, T.Nomura, N.Nakamura
  • Journal Title: Radiat.Res. 173 Pages: 205-213
  • Peer Reviewed
• [Journal Article] Clinical outcome of resected solid-type small-sized c-stage IA non-small cell lung cancer (2010)
  • Author(s): Inoue M , Minami M, Sawabata N, Utsumi T, Kadota Y, Shigemura N, Okumura M
  • Journal Title: Eur J Cardiothorac Surg. 37 Pages: 1445-9
  • Peer Reviewed
• [Journal Article] Radiation dose-rate effect on mutation induction in spleen and liver of gtp delta mice. (2010)
  • Author(s): Okudaira, N.(1番目), Fujikawa K(3番目), T. Ono(16番目)(16名)
  • Journal Title: Radiation Res. 171 Pages: 136-147
  • Peer Reviewed
• [Journal Article] Effects of fission neutrons on human thyroid tissues maintained in SCID mice. (2010)
  • Author(s): Adachi, S.
  • Journal Title: Mutation Res. Volume: 696 Pages: 107-113
  • Peer Reviewed
• [Journal Article] Radiation dose-rate effect on mutation induction in spleen and liver of gtp delta mice. (2010)
  • Author(s): Okudaira, N.
  • Journal Title: Radiation Res. Volume: 171 Pages: 136-147
  • Peer Reviewed
• [Journal Article] Clinical outcome of resected solid-type small-sized c-stage IA non-small cell lung cancer. (2010)
  • Author(s): Masayoshi Inoue
  • Journal Title: European J.Cardio-thoracic Surgery Volume: 37 Pages: 1445-1449
  • Peer Reviewed
• [Journal Article] Optimal sampling methods for margin cytology examination following lung excision (2010)
  • Author(s): Tomoki Utsumi
  • Journal Title: Interactive Cardio-Vascular and Thoracic Surgery Volume: 10 Pages: 434-436
  • Peer Reviewed
• [Journal Article] No evidence of increased mutation rates at microsatellite loci in offspring of A-bomb survivors. (2010)
  • Author(s): M.Kodaira
  • Journal Title: Radiation Research 173 Pages: 205-213
  • Peer Reviewed
• [Journal Article] Effects of Fission Neutrons on Human Thyroid Tissues Maintained in SCID Mice. (2010)
  • Author(s): Shigeki Adachi
  • Journal Title: Mutation Research 696 Pages: 107-113
  • Peer Reviewed
• [Journal Article] 宇宙環境の人体影響評価(2009年度ワーキンググループ活動報告) (2010)
  • Author(s): 野村大成
  • Journal Title: Space Utilization Research 26 Pages: 249-251
  • NAID: 120006830483
  • Peer Reviewed
• [Journal Article] Optimal sampling methods for margin cytology examination following lung excision (2009)
  • Author(s): Utsumi T , Sawabata N, Inoue M, Okumura M
  • Journal Title: Interact Cardiovasc Thorac Surg. 2010(10) Pages: 434-6
  • Peer Reviewed
• [Journal Article] Distribution of receptor glycolipids for Lactobacilli in murine digestive tract and production of antibodies cross-reactive with them by immunization of rabbits with Lactobacilli. (2009)
  • Author(s): Iwamori M, Shibagaki T, Nakata Y, Adachi S, Nomura T.
  • Journal Title: J Biochem. 146(2) Pages: 185-91
  • NAID: 10026302610
  • Peer Reviewed
• [Journal Article] Rapid diagnosis of lymph node metastasis in lung cancer with loop-mediated isothermal amplification assay using. (2009)
  • Author(s): Maeda J, Inoue M, Nakabayashi K, Otomo Y, Shintani Y, Ohta M, Okumura M, Matsuura N.
