Chemical synthesis of glycans and glycoconjugates for elucidation of their functions in immune and nerve system

• Project/Area Number: 20241053
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Living organism molecular science
• Research Institution: Osaka University
• Principal Investigator: FUKASE Koichi Osaka University, 大学院・理学研究科, 教授 (80192722)
• Co-Investigator(Kenkyū-buntansha): FUJIMOTO Yukari 大阪大学, 大学院・理学研究科, 准教授 (00362616) ; TANAKA Katsunori 大阪大学, 大学院・理学研究科, 助教 (00403098)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥28,860,000 (Direct Cost: ¥22,200,000、Indirect Cost: ¥6,660,000); Fiscal Year 2010: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000); Fiscal Year 2009: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
• Keywords: 糖鎖 / 自然免疫 / PETイメージング / グリコシル化 / 固相合成 / 免疫増強 / 複合糖質 / 糖タンパク質 / 免疫増強作用

Research Abstract

New synthetic methods have been developed for glycans and glycoconjugates and applied them to the synthesis of complex bioactive molecules for the elucidation of action mechanisms. In particular, immunostimulating or immunomodulating glycoconjugates from bacteria were synthesized for elucidation of the recognition with innate immune receptors. Synthetic ligands for the innate immune receptors were used for the immune regulation. Bio-imaging studies of glycans and glycoproteins were also studied for the dynamic and kinetic analysis of glycans to unveil the unknown function of glycans.

Research Products

• [Journal Article] Structures, Synthesis, and Human Nod1 Stimulation of Immunostimulatory Bacterial Peptidoglycan Fragments in the Environment (2011)
  • Author(s): Fujimoto, Y., Fukase, K., et al.
  • Journal Title: J.Nat.Prod. Volume: (in press 未定)
  • Peer Reviewed
• [Journal Article] Non-invasive imaging of dendrimer-type N-glycan clusters : in vivo dynamics dependence on oligosaccharide structure. (2010)
  • Author(s): Tanaka, K., Siwu, R.O.E., Minami, K., Hasegawa, K., Nozaki, S., Kanayama, Y., Koyama, K., Chen, C.W., Paulson, C.J., Watanabe, Y., Fukase, K.
  • Journal Title: Angew.Chem.Int.Ed. 49 Pages: 8195-8200
  • Peer Reviewed
• [Journal Article] Characterization of natural human nucleotide-binding oligomerization domain protein 1 (NOD1) ligands from bacterial culture supernatant for elucidation of immune modulators in the environment. (2010)
  • Author(s): Pradipta, A.R., Fujimoto, Y., Hasegawa, M., Inohara, N., Fukase, K.
  • Journal Title: J.Biol.Chem. 285(31) Pages: 23607-23613
  • Peer Reviewed
• [Journal Article] A combined 6p-azaelectrocyclization/ staudinger approach to protein & cell engineering : non-invasive tumor targeting by N-Glycan-engineered lymphocytes. (2010)
  • Author(s): Tanaka, K., Minami, K., Tahara, T., Siwu, E.R.O., Koyama, K., Nozaki, S., Onoe, H., Watanabe, Y., Fukase, K.
  • Journal Title: J.Carbohydr.Chem. 29 Pages: 118-132
  • Peer Reviewed
• [Journal Article] Electrocyclization-based labeling allows efficient in Vivo imaging of cellular trafficking. (2010)
  • Author(s): Tanaka, K., Minami, K., Tahara, T., Fujii, Y., Siwu, E.R.O., Nozaki, S.; Onoe, H., Yokoi, S., Koyama, K., Watanabe, Y., Fukase, K.
  • Journal Title: Chem Med Chem (5) Pages: 841-845
  • Peer Reviewed
• [Journal Article] Key st std lipopolysaccharide triggering the innate immune system of higher animals : Chemical synthesis and functional studies. (2010)
  • Author(s): Kusumoto, S., Fukase, K., Shiba.
  • Journal Title: Proc.Jpn.Acad., Ser.B 86(4) Pages: 322-337
  • Peer Reviewed
• [Journal Article] Nod1 ligands induce site-specific vascular inflammation (2010)
  • Author(s): Nishio, H., Fukase, K., et al
  • Journal Title: Arterioscler.Thromb.Vasc.Biol Volume: (in press 未定)
  • NAID: 120005107977
  • Peer Reviewed
• [Journal Article] Failure of mycoplasma lipoprotein MALP-2 to induce NK cell activation through dendritic cell TLR2 (2010)
  • Author(s): Sawahata, R., Fukase, K., et al
  • Journal Title: Microbes Infect Volume: (in press 未定)
  • NAID: 120002912001
  • Peer Reviewed
• [Journal Article] Widely applicable deprotection method of 2,2,2-trichloroethoxy carbonyl (Troc) group using tetrabutylammonium fluoride (2010)
  • Author(s): Huang, C-y., Fukase, K., etal.
  • Journal Title: J.Carbohydr.Chem. Volume: 29 Pages: 1-9
  • Peer Reviewed
• [Journal Article] Asymmetric synthesis of ^<14>C-labeled L-Proparagylglycine (2010)
  • Author(s): Kurosawa, M., Fukase, K., et al.
  • Journal Title: Radioisotopes Volume: 59(12) Pages: 17-22
  • Peer Reviewed
• [Journal Article] The peptide sequence of diacyl lipopeptides determines dendritic cell TLR2-mediated NK activation (2010)
  • Author(s): Azuma, M., Fukase, K., et al
  • Journal Title: PLoS On Volume: 5(9)
  • NAID: 120002414850
  • Peer Reviewed
• [Journal Article] Noninvasive imaging of dendrimer-type N-glycan clusters : in vivo dynamics dependence on oligosaccharide structure (2010)
  • Author(s): Tanaka, K., Fukase, K., et al.
  • Journal Title: Angew.Chem.Int.Ed. Volume: 49 Pages: 8195-8200
  • Peer Reviewed
• [Journal Article] Characterization of natural human nucleotide-binding oligomerization domain protein 1 (NOD1) ligands from bacterial culture supernatant for elucidation of immune modulators in the environment (2010)
  • Author(s): Pradipta, A.R., Fukase, K., et al.
  • Journal Title: J.Biol.Chem. Volume: 285(31) Pages: 23607-23613
  • Peer Reviewed
• [Journal Article] New strategy in synthetic biology : from enzyme inhibition and natural products synthesis to PET imaging by 6_II-azaelectrocyclization (2010)
  • Author(s): Tanaka, K., Fukase, K, et al.
  • Journal Title: The Chemical Record Volume: 10 Pages: 119-139
  • Peer Reviewed
• [Journal Article] A combined 6p-azaelectrocyclization/staudinger approach to protein & cell engineering : non-invasive tumor targeting by N-Glycan-engineered lymphocytes (2010)
  • Author(s): Tanaka, K., Fukase, K., et al.
  • Journal Title: J.Carbohydr.Chem. Volume: 29 Pages: 118-132
  • Peer Reviewed
• [Journal Article] Probe design and synthesis of Gal β(1-3)[NeuAcα(2-6)]GlcNAcβ(1-2)Man motif of N-glycan (2010)
  • Author(s): Bao, G.-m., Fukase, K., et al.
  • Journal Title: Bioorg.Med.Chem. Volume: 18 Pages: 3760-3766
  • Peer Reviewed
• [Journal Article] Electrocyclization-based labeling allows efficient in Vivo imaging of cellular trafficking (2010)
  • Author(s): Tanaka, K., Fukase, K., et al.
  • Journal Title: ChemMedChem Volume: 5 Pages: 841-845
  • Peer Reviewed
• [Journal Article] Key structures of bacterial peptidogllyan and lipopolysaccharide triggering the innate immune system of higher animals : Chemical synthesis and functional studies (2010)
  • Author(s): Kusumoto, S., Fukase, K., et al.
  • Journal Title: Proc.Jpn.Acad. Volume: 86(4) Pages: 322-337
  • Peer Reviewed
• [Journal Article] Structural prerequisites for endotoxic activity in the Limulustest as compared to cytokine production in mononuclear cells (2010)
  • Author(s): Gutsmann, T., Fukase, K., et al.
  • Journal Title: Innate Immun. Volume: 16(1) Pages: 39-47
  • Peer Reviewed
• [Journal Article] Nucleotide oligomerization binding domain-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo (2010)
  • Author(s): Asano, J., Fukase, K., et al.
  • Journal Title: J.Immunol. Volume: 184(2) Pages: 736-745
  • Peer Reviewed
• [Journal Article] Multimeric bivalent immunogens from recombinant tetanus toxin H_C fragment, synthetic hexasaccharides, and a glycopeptide adjuvant (2010)
  • Author(s): Bongat, F.G.A., Fukase, K., et al.
  • Journal Title: Glycoconj.J. Volume: 27 Pages: 69-77
  • Peer Reviewed
• [Journal Article] Acid-mediated reactions under micro-fluidic conditions : a new strategy for practical synthesis of bio-functional natural products (2010)
  • Author(s): Tanaka, K.
  • Journal Title: Journal of Organic Chemistry-Thematic series "Flow Chemistry" (in press)
  • Peer Reviewed
• [Journal Article] Nucleotide oligomerization binding domain-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo (2010)
  • Author(s): Asano, J.
  • Journal Title: J.Immunol 184 Pages: 736-745
  • Peer Reviewed
• [Journal Article] Multimeric bivalent immunogens from recombinant tetanus toxin H_c fragment, synthetic hexasaccharides, and a glycopeptide adjuvant (2010)
  • Author(s): Bongat, F.G.A.
  • Journal Title: Glycoconj.J. 27 Pages: 69-77
  • Peer Reviewed
• [Journal Article] Lipopeptides from Staphylococcus aureus as Tlr2 Ligands : Prediction with mRNA Expression. (2009)
  • Author(s): Fujimoto, Y., Hashimoto, M., Furuyashiki, M., Katsumoto, M., Seya, T., Suda, Y., Fukase, K.
  • Journal Title: ChemBioChem. 10(14) Pages: 2311-2315
  • Peer Reviewed
• [Journal Article] Chemical N-glycosylation by asparagine under integrated microfluidic/batch conditions. (2009)
  • Author(s): Tanaka, K., Miyagawa, T., Fukase, K.
  • Journal Title: Synlett 10 Pages: 1571-1574
  • Peer Reviewed
• [Journal Article] Synthesis of crosslinked peptidoglycan fragments for investigation of their immunobiological functions. (2009)
  • Author(s): Fujimoto, Y., Konishi, Y., Kubo, O., Hasegawa, M., Inohara, N., Fukase, K.
  • Journal Title: Tetrahedron Lett. 50 Pages: 3631-3634
  • Peer Reviewed
• [Journal Article] Synthesis of a sialic acid containing complex-type N-glycan on a solid support. (2009)
  • Author(s): Tanaka, K., Fujii, Y., Tokimoto, H., Mori, Y. Tanaka, S. Bao, G., Siwu, E.R.O., Nakayabu, A., Fukase, K.
