Construction of Drug-Discovering System by using Multiple Fluorescent Labels on Peptide Library
| Project/Area Number |
20241054
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Okayama University |
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Principal Investigator |
SISIDO Masahiko Okayama University, 大学院・自然科学研究科, 特命教授(研究) (60026268)
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| Co-Investigator(Kenkyū-buntansha) |
KITAMATSU Mizuki 岡山大学, 大学院・自然科学研究科, 助教 (60379716)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥44,590,000 (Direct Cost: ¥34,300,000、Indirect Cost: ¥10,290,000)
Fiscal Year 2010: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2009: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2008: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
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| Keywords | 蛍光性アミノ酸 / ペプチドライブラリー / がん細胞 / インビトロスクリーニング / ステルス標識 / 2次元蛍光スペクトル / ペプチド / スクリーニング / 蛍光標識 / 細胞識別 |
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| Research Abstract |
A lot of researchers have been trying to discover peptides that bind onto specific cancer cells, however, without success. A major reason for the unsucceesful attempts may be that the discovery processes have been done under conditions far from the conditions inside the living body. The purpose of this project is to establish a novel screening process by using multiple fluorescent labels on peptide library. Putting a solution of the peptide library onto cancer cells and identifying those bound onto the cells with fluorescence spectroscopy, we found several cancer cell specific octapeptides.
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Report
(4 results)
Research Products
(46 results)
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[Journal Article]2009
Author(s)
T.Ohtsuki, M.Sisido
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Journal Title
The central dogma : from DNA to RNA, and to protein. In "Automation in Proteomics and Genomics"(Wiley)
Pages: 3-20
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