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Investigation of Rapid and Continuous Separation Principle for Micro/Nano Structures Using Hydrodynamic Methods

Research Project

Project/Area Number 20241031
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Microdevices/Nanodevices
Research InstitutionChiba University

Principal Investigator

SEKI Minoru  千葉大学, 大学院・工学研究科, 教授 (80206622)

Co-Investigator(Renkei-kenkyūsha) KUSHIDA Masato  千葉大学, 大学院・工学研究科, 准教授 (70177989)
YAMADA Masumi  千葉大学, 大学院・工学研究科, 特任准教授 (30546784)
Project Period (FY) 2008 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥50,310,000 (Direct Cost: ¥38,700,000、Indirect Cost: ¥11,610,000)
Fiscal Year 2011: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
Fiscal Year 2009: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2008: ¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000)
Keywords分離工学 / 微粒子分級 / 流体素子 / セルソーター / マイクロ流体工学 / 血液分析 / マイクロ・ナノデバイス / 細胞解析 / 血球分離 / マイクロスフィア / 液滴 / マイクロフルイディクス
Research Abstract

Novel hydrodynamic separation/classification principles using micro/nano-fluidic devices (PFF and HDF) were proposed for collecting uniform micro/nano structures such as particles, biological cells, droplets, bubbles, or supra-molecules with the diameter from sub-micron to several tens of microns. In this study, the mechanisms of the proposed separation schemes and the limit of application were investigated and clarified. And also, various separation systems using PFF or HDF methods were examined. Future applications in various basic studies and industrial fields are expected.

Report

(6 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (124 results)

All 2012 2011 2010 2009 2008 Other

All Journal Article (30 results) (of which Peer Reviewed: 28 results) Presentation (78 results) Book (10 results) Remarks (1 results) Patent(Industrial Property Rights) (5 results)

  • [Journal Article] Isolation of Cell Nuclei in Microchannels by Short-term Chemical Treatment via Two-Step Carrier Medium Exchange2012

    • Author(s)
      K. Toyama, M. Yamada, M. Seki
    • Journal Title

      Biomedical Microdevices

      Volume: 14 Issue: 4 Pages: 751-757

    • DOI

      10.1007/s10544-012-9653-8

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Generation of Uniform-Size Droplets by Multistep Hydrodynamic Droplet Division in Microfluidic Circuits2012

    • Author(s)
      T. Moritani, M. Yamada, M. Seki
    • Journal Title

      Microfluidics and Nanofluidics

      Volume: 11 Issue: 5 Pages: 601-610

    • DOI

      10.1007/s10404-011-0826-1

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fluidic Shear-Assisted Formation of Actuating Multilamellar Lipid Tubes Using Microfabricated Nozzle Array Device2012

    • Author(s)
      M. Masubuchi, T. Toyota, M. Yamada, M. Seki
    • Journal Title

      Chemical Communications

      Volume: 47 Issue: 29 Pages: 8433-8455

    • DOI

      10.1039/c1cc11510c

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Microfluidic Counterflow Centrifugal Elutriation System for Sedimentation-based Cell Separation2012

    • Author(s)
      T.Morijiri, M.Yamada, T.Hikida, M.Seki
    • Journal Title

      Microfluidics and Nanofluidics

      Volume: 12(印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blood Cell Classification Utilizing Hydrodynamic Filtration2011

    • Author(s)
      M. Matsuda, M. Yamada, M. Seki
    • Journal Title

      Electronics and Communications in Japan

      Volume: 94 Issue: 1 Pages: 1-6

    • DOI

      10.1002/ecj.10281

    • NAID

      10024471301

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sedimentation Pinchedflow Fractionation for Size and Densitybased Particle Sorting in Microchannels2011

    • Author(s)
      T. Morijiri, S. Sunahiro, M. Senaha, M. Yamada, M. Seki
    • Journal Title

      Microfluidics and Nanofluidics

      Volume: 11 Issue: 1 Pages: 105-110

    • DOI

      10.1007/s10404-011-0785-6

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Observation of Non-spherical Particle Behaviors for Continuous Shape-based Separation Using Hydrodynamic Filtration2011

    • Author(s)
      S. Sugaya, M. Yamada M. Seki
    • Journal Title

      Biomicrofluidics

      Volume: 5 Issue: 2

    • DOI

      10.1063/1.3580757

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Observation of Non-spherical Particle Behaviors for Continuous Shape-based Separation Using Hydrodynamic Filtration2011

    • Author(s)
      S.Sugaya, M.Yamada, M.Seki
    • Journal Title

      Biomicroluidics 5(in press)

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Blood Cell Classification Utilizing Hydrodynamic Filtration2011

    • Author(s)
      Miyuki Matsuda, Masumi Yamada, Minoru Seki
    • Journal Title

      Electronics and Communications in Japan

      Volume: 94(1) Pages: 1-6

    • NAID

      10024471301

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sedimentation Pinched-flow Fractionation for Size and Density-based Particle Sorting in Microchannels2011

    • Author(s)
      Tomoji Morijiri, Satoshi Sunahiro, Masashi Senaha, Masumi Yamada, Minoru Seki
    • Journal Title

