Invasiveness acquired during EMT

• Project/Area Number: 20247027
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cell biology
• Research Institution: Hokkaido University (2009-2011); Osaka Bioscience Institute (2008)
• Principal Investigator: SABE Hisataka 北海道大学, 大学院・医学研究科, 教授 (40187282)
• Project Period (FY): 2008 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥32,240,000 (Direct Cost: ¥24,800,000、Indirect Cost: ¥7,440,000); Fiscal Year 2011: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000); Fiscal Year 2010: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000); Fiscal Year 2009: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
• Keywords: EMT / 浸潤 / Arf GTPases / E-cadherin / endocytosis / AMAP1 / TGFβ1 / p53 / 細胞浸潤 / Arf6 / GEP100

Research Abstract

This study aims to understand precise mechanisms by which epithelial cells acquire invasiveness during their epithelial-mesenchymal transdifferentiation (EMT). Inactivation of E-cadherin and activation of some integrins are hallmark characteristics during EMT and necessary for the invasiveness. This study identified fine mechanisms as to how these cell adhesion molecules are regulated during EMT of mammary epithelial cells.

Research Products

• [Journal Article] Rab5c mediates AMAP1-PRKD2 complex to enhance β1 integrin recycling in EGF-induced cancer invasion (2012)
  • Author(s): Onodera Y., Nam JM., Hashimoto A., Norman JC., Shirato H., Hashimoto S. and Sabe H.
  • Journal Title: J.Cell Biol Volume: (in press)
  • Peer Reviewed
• [Journal Article] GBF1 bears a novel phosphatidylinositol-phosphate binding module, BP3K, to link PI3Kg activity with Arf1 activation involved in GPCR-mediated neutrophil chemotaxis and superoxide production (2012)
  • Author(s): Mazaki Y., Nishimura Y. and Sabe H.
  • Journal Title: Mol. Cell Biol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Grp1 plays a key role in linking insulin signaling to glut4 recycling (2012)
  • Author(s): Li J., Malaby AW., Famulok M., Sabe H., Lambright DG.and Hsu VW.
  • Journal Title: Dev Cell Volume: (in press)
  • Peer Reviewed
• [Journal Article] Grp1 plays a key role in linking insulin signaling to glut4 recycling (2012)
  • Author(s): Li J., Malaby AW., Famulok M., Sabe H., Lambright DG., Hsu VW.
  • Journal Title: Dev Cell. Volume: (in press)
  • Peer Reviewed
• [Journal Article] EphrinA1-EphA2 signal induces compaction and polarization of Madin-Darby canine kidney cells by inactivating Ezrin through negative regulation of RhoA (2011)
  • Author(s): Wakayama Y., Miura K., Sabe H. and Mochizuki N.
  • Journal Title: J Biol Chem Volume: 286 Issue: 51 Pages: 44243-44253
  • DOI: 10.1074/jbc.m111.267047
  • Peer Reviewed
• [Journal Article] GEP100-Arf6-AMAP1-cortactin pathway frequently used in cancer invasion is activated by VEGFR2 to promote angiogenesis (2011)
  • Author(s): Hashimoto A., Hashimoto S., Ando R., Noda K., Ogawa E., Kotani H., Hirose M., Menju T., Morishige M., Manabe T., Toda Y., Ishida S. and Sabe H.
  • Journal Title: PLoS One Volume: 6 Issue: 8 Pages: e23359-e23359
  • DOI: 10.1371/journal.pone.0023359
  • NAID: 120003295085
  • Peer Reviewed
• [Journal Article] Engagement of overexpressed Her2 with GEP100 induces autonomous invasive activities and provides a biomarker for metastases of lung adenocarcinoma (2011)
  • Author(s): Menju T., Hashimoto S., Hashimoto A., Otsuka Y., Handa H., Ogawa E., Toda Y., Wada H., Date H. and Sabe H.
  • Journal Title: PLoS One Volume: 6 Issue: 9 Pages: e25301-e25301
  • DOI: 10.1371/journal.pone.0025301
  • NAID: 120003464637
  • Peer Reviewed
• [Journal Article] Cancer early dissemination : cancerous epithelial-mesenchymal transdifferentiation and transforming growth factor β signalling (2011)
  • Author(s): Sabe H.
  • Journal Title: J Biochem Volume: 149 Issue: 6 Pages: 633-639
  • DOI: 10.1093/jb/mvr044
  • NAID: 10030585535
  • Peer Reviewed
• [Journal Article] GEP100-Arf6-AMAP1-Cortactin Pathway Frequently Used in Cancer Invasion Is Activated by VEGFR2 to Promote Angiogenesis (2011)
  • Author(s): Hashimoto A, et al.
  • Journal Title: PLoS One. Volume: 6
  • Peer Reviewed
• [Journal Article] Zyxin mediates actin fiber reorganization in epithelial-mesenchymal transition and contributes to endocardial morphogenesis (2009)
  • Author(s): Mori M., Nakagami H., Koibuchi N., Miura K., Takami Y., Koriyama H., Hayashi H., Sabe H., Mochizuki N., Morishita R. and Kaneda Y.