  • Journal Title: Chem.Asian J. 4 Pages: 574-580
  • Peer Reviewed
• [Journal Article] Chemical synthesis of bacterial lipid A (2009)
  • Author(s): Kusumoto, S.
  • Journal Title: Microbial Glycobiology 2009 Pages: 415-427
  • Peer Reviewed
• [Journal Article] Library-directed Solution- and Solid-phase Synthesis of 2,4-Disubstituted Pyridines : One-pot Approach through 6.pi.-Azaelectrocyclization (2009)
  • Author(s): Sakaguchi, T.
  • Journal Title: Chemistry--An Asian Journal 4(10) Pages: 1573-1577
  • Peer Reviewed
• [Journal Article] Lipopeptides from Staphylococcus aureus as Tlr2 Ligands: Prediction with mRNA Expression (2009)
  • Author(s): Fujimoto, Y.
  • Journal Title: ChemBioChem 10(14) Pages: 2311-2315
  • Peer Reviewed
• [Journal Article] Renaissance of Traditional Organic Reactions under Microfluidic Conditions : A New Paradigm for Natural Products Synthesis (2009)
  • Author(s): Tanaka, K
  • Journal Title: Organic Process Research & Development 13(5) Pages: 983-990
  • Peer Reviewed
• [Journal Article] WaaA of the hyperthermophilic bacterium aquifex aeolicus is a monofunctional 3-deoxy-D-manno-oct-2-ulosonic acid transferase involved in lipopolysaccharide biosynthesis (2009)
  • Author(s): Mamat, U.
  • Journal Title: J.Biol.Chem. 284(33) Pages: 22248-22262
  • Peer Reviewed
• [Journal Article] Chemical N-glycosylation by asparagine under integrated microfluidic/batch conditions (2009)
  • Author(s): Tanaka, K.
  • Journal Title: Synlett 10 Pages: 1571-1574
  • Peer Reviewed
• [Journal Article] Synthesis of crosslinked peptidoglycan fragments for investigation of their immunobioloeical functions (2009)
  • Author(s): Fujimoto, Y.
  • Journal Title: Tetrahedron Lett. 50 Pages: 3631-3634
  • Peer Reviewed
• [Journal Article] Characterization of N-terminal structure of TLR2-activating lipoprotein in staphylococcus aureus (2009)
  • Author(s): Tawaratsumida, K.
  • Journal Title: J.Biol.Chem 284 Pages: 9147-9152
  • Peer Reviewed
• [Journal Article] Synthesis of a sialic acid containing complex-type N-glycan on a solid support (2009)
  • Author(s): Tanaka, K.
  • Journal Title: Chem.Asian J. 4 Pages: 574-580
  • Peer Reviewed
• [Journal Article] Synthesis of a sialic acid containing complex-type N-glycan on a solid support (2009)
  • Author(s): Katsumoto, M.
  • Journal Title: Peptide Science 2008 Pages: 155-156
  • Peer Reviewed
• [Journal Article] Practical synthesis of a manb(1-4)GlcNTroc fragment via microfluidic b-mannosylation (2009)
  • Author(s): Tanaka, K.
  • Journal Title: J.Carbohydr.Chem 28(1) Pages: 1-11
  • Peer Reviewed
• [Journal Article] 糖鎖のインビボバイオイメージング (2009)
  • Author(s): 田中克典, 深瀬浩一
  • Journal Title: 複合糖質の化学と最新応用技術 Pages: 235-244
• [Journal Article] (2009)
  • Author(s): 田中克典, 深瀬浩一
  • Journal Title: 第三の生命鎖「糖鎖」を活用・制御するケミカルバイオロジー,月刊BIO INDUSTRY(シーエムシー出版) Pages: 29-36
• [Journal Article] Library-directed synthesis of N-Glycans : synthesis of sialic acid-containing complex-type N-Glycan on solid-supports (2009)
  • Author(s): Tanaka, K.
  • Journal Title: Chem. Asian J. (in press)
  • Peer Reviewed
• [Journal Article] Practical synthesis of a manb(l-4)GlcNTroc fragment via microfluidic b-mannosylation (2009)
  • Author(s): Tanaka, K.
  • Journal Title: J. Carbohydr. Chem. 28 Pages: 1-11
  • Peer Reviewed
• [Journal Article] Synthesis of diaminopimelic acid containing peptidoglycan fragments and tracheal cytotoxin (TCT) and investigation of their biological functions. (2008)
  • Author(s): Kawasaki, A., Karasudani, Y., Otsuka, Y., Hasegawa, M., Inohara, N., Fujimoto, Y., Fukase, K.
  • Journal Title: Chem., Eur., J. 14 Pages: 10318-10330
  • Peer Reviewed
• [Journal Article] Synthesis of Rubrivivax gelatinosus lipid A and analogues for investigation of the structural basis for immunostimulating and inhibitory activities. (2008)
  • Author(s): Fukase, Y., Fujimoto, Y., Adachi, Y., Suda, Y., Kusumoto, S., Fukase, K.
  • Journal Title: Bull.Chem.Soc.Jpn. BCSJ Award article 81 Pages: 796-819
  • NAID: 10021076555
  • Peer Reviewed
• [Journal Article] A submicrogram scale protocol for biomolecule-based PET imaging by rapid 6π-azaelectrocyclization : visualization of sialic acid dependent circulatory3 residence of glycoproteins. (2008)
  • Author(s): Tanaka, K., Masuyama, T., Hasegawa, K., Tahara, T., Mizuma, H., Wada, Y., Watanabe, Y., Fukase, K.
  • Journal Title: Angew.Chem.Int.Ed. 47 Pages: 102-105
  • Peer Reviewed
• [Journal Article] Cross-tolerization between Nod1 and Nod2 signaling results in reduced refractoriness to bacterial infection in Nod2-deficient macrophages (2008)
  • Author(s): Kim, Y. -G.
  • Journal Title: J. Immunol. 181 Pages: 4340-4346
  • Peer Reviewed
• [Journal Article] Synthesis of diaminopimelic acid containing peptidoglycan fragments and tracheal cytotoxin (TCT) and investigation of their biological functios. (2008)
  • Author(s): Kawasaki, A.
  • Journal Title: Chem., Eur., J. 14 Pages: 10318-10330
  • Peer Reviewed
• [Journal Article] Autophagic control of listeria through intracellular innate immune recognition in drosophila. (2008)
  • Author(s): Yano, T.
  • Journal Title: Nature Immunoloogy 9 Pages: 908-916
  • Peer Reviewed
• [Journal Article] A new catch-and-release purification method using a levulinyl group as a tag and its application to oligosaccharide synthesis. (2008)
  • Author(s): Izumi, M.
  • Journal Title: Chem. Lett. 37 Pages: 1030-1031
  • Peer Reviewed
• [Journal Article] Recent advances in positron emission tomography (PET) imaging of biomolecules : form chemical labeling to cancer diagnostics. (2008)
  • Author(s): Tanaka, K.
  • Journal Title: Mini-reviews in Organic Chemistry 5 Pages: 153-162
  • Peer Reviewed
• [Journal Article] Efficient aldol condensation in aqueous biphasic system under microfluidic conditions (2008)
  • Author(s): Tanaka, K.
  • Journal Title: Tetrahedron Lett. 49 Pages: 2010-2012
  • Peer Reviewed
• [Journal Article] Molecular cloning and functional characterization of porcine nucleotide-binding oligomerization domain-1 (NOD1) recognizing minimum agonists (2008)
  • Author(s): Tohno, M.
  • Journal Title: Mol. Immunol. 45 Pages: 1807-1817
  • Peer Reviewed
• [Journal Article] Autophagic control of listeria through intracellular innate immune recognition in drosophila (2008)
  • Author(s): Yano, T.
  • Journal Title: Nat. Immunol. 9 Pages: 908-916
  • Peer Reviewed
• [Journal Article] A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kB activation. (2008)
  • Author(s): Hasegawa, M.
  • Journal Title: EMBO J. 27 Pages: 373-383
  • Peer Reviewed
• [Journal Article] Differential activation of human TLR4 by escherichia coli and shigella flexneri 2a lipopolysaccharide : combined effects of lipid A acylation state and TLR4 polymorphisms on signaling. (2008)
  • Author(s): Rallabhandi, P.
  • Journal Title: J. Immunol. 180 Pages: 1139-1147
  • Peer Reviewed
• [Journal Article] Synthesis of Rubrivivax gelatinosus lipid A and analogues for investigation of the structural basis for immunostimulating and inhibitory activities (2008)
  • Author(s): Fukase, Y.
  • Journal Title: Bull. Chem. Soc. Jpn. 81 Pages: 796-819
  • NAID: 10021076555
  • Peer Reviewed
• [Journal Article] PET (positron emission tomography) imaging of biomolecules using me tal-DOTA complexes : a new collaborative challenge by chemists, biologists, and physicians for future diagnostics and exploration of in vivo dynamics. (2008)
  • Author(s): Tanaka, K.
  • Journal Title: Org. Biomol. Chem. 6 Pages: 815-828
  • Peer Reviewed
• [Journal Article] A submicrogram scale protocol for biomolecule-based PET imaging by rapid 6π-azaelectrocyclization : visualization of sialic acid dependent circulatory3 residence of glycoproteins. (2008)
  • Author(s): Tanaka, K.