  • Journal Title: Carcinoembryonic antigen-mRNA Lung cancer 65 Pages: 324-327
  • Peer Reviewed
• [Journal Article] Microdosimetry on a mini-reactor UTR-KINKI for educational uses and biological researches (2009)
  • Author(s): Endo, S., K.Tanaka, K.Fujikawa, T.Horiguchi, T.Itoh, Y.Onizuka, M.Hoshi, A.Murakata, Y.Kojima, K.Shizuma
  • Journal Title: Journal of Radiation Research 50 Pages: 83-87
  • NAID: 110007042072
  • Peer Reviewed
• [Journal Article] Distribution of receptor glycolipids for Lactobacilli in murine digestive tract and production of antibodies cross-reactive with them by immunization of rabbits with Lactobacilli. (2009)
  • Author(s): Iwamori M
  • Journal Title: J Biochem. 146(2) Pages: 185-191
  • Peer Reviewed
• [Journal Article] Microdosimetry on a mini-reactor UTR-KINKI for educational uses andbiological researches. (2009)
  • Author(s): Endo, S.
  • Journal Title: Journal of Radiation Research 50 Pages: 83-87
  • Peer Reviewed
• [Journal Article] WT1 IgG antibody for early detection of nonsmall cell lung cancer and as its prognostic factor. (2009)
  • Author(s): Oji Y
  • Journal Title: International J Cancer 125 Pages: 381-387
  • Peer Reviewed
• [Journal Article] Prognostic significance of heat shock protein 105 in lung adenocarcinoma. (2009)
  • Author(s): Oda T
  • Journal Title: Molecular Medicine 2 Pages: 603-607
  • Peer Reviewed
• [Journal Article] Expression of CUB domain containing protein(CDCP1)is correlated with prognosis and survival of patients with adenocarcinoma of lung. (2009)
  • Author(s): Ikeda J
  • Journal Title: Cancer Science 100(3) Pages: 429-433
  • Peer Reviewed
• [Journal Article] Tumorigenic role of orphan nuclear receptor NROB1 in lung adenocarcinoma. (2009)
  • Author(s): Oda T
  • Journal Title: American Journal of Pathology 175 Pages: 1235-1245
  • Peer Reviewed
• [Journal Article] Rapid diagnosis of lymph node metastasis in lung cancer with loop-mediated isothermal amplification assay using carcinoembryonic antigen-mRNA. (2009)
  • Author(s): Maeda J
  • Journal Title: Lung Cancer 65 Pages: 324-327
  • Peer Reviewed
• [Journal Article] Doubling time of lung cancer determined using three-dimensional volumetric software : Comparison of squamous cell carcinoma and adenocarcinoma. (2009)
  • Author(s): Honda O
  • Journal Title: Lung Cancer 66 Pages: 211-217
  • Peer Reviewed
• [Journal Article] Microdosimetry on a mini-reactor UTR-KINKI for educational uses and biological researches (2009)
  • Author(s): Endo, S.
  • Journal Title: Journal of Radiation Research 50 Pages: 83-87
  • Peer Reviewed
• [Journal Article] ヒト臓器・組織置換マウス等を用いた宇宙放射線の人体および継世代リスクの基礎評価 (2009)
  • Author(s): 野村大成
  • Journal Title: 第25回宇宙利用シンポジウム発表論文集 25 Pages: 42-45
  • NAID: 120006830504
  • Peer Reviewed
• [Journal Article] 宇宙環境の人体影響研究班ワーキンググループ報告 (2009)
  • Author(s): 野村大成
  • Journal Title: 第25回宇宙利用シンポジウム発表論文集 25 Pages: 46-48
  • Peer Reviewed
• [Journal Article] Experimental Derivation of Relative Biological Effectiveness of A-Bomb Neutrons in Hiroshima and Nagasaki and Implications for Risk Assessment. (2008)
  • Author(s): Sasaki, M.S., Nomura, T., Ejima, Y., Utsumi, H., Endo, S., Saito, I., Itoh, T., Hoshi, M.
  • Journal Title: Radiat. Res. 170 Pages: 101-117
  • Peer Reviewed
• [Journal Article] Differential radiation sensitivity to morphological, functional and molecular changes of human thyroid tissues and bone marrow cells maintained in SCID mice. (2008)
  • Author(s): T.Nomura, T.Hongyo, H.Nakajima, L.Y.Li, M.Syaifudin, S.Adachi, H.Ryo, R.Baskar, K.Fukuda, Y.Oka, H.Sugiyama, F.Matsuzuka.
