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Exposure assessment of polybrominated diphenyl ethers (PBDEs) to human newborns and development of evaluation method

Research Project

Project/Area Number 20241016
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Risk sciences of radiation/Chemicals
Research InstitutionChiba University

Principal Investigator

MORI CHISATO  Chiba University, 大学院・医学研究院, 教授 (90174375)

Co-Investigator(Kenkyū-buntansha) KOMIYAMA Masatoshi  千葉大学, 大学院・医学研究院, 准教授 (70175339)
TODAKA Emiko  千葉大学, 予防医学センター, 准教授 (30334212)
MATSUNO Yoshiharu  千葉大学, 予防医学センター, 准教授 (00376378)
深田 秀樹  千葉大学, 予防医学センター, 特任准教授 (00359598)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥27,430,000 (Direct Cost: ¥21,100,000、Indirect Cost: ¥6,330,000)
Fiscal Year 2010: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2009: ¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
Keywords臭素系難燃剤 / PBDE / PCB / 乳幼児 / 住環境 / 乳幼児期 / 臭素系化合物 / 室内汚染 / 臭素系化学物
Research Abstract

The purposes of this research were the exposure assessment of polybrominated diphenyl ethers (PBDEs) from the environment and the risk assessment of PBDEs on humans and animals.
The results of this study clarified : (a) the concentration level of PBDEs from electrical facilities indoor air, (b) exposure assessment of human blood samples of PBDEs, (c) risk using mice. These new findings will help to develop the environmental preventive medicine to decrease the risk by artificial chemicals on future generations.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (46 results)

All 2011 2010 2009 2008 Other

All Journal Article (17 results) (of which Peer Reviewed: 8 results) Presentation (25 results) Book (4 results)

  • [Journal Article] 化学物資の次世代への影響-長期晩発影響とエピジェネティック変異による影響-2010

    • Author(s)
      森千里
    • Journal Title

      保健の科学 52

      Pages: 15-19

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Journal Article] 臭素系難燃剤による胎児への影響に関する最近の知見2009

    • Author(s)
      川城由紀子、松野義晴、深田秀樹、森千里
    • Journal Title

      医学の歩み 228

      Pages: 785-786

    • Related Report
      2010 Final Research Report
  • [Journal Article] ケミレス"環境医学-化学物質を削減した社会づくりポリ塩化ビフェニル(PCB)を指標とした化学物質の健康診断と削減方法の開発2009

    • Author(s)
      深田秀樹、森千里
    • Journal Title

      医学の歩み 228

      Pages: 785-786

    • Related Report
      2010 Final Research Report
  • [Journal Article] Establishment of sustainable health science for future generations : from a hundred years ago to a hundred years in the future2009

    • Author(s)
      Mori C, Todaka E
    • Journal Title

      Environ. Health Prev.Med. 14

      Pages: 1-6

    • NAID

      10026957962

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 特集:子どもと環境化学物質-病が"プログラム"される可能性シックハウス症候群はなぜ滅らないか-解決の道筋をつけるために2009

    • Author(s)
      戸高恵美子、森千里
    • Journal Title

      科学 79

      Pages: 989-991

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 環境ホルモンの本質:未来世代への影響2009

    • Author(s)
      森千里
    • Journal Title

      Endocrine Disrupter News Letter 12

      Pages: 1-1

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 特集:小児疾患における臨床遺伝学進歩 環境と遺伝-エピジェネティック-2009

    • Author(s)
      深田秀樹、川城由紀子、松野義晴、森千里
    • Journal Title

      小児科 50

      Pages: 823-827

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 小児の複合汚染と予防的対策2009

    • Author(s)
      森千里
    • Journal Title

      化学物質と環境 96

      Pages: 13-14

    • Related Report
      2009 Annual Research Report
  • [Journal Article] "ケミレス"環境医学-化学物質を削減した社会づくり ポリ塩化ビフェニル(PCB)を指標とした化学物質の健康診断と削減方法の開発2009

    • Author(s)
      深田秀樹、森千里
    • Journal Title

      医学のあゆみ 228

      Pages: 776-770

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 臭素系難燃剤による胎児への影響に関する最近の知見2009

    • Author(s)
      川城由紀子、松野義晴、森千里
    • Journal Title

      医学のあゆみ 228

      Pages: 785-786

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Perinatal Exposure to Brominated Flame Retardants and Polychlorinated Biphenyls in Japan2008