  • Journal Title: Angew. Chem. Int. Ed. 47 Pages: 102-105
  • Peer Reviewed
• [Presentation] 有機合成と生体イメージングを用いて糖鎖の生物機能を解明する (2011)
  • Author(s): 深瀬浩一
  • Organizer: 第4回生体分子科学シンポジウム
  • Place of Presentation: 大阪府立大学理学系研究科(招待講演)
  • Year and Date: 2011-03-04
• [Presentation] 特別企画講演:標的指向型ライブラリー構築と生命科学への貢献 (2011)
  • Author(s): 深瀬浩一
  • Organizer: 日本化学会第91回春季年会
  • Place of Presentation: 神奈川大学
• [Presentation] 学術賞受賞講演:精密有機合成と生体イメージングを基盤とする生物活性複合糖質の機能解明 (2011)
  • Author(s): 深瀬浩一
  • Organizer: 日本化学会第91回春季年会
  • Place of Presentation: 神奈川大学
• [Presentation] 標的指向型ライブラリー構築と生命科学への貢献 (2011)
  • Author(s): 深瀬浩一
  • Organizer: 日本化学会第91回春季年会
  • Place of Presentation: 神奈川大学(招待講演)
• [Presentation] 精密有機合成と生体イメージングを基盤とする生物活性複合糖質の機能解明 (2011)
  • Author(s): 深瀬浩一
  • Organizer: 日本化学会第91回春季年会
  • Place of Presentation: 神奈川大学(招待講演)
• [Presentation] 免疫制御を指向したケミカルグリコバイオロジー (2011)
  • Author(s): 深瀬浩一
  • Organizer: 日本化学会第91回春季年会
  • Place of Presentation: 神奈川大学(招待講演)
• [Presentation] 自然免疫活性化物質と発酵食品 (2011)
  • Author(s): 藤本ゆかり、深瀬浩一
  • Organizer: 日本化学会第91回春季年会
  • Place of Presentation: 神奈川大学
• [Presentation] 寄生性細菌由来リボ多糖部分構造の合成および免疫活性化機構解明と制御 (2011)
  • Author(s): 下山敦史、深瀬浩一
  • Organizer: 日本化学会第91回春季年会
  • Place of Presentation: 神奈川大学
• [Presentation] 免疫刺激作用を持つイノシトールリン脂質合成を指向したmyo-イノシトールの選択的リン酸化反応の研究 (2011)
  • Author(s): 佐藤昌紀、深瀬浩一
  • Organizer: 日本化学会第91回春季年会
  • Place of Presentation: 神奈川大学
• [Presentation] 細菌細胞壁ペプチドグリカン受容体Nod1の天然型リガンドの同定 (2011)
  • Author(s): PRADIPTA A.R.、深瀬浩一
  • Organizer: 日本化学会第91回春季年会
  • Place of Presentation: 神奈川大学
• [Presentation] コアフコースを持つ複合型N-結合型糖鎖の合成研究 (2011)
  • Author(s): 宮川卓也、深瀬浩一
  • Organizer: 日本化学会第91回春季年会
  • Place of Presentation: 神奈川大学
• [Presentation] ペプチドグリカン受容体Nod1リガンド標識体の合成研究 (2011)
  • Author(s): 伊東陽子、深瀬浩一
  • Organizer: 日本化学会第91回春季年会
  • Place of Presentation: 神奈川大学
• [Presentation] N5-Acシアル酸糖供与体を用いた実践的α-シアリル化反応 (2011)
  • Author(s): 内梨洋介、深瀬浩一
  • Organizer: 日本化学会第91回春季年会
  • Place of Presentation: 神奈川大学
• [Presentation] 認識タンパク 質探索・解析を目指したペプチドグリカン・フラグメントライブラリ構築 (2011)
  • Author(s): 王寧、深瀬浩一
  • Organizer: 日本化学会第91回春季年会
  • Place of Presentation: 神奈川大学
• [Presentation] Porphyromonas gingivalisリピドAの合成及び免疫調節活性Synthesis and Immunomodulatory Activities of Porphyromonas gingivalis Lipid A (2011)
  • Author(s): 佐伯昭典、深瀬浩一
  • Organizer: 日本化学会第91回春季年会
  • Place of Presentation: 神奈川大学
• [Presentation] シクロプロパン環を有する細菌由来脂肪酸の合成研究 (2011)
  • Author(s): 浅田早織、深瀬浩一
  • Organizer: 日本化学会第91回春季年会
  • Place of Presentation: 神奈川大学
• [Presentation] Entamoeba histolytica由来NKT細胞刺激作用を有するイノシトールリン脂質の合成研究 (2011)
  • Author(s): 梅垣大地、深瀬浩一
  • Organizer: 日本化学会第91回春季年会
  • Place of Presentation: 神奈川大学
• [Presentation] 寄生性細菌由来リボ多糖部分構造の合成とその機能解析 (2011)
  • Author(s): 下山敦史、深瀬浩一
  • Organizer: 第11回生理活性をあまり意図しない自由な天然物合成勉強会
  • Place of Presentation: 東京大学(東京都)
• [Presentation] Synthesis of Polylysine-Based N-Glycan Dendrimers as Nonin vasive Imaging Tacers (2010)
  • Author(s): K, Tanaka, K.Fukase
  • Organizer: 5^<th> International Peptide Symposium
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2010-12-06
• [Presentation] Innate Immunostimulatory Lipopeptides of Staphylococcus aureus as TLR2 Ligands ; Prediction with mRNA Expression, Synthesis, and NK cell Activation (2010)
  • Author(s): Y.Fujimoto, K.Fukase
  • Organizer: 5^<th> International Peptide Symposium
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2010-12-06
• [Presentation] Peptidoglycan Fragments Released to the Environment ; Analysis, Chemical Synthesis and Nod1 Stimulation (2010)
  • Author(s): Y.Fujimoto, K.Fukase
  • Organizer: 5^<th> Interllational Peptide Symposium
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2010-12-06
• [Presentation] Visualization of N-Glycan dynamics in living animals : A new strategy from synthetic chemistry & molecular imaging (2010)
  • Author(s): K.Tanaka
  • Organizer: Asian Communications of Glycobiology and Glycotechnology (ACGG)
  • Place of Presentation: 台北(台湾)
  • Year and Date: 2010-10-29
• [Presentation] 非侵襲的イメージングを用いたタンパク質、細胞、およびデンドリマー上のN-結合型糖鎖の機能解析-N-革結合型糖鎖による非侵襲的イメージングとターゲティング- (2010)
  • Author(s): 田中克典、深瀬浩一
  • Organizer: 第59回高分子学会
  • Place of Presentation: 北海道大学
  • Year and Date: 2010-09-15
• [Presentation] Azaelectrocyclization-Based Labeling & Engineering Allow Non-Invasive Imaging of Cellular Trafficking and Tumor Targeting by Lymphocytes (2010)
  • Author(s): K.Tanaka, K.Fukase
  • Organizer: World Molecular Imaging Congress (WMIC)
  • Place of Presentation: 京都国際会館(京都府)
  • Year and Date: 2010-09-09
• [Presentation] Entamoeba histolytica由来NKT細胞刺激作用を有するイノシトールリン脂質の合成研究 (2010)
  • Author(s): 佐藤昌紀、深瀬浩一
  • Organizer: 第37回有機反応懇談会
  • Place of Presentation: 京都大学宇治キャンパス
  • Year and Date: 2010-08-02
• [Presentation] 自然免疫活性化機構解明を目指したポルフィロモナス・ジンジバリス菌リピドAの網羅的合成 (2010)
  • Author(s): 佐伯昭典、深瀬浩一
  • Organizer: 第37回有機反応懇談会
  • Place of Presentation: 京都大学宇治キャンパス
  • Year and Date: 2010-08-02
• [Presentation] Syntheses and biological activities of lipid A and Kdo-lipid A from parasitic bacteria (2010)
  • Author(s): K.Fukase
  • Organizer: Deciphering links between pathogen sensorsand inflammatory diseases Institute of Medical Science
  • Place of Presentation: the University of Tokyo(招待講演)
  • Year and Date: 2010-07-28
• [Presentation] Azaelectrocyclization-Based Labelling and Bioconjugation of Proteins and Living Cells : Application to Imaging of N-Glycansand Lymphocytes (2010)
  • Author(s): K.Fukase
  • Organizer: The 4th HiPep-Okinawa International Workshop
  • Place of Presentation: Okinawa Industry Support Center(招待講演)
  • Year and Date: 2010-07-09
• [Presentation] Peptidoglycan Fragments Library for Exploring Recognition Proteins (2010)
  • Author(s): N.Wang, K.Fukase
  • Organizer: 45回天然物化学談話会
  • Place of Presentation: ホテル名山荘(愛知県)
  • Year and Date: 2010-07-06
• [Presentation] マイクロフローシステムを用いた実用的なa-シアリル化反応の開発とポリシアル酸合成への展開 (2010)
  • Author(s): 内梨洋介、深瀬浩一
  • Organizer: 第11回 関西グライコサイエンスフォーラム
  • Place of Presentation: 大阪市立大学 学術情報総合センター
  • Year and Date: 2010-05-15
• [Presentation] in vivo生体分子科学を目指した生物活性プローブの創成:糖鎖のPETイメージングプローブとSH2ドメインミミック (2010)
  • Author(s): 深瀬浩一
  • Organizer: 第16回数理医学研究会
  • Place of Presentation: 大阪大学(大阪)
  • Year and Date: 2010-02-20
• [Presentation] タンパク質、糖鎖の迅速標識法とPETへの応用 (2010)
  • Author(s): 深瀬浩一
  • Organizer: 保健医療分野における基礎研究推進事業「TGF-β活性化反応を標的とした肝疾患の新規診断法、治療・予防法の開発」研究班シンポジウム
  • Place of Presentation: 千里ライフサイエンスセンター(大阪)
  • Year and Date: 2010-02-20
• [Presentation] Synthetic approach for in vivo functional studies of glycans : Application of PETimaging (2010)
  • Author(s): 深瀬浩一
  • Organizer: The 2010 InternationalChemical Congress of Pacific Basin Societies(Pacifichem 2010)
  • Place of Presentation: Honolulu, USA, Invited
• [Presentation] Study of microfluidic reactionstoward production of biofunctional molecules : Application to glycan synthesis (2010)
  • Author(s): 深瀬浩一
  • Organizer: The 2010 International Chemical Congress of PacificBasin Societies (Pacifichem 2010)
  • Place of Presentation: Honolulu, USA, Invited
• [Presentation] Synthetic Approach for Elucidating Glycan Codes (2010)
  • Author(s): Koichi Fukase, Yukari Fujimoto, Katsunori Tanaka
  • Organizer: The 5th InternationalConference on Cutting-Edge Organic Chemistryin Asia (ICCEOCA-5)
  • Place of Presentation: Hsinchu, Taiwan, Invited
• [Presentation] Synthetic Approach toward Understanding In Vivo Functions of Glycans (2010)
  • Author(s): 深瀬浩一
  • Organizer: The 25th International CarbohydrateSymposium (ICS 2010)
  • Place of Presentation: Makuhari Messe(Chiba), Invited
• [Presentation] Synthetic approach for in vivo functional studies of glycans : Application of PET imaging (2010)
  • Author(s): K.Fukase
  • Organizer: The 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010)
  • Place of Presentation: Honolulu, USA(招待講演)
• [Presentation] Study of microfluidic reactions toward production of biofunctional molecules : Application to glycan synthesis (2010)
  • Author(s): Koichi Fukase
  • Organizer: The 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010)
  • Place of Presentation: Honolulu, USA(招待講演)
• [Presentation] Azaelectrocyclization-Based Labeling and Engineering of Proteins & Living Cells : Application to Non-invasive Imaging of N-Glycans (2010)
