Construction of large-scale two-dimensional aperiodic address-space patters on heat-resistant periodic DNA arrays

• Project/Area Number: 20241029
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Nanomaterials/Nanobioscience
• Research Institution: The University of Tokyo
• Principal Investigator: SUYAMA Akira The University of Tokyo, 大学院・総合文化研究科, 教授 (90163063)
• Co-Investigator(Kenkyū-buntansha): FUJIMOTO Kenzo 北陸先端科学技術大学院大学, マテリアルサイエンス研究科, 教授 (90293894)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥50,310,000 (Direct Cost: ¥38,700,000、Indirect Cost: ¥11,610,000); Fiscal Year 2010: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000); Fiscal Year 2009: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000); Fiscal Year 2008: ¥34,190,000 (Direct Cost: ¥26,300,000、Indirect Cost: ¥7,890,000)
• Keywords: DNAナノテクノロジー / DNAデバイス / DNAアレイ / セルフアセンブリ / ナノテクノロジー / ナノデバイス / ボトムアップ / DNA光クロスリンク / フォトライゲーション

Research Abstract

For the production of nano-devices and functional materials DNA nanostructures constructed by self-assembly of DNA strands are promising scaffolds to control positioning of very small parts with nanometer-scale precision. We have developed a method for programmable construction of DNA scaffolds that have large-scale two-dimensional aperiodic address-space patterns on heat-resistant periodic DNA tile arrays.