    • Author(s)
      Kawashiro Y, Fukata H, Omori-Inoue M, Kubonoya K, Jotaki T, Takigami H, Sakai S, Mori C
    • Journal Title

      Endocrine Journal 55

      Pages: 1071-1084

    • NAID

      10023973225

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Strong correlation between the concentration of dioxins and total PCBs in current Japanese people2008

    • Author(s)
      Mori C, Fukata H, Sakurai K, Jotaki T, Todaka E, Saito Y
    • Journal Title

      Chemosphere 73

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of high-dose exposure to polybrominated dipheny l ethers on human umbilical vein endothelal cells: analysis by microarray technique.2008

    • Author(s)
      Kawashiro Y, Fukata H, Sato K, Takigami H, Aburatani H and Mori C
    • Journal Title

      Persistent Organic Pollutants (POPs) Research in Asia

      Pages: 126-131

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Perinatal Exposure to Brominated Flame Retardants and Polyclilorinated Biphenyls in Japan.2008

    • Author(s)
      Kawashiro Y, Fukata H, Omori-Inoue M, Kubonoya. K, Jotaki T, Takigami H, Sakai S and Mori C
    • Journal Title

      Endocrine Journal, 55 55

      Pages: 1071-1084

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Strong correlation between the concentration of dioxins and total PCBs in current Japanese people.2008

    • Author(s)
      Mori c, Fukata H, Sakurai K, Jotaki T,Todaka E and Saito Y
    • Journal Title

      Chemosphere 73

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New point for evaluation of environmental pollutants including endocrine disrupting chemicals and polybrominated diphenyl ethers (PBDEs) on male reproductive system

    • Author(s)
      C.Mori, H.Miyaso, N.Nakamura, Y.Matsuno Y, E.Todaka
    • Journal Title

      Proceeding book of the 11th International symposium on Spermatology (in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] New point for evaluation of environmental pollutants includin gendocrine disrupting chemicals and polybrominated diphenyl ethers(PBDEs) on male reproductive system.

    • Author(s)
      C.Mori, H.Miyaso, N.Nakamura, Y.Matsuno Y, E.Todaka
    • Journal Title

      Proceeding book of the 11th International symposium on Spermatology

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Correlation between Polybrominated Diphenyl Ethers (PBDEs) and Persistent Organic Pollutants (POPs) or Heavy Metals Detected in Umbilical Cords2011

    • Author(s)
      Y.Igoshi, S.Ochiail, E.Todaka, Y.Matsuno, N.Shimojo, Y.Kohno, C.Mori
    • Organizer
      50^<th> Anniversary Annual Meeting & ToxExpo
    • Place of Presentation
      Washington, D.C.USA
    • Year and Date
      2011-03-09
    • Related Report
      2010 Final Research Report
  • [Presentation] Correlation between Polybrominated Diphenyl Ethers (PBDEs) and Persistent Organic Pollutants (POPs) or Heavy Metals Detected in Umbilical Cords2011

    • Author(s)
      Y.Igoshi, S.Ochiail, E.Todaka, Y.Matsuno, N.Shimojo, Y.Kohno, C.Mori
    • Organizer
      50th Anniversary Annual Meeting & ToxExpo
    • Place of Presentation
      Washington, D.C.USA
    • Year and Date
      2011-03-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] The Effect of Neonatal Exposure to Deca-Brominated Diphenyl Ether on Apical Ectoplasmic Specialization Mouse Testis2011

    • Author(s)
      H.Miyaso, Y.Matsuno, M.Komiyama, S.Ochiai, Y.Igoshi, C.Mori
    • Organizer
      50^<th> Anniversary Annual Meeting & ToxExpo
    • Place of Presentation
      Washington, D.C.USA
    • Year and Date
      2011-03-07
    • Related Report
      2010 Final Research Report
  • [Presentation] Analysis Transfer Rate of Congeners of PCBs and OH-PCBS From Mother to Fetus Through Placenta in Human2011

    • Author(s)
      C.Mori, E.Todaka, Y.Matsuno, T.Fujisaki, M.Shimoda, H.Nakaoka, M.Hanazato
    • Organizer
      50^<th> Anniversary Annual Meeting & ToxExpo
    • Place of Presentation
      Washington, D.C.USA
    • Year and Date
      2011-03-07
    • Related Report
      2010 Final Research Report
  • [Presentation] The Effect of Neonatal Exposure to Deca-Brominated Diphenyl Etheron Apical Ectoplasmic Specialization Mouse Testis2011