      Microfluidics and Nanofluidics

      Volume: 10

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Observation of Non-spherical Particle Behaviors for Continuous Shape-based Separation Using Hydrodynamic Filtration2011

    • Author(s)
      Sari Sugaya, Masumi Yamada, Minoru Seki
    • Journal Title

      Biomicrofluidics

      Volume: 15(2)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] マイクロ流体デバイスを用いた微粒子・細胞のソーティング2010

    • Author(s)
      関実
    • Journal Title

      BIO INDUSTRY(バイオインダストリー) 2010(3)

      Pages: 37-42

    • Related Report
      2009 Annual Research Report
  • [Journal Article] In-channel Focusing of Flowing Microparticles Utilizing Hydrodynamic Filtration2009

    • Author(s)
      R. Aoki, M. Yamada, M. Yasuda M. Seki
    • Journal Title

      Microfluidics and Nanofluidics

      Volume: 6 Issue: 4 Pages: 571-576

    • DOI

      10.1007/s10404-008-0334-0

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] In-channel Focusing of Flowing Microparticles Utilizing Hydrodynamic Filtration2009

    • Author(s)
      R.Aoki, M.Yamada, M.Yasuda, M.Seki
    • Journal Title

      Microfluidics and Nanofluidies 6

      Pages: 571-576

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] In-channel Focusing of Flowing Microparticles Utilizing Hydrodynamic Filtration2009

    • Author(s)
      Ryota Aoki, Masumi Yamada, Masahiro Yasuda, Minoru Seki
    • Journal Title

      Microfluid. Nanofluid. 6(4)

      Pages: 571-576

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In-channel Focusing of Flowing Microparticles Uti1izing Hydrodynamic Filtrat ion2009

    • Author(s)
      R. Aoki, M. Yamada, M.Yasuda, M. Seki
    • Journal Title

      Microflaidics and Nanofluidics. 6

      Pages: 571-576

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Continuous and Size-Dependent Sorting of Emulsion Droplets Using Hydrodynamics in Pinched Microchannel2008

    • Author(s)
      H. Maenaka, M. Yamada, M. Yasuda, M. Seki
    • Journal Title

      Langmuir

      Volume: 24 Issue: 8 Pages: 4405-4410

    • DOI

      10.1021/la703581j

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Millisecond Treatment of Cells Using Microfluidic Devices via Two-Step Carrier-Medium Exchange2008

    • Author(s)
      M. Yamada, J. Kobayashi, M. Yamato, M. Seki, T. Okano
    • Journal Title

      Lab Chip

      Volume: 8 Issue: 5 Pages: 772-778

    • DOI

      10.1039/b718281c

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Continuous and Precise Particle Separation by Electroosmotic Flow Control in Microfluidic Devices2008

    • Author(s)
      T. Kawamata, M. Yamada, M. Yasuda, M. Seki
    • Journal Title

      Electrophoresis

      Volume: 29 Issue: 7 Pages: 1423-1430

    • DOI

      10.1002/elps.200700658

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Continuous and Size-Dependent Sorting of Emulsion Droplets Using Hydrodynamics in Pinched Microchannel2008

    • Author(s)
      H.Maenaka, M.Yamada, M.Yasuda, M.Seki
    • Journal Title

      Langmuir 24

      Pages: 4405-4410

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Millisecond Treatment of Cells Using Microfluidic Devices via Two-Step Carrier-Medium Exchange2008

    • Author(s)
      M.Yamada, J.Kobayashi, M.Yamato, M.Seki T.Okano
    • Journal Title

      Lab Chip 8

      Pages: 772-778

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Continuous and Precise Particle Separation by Electroosmotic Flow Control in Microfluidic Devices2008

    • Author(s)
      T.Kawamata, M.Yamada, M.Yasuda, M.Seki
    • Journal Title

      Electrophoresis 29

      Pages: 1423-1430

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Continuous and Precise Particle Separation by Electroosmotic Flow Control in Microfluidic Devices2008

    • Author(s)
      T. Kawamata, M. Yamada, M. Yasuda, M. Seki
    • Journal Title

      Electropboresis 29

      Pages: 1423-1430

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Millisecond Treatmeiit of Cells Using Microfluidic Devices via Two-step Carrier-Medium Exchange2008

    • Author(s)
      M. Yamada, J. Kobayashi, M. Yamato, M. Seki, T. Okano
    • Journal Title

      Lab Chip 8

      Pages: 772-778

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Continuous and Size-Dependent Sorting of Emu Is ion Droplets Using Hydrodynamics in Pinched Microchannels2008

    • Author(s)
      H. Maenaka, M. Yamada, M. Yasuda, M. Seki
    • Journal Title

      Langauir 24

      Pages: 4405-4410

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polymer Surface Morphology Control by Reactive Ion Etching for Microfluidic Devices2008

    • Author(s)
      H. Nabesawa, T. Hitobo, S. Wakabayashi, T. Asaii, T.Abe, M. Seki
    • Journal Title

      Sensor and Actuators B 132

      Pages: 637-643

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HydrodyEamic Control of Droplet Division in Bi furcating Microchannel and Its Application to Particle Synthesis2008