  • Author(s): K.Tanaka, K.Fukase
  • Organizer: The 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010)
  • Place of Presentation: Honolulu, USA
• [Presentation] Parasitic Bacterial Lipopolysaccharide Partial Structures ; Synthesis and Immunoregulatory Functions (2010)
  • Author(s): A.Shimoyama, K.Fukase
  • Organizer: The 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010)
  • Place of Presentation: Honolulu, USA
• [Presentation] Peptidoglycan fragment library for exploring recognition proteins (2010)
  • Author(s): Ning Wang, K.Fukase
  • Organizer: The 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010)
  • Place of Presentation: Honolulu, USA
• [Presentation] Synthesis of a-Sialosides under Microfluidic Conditions (2010)
  • Author(s): Y.Uchinashi, K.Fukase
  • Organizer: The 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010)
  • Place of Presentation: Honolulu, USA
• [Presentation] Synthetic study of unique phosphatidylinositol structures from Entamoeba histolytica for investigation of NKT cell activation (2010)
  • Author(s): M.Sato, K.Fukase
  • Organizer: The 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010)
  • Place of Presentation: Honolulu, USA
• [Presentation] Natural human Nod1 ligand released in bacterial supernatants ; Structural elucidation and chemical synthesis of peptidogly can fragments (2010)
  • Author(s): A.R.Pradipta, K.Fukase
  • Organizer: The 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010)
  • Place of Presentation: Honolulu, USA
• [Presentation] Synthesis of fluorescence-labeled Nod1/Nod2 ligands for elucidation of immunostimulating mechanism of bacterial cell wall peptidoglycan (2010)
  • Author(s): K.Fujiki, K.Fukase
  • Organizer: The 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010)
  • Place of Presentation: Honolulu, USA
• [Presentation] Synthetic Approach for Elucidating Glycan Codes (2010)
  • Author(s): K.Fukase
  • Organizer: The 5th International Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA-5)/ The 1st New phase International Conference on Cutting-Edge Organic Chemistry in Asia (NICCEOCA-1)
  • Place of Presentation: Hsinchu, Taiwan(招待講演)
• [Presentation] Synthetic Approach for Elucidation of Biological Relevance of Glycans (2010)
  • Author(s): K.Fukase
  • Organizer: The Sixth International Symposium on Integrated Synthesis (ISIS-6)
  • Place of Presentation: Seaside Hotel Maiko Villa Kobe(招待講演)
• [Presentation] Chemical conjugation of immunoadjuvant complex aimed at immunological control (2010)
  • Author(s): Y.Kajiki, K.Fukase
  • Organizer: The Sixth International Symposium on Integrated Synthesis (ISIS-6)
  • Place of Presentation: Seaside Hotel Maiko Villa Kobe(招待講演)
• [Presentation] Synthesis, of Polylysine-Based Glycodendrimer Through Self-Activating Click Reaction (2010)
  • Author(s): T.Watanabe, K.Fukase
  • Organizer: The Sixth International Symposium on Integrated Synthesis (ISIS-6)
  • Place of Presentation: Seaside Hotel Maiko Villa Kobe(招待講演)
• [Presentation] Microfluidic Procedures in Oligosaccharides Synthesis : Innovative Chemical Transformation to Sialoglycans (2010)
  • Author(s): Y.Uchinashi, K.Fukase
  • Organizer: International Symposium on Environmentally Benign Synthesis
  • Place of Presentation: Osaka Univ.Nakanoshima Center
• [Presentation] Comprehensive Chemical Synthesis of Peptidoglycan Fragments for Exploring Recognition Proteins. (2010)
  • Author(s): N.Wang, K.Fukase
  • Organizer: International Symposium on Environmentally Benign Synthesis
  • Place of Presentation: Osaka Univ.Nakanoshima Center
• [Presentation] Peptidoglycan fragments released to the environment ; Analysis, chemical synthesis and Nod1 stimulation (2010)
  • Author(s): Y.Fujimoto, K.Fukase
  • Organizer: 2010 Joint Meeting between the Society for Leukocyte Biology & the International Endotoxin and Innate Immunity Society
  • Place of Presentation: Vancourver, Canada
• [Presentation] Innate Immunostimulatory Lipopeptides of Staphylococcus aureus as TLR2 Ligands ; Prediction with mRNA Expression, Chemical Synthesis, and TLR2-mediated NK Activation (2010)
  • Author(s): Y.Fujimoto, K.Fukase
  • Organizer: 2010 Joint Meeting between the Society for Leukocyte Biology & the International Endotoxin and Innate Immunity Society
  • Place of Presentation: Vancourver, Canada
• [Presentation] アザ電子環状反応を基盤とするタンパク質および細胞表層の高速標識化とN-結合型糖鎖の"生きている動物内"でのイメージング (2010)
  • Author(s): 田中克典、深瀬浩一
  • Organizer: 第52回天然有機化合物討論会
  • Place of Presentation: グランシップ(静岡県)
• [Presentation] 細菌細胞壁ペプチドグリカンによる免疫活性化機構解明を目指したNod1/Nod2リガンド標識体の合成 (2010)
  • Author(s): 藤木勝将、深瀬浩一
  • Organizer: 第4回バイオ関連化学シンポジウム
  • Place of Presentation: 大阪大学
• [Presentation] 高速6π-アザ電子環状反応による高速アミノ基標識キット、STELLA+の開発 (2010)
  • Author(s): 田中克典、深瀬浩一
  • Organizer: 第4回バイオ関連化学シンポジウム
  • Place of Presentation: 大阪大学
• [Presentation] ポリリジンデンドリマー型糖鎖クラスターの効率的合成を基盤としたN-結合型糖鎖の非侵襲的イメージング (2010)
  • Author(s): 田中克典、深瀬浩一
  • Organizer: 第4回バイオ関連化学シンポジウム
  • Place of Presentation: 大阪大学
• [Presentation] 寄生性細菌リボ多糖部分構造の効率的合成とその免疫調節作用の解析 (2010)
  • Author(s): 下山敦史、深瀬浩一
  • Organizer: 第27回有機合成化学セミナー
  • Place of Presentation: シーサイドホテル舞子ビラ神戸
• [Presentation] アスパラギン結合型糖タンパク質糖鎖の合成を指向したマイクロフロー/バッチ混合系でのN-グリコシル化反応の開発 (2010)
  • Author(s): 宮川卓也、深瀬浩一
  • Organizer: 第27回有機合成化学セミナー
  • Place of Presentation: シーサイドホテル舞子ビラ神戸
• [Presentation] Noninvasive PET & Fluorescence Imaging of N-Glycans : Sialic Acid-Dependent In Vivo Dynamics of Proteins, Glycoclusters and Living Cells (2010)
  • Author(s): K.Tanaka, K.Fukase
  • Organizer: Sialoglyco 2010
  • Place of Presentation: Potsdam, Germany
• [Presentation] Synthesis of α-Sialosides under Microfluidic Conditions (2010)
  • Author(s): K.Fukase
  • Organizer: Saloglyco 2010
  • Place of Presentation: Potsdam, Germany
• [Presentation] Synthetic Approach toward Understanding In Vivo Functions of Glycans (2010)
  • Author(s): K.Fukase
  • Organizer: The 25th International Carbohydrate Symposium (ICS 2010)
  • Place of Presentation: 幕張メッセ(千葉県)(招待講演)
• [Presentation] Synthesis of Parasitic Bacterial Lipopolysaccharide Partial Structures for Elucidation of the Immunoregulating Function (2010)
  • Author(s): A.Shimoyama, K.Fukase
  • Organizer: The 25th International Carbohydrate Symposium (ICS 2010)
  • Place of Presentation: 幕張メッセ(千葉県)
• [Presentation] Natural human Nod1 ligand released from bacterial supernatants (2010)
  • Author(s): A.R.Pradipta, K.Fukase
  • Organizer: The 25th International Carbohydrate Symposium (ICS 2010)
  • Place of Presentation: 幕張メッセ(千葉県)
• [Presentation] Practical Microfluidic Procedures for a-Sialylation (2010)
  • Author(s): K.Tanaka, K.Fukase
  • Organizer: The 25th International Carbohydrate Symposium (ICS 2010)
  • Place of Presentation: 幕張メッセ(千葉県)
• [Presentation] Peptidoglycan Fragments Library for Exploring Recognition Proteins (2010)
  • Author(s): Wang, Ning, K.Fukase
  • Organizer: The 25th International Carbohydrate Symposium (ICS 2010)
  • Place of Presentation: 幕張メッセ(千葉県)
• [Presentation] Synthetic Study and Biological Investigation of New N-Glycan in Mouse Brain (2010)
  • Author(s): G.M.Bao, K.Fukase
  • Organizer: The 25th International Carbohydrate Symposium (ICS 2010)
  • Place of Presentation: 幕張メッセ(千葉県)
• [Presentation] Chemistry-based Protein & Cell-Surface Engineering by N-Glycans (2010)
  • Author(s): K.Tanaka, K.Fukase
  • Organizer: The 25th International Carbohydrate Symposium (ICS 2010)
  • Place of Presentation: 幕張メッセ(千葉県)
• [Presentation] Remarkable Structural Dependency of N-Glycan Clusters on In Vivo Dynamics (2010)
  • Author(s): E.R.Siwu, K.Fukase
  • Organizer: The 25th International Carbohydrate Symposium (ICS 2010)
  • Place of Presentation: 幕張メッセ(千葉県)
• [Presentation] Synthesis of fluorescence-labeled Nod1/Nod2 ligands for elucidation of immunostimulating mechanism of bacterial cell wall peptidoglycan (2010)
  • Author(s): K.Fujiki, K.Fukase
  • Organizer: The 25th International Carbohydrate Symposium (ICS 2010)
  • Place of Presentation: 幕張メッセ(千葉県)
• [Presentation] 細胞内自然免疫受容体Nod1リガンドの標識体の合成研究 (2010)
  • Author(s): 伊東陽子、深瀬浩一
