| Project/Area Number |
20247024
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIGUCHI Osamu 東京大学, 医科学研究所, 准教授 (50361720)
MASHIMA Ryuichi 東京大学, 医科学研究所, 助教 (00401365)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥29,120,000 (Direct Cost: ¥22,400,000、Indirect Cost: ¥6,720,000)
Fiscal Year 2010: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2009: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
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| Keywords | シグナル伝達 / アダプター / タンパク質チロシンキナーゼ / 細胞・組織 / 細胞内情報伝達 |
|---|
| Research Abstract |
To understand molecular signaling involved in neuromuscular synaptogenesis, hematopoiesis, and related disorders, we focused on the Dok-family of adaptor proteins. Our findings together revealed that the cytoplasmic protein Dok-7 directly interacts with the receptor tyrosine kinase MuSK and activates it to form neuromuscular synapses. We also revealed that autoantibodies to Lrp4, a MuSK's coreceptor, in patients with myasthenia gravis, and that Dok-1/2/3 suppress histiocytic sarcoma.
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