    • Author(s)
      M. Yamada, S.Doi, H.Maenaka, M. Yasuda, M. Seki
    • Journal Title

      J. Colloid Interface Sci. 321

      Pages: 401-407

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 水力学的濾過法を用いた血液細胞の分級(Blood Cell Classification Utilizing Hydrodynamic Filtration)2008

    • Author(s)
      松田美由紀, 山田真澄, 関実
    • Journal Title

      IEEJ Trans E(電気学会論文誌E) 128

      Pages: 396-401

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Patterning React ive Microdomains inside PDMS Microchannels by Trapping and Mel ting Functional Polymer Particles2008

    • Author(s)
      M. Yamamoto, M. Yamada, N. Nonaka, S.Fukushima, M. Yasuda, M. Seki
    • Journal Title

      J. Am Chem.soc 130

      Pages: 14044-14045

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] マイクロ/ナノ空間を利用した分離技術(Separat ion Technologies Utilizing Micro/Nano Space)2008

    • Author(s)
      関実
    • Journal Title

      分離技術 38

      Pages: 130-134

    • Related Report
      2008 Annual Research Report
  • [Presentation] マイクロ流体システムにおける微量操作と分離法に関する研究2012

    • Author(s)
      関実
    • Organizer
      化学工学会第77年会
    • Place of Presentation
      工学院大学(依頼講演:研究賞受賞記念講演)
    • Year and Date
      2012-03-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Microfluidic Separation of Particles and Its Applications2012

    • Author(s)
      Minoru Seki
    • Organizer
      化学工学会第77年会
    • Place of Presentation
      工学院大学(依頼講演)
    • Year and Date
      2012-03-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 連続的二因子細胞分離のための水力学的濾過-磁気泳動複合型マイクロデバイスの開発2012

    • Author(s)
      水野雅啓, 遠山郁, 三田村龍典, 山田真澄, 関実
    • Organizer
      化学工学会第77年会
    • Place of Presentation
      工学院大学
    • Year and Date
      2012-03-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] マイクロ流体システムにおける微量操作と分離法に関する研究2012

    • Author(s)
      関実
    • Organizer
      化学工学会第77年会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] Fabrication of Complex Hydrogel Materials by Utilizing Microfluidics and Micromolding2011

    • Author(s)
      M.Yamada, Y.Naganuma, M.Yamada, S.Kakegawa, S.Sugaya, M.Seki
    • Organizer
      2011 MRS Fall Meeting
    • Place of Presentation
      Boston, USA(招待講演)
    • Year and Date
      2011-11-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 並列化HDF流路を用いたハイスループット粒子/細胞分離システムの開発2011

    • Author(s)
      田村篤史, 菅谷紗里, 山田真澄, 関実
    • Organizer
      第24回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      大阪府立大学
    • Year and Date
      2011-11-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Microfluidics and Microfabrication Technology for Highly Precise Cell Manipulation and Cultivation2011

    • Author(s)
      M.Yamada, M.Seki
    • Organizer
      2011 International Symposium on Micro-Nano Mechatronics and Human Science (MHS2011)
    • Place of Presentation
      名古屋大学(招待講演)
    • Year and Date
      2011-11-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] Fluidic Shear-assisted Self-assembly to Form Actuating Multilamellar Lipid Tubes Using Microfabricated Nozzle Array2011

    • Author(s)
      M.Masubuchi, T.Toyota, M.Yamada, M.Seki
    • Organizer
      MRS Technology Development Workshop Series, Directed Self-Assembly of Materials Workshop
    • Place of Presentation
      Nashville, USA
    • Year and Date
      2011-09-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Continuous and Rapid Separation of Cells Using Microfluidic Systems2011

    • Author(s)
      M.Yamada, S.Sugaya, M.Seki
    • Organizer
      Sixth Japan-China Workshop on Chemical Engineering 2011
    • Place of Presentation
      Wuhan, China(依頼講演)
    • Year and Date
      2011-06-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] マイクロノズルアレイによって形成されたチューブ状多重膜ジャイアントベシクルの自発運動2011

    • Author(s)
      豊田太郎, 増渕茉奈美, 山田真澄, 関実
    • Organizer
      第11回東京大学生命科学シンポジウム
    • Place of Presentation
      東京大学
    • Year and Date
      2011-05-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] Microfluidics and Microfabrication Technology for Highly Precise Cell Manipulation and Cultivation,2011

    • Author(s)
      M. Yamada, M. Seki
    • Organizer
      2011 Intl Symp. on Micro-Nano Mechatronics and Human Science (IEEE-MHS2011)
    • Place of Presentation
      Nagoya, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Tilted-Branch Hydrodynamic Filtration for Length-dependent Sorting of Rod-like Particles2011

    • Author(s)
      A. Tamura, S. Sugaya, M. Yamada, M. Seki
    • Organizer
      15th Intl Conf. on Miniaturized Systems for Chem. and Life Sci. (MicroTAS2011)
    • Place of Presentation
      Seattle, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Continuous Microfluidic Processes for Cell Manipulation, Separation, and Cultivation Systems2011