  • Organizer: 第43回若手ペプチド夏の勉強会
  • Place of Presentation: ウェルネスパーク五色(兵庫)
• [Presentation] 免疫制御を目指したアジュバント複合体の合成研究 (2010)
  • Author(s): 加治木泰範、深瀬浩一
  • Organizer: 第43回若手ペプチド夏の勉強会
  • Place of Presentation: ウェルネスパーク五色(兵庫)
• [Presentation] Synthesis and Immunoregulating Function of Parasitic Bacterial Lipopolysaccharide Partial Structures (2010)
  • Author(s): A.Shimoyama, K.Fukase
  • Organizer: 28th Naito Conference
  • Place of Presentation: Shonann Kokusai mura Center, Kanagawa
• [Presentation] イメージングを利用した糖鎖の新しい機能探索 (2010)
  • Author(s): 深瀬浩一
  • Organizer: 平成22年度生理学研究所研究会
  • Place of Presentation: 生理学研究所(愛知県)(招待講演)
• [Presentation] Synthesis of new probes for chemical glycobiology : applicationto PET and fluorescent imaging of glycoproteins, glycoclusters, and living cells (2010)
  • Author(s): K.Fukase
  • Organizer: 1st Asian Chemical Biology Conference
  • Place of Presentation: Seoul, Korea
• [Presentation] マイクロフロー系反応を活用したシアル酸含有糖鎖の実用的合成と分子イメージングへの展開 (2010)
  • Author(s): 内梨洋介、深瀬浩一
  • Organizer: 日本ケミカルバイオロジー学会 第5回年会
  • Place of Presentation: 慶応大学 日吉キャンパス(神奈川県)
• [Presentation] 細菌細胞壁ペプチドグリカンによる免疫活性化機構解明を目指したNod1/Nod2リガンド蛍光標識体の合成 (2010)
  • Author(s): 藤木勝将、深瀬浩一
  • Organizer: 日本ケミカルバイオロジー学会 第5回年会
  • Place of Presentation: 慶応大学 日吉キャンパス(神奈川県)
• [Presentation] Synthetic Approach for In Vivo Functioal Studies of Glycans (2010)
  • Author(s): K.Fukase
  • Organizer: The 21st French-Japanese Symposium on Medicinal and Fine Chemiystry (FJS2010)
  • Place of Presentation: Kyoto Garden Palace
• [Presentation] Synthesis and Immunostimulatory Activities of Lipid A from Porphyromonas Gingivalis (2010)
  • Author(s): A.Saeki, K.Fukase
  • Organizer: The 21st French-Japanese Symposium on Medicinal and Fine Chemistry (FJS2010)
  • Place of Presentation: Kyoto Garden Palace
• [Presentation] Synthesis of Petidoglycan Fragment Library for Investigating Their Biofunctions (2010)
  • Author(s): N.Wang, K.Fukase
  • Organizer: The 21st French-Japanese Symposium on Medicinal and Fine Chemistry (FJS2010)
  • Place of Presentation: Kyoto Garden Palace
• [Presentation] Non-Invasive In Vivo Imaging of N-Glycans (2010)
  • Author(s): K.Tanaka, K.Fukase
  • Organizer: International Symposium on Organelle Networks : Interface among Infection-Immunity, Cell Biology and Glycobiology
  • Place of Presentation: 千里ライフサイエンスセンター(大阪)
• [Presentation] Synthesis of parasitic bacterial lipopolysaccharide partial structures for elucidation of immunoregulating function (2010)
  • Author(s): A.Shimoyama, K.Fukase
  • Organizer: International Symposium on Organelle Networks : Interface among Infection-Immunity, Cell Biology and Glycobiology
  • Place of Presentation: 千里ライフサイエンスセンター(大阪)
• [Presentation] Synthesis of GPI structure of EhPIa and EhPIb from Entamoeba histolytica, which activate NKT cell (2010)
  • Author(s): M.Sato, K.Fukase
  • Organizer: International Symposium on Organelle Networks : Interface among Infection-Immunity, Cell Biology and Glycobiology
  • Place of Presentation: 千里ライフサイエンスセンター(大阪)
• [Presentation] Practical Microfluidic Procedures for a-Sialylation (2010)
  • Author(s): Y.Uchinashi, K.Fukase
  • Organizer: International Symposium on Organelle Networks : Interface among Infection-Immunity, Cell Biology and Glycobiology
  • Place of Presentation: 千里ライフサイエンスセンター(大阪)
• [Presentation] ランチオニン含有細菌細胞壁ペプチドグリカン部分構造の合成 (2010)
  • Author(s): 大塚祐治
  • Organizer: 日本化学会第90回春季年会
  • Place of Presentation: 近畿大学(大阪)
• [Presentation] 6π-電子環状反応を用いたタンパク質への糖鎖エンジニアリング (2010)
  • Author(s): 南香莉
  • Organizer: 日本化学会第90回春季年会
  • Place of Presentation: 近畿大学(大阪)
• [Presentation] 広幅経路のマイクロミキサーを活用した実用的α-シアリル化反応 (2010)
  • Author(s): 内梨洋介
  • Organizer: 日本化学会第90回春季年会
  • Place of Presentation: 近畿大学(大阪)
• [Presentation] マイクロフローシステムを用いたグリコシル重合反応の制御 (2010)
  • Author(s): 中藪愛子
  • Organizer: 日本化学会第90回春季年会
  • Place of Presentation: 近畿大学(大阪)
• [Presentation] マイクロフロー/バッチ混合系を用いたN-グリコシル化反応 (2010)
  • Author(s): 宮川卓也
  • Organizer: 日本化学会第90回春季年会
  • Place of Presentation: 近畿大学(大阪)
• [Presentation] 細菌細胞壁ペプチドグリカン受容体Nod1の天然型リガンドの同定 (2010)
  • Author(s): PRADIPTA, Ambara Rachmat
  • Organizer: 日本化学会第90回春季年会
  • Place of Presentation: 近畿大学(大阪)
• [Presentation] 免疫活性化機構解明を目指したペプチドグリカン蛍光標識体の合成研究 (2010)
  • Author(s): 藤木勝将
  • Organizer: 日本化学会第90回春季年会
  • Place of Presentation: 近畿大学(大阪)
• [Presentation] Helicobacter pyloriリポ多糖部分構造の合成および免疫活性化機構解明と制御 (2010)
  • Author(s): 下山敦史
  • Organizer: 日本化学会第90回春季年会
  • Place of Presentation: 近畿大学(大阪)
• [Presentation] Integrated Microfluidic/Batch Conditions for Practical N-Glycosylation (2010)
  • Author(s): Katsunori Tanaka
  • Organizer: 11th International Conference on Microreaction Technology (IMRET 11)
  • Place of Presentation: Kyoto Research Park (Kyoto)
• [Presentation] イメージングを活用した糖鎖のin vivo生体分子科学 (2010)
  • Author(s): 深瀬浩一
  • Organizer: 第12回 生命化学研究会
  • Place of Presentation: 芦原温泉 清風荘(福井)
• [Presentation] ランチオニン含有ペプチドグリカン部分構造の合成とその免疫刺激活性 (2009)
  • Author(s): 大塚祐治
  • Organizer: 第29回有機合成若手セミナー
  • Place of Presentation: 甲南大学ポートアイランド(神戸)
  • Year and Date: 2009-11-24
• [Presentation] マイクロ系内でのグリコシルカチオンの制御に基づく実用的フロー糖鎖合成 (2009)
  • Author(s): 中薮愛子
  • Organizer: 第29回有機合成若手セミナー
  • Place of Presentation: 甲南大学ポートアイランド(神戸)
  • Year and Date: 2009-11-24
• [Presentation] Synthesis of Parasitic Bacterial Lipopolysaccharide Partial Structures for Elucidation and Regulation of Innate Immune System (2009)
  • Author(s): Y.Fujimoto
  • Organizer: The 3rd Japanese-German Core-to Core Meeting
  • Place of Presentation: Cairn, Germany
  • Year and Date: 2009-11-10
• [Presentation] 集積型合成を目指したマイクロフロー合成研究:フロー・マイクロ合成研究会第4回銅金賞受賞講演 (2009)
  • Author(s): 深瀬浩一
  • Organizer: フロー・マイクロ合成研究会第21回公開講演会
  • Place of Presentation: 大阪科学技術センター
  • Year and Date: 2009-08-07
• [Presentation] 集積型合成を目指したマイクロフロー合成研究 (2009)
  • Author(s): 深瀬浩一
  • Organizer: フロー・マイクロ合成研究会 第21回公開講演会
  • Place of Presentation: 大阪科学技術センター(大阪)
  • Year and Date: 2009-08-07
• [Presentation] 有機合成で生物機能に迫る:マイクロフロー合成と固相合成による糖鎖構築と糖鎖の新機能解析 (2009)
  • Author(s): 深瀬浩一
  • Organizer: 第34回有機反応懇談会
  • Place of Presentation: 関西学院大学(招待講演)
  • Year and Date: 2009-08-03
• [Presentation] 有機合成で生物機能に迫る:マイクロフロー合成と固相合成による糖鎖構築と糖鎖の新機能解析 (2009)
  • Author(s): 深瀬浩一
  • Organizer: 第34回有機反応懇談会
  • Place of Presentation: 関西学院大学(三田)
  • Year and Date: 2009-08-03
• [Presentation] 酸性糖KDOを含むリポ多糖活性部分構造合成と機能解析 (2009)
  • Author(s): 下山敦史
  • Organizer: 第34回有機反応懇談会
  • Place of Presentation: 関西学院大学(神戸)
  • Year and Date: 2009-08-03
• [Presentation] イミデート構造内包型脱離基を用いた立体選択的グリコシル化反応 (2009)
  • Author(s): 森修子
  • Organizer: 第34回有機反応懇談会
  • Place of Presentation: 関西学院大学(神戸)
  • Year and Date: 2009-08-03
• [Presentation] タンパク質、および細胞上での革新的有機合成反応の開発:6p-アザ電子環状反応を用いたシンセティックバイオロジー (2009)
  • Author(s): Eric R.O.Siwu
  • Organizer: 第34回有機反応懇談会
  • Place of Presentation: 関西学院大学(神戸)
  • Year and Date: 2009-08-03
• [Presentation] マイクロリアクターを利用した実用的有機合成 : 糖鎖合成を中心とした展開 (2009)
  • Author(s): 深瀬浩一
  • Organizer: 京都大学桂キャンパス講演会マイクロ合成化学の新潮流
  • Place of Presentation: kyoto
  • Year and Date: 2009-01-30
• [Presentation] Synthesisof new probes for chemical glycobiology : application to PET and fluorescent imaging of glycoproteins, glycoclusters, and living cells (2009)
  • Author(s): Koichi Fukase, Katsunori Tanaka, TatsuroMasuyama, Kaori Minami, Eric R.O. Siwu, KokiHasegawa, Tsuyoshi Tahara, Hiroshi Mizuma, Yasuhiro Wada, Yasuyoshi Watanabe
  • Organizer: The Second International Symposium on Combinatorial Sciences in Chemistry, Biology,Catalysts and Materials (SCS09)
  • Place of Presentation: Beijin, China, Invited
• [Presentation] 有機合成で生物機能に迫る:マイクロフロー合成と固相合成による糖鎖構築と糖鎖の新機能解析 (2009)
  • Author(s): 深瀬浩一
  • Organizer: 第29回日本糖質学会年会
  • Place of Presentation: 世界生活文化センター(岐阜県)招待講演
• [Presentation] Molecular Probe Method for Studying the Biofunctional Role of Glycoconjugates (2009)
  • Author(s): 深瀬浩一
  • Organizer: The 25th Naito Conference, Chemical Biology II-An Emerging Filed Inspired by Natural Product Chemistry-
  • Place of Presentation: Shateraise Gateaux Kingdom Sapporo (Hokkaido), Invited
• [Presentation] 糖鎖の合成とin vivo生体分子科学 (2009)
  • Author(s): 深瀬浩一
  • Organizer: 第44回天然物化学談話会
  • Place of Presentation: つくばグランドホテル(茨城県)(招待講演)