    • Author(s)
      H.Miyaso, Y.Matsuno, M.Komiyama, S.Ochiai, Y.Igoshi, C.Mori
    • Organizer
      50th Anniversary Annual Meeting & ToxExpo
    • Place of Presentation
      Washington, D.C.USA
    • Year and Date
      2011-03-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Analysis Transfer Rate of Congeners of PCBs and OH-PCBS From Mother to Fetus Through Placenta in Human2011

    • Author(s)
      C.Mori, E.Todaka, Y.Matsuno, T.Fujisaki, M.Shimoda, H.Nakaoka, M., Hanazato
    • Organizer
      50th Anniversary Annual Meeting & ToxExpo
    • Place of Presentation
      Washington, D.C.USA
    • Year and Date
      2011-03-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Current fetal exposure level of endocrine disruptors, heavy metals and brominated flame retardants in Japan2010

    • Author(s)
      C.Mori, Y.Matsuno, H.Nakaoka, M.Hanazato, E.Todaka
    • Organizer
      ISES-ISEE 2010
    • Place of Presentation
      Invited, Seoul, Korea
    • Year and Date
      2010-08-30
    • Related Report
      2010 Final Research Report
  • [Presentation] Current fetal exposure level of endocrine disruptors, heavy metals and brominated flame retardants in Japan(Invited)2010

    • Author(s)
      C.Mori, Y.Matsuno, H.Nakaoka, M.Hanazato, E.Todaka
    • Organizer
      ISES-ISEE 2010
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2010-08-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cohort study on infant atopic dermatitis and fetal exposure to persistent organic pollutants (POPs), heavy metals and brominated flame retardants (BFRs)2010

    • Author(s)
      C.Mori, E.Todaka, Y.Matsuno, H.Nakaoka, M.Hanazato, S. Suzuki, N.Shimojo, Y.Kono
    • Organizer
      The Power of Programming
    • Place of Presentation
      Munchen, Germany
    • Year and Date
      2010-05-07
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Concentrations of the total PBDEs in Japanese human blood2010

    • Author(s)
      Y.Matsuno, H.Fukata, Y Kawashiro, H.Takigami, H.Nakaoka, E Todaka, C.Mori
    • Organizer
      5th International Symposium on Brominated Flame Retardants (BFR2010)
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-04-08
    • Related Report
      2010 Final Research Report
  • [Presentation] Concentrations of the total PBDEs in Japanese human blood2010

    • Author(s)
      Y.Matsuno, H.Fukata, Y Kawashiro, H.Takigami, H.Nakaoka, E Todaka, C.Mori.
    • Organizer
      5th International Symposium on Brominated Flame Retardants (BFR2010).
    • Place of Presentation
      Kkyoto, Japan
    • Year and Date
      2010-04-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Association between exposure to organochlorines and the occurrence of atopic dermatitis in Japanese infant2009

    • Author(s)
      C.Mori
    • Organizer
      ISES 2009 annual conference : transforming exposure science in the 21st century
    • Place of Presentation
      Minneapolis, Minnesota, USA
    • Year and Date
      2009-11-02
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Application of health examination system of total PCBs to prevental prenatal and lactational exposure of persistent organic polutants (POPs)2009

    • Author(s)
      C.Mori, H.Fukata
    • Organizer
      3rd WHO international conference on children's health and the environment
    • Place of Presentation
      Busan, Korea
    • Year and Date
      2009-06-08
    • Related Report
      2010 Final Research Report
  • [Presentation] Recent findings on effects of chemical exposure to children's health.2009

    • Author(s)
      C.Mori
    • Organizer
      KIDS workshop 2009 in NIRS
    • Place of Presentation
      Chiba, Japan
    • Related Report
      2009 Annual Research Report
  • [Presentation] Exposure assessment of PCBs in the current Japanese people2009

    • Author(s)
      C.Mori
    • Organizer
      ISES 2009 annual conference : transforming exposure science in the 21st century
    • Place of Presentation
      Minneapolis, Minnesota, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] Comparison of the blood levels of PCBs between fetuses and infants with longer lactational period in Japan2009