    • Author(s)
      M. Yamada, M. Seki
    • Organizer
      The 11th Intl Symp. on Microchem. and Microsys. (ISMM2011)
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2011 Final Research Report
  • [Presentation] 水力学的濾過法を用いた非球形粒子の分離における流路形状依存性の評価2011

    • Author(s)
      田村篤史, 菅谷紗里, 山田真澄, 関実
    • Organizer
      第23回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      千葉大学
    • Related Report
      2011 Annual Research Report
  • [Presentation] 水力学的濾過法と磁気泳動による二次元細胞分離装置の開発2011

    • Author(s)
      三田村龍典, 遠山郁, 山田真澄, 関実
    • Organizer
      第23回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      千葉大学
    • Related Report
      2011 Annual Research Report
  • [Presentation] 微小流路構造を用いた多段階分割による単分散液滴の生成2011

    • Author(s)
      森谷樹, 小林あおい, 山田真澄, 関実
    • Organizer
      第23回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      千葉大学
    • Related Report
      2011 Annual Research Report
  • [Presentation] マイクロ流体デバイスを利用した制御可能な多重脂質膜チューブの作製2011

    • Author(s)
      増渕茉奈美, 豊田太郎, 山田真澄, 関実
    • Organizer
      細胞を創る研究会3.0
    • Place of Presentation
      東京大学駒場II(依頼講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Tilted-Branch Hydrodynamic Filtration for Length-dependent Sorting of Rod-like Particles2011

    • Author(s)
      A.Tamura, S.Sugaya, M.Yamada, M.Seki
    • Organizer
      15th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS2011)
    • Place of Presentation
      Seattle, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] Development of Magnetophoresis-assisted Hydrodynamic Filtration System for Continuous Two-dimensional Cell Sorting2011

    • Author(s)
      R.Mitamura, M.Mizuno, Kaori Toyama, M.Yamada, M.Seki
    • Organizer
      15th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS2011)
    • Place of Presentation
      Seattle, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effect of Microchannel Geometry on the Separation Efficiency of Non-spherical Particles Using Hydrodynamic Filtration2011

    • Author(s)
      A.Tamura, S.Sugaya, M.Yamada, M.Seki
    • Organizer
      The 11th International Symposium on Microchemistry and Microsystems (ISMM2011)
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2011 Annual Research Report
  • [Presentation] Continuous Microfluidic Processes for Cell Manipulation, Separation, and Cultivation Systems2011

    • Author(s)
      M.Yamada, M.Seki
    • Organizer
      The 11th International Symposium on Microchemistry and Microsystems (ISMM2011)
    • Place of Presentation
      Seoul, Korea(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Formation of Self-actuating Lipid Tubes Using Microfabricated Picoliter Nozzle Array2011

    • Author(s)
      Masubuchi, T.Toyota, M.Yamada, M.Seki
    • Organizer
      IEEE The 24th International Conference on Micro Electro Mechanical Systems(MEMS2011)
    • Place of Presentation
      Cancun, Mexico
    • Related Report
      2010 Annual Research Report
  • [Presentation] フルイディクスによる細胞アセンブリの現状2010

    • Author(s)
      関実
    • Organizer
      バイオアセンブラ講演会
    • Place of Presentation
      東京女子医大
    • Year and Date
      2010-11-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] マイクロフルイディクスを応用した微量液体の秤取-混合・反応と細胞選抜.処理・培養技術2010

    • Author(s)
      関実
    • Organizer
      第1回創薬システム研究会
    • Place of Presentation
      東葛テクノプラザ(千葉)(招待講演)
    • Year and Date
      2010-09-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Continuous and Rapid Separation of Soft Matters Using Microfluidic Systems2010

    • Author(s)
      M. Seki, M. Yamada
    • Organizer
      Pacifichem 2010
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Bubble-based Continuous Separation System in Microfluidic Device2010

    • Author(s)
      A. Kobayashi, M. Yamada, M. Seki
    • Organizer
      MicroTAS2010
    • Place of Presentation
      Groningen, The Netherlands
    • Related Report
      2011 Final Research Report
  • [Presentation] Two-dimensional Cell Sorting Device Employing Pinched-flow Fractionation and Magnetophoresis2010

    • Author(s)
      M. Senaha, R. Mitamura, M. Yamada, M. Seki
    • Organizer
      MicroTAS2010
    • Place of Presentation
      Groningen, The Netherlands
    • Related Report
      2011 Final Research Report
  • [Presentation] Isolation of Cell Nucleus by Short-time Chemical Treatment in Carrier-medium Exchange Microchannels2010

    • Author(s)
      K.Toyama, M.Yamada, M.Seki
    • Organizer
      14th Intl.Conff.on Miniaturized Systems for Chem.and Life Sci.(MicroTAS2010)
    • Place of Presentation
      Groningen, The Netherlands.
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Two-dimensional Cell Sorting Device Employing Pinched-flow Fractionation and Magnetophoresis2010

    • Author(s)
      M.Senaha, R.Mitamura, M.Yamada, M.Seki
    • Organizer
      MicroTAS2010
    • Place of Presentation
      Groningen, The Netherlands.
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Microfluidic Device for Cell Nucleus Isolation by Short-time Chemical Treatment2010