• [Presentation] Chemical Glycobiology of Self/Non-self Recognition (2009)
  • Author(s): 深瀬浩一
  • Organizer: Gordon Research Conferences, Carbohydrates
  • Place of Presentation: Tilton School, Tilton, NH,Invited
• [Presentation] シンポジウム「ケミカルバイオロジー研究の最前線-新分野としての未来-」自己と非自己の認識に関するケミカルグリコバイオロジー (2009)
  • Author(s): 深瀬浩一
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 日本大学(千葉県)(招待講演)
• [Presentation] Synthetic approach for in vivo functional studies of glycans : a pplication of PET imaging (2009)
  • Author(s): Koichi Fukase
  • Organizer: Korean Society for Glycoscience
  • Place of Presentation: Daejeon, Korea
• [Presentation] Synthesis of Peptidoglycan Fragments with a New Disaccharide Building Block (2009)
  • Author(s): C.Huang
  • Organizer: IKCOC-11
  • Place of Presentation: Kyoto Royal Hotel (Kyoto)
• [Presentation] Glycosylation in Microfluidic and on Solid Supports : Synthesis of Sialic Acid-Containing Complex-type N-Glycan (2009)
  • Author(s): Aiko Nakayabu
  • Organizer: IKCOC-11
  • Place of Presentation: Kyoto Royal Hotel (Kyoto)
• [Presentation] Natural Nod1 ligands released from bacteria : Isolation, chara cterization, and chemical synthesis (2009)
  • Author(s): Ambara R.Pradipta
  • Organizer: 20th Joint Glycobiology Meeting of the Study Groups for Glycobiology from Netherlands, Belgium, France and Germany
  • Place of Presentation: Cairn, Germany
• [Presentation] Synthesis of Glycans by Integration of Solid-phase and Microfluidic Method (2009)
  • Author(s): Koichi Fukase
  • Organizer: 5th Spanish-Portuguese-Japanese Organic Chemistry Symposium (5th SPJ-OCS)
  • Place of Presentation: Osaka Univ. (Osaka)
• [Presentation] ランチオニン含有ペプチドグリカン部分構造の合成とその免疫刺激活性 (2009)
  • Author(s): 大塚祐治
  • Organizer: 第46回ペプチド討論会
  • Place of Presentation: 北九州国際会議場(北九州)
• [Presentation] Synthetic studies of glycans and glyco-probes for chemical glycobiology (2009)
  • Author(s): Koichi Fukase
  • Organizer: Simposium Nasional Kimia Bahan Alam XVII
  • Place of Presentation: Semarang, Indonesia
• [Presentation] 自然免疫を活性化する細菌細胞壁ペプチドグリカン・フラグメントの構造解析、合成と機能 (2009)
  • Author(s): 藤本ゆかり
  • Organizer: 第51回 天然有機化合物討論会
  • Place of Presentation: 名古屋市公会堂(名古屋)
• [Presentation] Natural Nod1 ligands released from bacteria : Isolation, characterization, and chemical synthesis (2009)
  • Author(s): Ambara R.Pradipta
  • Organizer: GCOE 分野融合若手研究会
  • Place of Presentation: 伊勢かぐらばリゾート千の杜(三重)
• [Presentation] Nanomolar-Scale Lysine Labeling by 6□-Azaelectrocyclization : Biomolecule- and Whole Cell-Based In Vivo Imaging and Tumor Targeting (2009)
  • Author(s): K.Minami,
  • Organizer: Combinatorial Chemistry and Chemical Biology toward A New Paradigm for Drug Discovery (CCCB)
  • Place of Presentation: Senri Life Science Center (Osaka)
• [Presentation] Immunobiological Functions of Bacterial Peptidoglycan ; Investigation with Chemically Synthesized Fragments Library (2009)
  • Author(s): Y.Fujimoto
  • Organizer: Combinatorial Chemistry and Chemical Biology toward A New Paradigm for Drug Discovery (CCCB)
  • Place of Presentation: Senri Life Science Center (Osaka)
• [Presentation] Innate Immunostimulatory Lipopeptides of Staphylococcus aureus as TLR2 Ligands ; Prediction with mRNA Expression, Chemical Synthesis, and Immunostimulatory Activities (2009)
  • Author(s): Y.Fujimoto
  • Organizer: Combinatorial Chemistry and Chemical Biology toward A New Paradigm for Drug Discovery (CCCB)
  • Place of Presentation: Senri Life Science Center (Osaka)
• [Presentation] Synthesis of Parasitic Bacterial Lipopolysaccharide Partial Structures for Elucidation and Regulation of Innate Immune System (2009)
  • Author(s): Atsushi Shimoyama
  • Organizer: Combinatorial Chemistry and Chemical Biology toward A New Paradigm for Drug Discovery (CCCB)
  • Place of Presentation: Senri Life Science Center (Osaka)
• [Presentation] Synthesis and innate immunostimulating activities of bacterial cell wall peptidoglycan partial structures containing lanthionine (2009)
  • Author(s): Yuji Otsuka
  • Organizer: Combinatorial Chemistry and Chemical Biology toward A New Paradigm for Drug Discovery (CCCB)
  • Place of Presentation: Senri Life Science Center (Osaka)
• [Presentation] In Vivo Imaging of N-Glycan Dendrimers by Fluorescence and Positron Emission Tomography (PET) (2009)
  • Author(s): Eric R.O.Siwu
  • Organizer: Combinatorial Chemistry and Chemical Biology toward A New Paradigm for Drug Discovery (CCCB)
  • Place of Presentation: Senri Life Science Center (Osaka)
• [Presentation] Convergent Synthesis of N-linked Glycan through Microfluidic & Solid-supported Glycosylation (2009)
  • Author(s): Aiko Nakayabu
  • Organizer: Combinatorial Chemistry and Chemical Biology toward A New Paradigm for Drug Discovery (CCCB)
  • Place of Presentation: Senri Life Science Center (Osaka)
• [Presentation] Integrated Microfluidic/Batch Conditions for Practical N-Glycosylation (2009)
  • Author(s): Takuya Miyagawa
  • Organizer: Combinatorial Chemistry and Chemical Biology toward A New Paradigm for Drug Discovery (CCCB)
  • Place of Presentation: Senri Life Science Center (Osaka)
• [Presentation] Synthesis of new probes for chemical glycobiology : application to PET and fluorescent imaging of glycoproteins, glycoclusters, and living cells (2009)
  • Author(s): Koichi Fukase
  • Organizer: The Second International Symposium on Combinatorial Sciences in Chemistry, Biology, Catalysts and Materials (SCS09)
  • Place of Presentation: Beijin, China
• [Presentation] Study of microfluidic reactions toward production of biofunctional molecules : application to glycan synthesis (2009)
  • Author(s): Koichi Fukase
  • Organizer: GRATAMA WORKSHOP 2009
  • Place of Presentation: Delft, Netherlands
• [Presentation] In vivo imaging of glycoproteins and glycoclusters (2009)
  • Author(s): Koichi Fukase
  • Organizer: 2nd Switzerland-Japan Biomolecular Chemistry Symposium
  • Place of Presentation: Tokyo Univ. (Tokyo)
• [Presentation] Isolation and Characterization of Natural Nod1 Ligands from Bacterial Culture Supernatant (2009)
  • Author(s): Ambara R.Pradipta
  • Organizer: 2nd Switzerland-Japan Biomolecular Chemistry Symposium
  • Place of Presentation: Tokyo Univ. (Tokyo)
• [Presentation] マイクロフロー/バッチ混合系を用いたグリコシル化反応の開発 (2009)
  • Author(s): 宮川卓也
  • Organizer: 第29回日本糖質学会年会
  • Place of Presentation: 世界生活文化センター(高山)
• [Presentation] In Vivo Imaging of N-Glycan Dendrimers by Fluorescence and Positron Emission Tomography (PET) (2009)
  • Author(s): Eric R.O.Siwu
  • Organizer: 第29回日本糖質学会年会
  • Place of Presentation: 世界生活文化センター(高山)
• [Presentation] Molecular Probe Method for Studying the Biofunctional Role of Glycoconjugates (2009)
  • Author(s): Koichi Fukase
  • Organizer: The 25th Naito Conference, Chemical Biology II -An Emerging Filed Inspired by Natural Product Chemistry
  • Place of Presentation: Chateraise Gateaux Kingdom (Sapporo)
• [Presentation] ランチオニン含有ペプチドグリカン部分構造の合成とその免疫刺激活性 (2009)
  • Author(s): 大塚祐治
  • Organizer: 第42回若手ペプチド夏の勉強会
  • Place of Presentation: 八王子セミナーハウス(東京)
• [Presentation] Fast Labeling of Lysines Via 6π-Azaelectrocyclization : Application to Pet Imaging of Glycoproteins and Glycociusters (2009)
  • Author(s): Koichi. Fukase
  • Organizer: 15th European Carbohydrate Symposium (eurocarb 15)
  • Place of Presentation: Vienna, Austria
• [Presentation] Synthesis and Blofunction of Nodl ligands of peptidoglycan ; Innate Immunostimulating Glycoconjugates from bacteria (2009)
  • Author(s): Y.Fujimoto
  • Organizer: 15th European Carbohydrate Symposium (eurocarb 15)
  • Place of Presentation: Vienna, Austria
• [Presentation] In Vivo Imaging of N-Glycan Dendrimers by Fluorescence and Positron Emission Tomography (PET) (2009)
  • Author(s): Eric R.O.Siwu
  • Organizer: 15th European Carbohydrate Symposium (eurocarb 15)
  • Place of Presentation: Vienna, Austria
• [Presentation] 糖鎖の合成とin vivo生体分子科学 (2009)
  • Author(s): 深瀬浩一
  • Organizer: 第44回天然物化学談話会
  • Place of Presentation: つくばグランドホテル(つくば)
• [Presentation] 免疫活性化機構解明を目指したペプチドグリカンフラグメントと蛍光イメージングのための分子プローブの合成研究 (2009)
  • Author(s): 藤木勝将
  • Organizer: 第44回天然物化学談話会
  • Place of Presentation: つくばグランドホテル(つくば)
