| Project/Area Number |
20241053
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Osaka University |
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Principal Investigator |
FUKASE Koichi Osaka University, 大学院・理学研究科, 教授 (80192722)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIMOTO Yukari 大阪大学, 大学院・理学研究科, 准教授 (00362616)
TANAKA Katsunori 大阪大学, 大学院・理学研究科, 助教 (00403098)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥28,860,000 (Direct Cost: ¥22,200,000、Indirect Cost: ¥6,660,000)
Fiscal Year 2010: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2009: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
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| Keywords | 糖鎖 / 自然免疫 / PETイメージング / グリコシル化 / 固相合成 / 免疫増強 / 複合糖質 / 糖タンパク質 / 免疫増強作用 |
|---|
| Research Abstract |
New synthetic methods have been developed for glycans and glycoconjugates and applied them to the synthesis of complex bioactive molecules for the elucidation of action mechanisms. In particular, immunostimulating or immunomodulating glycoconjugates from bacteria were synthesized for elucidation of the recognition with innate immune receptors. Synthetic ligands for the innate immune receptors were used for the immune regulation. Bio-imaging studies of glycans and glycoproteins were also studied for the dynamic and kinetic analysis of glycans to unveil the unknown function of glycans.
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