    • Author(s)
      Toyama, M.Yamada, M.Seki
    • Organizer
      The 10th International Symposium on Microchemistry and Microsystems (ISMM2010)
    • Place of Presentation
      Hong Kong
    • Related Report
      2010 Annual Research Report
  • [Presentation] 瞬間的化学処理による細胞核単離のためのマイクロ流体システムの開発2010

    • Author(s)
      遠山郁, 山田真澄, 関実
    • Organizer
      第21回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      東京大学
    • Related Report
      2010 Annual Research Report
  • [Presentation] 流路内を移動するマイクロバブルを担体とした新規連続的分離手法の提案2010

    • Author(s)
      小林あおい, 山田真澄, 関実
    • Organizer
      第21回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      東京大学
    • Related Report
      2010 Annual Research Report
  • [Presentation] マイクロ流路内での瞬間的化学処理による細胞核単離システムの開発2010

    • Author(s)
      遠山郁, 山田真澄, 関実
    • Organizer
      化学工学会第42回秋季大会
    • Place of Presentation
      同志社大学(京都)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 磁気泳動とPFF法を利用した連続的2次元細胞分離システムの開発2010

    • Author(s)
      瀬名波匡, 山田真澄, 関実
    • Organizer
      化学工学会第42回秋季大会
    • Place of Presentation
      同志社大学(京都)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Continuous Separation of Micro/Nano Structures Using Microfluidic Systems2010

    • Author(s)
      M.Seki
    • Organizer
      Ultra-Sonic Standing Wave Network 2010(USWnet 2010)
    • Place of Presentation
      Groningen, The Netherlands(invited)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Two-dimensional Cell Sorting Device Employing Pinched-flow Fractionation and Magnetophoresis2010

    • Author(s)
      M.Senaha, R.Mitamura, M.Yamada, M.Seki
    • Organizer
      14th International Conference on Miniaturized Systems for Chemistry and Life Sciences(uTAS2010)
    • Place of Presentation
      Groningen, The Netherlands
    • Related Report
      2010 Annual Research Report
  • [Presentation] Bubble-based Continuous Separation System in Microfluidic Device2010

    • Author(s)
      A.Kobayashi, M.Yamada, M.Seki
    • Organizer
      14th International Conference on Miniaturized Systems for Chemistry and Life Sciences(uTAS2010)
    • Place of Presentation
      Groningen, The Netherlands
    • Related Report
      2010 Annual Research Report
  • [Presentation] Formation and Actuation of Multilamellar Lipid Tubes Using Microfluidic Picoliter Dispensing Array2010

    • Author(s)
      M.Masubuchi, M.Yamada, T.Toyota, M.Seki
    • Organizer
      14th International Conference on Miniaturized Systems for Chemistry and Life Sciences(uTAS2010)
    • Place of Presentation
      Groningen, The Netherlands
    • Related Report
      2010 Annual Research Report
  • [Presentation] Isolation of Cell Nucleus by Short-time Chemical Treatment in Carrier-medium Exchange Microchannels2010

    • Author(s)
      K.Toyama, M.Yamada, M.Seki
    • Organizer
      14th International Conference on Miniaturized Systems for Chemistry and Life Sciences(uTAS2010)
    • Place of Presentation
      Groningen, The Netherlands
    • Related Report
      2010 Annual Research Report
  • [Presentation] Microfluidic Counterflow Centrifugal Elutriation for Cell Separation Using Density-gradient Media2010

    • Author(s)
      T.Morijiri, T.Hikida, M.Yamada, M.Seki
    • Organizer
      14th International Conference on Miniaturized Systems for Chemistry and Life Sciences(uTAS2010)
    • Place of Presentation
      Groningen, The Netherlands
    • Related Report
      2010 Annual Research Report
  • [Presentation] マイクロ流路を用いた微小エルトリエーターによる細胞分離2010

    • Author(s)
      疋田敏勝, 森尻智樹, 山田真澄, 関実
    • Organizer
      化学工学会第42回秋季大会
    • Place of Presentation
      同志社大学(京都)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development of Microfluidic Cell Nucleus Separator Employing Rapid Chemical Treatment2010

    • Author(s)
      K.Toyama, M.Yamada, M.Seki
    • Organizer
      2010 International Symposium on Micro-Nano Mechatronics and Human Science (MHS2010)
    • Place of Presentation
      Nagoya, Japan(依頼講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Continuous and Rapid Separation of Bio-Soft Matters Using Microfluidic Systems2010

    • Author(s)
      M.Seki, M.Yamada
    • Organizer
      2010 AIChE Annual Meeting
    • Place of Presentation
      Salt Lake City, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] マイクロ流体デバイスを用いた粒子・細胞・液滴操作2010

    • Author(s)
      関実
    • Organizer
      第3回細胞を創る研究会
    • Place of Presentation
      東京大学(駒場)(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 細胞分離のための微小エルトリエーターの開発2010

    • Author(s)
      森尻智樹, 疋田敏勝, 山田真澄, 関実
    • Organizer
      第3回細胞を創る研究会
    • Place of Presentation
      東京大学(駒場)
    • Related Report
      2010 Annual Research Report
  • [Presentation] マイクロ流体デバイスを利用した制御可能な多重脂質膜チューブの作製2010

