| Budget Amount *help |
¥43,290,000 (Direct Cost: ¥33,300,000、Indirect Cost: ¥9,990,000)
Fiscal Year 2010: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
Fiscal Year 2009: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
Fiscal Year 2008: ¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
|
|---|
| Research Abstract |
The endoplasmic reticulum (ER) membrane-bound transcription factor ATF6 translocates to the Golgi apparatus upon ER stress to be activated by proteolysis. We demonstrate that the luminal domain of ATF6 alone is sufficient for sensing ER stress. ATF6α knockout mice develop normally, however, ATF6α knockout mice exhibit liver dysfunction and steatosis upon intraperitoneal injection of the ER stress-inducing reagent tunicamycin. We point out suppression of very-low-density lipoprotein formation, which is responsible for release of neutral lipids from liver, due to the destabilized apolipoprotein B-100 as a cause of liver steatosis.
|