• [Presentation] マイクロフロー/バッチ混合系を用いたN-グリコシル化反応の開発 (2009)
  • Author(s): 宮川卓也
  • Organizer: 第44回天然物化学談話会
  • Place of Presentation: つくばグランドホテル(つくば)
• [Presentation] Chemical Glycobiology of Self/Non-self Recognition (2009)
  • Author(s): Koichi Fukase
  • Organizer: Gordon Research Conferences, Carbohydrates
  • Place of Presentation: Tilton, NH
• [Presentation] アスパラギン結合型糖タンパク質糖鎖クラスターの蛍光およびPETイメージング (2009)
  • Author(s): Eric R.O.Siwul
  • Organizer: 日本ケミカルバイオロジー学会 第4回年会
  • Place of Presentation: 神戸市産業振興センター(神戸)
• [Presentation] 自然免疫活性化機構解明と制御を目指した寄生性細菌リポ多糖部分構造の合成研究 (2009)
  • Author(s): 下山敦史
  • Organizer: 日本ケミカルバイオロジー学会 第4回年会
  • Place of Presentation: 神戸市産業振興センター(神戸)
• [Presentation] Innate immunostimulating peptidoglycan fragments from bacteria ; Structure elucidation and chemical synthesis of Nod1 ligand (2009)
  • Author(s): Ambara R.Pradipta
  • Organizer: 日本ケミカルバイオロジー学会 第4回年会
  • Place of Presentation: 神戸市産業振興センター(神戸)
• [Presentation] ポスタータイトル:高速6π-アザ電子環状反応を用いた細胞表層への化学的標識と糖鎖エンジニアリング:細胞のインビボイメージング (2009)
  • Author(s): 南香莉
  • Organizer: 日本ケミカルバイオロジー学会 第4回年会
  • Place of Presentation: 神戸市産業振興センター(神戸)
• [Presentation] 自己と非自己の認識に関するケミカルグリコバイオロジー (2009)
  • Author(s): 深瀬浩一
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 舟橋
• [Presentation] 紅色光合成細菌リピドAとその類縁体の効率的な合成と機能 (2009)
  • Author(s): 藤本ゆかり
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 舟橋
• [Presentation] 免疫刺激活性をもつPorphyromonas gingivalisリピドAの合成研究 (2009)
  • Author(s): 笠松千郁
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 舟橋
• [Presentation] 高度好熱菌Thermus thermophilus由来リン酸化糖脂質およびその類縁体の合成と免疫刺激活性 (2009)
  • Author(s): 光延邦浩
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 舟橋
• [Presentation] ランチオニン含有細菌細胞壁ペプチドグリカン部分構造の合成 (2009)
  • Author(s): 大塚祐治
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 舟橋
• [Presentation] Latentなイミデート構造を脱離基に用いた立体選択的グリコシル化反応 (2009)
  • Author(s): 森修子
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 舟橋
• [Presentation] Synthesis of peptidoglycan fragments and their labeled derivatives for elucidation of immunostimulating mechanism (2009)
  • Author(s): K. Fujiki
  • Organizer: Clinical and Traslational Research on Cancer : Glycomics Application
  • Place of Presentation: Ise-Shima
• [Presentation] Isolation and structure elucidation of immunostimulatory native Nod1 ligand (2009)
  • Author(s): A. R. Pradipta
  • Organizer: Clinical and Traslational Research on Cancer : Glycomics Application
  • Place of Presentation: Ise-Shima
• [Presentation] Synthesis of Sialic Acid-containing Complex-type N-Glycan on Solid-supports (2009)
  • Author(s): G. Bao
  • Organizer: Clinical and Traslational Research on Cancer : Glycomics Application
  • Place of Presentation: Ise-Shima
• [Presentation] ダイナミックコンビナトリアルケミストリー/自己活性化型Click反応を用いたGrb2-SH2ドメインイディオタイプ創製への新規アプローチ (2008)
  • Author(s): 白坏早苗
  • Organizer: 先端科学セミナー京都 ケミカルバイオロジーシンポジウム
  • Place of Presentation: kyoto
  • Year and Date: 2008-12-15
• [Presentation] 高速アザ電子環状反応を用いた生細胞表層の蛍光および糖鎖標識化法 (2008)
  • Author(s): 南香莉
  • Organizer: 先端科学セミナー京都 ケミカルバイオロジーシンポジウム
  • Place of Presentation: kyoto
  • Year and Date: 2008-12-15
• [Presentation] 超高速電子環状反応を基盤としたPETイメージング : インビボ糖鎖関連物質ダイナミクス (2008)
  • Author(s): Eric R. O. Siwu
  • Organizer: 先端科学セミナー京都 ケミカルバイオロジーシンポジウム
  • Place of Presentation: kyoto
  • Year and Date: 2008-12-15
• [Presentation] Synthesis of glycan libraries for elucidation of their biofunctions (2008)
  • Author(s): K. Fukase
  • Organizer: International Symposium on Systems Glycobio logy-A Bridge between Functional Glycomics and Chemical Biology
  • Place of Presentation: Tokyo
  • Year and Date: 2008-12-05
• [Presentation] Library-Directed Solid-Phase Synthesis of N-Linked Glycans (2008)
  • Author(s): K. Fukase
  • Organizer: The 9th International Symposium on Organic Reactions
  • Place of Presentation: Chiayi, Taiwan
  • Year and Date: 2008-11-20
• [Presentation] Synthesis of Molecular Probes for Chemical Glycobiology : Application to PET Imaging (2008)
  • Author(s): K. Fukase
  • Organizer: Workshop on Frontier Organic Synthesis and Glycoscience
  • Place of Presentation: Taiwan
  • Year and Date: 2008-11-19
• [Presentation] First Positron Emission Tomography (PET) Imaging of Glycoproteins and Glycodendrimers by Efficient Chemical Labeling with[^<68>Ga]-DOTA, Consortium for Functional Glycomics (HGPI) (2008)
  • Author(s): K. Tanaka
  • Organizer: 8th HGPI meeting
  • Place of Presentation: Fort worth, U.S.A.
  • Year and Date: 2008-11-13
• [Presentation] Synthesis and Biological Activity of Helicobacter pylori Lipopolysaccharide Partial Structures (2008)
  • Author(s): A. Shimoyama
  • Organizer: 8th HGPI meeting
  • Place of Presentation: Fort worth, U.S.A.
  • Year and Date: 2008-11-13
• [Presentation] Synthesis and biofunctional study of glycoconjugates (2008)
  • Author(s): K. Fukase
  • Organizer: International Seminar on Chemistry 2008
  • Place of Presentation: Indonesia
  • Year and Date: 2008-11-03
• [Presentation] A Submicrogram-Scale PET, Imaging of Biomolecules : New Labeling of Lysines via 6p-Azaelectrocyclization (2008)
  • Author(s): K. Tanaka
  • Organizer: World Molecular Imaging Congress
  • Place of Presentation: France
  • Year and Date: 2008-09-13
• [Presentation] ペプチド・タンパク質、抗体の革新的標識法とPETによる動態解析への応用 (2008)
  • Author(s): 深瀬浩一
  • Organizer: 第2回ミニシンポジウムバイオ医薬品のマイクロドーズ・早期探索臨床試験の意義と課題、医薬品開発支援機構(APDD)・マイクロドーズ・探索臨床試験研究会共催
  • Place of Presentation: 東京大学薬学部(招待講演)
  • Year and Date: 2008-08-09
• [Presentation] ペプチド・タンパク質、抗体の革新的標識法とPETによる動態解析への応用 (2008)
  • Author(s): 深瀬浩一
  • Organizer: 第2回ミニシンポジウムバイオ医薬品のマイクロドーズ・早期探索臨床試験の意義と課題
  • Place of Presentation: 東京
  • Year and Date: 2008-08-09
• [Presentation] マイクロフローグリコシル化反応を活用したN-結合型糖タンパク質糖鎖の合成 (2008)
  • Author(s): 森康貴
  • Organizer: 第35回有機反応懇談会
  • Place of Presentation: 大阪
  • Year and Date: 2008-08-01
• [Presentation] 免疫刺激活性を持つペプチドグリ カン部分構造の合成 (2008)
  • Author(s): 大塚祐治
  • Organizer: 第35回有機反応懇談会
  • Place of Presentation: 大阪
  • Year and Date: 2008-08-01
• [Presentation] 3-Nitro-2-pyridyl基を脱離基として用いたグリコシル化反応の研究 (2008)
  • Author(s): 森修子
  • Organizer: 第35回有機反応懇談会
  • Place of Presentation: 大阪
  • Year and Date: 2008-08-01
• [Presentation] 高速アザ電子環状反応を用いた生細胞表層の蛍光および糖鎖標識法 (2008)
  • Author(s): 南香莉
  • Organizer: 第35回有機反応懇談会
  • Place of Presentation: 大阪
  • Year and Date: 2008-08-01
• [Presentation] 免疫刺激活性を持つペプチドグリカン部分構造の合成 (2008)
  • Author(s): 大塚祐治
  • Organizer: 第35回有機反応懇談会
  • Place of Presentation: 大阪
  • Year and Date: 2008-08-01
• [Presentation] 化学合成で糖鎖の生物機能を解析する (2008)
  • Author(s): 深瀬浩一
  • Organizer: 理研シンポジウム第3回有機合成化学のフロンティア
  • Place of Presentation: 理化学研究所和光研究所(埼玉県)(招待講演)
  • Year and Date: 2008-07-07
• [Presentation] 化学合成で糖鎖の生物機能を解析する (2008)
  • Author(s): 深瀬浩一
  • Organizer: 理研シンポジウム 第3回有機合成化学のフロンティア
  • Place of Presentation: 埼玉
  • Year and Date: 2008-07-07
• [Presentation] 超高速化学標識法の開発を基盤とした糖タンパク質、糖鎖付加人工抗体、および糖鎖クラスターのPETイメージング (2008)
  • Author(s): 田中克典
  • Organizer: 第9回関西グライコサイエンスフォーラム
  • Place of Presentation: 大阪
  • Year and Date: 2008-05-17
• [Presentation] Chemical synthesis of bacterial PAMPs for elucidation and regulation of innate immune response (2008)
  • Author(s): 深瀬浩一
  • Organizer: 10th Biennial Meeting of the International Endotoxin and Innate Immunity Society (IEIIS2008)
  • Place of Presentation: Edinburgh, UK, Invited
• [Presentation] 生理活性物質のプロセス合成を意図したマイクロフロー反応の開発 (2008)
  • Author(s): 森康貴
  • Organizer: 第27回メディシナルケミストリーシンポジウム
  • Place of Presentation: 大阪
• [Presentation] Synthesis of Peptidoglycan Fragments on Solid-Phase Supports (2008)
  • Author(s): C. -Y. Huang
  • Organizer: The 9th International Symposium on Organic Reactions
  • Place of Presentation: Chiayi, Taiwan
• [Presentation] Making probes for chemical glycobiology : elucidation of innate immunity and PET imaging of biomolecules (2008)
  • Author(s): K. Fukase
  • Organizer: 2008 RIKEN Conference Chemical Biology
  • Place of Presentation: Narita
• [Presentation] Synthesis and Biological Activity of Helicobacter pylori Lipopolysaccharide Partial Structures (2008)
  • Author(s): A. Shimoyama
  • Organizer: Glycobiology2008
  • Place of Presentation: Fort Worth, U.S.A.