  • Journal Title: Mutat Res. 657(1) Pages: 68-76
  • Peer Reviewed
• [Journal Article] Trangenerational effects from exposure to environmental toxic substance. (2008)
  • Author(s): T.Nomura
  • Journal Title: Mutat.Res.Rev. 659 Pages: 185-193
  • Peer Reviewed
• [Journal Article] Nasal NK/T-cell lymphoma : epidemiology and pathogenesis. (2008)
  • Author(s): K.Aozasa, T.Katakuwa, T.Hongyo, W-I.Yang
  • Journal Title: Int J Hematol 87 Pages: 110-117
  • NAID: 10021255347
  • Peer Reviewed
• [Journal Article] Heterologous carcinosarcoma of Douglas' pouch with adenocarcinomas of the fallopian tube and the peritoneal cavity (2008)
  • Author(s): T.R.Kataoka, H.Shinoda, M.Yanagawa, S.Kamiura, Y.Nishizawa, T.Hongyo
  • Journal Title: Pathology 40(6) Pages: 641-645
  • Peer Reviewed
• [Journal Article] Clinicopathologic factors influencing postoperative prognosis in patients with smallsized adenocarcinoma of the lung. (2008)
  • Author(s): I noue M, Takakura T, Minami M, Shiono H, Utsumi T, Kadota Y, Nasu T, Aozasa K, Okumura M.
  • Journal Title: J.Thorac Cardiovas.Surg. 135 Pages: 830-836
  • Peer Reviewed
• [Journal Article] Comparative susceptibility of kidney and gillcells of medaka fish (Oryzias latipes) to spontaneous and X-ray-induced micronucleus formation (2008)
  • Author(s): Takai, A., A.Kagawa, K.Fujikawa
  • Journal Title: Gene and Environment 30 Pages: 48-52
  • Peer Reviewed
• [Journal Article] Trangenerational effects from exposure to environmental toxic substance (2008)
  • Author(s): Taisei Nonura
  • Journal Title: Mutat. Res. Rev. 659 Pages: 185-193
  • Peer Reviewed
• [Journal Article] Differential radiation sensitivity to morphological, functional and molecular changes of human thyroid tissues and bone marrow cells maintained in SCID mice (2008)
  • Author(s): Taisei Nomura
  • Journal Title: Mutat Res. 657(1) Pages: 68-76
  • Peer Reviewed
• [Journal Article] Detection of occult lymph node metastasis in lung cancer patients using molecular technique : A review (2008)
  • Author(s): Inoue M.
  • Journal Title: Research Media 2 Pages: 141-149
  • Peer Reviewed
• [Journal Article] Clinicopathologic factors influencing postoperative prognosis in patients with small-sized adenocarcinoma of the lung (2008)
  • Author(s): Inoue M.
  • Journal Title: J Thorac Cardiovasc Surg 135 Pages: 830-836
  • Peer Reviewed
• [Journal Article] Comparative susceptibility of kidney and gill cells of medaka fish (Oryzias latipes) to spontaneous and X-ray-induced micronucleus formation (2008)
  • Author(s): Takai, A.
  • Journal Title: Gene and Environment 30 Pages: 48-52
  • Peer Reviewed
• [Journal Article] 原爆被爆者の子供におけるマイクロサテライト突然変異のスクリーニング (2008)
  • Author(s): 小平美江子
  • Journal Title: 長崎医学会雑誌(Nagasaki Med J) 83 Pages: 345-348
• [Presentation] Carcinogenicity of Urethane (Ethyl Carbamate) in Mice And Humans. (2010)
  • Author(s): Nomura T.
  • Organizer: 2nd Asian Conference on Environmental Mutagens
  • Place of Presentation: Pattaya, Thailand.
• [Presentation] Biological Consequences and Health Risk from Low and Low Dose Rate Radiation Exposures in Mice and Humans. (2010)
  • Author(s): Nomura T.
  • Organizer: LOWRAD 2010
  • Place of Presentation: Barcelona, Spain.
• [Presentation] Novel approach for detection of isolated tumor cells in pulmonary vein using negative selection method : morphological classification and clinical implications (2010)
  • Author(s): Okumura M
  • Organizer: EACTS Annual Meeting (24th)
  • Place of Presentation: Geneva, Swiss
• [Presentation] The use of Active Hexose Co-related Compound in the Treatment of Head & Neck Cancer Patients. (2010)
  • Author(s): Nomura T.
  • Organizer: The 18th International Congress on Nutrition and Integrative Medicine.