Research Products

• [Journal Article] Rigid DNA scaffolds stabilized by photo-cross-linking reaction. (2011)
  • Author(s): M.Tagawa, K.Shoda, K.Fujimoto, A.Suyama
  • Journal Title: Small (to be submitted)
  • Peer Reviewed
• [Journal Article] AFM imaging on DNA double strands in DNA nanostructures (2011)
  • Author(s): S.Tanaka, M.Tagawa, K.Suzuki, S.Kitamura, A.Suyama
  • Journal Title: Nano Letter (to be submitted)
  • Peer Reviewed
• [Journal Article] Photoreversible DNA end capping for the formation of hairpin structures (2010)
  • Author(s): Y.Yoshimura, H.Okada, K.Fujimoto
  • Journal Title: Organic & Biomolecular Chemistry Vol.8 Pages: 1523-1526
  • Peer Reviewed
• [Journal Article] Photoreversible DNA end capping for the formation of hairpin structures (2010)
  • Author(s): Y.Yoshimura, H.Okada, K.Fujimoto
  • Journal Title: Organic & Biomolecular Chemistry 8 Pages: 1523-1526
  • Peer Reviewed
• [Journal Article] A new approach for reversible RNA Photoctosslinking reaction application to sequence-specific RNA selection (2009)
  • Author(s): Y.Yoshimura, H.Okada, K.Fujimoto
  • Journal Title: ChemBioChem Vol.8 Pages: 1473-1476
  • Peer Reviewed
• [Journal Article] A new approach for reversible RNA photocrosslinking reaction : application to sequence-specific RNA selection (2009)
  • Author(s): Y.Yoshimura, T.Ohtake, H.Okada, K.Fujimoto
  • Journal Title: ChemBioChem 10 Pages: 1473-1476
  • Peer Reviewed
• [Journal Article] Programmable self-assembly for the construction of aperiodic address space on heat-resistant periodic DNA array (2008)
  • Author(s): M.Tagawa, K.Shohda, A.Suyama
  • Journal Title: Proceeding of The 5^<th> Annual Conference on Foundation of Nanoscience : Self-assembled Architectures and Devices Pages: 152-153
  • Peer Reviewed
• [Journal Article] Ultrafast reversible photo-cross-linking reaction : Toward in situ DNA manipulation (2008)
  • Author(s): Y.Yoshimura, K.Fujimoto
  • Journal Title: Organic Letters Vol.10 Pages: 3227-3230
  • Peer Reviewed
• [Journal Article] Programmable self-assembly for the construction of aperiodic address space on heat-resistant periodic DNA array. (2008)
  • Author(s): M. Tagawa, K. Shoda, and A. Suyama
  • Journal Title: Proceeding of The 5th Annual Conference on Foundations of Nanoscience: Self-assembled Architectures and Devices Pages: 152-153
  • Peer Reviewed
• [Journal Article] Ultrafast reversible photo-cross-linking reaction: Toward in situ DNA manipulation (2008)
  • Author(s): Y. Yoshimura and K. Fujimoto
  • Journal Title: Organic Letters 10 Pages: 3227-3230
  • Peer Reviewed
• [Presentation] AFM Imaging on Double Stranded Structures of Algorithmically Assembled DNA Tiles in Liquid (2010)
  • Author(s): S.Tanaka, M.Tagawa, K.Suzuki, S.Kitamura, A.Suyama
  • Organizer: 18th International Colloquium on Scanning ProbeMicroscopy
  • Place of Presentation: 伊豆熱川
  • Year and Date: 2010-12-10
• [Presentation] AFM Imaging on Double Stranded Structures of Algorithmically Assembled DNA Tiles in Liquid (2010)
  • Author(s): S.Tanaka, M.Tagawa, K.Suzuki, S.Kitamura, A.Suyama
  • Organizer: 18th International Colloquium on Scanning Probe Microscopy
  • Place of Presentation: 伊豆熱川(熱ッハイツ)
  • Year and Date: 2010-12-10
• [Presentation] Non-periodic and large-scale two-dimensional nano-patterns constructed on periodic DNA tile arrays (2010)
  • Author(s): K.Ara, M.Tagawa, K.Shoda, K.Fujimoto, A.Suyama
  • Organizer: 第48回日本生物物理学会年会
  • Place of Presentation: 仙台
  • Year and Date: 2010-09-21
• [Presentation] Non periodic and large-scale two-dimensional nano-patterns constructed on periodic DNA file arrays. (2010)
  • Author(s): K.Ara, M.Tagawa, K.Shoda, K;Fujimoto, A.Suyama
  • Organizer: 第48回日本生物物理学会年会
  • Place of Presentation: 仙台(東北大学)
  • Year and Date: 2010-09-21
• [Presentation] Autonomous molecular computer with DNA and RNA put in the right place (2010)
  • Author(s): 陶山明
  • Organizer: 16th International Conference on DNA Computing and Molecular Programming
  • Place of Presentation: Hong Kong, China
  • Year and Date: 2010-06-16
• [Presentation] Autonomous molecular computer with DNA and RNA put in the right place. (2010)
  • Author(s): A.Suyama
  • Organizer: 16th International Conference on DNA Computingand Molecular Programming
  • Place of Presentation: Hong Kong, China
  • Year and Date: 2010-06-16
• [Presentation] 光応答能を有する核酸誘導体によるプログラマブルなナノシステムの創製 (2009)
  • Author(s): 藤本健造
  • Organizer: 高分子討論会2009
  • Place of Presentation: 熊本
  • Year and Date: 2009-09-17
• [Presentation] 光応答能を有する核酸誘導体によるプログラマブルなナノシステムの創製 (2009)
  • Author(s): 藤本健造
  • Organizer: 高分子討論会2009
  • Place of Presentation: 熊本大学
  • Year and Date: 2009-09-17
• [Presentation] Autonomous DNA computer and its application to genetic diagnosis, gene network (2009)
  • Author(s): 陶山明
  • Organizer: Ecole de Physique des Houches-Physics od DNA Assembly
  • Place of Presentation: Les Houches, France
• [Presentation] Autonomous DNA computer and its application to genetic diagnosis, gene networl (2009)
  • Author(s): Akira Suyama
  • Organizer: Ecole de Physique des Houches-Physics of DNA Assembly
  • Place of Presentation: Les Houches, France
• [Presentation] ナノ部品のプログラム可能なセルフアセンブリのための二次元DNAアレイの構築 (2008)
  • Author(s): 田川美穂、大谷直、庄田耕一郎、陶山明
  • Organizer: 第46回日本生物物理学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2008-12-03
• [Presentation] ナノ部品のプログラム可能なセルフアセンブリのための二次元DNAアレイの構築 (2008)
  • Author(s): 田川美穂,大谷直,庄田耕一郎,陶山明
  • Organizer: 第46回日本生物物理学会年会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2008-12-03
• [Presentation] Nanodevice gene (2008)
  • Author(s): 陶山明
  • Organizer: 4^<th> Handai Nanoscience and Nanotechnology International Symposium
  • Place of Presentation: 大阪
  • Year and Date: 2008-09-30
• [Presentation] Nanodevice gene (2008)
  • Author(s): Akira Suyama
  • Organizer: 4th Handai Nanoscience and Nanotechnology International Symposium
  • Place of Presentation: 大阪大学
  • Year and Date: 2008-09-30