    • Author(s)
      C.Mori, H.Fukata
    • Organizer
      46th Congress of the European societies of toxicology
    • Place of Presentation
      Dresden, Germany
    • Related Report
      2009 Annual Research Report
  • [Presentation] Application of health examination system of total PCBs to prevental prenatal and lactational exposure of presistent organic polutants(POPs).2009

    • Author(s)
      C.Mori, H.Fukata
    • Organizer
      3rd WHO international conference on children's health and the environment
    • Place of Presentation
      Dresden, Germany
    • Related Report
      2009 Annual Research Report
  • [Presentation] 胎児の複合汚染とアレルギー疾患との関連、そして次世代の健康を守るための化学物質の健康診断システム(シンポジウム「子どもと免疫」)2009

    • Author(s)
      森千里
    • Organizer
      第16回日本免疫毒性学会学術学会
    • Place of Presentation
      旭川、北海道
    • Related Report
      2009 Annual Research Report
  • [Presentation] 小児の有機塩素系化学物質曝露とアレルギー疾患との関連性について2009

    • Author(s)
      深田秀樹、鈴木修一、下條直樹、河野陽一、森千里
    • Organizer
      第18回日本臨床環境医学会学術集会
    • Place of Presentation
      岡山、岡山
    • Related Report
      2009 Annual Research Report
  • [Presentation] Occurrence and control strategy of POPs-Japan experience2008

    • Author(s)
      Mori C, Todaka E
    • Organizer
      2008 Conference on persistent organic pollutants and dioxin
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2008-09-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Occurrence and control strategy of POPs ' Japan experience.2008

    • Author(s)
      Mori c, Todaka E
    • Organizer
      2008 Conference on persistent organic pollutants and dioxin
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2008-09-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] Current exposure level of total PCBs of Japanese people from newborn to 80 years old.2008

    • Author(s)
      Mori c, Fukata H
    • Organizer
      ISEE-EAC 2008
    • Place of Presentation
      Jeju, Korea
    • Related Report
      2008 Annual Research Report
  • [Presentation] 予防医学推進のための日本人の蓄積性化学物質への曝露実態の調査・解析2008

    • Author(s)
      深田秀樹, 角田和彦, 川城由紀子, 松野義晴, 森千里
    • Organizer
      第17回日本臨床環境医学会学術集会
    • Place of Presentation
      旭川市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 合成エストロゲンに曝露されたマウス雄胎児の精巣生殖細胞におけるDNAメチル化酵素遺伝子の発現2008

    • Author(s)
      小野田訓子, 長尾哲二, 森千里
    • Organizer
      日本環境変異原学会第37回大会
    • Place of Presentation
      宜野湾市
    • Related Report
      2008 Annual Research Report
  • [Presentation] ポリ塩化ビフェニル(PCBs)がヒト臍帯静脈平滑筋細胞(HUVSMCs)の遺伝子発現に及ぼす影響2008

    • Author(s)
      森可奈, 川城由紀子, 深田秀樹, 松野義晴, 滝上英孝, 油谷浩幸, 森千里
    • Organizer
      環境ホルモン学会第11回研究発表会
    • Place of Presentation
      千代田区
    • Related Report
      2008 Annual Research Report
  • [Book] Environmental contaminants and children's health Sustainable health science for future generations2011

    • Author(s)
      森千里, 戸高恵美子
    • Total Pages
      133
    • Publisher
      MARUZEN PLANET Co.,Ltd.
    • Related Report
      2010 Final Research Report
  • [Book] Environmental contaminants and children's health (Sustainable health science for future generations)2011

    • Author(s)
      C.Mori, E.Todaka
    • Total Pages
      133
    • Publisher
      MARUZEN PLANET Co., Ltd.
    • Related Report
      2010 Annual Research Report
  • [Book] 見直されたレジン(陰イオン交換樹脂)-その位置づはと使い方Topics陰イオン交換樹脂による体内ダイオキシン類・PCBs削減の試み2010

    • Author(s)
      持田陽司、森千里
    • Total Pages
      113
    • Publisher
      フジメディカル出版(担当89-95)
    • Related Report
      2009 Annual Research Report
  • [Book] へその緒が語る体内汚染-未来世代を守るために-2008

    • Author(s)
      森千里、戸高恵美子
    • Total Pages
      207
    • Publisher
      技術評論社
    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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