    • Author(s)
      増渕茉奈美, 山田真澄, 豊田太郎 関実
    • Organizer
      第22回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      名古屋大学
    • Related Report
      2010 Annual Research Report
  • [Presentation] ピコリットル秤取アレイ構造を利用した多重脂質膜チューブの作製2010

    • Author(s)
      増渕茉奈美, 山田真澄, 豊田太郎, 関実
    • Organizer
      第22回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      名古屋大学
    • Related Report
      2010 Annual Research Report
  • [Presentation] Continuous and Rapid Separation of Soft Matters Using Microfluidic Systems2010

    • Author(s)
      M.Seki, M.Yamada
    • Organizer
      Pacifichem 2010
    • Place of Presentation
      Honolulu, Hawaii(invited)
    • Related Report
      2010 Annual Research Report
  • [Presentation] マイクロ流体デバイスを用した細胞の形状依存分離法の開発2010

    • Author(s)
      菅谷紗里, 山田真澄, 関実
    • Organizer
      化学工学会 第75年会
    • Place of Presentation
      鹿児島大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高分子微粒子を利用したPDMS基板における微小ハイドロゲルパターニング法の開発2010

    • Author(s)
      福島しづか, 山田真澄, 関実
    • Organizer
      化学工学会 第75年会
    • Place of Presentation
      鹿児島大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] マイクロ流体デバイスを用いた新は規バイオ操作システムの提案2009

    • Author(s)
      山田真澄, 関実
    • Organizer
      INCHEM TOKYO 2009『産学官マッチングフォーラム』
    • Place of Presentation
      ビッグサイト,東京
    • Year and Date
      2009-11-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Rapid Handling of Biological Soft Matter Using Microfluidic Devices2009

    • Author(s)
      Minoru Seki (Invited)
    • Organizer
      The 2nd Annual Iternational Conference on Biosensors, Biochips, and Bioelectronic Devices (Biotronics 2009)
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2009-10-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] Continuous Separation of Micro/Nano-Structures Using Microfluidic Systems2009

    • Author(s)
      Minoru Seki (Invited)
    • Organizer
      Seoul National Universty Symposium on Microfluidics (SNU mini-lecture series 2009)
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2009-05-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] Continuous and Rapid Separation of Micro/Nano-Structures Using Microfluidic Systems2009

    • Author(s)
      M. Seki
    • Organizer
      13th Annual European Conf. on Micro & Nanoscale Technol. for the Biosci. (NanoBioTech-Montreux 2009)
    • Place of Presentation
      Montreux, Switzerland
    • Related Report
      2011 Final Research Report
  • [Presentation] Visualizing Non-spherical Particle Behaviors for Continuous Shape-based Separation Using Hydrodynamic Filtration2009

    • Author(s)
      S. Sugaya, M. Yamada, M. Seki
    • Organizer
      MicroTAS2009
    • Place of Presentation
      Jeju Island, Korea
    • Related Report
      2011 Final Research Report
  • [Presentation] Continuous and Rapid Separation of Micro/Nano-Structures Using Microfluidic Systems2009

    • Author(s)
      M.Seki (Invited)
    • Organizer
      13th Annual European Conference on Micro & Nanoscale Technologies for the Biosciences (NanoBioTech -Montreux 2009)
    • Place of Presentation
      Montreux, Switzerland.
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Visualizing Non-spherical Particle Behaviors for Continuous Shape-based Separation Using Hydrodynamic Filtration2009

    • Author(s)
      S.Sugaya, M.Yamada, M.Seki
    • Organizer
      MicroTAS2009
    • Place of Presentation
      Jeju Island, Korea.
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Microfluidic Cell Shape Dependent Separation2009

    • Author(s)
      Sari Sugaya, Minoru Seki
    • Organizer
      The 5th International Conference on Microtechnologies in Medicine and Biology(MMB 2009)
    • Place of Presentation
      Quebec City, Canada
    • Related Report
      2009 Annual Research Report
  • [Presentation] 遠心力を用いた比重差分級のためのPFF法の開発2009

    • Author(s)
      森尻智樹, 砂廣怜志, 瀬名波匡, 山田真澄, 関実
    • Organizer
      第19回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      広島大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] マイクロ流路内の遠心場を利用した微粒子の比重差分級法の開発2009

    • Author(s)
      森尻智樹, 砂廣怜志, 瀬名波匡, 山田真澄, 関実
    • Organizer
      化学工学会第41回秋季大会
    • Place of Presentation
      広島大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] ゾルゲル法を利用したポリマーマイクロデバイスの作製2009

    • Author(s)
      鈴木悠介, 山田真澄, 関実
    • Organizer
      化学工学会第41回秋季大会
    • Place of Presentation
      広島大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] Visualizing Non-spherical Particle Behaviors for Continuous Shapebased Separation Using Hydrodynamic Filtration2009

    • Author(s)
      Sari Sugaya, Masumi Yamada, Minoru Seki
    • Organizer
      The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS2009)
    • Place of Presentation
      Jeju Island, Korea
    • Related Report
      2009 Annual Research Report
  • [Presentation] Fabrication of Multilayer PDMS-PMMA Hybrid Microdevices by Bonding with Sol-gel Procedures2009

