| Budget Amount *help |
¥43,940,000 (Direct Cost: ¥33,800,000、Indirect Cost: ¥10,140,000)
Fiscal Year 2011: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2010: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Fiscal Year 2009: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2008: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
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| Research Abstract |
Protein motors show the superior abilities in working efficiently at the mild temperature by responding flexibly to the applied load. In this research project, protein machines were studied theoretically to reveal their physical principles :(1) Coarse-grained models were constructed to analyze the large structural fluctuation of myosins and other proteins, and the theoretical framework to understand allosteric transitions is developed,(2) the millisecond time-scale trajectories of moving proteins were simulated, and(3) the functional funnel hypothesis of molecular motors was proposed and critically examined.
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