• [Presentation] Synthesis of Glycans on Glycoproteins by Using Microreactor and Solid-phase Methodc (2008)
  • Author(s): K. Fukase
  • Organizer: Korea-Japan Joint Symposium on Functional Materials toward Future Catalysts : Chemistry Showcase
  • Place of Presentation: Daejeon, KOREA
• [Presentation] Synthesis and Immunostimulatory Activities of Lipopeptides from Gram-positive Bacteria (2008)
  • Author(s): M. Katsumoto
  • Organizer: 第45回ペプチド討論会
  • Place of Presentation: 東京
• [Presentation] Solid-Phase Synthesis of N-Linked Glycans (2008)
  • Author(s): K. Fukase
  • Organizer: 18th International Symposium on Fine Chemistry and Functional, Polymers (FCFP-XVIII) & IUPAC 4th International Symposium on Novel Materials and Synthesis(NMS-IV)
  • Place of Presentation: Zhenjiang, China
• [Presentation] 高度好熱菌 Thermus thermophilus由来糖脂質の合成と免疫刺激活性 (2008)
  • Author(s): 光延邦浩
  • Organizer: 第3回バイオ関連化学合同シンポジウム
  • Place of Presentation: 横浜
• [Presentation] Synthesis of Biofunctional Molecules Using Microfluidic Systems (2008)
  • Author(s): Y. Mori
  • Organizer: International Symposium on Micro Chemical Process and Synthesis
  • Place of Presentation: Kyoto
• [Presentation] Synthetic study of bacterial glycoconjugates for understanding the molecular basis of innate immune system (2008)
  • Author(s): Y. Fujimoto
  • Organizer: The 22nd Naito Conference on “Chemical Biology
  • Place of Presentation: Sapporo
• [Presentation] Acceleration of Cu(I)-Mediated Huisgen 1, 3-Dipolar Cycloaddition by Histidine Derivatives : Facile Synthesis of Glycodendrimers for PET Imaging (2008)
  • Author(s): E. R. O. Siwu
  • Organizer: The Fifth International Symposium on Integrated Synthesis(ISIS-5)
  • Place of Presentation: Kobe
• [Presentation] 超高速化学標識法の開発を基盤とした糖タンパク質、糖鎖付加人工抗体、および糖鎖クラスターのPETイメージング (2008)
  • Author(s): 田中克典
  • Organizer: FCCAセミナー/FCCAグライコサイエンス若手フォーラム
  • Place of Presentation: 筑波
• [Presentation] ヘリコバクター・ピロリ細胞表層成分リポ多糖部分構造の合成 (2008)
  • Author(s): 下山敦史
  • Organizer: FCCAセミナー/FCCAグライコサイエンス若手フォーラム
  • Place of Presentation: 筑波
• [Presentation] シアル酸含有N-結合型糖タンパク質糖鎖の固相合成 (2008)
  • Author(s): 中薮愛子
  • Organizer: FCCAセミナー/FCCAグライコサイエンス若手フォーラム
  • Place of Presentation: つくば
• [Presentation] 自然免疫活性化機構の解明を目指したヘリコバクター・ピロリ細胞表層成分リポ多糖部分構造の合成 (2008)
  • Author(s): 下山敦史
  • Organizer: 第28回日本糖質学会年会
  • Place of Presentation: つくば
• [Presentation] N-結合型糖タンパク質糖鎖の固相ライブラリー合成研究 (2008)
  • Author(s): Bao Guang-ming
  • Organizer: 第28回日本糖質学会年会
  • Place of Presentation: つくば
• [Presentation] 免疫刺激活性を持つグラム陽性菌由来リポペプチドの合成研究 (2008)
  • Author(s): 勝本麻美
  • Organizer: 41回 若手ペプチド夏の勉強会
  • Place of Presentation: 京都
• [Presentation] Chemical synthesis of bacterial PAMPs for elucidation and regulation of innate immune response (2008)
  • Author(s): K. Fukase
  • Organizer: 10th Biennial Meeting of the International Endotoxin and Innate Immunity Society (IEIIS2008)
  • Place of Presentation: Edinburgh, UK
• [Presentation] Synthesis of diaminopimelic acid containing peptidoglycan fragments and tracheal cytotoxin (TCT) for investigation of their biological functions (2008)
  • Author(s): Y. Fujimoto
  • Organizer: 10th Biennial Meeting of the International Endotoxin and Innate Immunity Society (IEIIS2008)
  • Place of Presentation: Edinburgh, UK
• [Presentation] Synthesis of Helicobacter pylori Lipopolysaccharide Partial Structures for Investigation of Their Biological Function (2008)
  • Author(s): A. Shimoyama
  • Organizer: 10th Biennial Meeting of the International Endotoxin and Innate Immunity Society (IEIIS2008)
  • Place of Presentation: Edinburgh, UK
• [Presentation] Synthesis of immunostimulatory peptidoglycan fragments recognized by the intracellular receptors (2008)
  • Author(s): Y. Fujimoto
  • Organizer: The International Conference on Biodiversity and Natural Products ((IUPAC) ICOB-6 and ISCNP-26)
  • Place of Presentation: Charlottetown, Canada
• [Presentation] Solid-Phase Synthesis of N-Linked Glycans (2008)
  • Author(s): K. Tanaka
  • Organizer: XXXIVInternational Carbojydrate Symposium
  • Place of Presentation: Oslo, Norway
• [Presentation] 高速アザ電子環状反応を用いた生細胞表層の蛍光および糖鎖標識法 (2008)
  • Author(s): 南香莉
  • Organizer: 第43回 天然物化学談話会
  • Place of Presentation: 大阪
• [Presentation] 免疫刺激活性を持つペプチドグリカン部分構造の合成 (2008)
  • Author(s): 大塚祐治
  • Organizer: 第43回 天然物化学談話会
  • Place of Presentation: 大阪
• [Presentation] Solid-Phase Synthesis of N-Linked Glycans (2008)
  • Author(s): K. Tanaka
  • Organizer: 17th International Conference on Organic Synthesis (ICOS)
  • Place of Presentation: Daejon, South Korea
• [Presentation] Acceleration of Cu(I) -Mediated Huisgen 1.3-Dipolar Cycloaddition by Histidine Derivatives : Facile Synthesis of Glycodendrimers for PET Imaging (2008)
  • Author(s): E. Siwu
  • Organizer: 17th International Conference on Organic Synthesis (ICOS)
  • Place of Presentation: Daejon, South Korea
• [Presentation] Synthetic study of glycoconjugates for elucidation of their biofunctions (2008)
  • Author(s): K. Fukase
  • Organizer: Strasbourg Delegates for Joint Symposium in Osaka 2008
  • Place of Presentation: Osaka
• [Presentation] Application of Rapid 6p-azaelectrocyclization to molecular imaging of biomolecules (2008)
  • Author(s): K. Tanaka
  • Organizer: Strasbourg Delegates for Joint Symposium in Osaka, 2008
  • Place of Presentation: Osaka
• [Presentation] Isolation and Structure Elucidation of Immunostimulatory Native Nod1 Ligands (2008)
  • Author(s): A. R. Pradipta
  • Organizer: Strasbourg Delegates for Joint Symposium in Osaka, 2008
  • Place of Presentation: Osaka
• [Presentation] Synthesis of Helicobacter pylori Lipopolysaccharide Partial Structures for Investigation of Their Biological Function (2008)
  • Author(s): A. Shimoyama
  • Organizer: Strasbourg Delegates for Joint Symposium in Osaka, 2008
  • Place of Presentation: Osaka
• [Presentation] Synthetic Study on N-Linked Glycan Library on Solid-Supports (2008)
  • Author(s): G. -m. Bao
  • Organizer: Strasbourg Delegates for Joint Symposium in Osaka, 2008
  • Place of Presentation: Osaka
• [Presentation] 有機合成で自然免疫の仕組みを探る : 細菌由来複合糖質の合成と機能研究 (2008)
  • Author(s): 深瀬浩一
  • Organizer: 日本農芸化学会中四国支部「農芸化学の未来開拓セミナー」
  • Place of Presentation: 岡山
• [Presentation] グラム陽性菌由来Toll様受容体2(TLR2)のリガンド同定を目指したリポペプチドの合成研究 (2008)
  • Author(s): 勝本麻美
  • Organizer: 日本ケミカルバイオロジー研究会 第3回年会
  • Place of Presentation: 東京
• [Presentation] New Labeling Method of Peptide and Protein via Rapid Azaelectrocyclization and Its Application to PET Imaging (2008)
  • Author(s): K. Fukase
  • Organizer: The 12th Akabori Conference 2008
  • Place of Presentation: Kyoto
• [Book] Self and nonself recognition with bacterial and animal glycans, surveys by synthetic chemistry, Methods in Enzymology (2010)
  • Author(s): Fujimoto, Y., Tanaka, K., Shimoyama, A., Fukase, K.
  • Total Pages: 478
• [Book] Methods in Enzymology (2010)
  • Author(s): Fujimoto, Y., Fukase, K
  • Publisher: Glycomics
• [Book] 創薬研究への分子イメージング応用 (2010)
  • Author(s): 田中克典、深瀬浩一
  • Publisher: メディカルドウ
• [Book] 『生体の科学』「糖鎖のかかわる病気」 (2010)
  • Author(s): 田中克典, 深瀬浩一
  • Publisher: (財)金原一郎記念医学医療振興財団/医学書院
• [Book] 第三の生命鎖「糖鎖」を活用・制御するケミカルバイオロジー、月刊バイオインダストリー (2010)
  • Author(s): 田中克典、深瀬浩一
  • Publisher: シーエムシー出版
• [Book] 化学フロンティア2010:生命現象を理解する分子ツール最前線-イメージングから生体機能解析まで-化学 (2010)
  • Author(s): 田中克典、深瀬浩一
  • Publisher: 化学同人
• [Book] 『生体の科学』「糖鎖のかかわる病気」 (2010)
  • Author(s): 田中克典, 深瀬浩一
  • Publisher: (財)金原一郎紀念医学医療振興財団/医学書院(In press)
• [Book] "Polymer-supported and Tag-assisted Methods in Oligosaccharide Synthesis" in Glycoscience : Chemistry and Chemical Biology I-III, 2^<nd> ed., B.O.Fraser-Reid, K.Tatsuta, J.Thiem, eds. (2010)
  • Author(s): Tanaka, K. ; Fukase, K.
  • Publisher: Springer, New York(In press)
• [Book] "Combinatorial Methods in Oligosaccharide Synthesis in Glycoscience : Chemistry and Chemical Biology I-III, 2^<nd> ed., B.O.Fraser-Reid, K.Tatsuta, J.Thiem, eds. (2010)
  • Author(s): Tanaka, K. ; Fujimoto, Y. ; Tanaka, S. ; Mori, Y. ; Fukase, K.
  • Publisher: Springer, New York(In press)
• [Book] Glycoscience 2008 (2009)
  • Author(s): Tanaka, K., Fujimoto., Y. Tanaka, S., Mori, T., Fukase, K
  • Publisher: Springer-Verlag(in press)
• [Book] Experimental Glycoscience (2008)
  • Author(s): Fukase, K., Fujimoto, Y., Tanaka, K.
  • Publisher: Springer-Verlag
• [Book] 化学同人、63 (9) (2008)
  • Author(s): 深瀬浩一, 藤本ゆかり
  • Publisher: 化学同人
• [Book] 生産と技術 (2008)
  • Author(s): 深瀬浩一
  • Publisher: (社)生産技術振興協会
• [Remarks] ホームページ
  • URL: http://www.chem.sci.osaka-u.ac.jp/lab/fukase/
• [Remarks]
  • URL: http://www.chem.sci.osaka-u.ac.jp/1ab/fukase/
• [Patent(Industrial Property Rights)] リジンデンドリマー型糖鎖クラスターの製造法とその応用 (2009)
  • Inventor(s): 深瀬浩一、田中克典、渡辺恭良、小山幸一
  • Industrial Property Rights Holder: 国立大学法人大阪大学、独立行政法人理化学研究所、キシダ化学株式会社
  • Filing Date: 2009-03-27