  • Place of Presentation: Sapporo, Japan.
• [Presentation] Biological Consequences and Health Concern from Low Dose and Low Dose Rate Radiations in Mice and Human Tissues. (2010)
  • Author(s): Nomura T.
  • Organizer: International workshop "Biological consequences and health risks of low-level exposure to ionizing radiation"
  • Place of Presentation: Richland, USA.
• [Presentation] Biological Consequences and Health Concern from Low Dose and Low Dose Rate Radiations in Mice and Human Tissues. (2010)
  • Author(s): Nomura T.
  • Organizer: International workshop "Biological consequences and health risks of low-level exposure to ionizing radiation"
  • Place of Presentation: Richland, USA
• [Presentation] The use of Active Hexose Co-related Compound in the Treatment of Head & Neck Cancer Patients. (2010)
  • Author(s): Parida D.K
  • Organizer: The 18^<th> International Congress on Nutrition and Integrative Medicine.
  • Place of Presentation: Sapporo
• [Presentation] Biological Consequences and Health Risk from Low and Low Dose Rate Radiation Exposures in Mice and Humans. (2010)
  • Author(s): Nomura T.
  • Organizer: LOWRAD 2010
  • Place of Presentation: Barcelona, Spain
• [Presentation] Carcinogenicity of Urethane (Ethyl Carbamate) in Mice And Humans. (2010)
  • Author(s): Nomura T.
  • Organizer: 2nd Asian Conference on Environmental Mutagens
  • Place of Presentation: Pattaya, Thailand
• [Presentation] scidマウスと野生型マウス系統におけるγ-H2AXフォーカス消長の比較 (2010)
  • Author(s): 中島裕夫
  • Organizer: 日本放射線影響学会第53回大会
  • Place of Presentation: 京都
• [Presentation] Differential Sensitivity of Mice and Human Tissues to Radiation Sources. (2009)
  • Author(s): Taisei Nomura.
  • Organizer: In : HIBMC/PMRC Joint Meeting
  • Place of Presentation: Tatsuno, Japan.
  • Year and Date: 2009-12-15
• [Presentation] Differential Sensitivity of Mice and Human Tissues to Radiation Sources. (2009)
  • Author(s): Taisei Nomura
  • Organizer: HIBMC/PMRC Joint Meeting
  • Place of Presentation: Tatsuno, Hyogo
  • Year and Date: 2009-12-15
• [Presentation] Surgical margin recurrence in cases of sublobar resection for small sized peripheral lung cancer (2009)
  • Author(s): Okumura M
  • Organizer: World Congress of Lung Cancer (13th)
  • Place of Presentation: San Francisco, USA.
• [Presentation] Isolated tumor cells in pulmonary vein blood of resected lung with non-small cell lung cancer: a pilot study of morphological qualification. (2009)
  • Author(s): Okumura M.
  • Organizer: World Congress of Lung Cancer (13th)
  • Place of Presentation: San Francisco, USA.
• [Presentation] Ecological decrease, biological concentration and genome stress of radionuclides in plants and animals after Chernobyl catastrophe. (2009)
  • Author(s): Nakajima H
  • Organizer: 10th International Conference on Environmental Mutagens (ICEM)
  • Place of Presentation: Firenze, Italy.
• [Presentation] Somatic stem cells of Atm-deficient mice are hypersensitive to X-rays for mutation but resistant for cell killing (2009)
  • Author(s): Fujikawa, K.
  • Organizer: The 10th International Conference on Environmental Mutagens
  • Place of Presentation: Firenze (Italy).
• [Presentation] Transgenerational health concerns from radiation in mice and humans. (2009)
  • Author(s): Taisei Nomura.
  • Organizer: In : The 15^<th> Alexander Hollaender Course ; Genome-Environment Interactions and Genetic Toxicology
  • Place of Presentation: Astana, Kazakhstan.
• [Presentation] Dietary Modulation to Prevent Cancer and Malformation in Mice. In : Dietary Modulation of Xenobiotics Transport and Metabolism. (2009)
  • Author(s): Taisei Nomura.
  • Organizer: 3rd Asian Pacific Regional Meeting of The International Society for the Study of Xenobiotics (ISSX)
  • Place of Presentation: Bangkok, Thailand.