    • Author(s)
      Yusuke Suzuki, Masumi Yamada, Minoru Seki
    • Organizer
      The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS2009)
    • Place of Presentation
      Jeju Island, Korea
    • Related Report
      2009 Annual Research Report
  • [Presentation] Microfabrication of Polymer Surface Using Colloidal Lithography and Reactive lon Etching2009

    • Author(s)
      Takaharu Hiruma, Hirofumi Nabesawa, Takeshi Hitobo, Shizuka Fukushima, Suguru Wakabayashi, Minoru Seki
    • Organizer
      The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS2009)
    • Place of Presentation
      Jeju Island, Korea
    • Related Report
      2009 Annual Research Report
  • [Presentation] 水力学的濾過法を作用した非球形粒子の分離と挙動解析2009

    • Author(s)
      菅谷紗理, 山田真澄, 関実
    • Organizer
      第20回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      金沢市
    • Related Report
      2009 Annual Research Report
  • [Presentation] Continuous and Rapid Separation of Micro/Nano-Structures Using Microfluidic Systems2009

    • Author(s)
      Minoru Seki (Invited)
    • Organizer
      The 13th Annual European Conference on Micro & Nanoscale Technologies for the Biosciences (NanoBio Tech-Montreux 2009)
    • Place of Presentation
      Montreux, Switzerland
    • Related Report
      2009 Annual Research Report
  • [Presentation] Microfluidic Cell Manipulation Systems2009

    • Author(s)
      Minoru Seki, Masuimi Yamada
    • Organizer
      The 9th Asia Pacific Biochemical Engineering Conference (APBioChEC2009)
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2009 Annual Research Report
  • [Presentation] Microfluidic Device for Continuous Shape-based Cell Separation2009

    • Author(s)
      Sari Sugaya, Masumi Yamada, Minoru Seki
    • Organizer
      The 15th Symposim of Young Asian Biochemical Engineers' Community (YABEC 2009)
    • Place of Presentation
      Xiamen, China
    • Related Report
      2009 Annual Research Report
  • [Presentation] Development of Centrifugal Micro Dispensing Array with Partial Solution Exchange for Biochemical Applications2009

    • Author(s)
      Kenji Asamura, Masumi Yamada, Minoru Seki
    • Organizer
      The 15th Symposium of Young Asian Biochemical Engineers' Community (YABEC 2009)
    • Place of Presentation
      Xiamen, China
    • Related Report
      2009 Annual Research Report
  • [Presentation] Pinched Flow Fractionation Device for Size and Density-Dependent Separation of Particles Utilizing Centrifugal Pumping2008

    • Author(s)
      S. Sunahiro, M. Senaha, M. Yamada, M. Seki
    • Organizer
      MicroTAS2008
    • Place of Presentation
      Diego, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Pinched Flow Fractionation Device for Size- and Density- Dependent Separation of Particles Utilizing Centrifugal Pumping2008

    • Author(s)
      S.Sunahiro, M.Senaha, M.Yamada, M.Seki
    • Organizer
      MicroTAS2008
    • Place of Presentation
      San Diego, USA.
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Pinched Flow Fractionation Device for Size- and Density-Dependent Separation of Particles Ut ilizing Centrifugal Pumping2008

    • Author(s)
      S. Sunahiro, M. Senaha, M. Yamada, M. Seki
    • Organizer
      12th Intl. Conf. on Miniaturized Systems for Chem. and Life Sci. (MicroTAS2008)
    • Place of Presentation
      San Diego, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Local Surface Modification Using Trapping and Melting of Polymer Microparticles for Diverse Patterning2008

    • Author(s)
      S. Fukushima, M. Yamada, M. Yamamoto, M. Seki
    • Organizer
      12th Intl. Conf. on Miniaturized Systems for Chem. and Life Sci. (MicroTAS2008)
    • Place of Presentation
      San Diego, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Deformed Droplet Breakup in Microfluidec Device for Smaller Particles Generation2008

    • Author(s)
      T. Moritani, S. Doi, M. Seki
    • Organizer
      12th Intl. Conf. on Miniaturized Systems for Chem. and Life Sci. (MicroTAS2008)
    • Place of Presentation
      San Diego, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Diverse Patterning of Micro-Channel Surface for Biologically-Active Modification Using Particle Trapping and Melting2008

    • Author(s)
      S. Fukushima, M. Yamada, M. Yamamoto, M. Seki
    • Organizer
      14th Symposium of Young Asia Biochemical Engineer's Community (YABEC2008)
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] Development of Microfluidic Devices for Enzymat ic Diagnosis of Inborn Metabolism Errors2008

    • Author(s)
      M. Mihashi, Y. Asano, M. Seki
    • Organizer
      14th Symposium of Young Asia Biochemical Engineer's Community (YABEC2008)
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] Local Surface Modi fication and Diverse Patterning within Microchannels Using Particle Trapping and Melting2008

    • Author(s)
      S. Fukushima, M. Yamada, M. Yamamoto, M. Seki
    • Organizer
      Internaional Symposium on Microchemistry and Microsystems 2008 (ISMM2008)
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] ピンチド・フロー・フラクショネーション法による微粒子分級のための流量制御2008

