| Project/Area Number |
20241045
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
基礎ゲノム科学
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
OGASAWARA Naotake Nara Institute of Science and Technology, 情報科学研究科, 教授 (10110553)
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| Co-Investigator(Kenkyū-buntansha) |
OSHIMA Taku 奈良先端科学技術大学院大学, 情報科学究科, 助教 (50346318)
KUROKAWA Ken 東京工業大学, 生命理工学研究科, 教授 (20343246)
TOBE Toru 大阪大学, 大学院・医学研究科, 准教授 (70207596)
SUZUKI Yutaka 東京大学, 大学院・新領域創成科学研究科, 准教授 (40323646)
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| Co-Investigator(Renkei-kenkyūsha) |
AIBA Hirofumi 名古屋大学, 生命農学研究科, 准教授 (60211687)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥50,440,000 (Direct Cost: ¥38,800,000、Indirect Cost: ¥11,640,000)
Fiscal Year 2010: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2009: ¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
Fiscal Year 2008: ¥25,870,000 (Direct Cost: ¥19,900,000、Indirect Cost: ¥5,970,000)
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| Keywords | ゲノム進化・再編 / ChIP-chip / 転写制御ネットワーク / ChAP-chip / Fur / H-NS / Zur / 転写ネットワーク / 大腸菌 / 病原性大腸菌 / 転写制御システム / ChIP-chip解析 / ChIP-seq解析 |
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| Research Abstract |
We performed ChIP-chip and ChAP-seq analysis to determine the diversity of binding profiles of transcriptional regulators and transcriptional networks among different E.coli strains. Our analysis revealed that the binding profiles are highly conserved in different E.coli strains, suggesting strongly that the binding profile of atranscriptional regulator is kept even in different E.coli strains which have highly diverse genome structures.
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