• [Presentation] Trans-generational effects of Radiation and Chemicals on Mice and Men - Cancer, Malformation and Molecular Changes. In ; Mega-Science Symposium. (2009)
  • Author(s): Taisei Nomura.
  • Organizer: 96^<th> Indian Science Congress
  • Place of Presentation: Shillong, India.
• [Presentation] Dietary Modulation to Prevent Cancer and Malformation in Mice. In : Dietary Modulation of Xenobiotics Transvort and Metabolism. (2009)
  • Author(s): Taisei Nomura
  • Organizer: 3rd Asian Pacific Regional Meeting of The International Society for the Study of Xenobiotics(ISSX)
  • Place of Presentation: Bangkok, Thailand
• [Presentation] Transgenerational health concerns from radiation in mice and humans. (2009)
  • Author(s): Taisei Nomura
  • Organizer: The 15^<th> Alexander Hollaender Course ; Genome-Environment Interactions and Genetic Toxicology
  • Place of Presentation: Astana, Kazakhstan
• [Presentation] Ecological decrease, biological concentration and genome stress of radionuclides in plants and animals after Chernobyl catastrophe. (2009)
  • Author(s): H.Nakajima
  • Organizer: 10th International Conference on Environmental Mutagens(ICEM)
  • Place of Presentation: Firenze-Italy
• [Presentation] Trans-generational effects of Radiation and Chemicals on Mice and Men -Cancer, Malformation and Molecular Changes. In ; Mega-Science Symposium (2009)
  • Author(s): Taisei Nomura
  • Organizer: 96^<th> Indian Science Congress
  • Place of Presentation: Shillong
• [Presentation] 放射線の次世代への影響 (2008)
  • Author(s): 野村大成
  • Organizer: 原水禁世界大会・長崎大会
  • Place of Presentation: 長崎市
  • Year and Date: 2008-08-08
• [Presentation] Transgenerational (hereditary) effects of radiation in mice and humans - molecular changes and cancer induction in the progeny. (2008)
  • Author(s): Taisei Nomura.
  • Organizer: 6^<th> LOW RAD International Conference
  • Place of Presentation: Lisbon, Portugal.
• [Presentation] Transgenerational (hereditary) effects of radiation in mice and humans - molecular changes and cancer induction in the progeny (2008)
  • Author(s): Taisei Nomura
  • Organizer: 6^<th> LOW RAD International Conference
  • Place of Presentation: Lisbon
• [Book] Transgenerational health concerns from radiation in mice and humans. Astana : Eurasian National University Press. In : Bersimbay RI, Au W, eds. Genome-environment interactions and genetic toxicology. (2010)
  • Author(s): Nomura T.
  • Publisher: 15^<th> Alexander Hollaender Course
• [Book] 知っておいてほしいダウン症候群の成因、「ダウン症候群児・者のヘルスケアマネジメント」 (2010)
  • Author(s): 藤川和男(分担執筆)
  • Publisher: かもがわ出版
• [Book] Transgenerational health concerns from radiation in mice and humans."Genome-environment interactions and genetic toxicology." (2010)
  • Author(s): Nomura T.
  • Publisher: Eurasian National University Press
• [Book] ショウジョウバエの再発見 (2008)
  • Author(s): 藤川和男
  • Total Pages: 182
  • Publisher: サイエンス社
• [Remarks] 報道関連情報
• [Remarks] 野村大成、東奥日報、神戸新聞他20紙以上、「識者評論:農産物放射線汚染」、内部被曝の防止必要、正確な測定値と説明を、他、3月22日、23日 2011年。
• [Remarks] 野村大成、日経産業新聞、薬事日報 他4紙、「レーザー駆動陽子線、医薬基盤研などがん治療へ実験」 2010年6月29日-7月9日朝刊
• [Remarks] 野村大成 産経新聞(夕刊)2009年11月26日 "2012年宇宙の旅-三菱重が衛星計画- 任務 新薬開発のため無重力に耐えよ"
• [Remarks] 野村大成 日刊薬業 2009年11月27日"基盤研 創薬研究で来年度から新プロジェクト"
• [Remarks] 野村大成 日経産業 2009年11月30日"疾患モデル動物開発参加 食品なども対象に"