    • Author(s)
      瀬名波匡, 関実
    • Organizer
      第17回科学とマイクロ・ナノシステム研究会講演会
    • Place of Presentation
      九州大学(福岡)
    • Related Report
      2008 Annual Research Report
  • [Book] 「イムノアッセイチップ」,in「バイオチップ実用化ハンドブック」2010

    • Author(s)
      関実
    • Total Pages
      610
    • Publisher
      NTS
    • Related Report
      2011 Final Research Report
  • [Book] バイオチップ実用化ハンドブック(監修金子周一,堀池靖浩「イムノアッセイチップ」)2010

    • Author(s)
      関実
    • Total Pages
      610
    • Publisher
      NTS
    • Related Report
      2010 Self-evaluation Report
  • [Book] バイオチップ実用化ハンドブック(監修金子周一, 堀池靖浩)2010

    • Author(s)
      関実
    • Total Pages
      610
    • Publisher
      エヌ・ティー・エス出版(NTS)
    • Related Report
      2010 Annual Research Report
  • [Book] 「粒子ハンドリング」,in「マイクロ・ナノ化学チップと医療・環境・バイオ分析」2009

    • Author(s)
      関実
    • Total Pages
      459
    • Publisher
      技術教育出版(NTS)
    • Related Report
      2011 Final Research Report
  • [Book] マイクロ・ナノ化学チップと医療・環境・バイオ分析(監修北森武彦「粒子ハンドリング」)2009

    • Author(s)
      関実
    • Total Pages
      459
    • Publisher
      技術教育出版(NTS)
    • Related Report
      2010 Self-evaluation Report
  • [Book] マイクロ・ナノ化学チップと医療・環境・バイオ分析(北森武彦監修)2009

    • Author(s)
      関実(分担)
    • Total Pages
      459
    • Publisher
      技術教育出版(NIS),Tokyo(2009)(分担17頁)
    • Related Report
      2009 Annual Research Report
  • [Book] 「粒子ハンドリング」, in「マイクロ・ナノ科学チップと医療・環境・バイオ分析」(北森武彦 監修), pp.62-782009

    • Author(s)
      関実(分担)
    • Total Pages
      459
    • Publisher
      技術教育出版(NTS)
    • Related Report
      2008 Annual Research Report
  • [Book] 「マイクロ・ナノ流体デバイスを用いた細胞,分離」,in「細胞分離・操作技術の最前線」2008

    • Author(s)
      関実
    • Total Pages
      387
    • Publisher
      シーエムシー
    • Related Report
      2011 Final Research Report
  • [Book] 細胞分離・操作技術の最前線(監修福田敏男・新井史人「マイクロ・ナノ流体デバイスを用いた細胞分離」)2008

    • Author(s)
      関実
    • Total Pages
      387
    • Publisher
      シーエムシー
    • Related Report
      2010 Self-evaluation Report
  • [Book] 「マイクロ・ナノ流体デバイスを用いた細胞分離」,in「細胞分離・操作技術の最前線」(監修 福田敏男・新井史人), pp.67-772008

    • Author(s)
      関実(分担)
    • Total Pages
      387
    • Publisher
      シーエムシー出版
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://chem.tf.chiba-u.jp/gacb01/Research/content-separation.html

    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] エルトリエータ用マイクロ流路システムおよび粒子分離方法2010

    • Inventor(s)
      関実, 山田真澄, 森尻智樹, 疋田敏勝
    • Industrial Property Rights Holder
      千葉大学
    • Industrial Property Number
      2010-223564
    • Filing Date
      2010-10-01
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 連続的2次元粒子分離装置および粒子分離方法2010

    • Inventor(s)
      関実, 山田真澄, 瀬名波匡, 三田村龍典
    • Industrial Property Rights Holder
      千葉大学
    • Industrial Property Number
      2010-223550
    • Filing Date
      2010-10-01
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Patent(Industrial Property Rights)] エルトリエータ用マイクロ流路システムおよび粒子分離方法2010

    • Inventor(s)
      関実,山田真澄,森尻智樹,疋田敏勝
    • Industrial Property Rights Holder
      千葉大学
    • Industrial Property Number
      2010-223564
    • Filing Date
      2010-10-01
    • Related Report
      2010 Self-evaluation Report
  • [Patent(Industrial Property Rights)] 連続的2次元粒子分離装置および粒子分離方法2010

    • Inventor(s)
      関実,山田真澄,瀬名波匡,三田村龍典
    • Industrial Property Rights Holder
      千葉大学
    • Industrial Property Number
      2010-223550
    • Filing Date
      2010-10-01
    • Related Report
      2010 Self-evaluation Report
  • [Patent(Industrial Property Rights)] エルトリエータ用マイクロ流路システムおよび粒子分離 方法2010

    • Inventor(s)
      関実, 山田真澄, 森尻智樹, 疋田敏勝
    • Industrial Property Rights Holder
      千葉大学
    • Industrial Property Number
      2010-223564
    • Filing Date
      2010-10-01
    • Related Report
      2010 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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