| Project/Area Number |
20247011
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KATADA Toshiaki The University of Tokyo, 大学院・薬学系研究科, 教授 (10088859)
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| Co-Investigator(Kenkyū-buntansha) |
KONTANI Kenji 東京大学, 大学院・薬学系研究科, 准教授 (30302615)
KAJIHO Hiroaki 東京大学, 大学院・薬学系研究科, 助教 (70401221)
FUKUYAMA Masamitsu 東京大学, 大学院・薬学系研究科, 助教 (20422389)
KOBAYASHI Tetsuo 東京大学, 大学院・薬学系研究科, 助教 (80433994)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥42,900,000 (Direct Cost: ¥33,000,000、Indirect Cost: ¥9,900,000)
Fiscal Year 2010: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2009: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2008: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
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| Keywords | タンパク質 / 遺伝子 / シグナル伝達 / G蛋白質 / 小胞輸送 / リソソーム / Gサイクル / ゲノムプロジェクト / Processing body |
|---|
| Research Abstract |
G proteins, which cycle between the two different GTP- and GDP-bound conformations (G cycles), play important roles as a "molecular switch" in many intracellular signaling pathways. In the Grant-in-Aid for Scientific Research (A), we investigated how G cycles are regulated dependent on their modes of actions in intracellular vesicle transport and found that novel G proteins containing unique biochemical properties and/or structures are involved in the regulation of endosome dynamics, such as lysosome biogenesis, endocytosis, and exocytosis.
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