  • Journal Title: Mol Biol Cell Volume: 20 Issue: 13 Pages: 3115-3124
  • DOI: 10.1091/mbc.e09-01-0046
  • Peer Reviewed
• [Journal Article] EphA2 engages Git1 to suppress Arf6 activity modulating epithelial cell-cell contacts (2009)
  • Author(s): Miura K., Nam JM., Kojima C., Mochizuki N. and Sabe H.
  • Journal Title: Mol Biol Cell Volume: 20 Issue: 7 Pages: 1949-1959
  • DOI: 10.1091/mbc.e08-06-0549
  • Peer Reviewed
• [Journal Article] The EGFR-GEP100-Arf6-AMAP1 signaling pathway specific to breast cancer invasion and metastasis (2009)
  • Author(s): Sabe H., Hashimoto S., Morishige M., Ogawa E., Hashimoto A., Nam JM., Miura K., Yano H.and Onodera Y.
  • Journal Title: Traffic Volume: 10 Issue: 8 Pages: 982-993
  • DOI: 10.1111/j.1600-0854.2009.00917.x
  • Peer Reviewed
• [Journal Article] EphA2 engages Git1 to suppress Arf6 activity modulating epithelial cell-cell contacts (2009)
  • Author(s): Miura K., Nam J.M., Kojima C., Mochizuki N., Sabe H.
  • Journal Title: Mol Biol Cell 20 Pages: 1949-1959
  • Peer Reviewed
• [Journal Article] The EGFR-GEP100-Arf6-AMAP1 signaling pathway specific to breast cancer invasion and metastasis (2009)
  • Author(s): Sabe H., Hashimoto S., Morishige M., Ogawa E., Hashimoto A., Nam J.M., Miura K., Yano H., Onodera Y.
  • Journal Title: Traffic 10 Pages: 982-993
  • Peer Reviewed
• [Journal Article] Zyxin mediates actin fiber reorganization in epithelial-mesenchymal transition and contributes to endocardial morphogenesis. (2009)
  • Author(s): Mori M
  • Journal Title: Molecular Biology of the cell 20 Pages: 3115-3124
  • Peer Reviewed
• [Journal Article] EphA2 engages Gitl to suppress Arf6 activity modulating epithelial cell-cell contacts. (2009)
  • Author(s): Miura K
  • Journal Title: Molecular Biology of the cell 20 Pages: 1949-1959
  • Peer Reviewed
• [Journal Article] The EGFR-GEP100-Arf6-AMAP1 signaling pathway specific to breast cancer invasion and metastasis. (2009)
  • Author(s): Sabe H
  • Journal Title: Traffic 10 Pages: 982-993
  • Peer Reviewed
• [Journal Article] EphA2 Engages Git1 to Suppress Arf6 Activity Modulating Epithelial Cell-Cell Contacts (2009)
  • Author(s): Koichi Miura
  • Journal Title: Molecular Biology of the Cell 20 Pages: 1949-1959
  • Peer Reviewed
• [Journal Article] The EGFR-GEP100-Arf6-AMAP1 Signaling Pathway Specific to Breast Cancer Invasion and Metastasis (2009)
  • Author(s): Hisataka Sabe
  • Journal Title: Traffic 10 Pages: 982-993
  • Peer Reviewed
• [Journal Article] The EGFR-GEP100-Arf6 pathway in breast cancer : Full invasiveness is not from the inside (2008)
  • Author(s): Sabe H., Hashimoto S., Morishige M., Hashimoto A. and Ogawa E.
  • Journal Title: Cell Adh Migr Volume: 2 Pages: 71-73
  • URL: http://www.landesbioscience.com/journals/celladhesion/SabeCAM2-2.pdf
  • Peer Reviewed
• [Journal Article] IRES-mediated translational control of AMAP1 expression during differentiation of monocyte U937 cells (2008)
  • Author(s): Miyata M., Raven JF., Baltzis D., Koromilas A.E. and Sabe H.
  • Journal Title: Cell Cycle Volume: 7 Pages: 3273-3281
  • URL: http://www.landesbioscience.com/journals/cc/MiyataCC7-20.pdf
  • Peer Reviewed
• [Journal Article] EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition (2008)
  • Author(s): Hirano M., Hashimoto S., Yonemura S., Sabe H.and Aizawa S.
  • Journal Title: J Cell Biol Volume: 182 Issue: 6 Pages: 1217-1230
  • DOI: 10.1083/jcb.200712086
  • Peer Reviewed
• [Journal Article] Fbx8 makes Arf6 refractory to function via ubiquitination (2008)
  • Author(s): Yano H., Kobayashi I., Onodera Y., Luton F., Franco M., Mazaki Y., Hashimoto S., Iwai K., Ronai Z. and Sabe H.
  • Journal Title: Mol Biol Cell Volume: 19 Issue: 3 Pages: 822-832
  • DOI: 10.1091/mbc.e07-08-0763
  • Peer Reviewed
• [Journal Article] GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion (2008)
  • Author(s): Morishige M., Hashimoto S., Ogawa E., Toda Y., Kotani H., Hirose M., Wei S., Hashimoto A., Yamada A., Yano H., Mazaki Y., Kodama H., Nio Y., Manabe T., Wada H., Kobayashi H. and Sabe H.
  • Journal Title: Nat Cell Biol Volume: 10 Issue: 1 Pages: 85-92
  • DOI: 10.1038/ncb1672
  • Peer Reviewed
• [Journal Article] EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during pithelial-mesenchymal transition (2008)
  • Author(s): Hirano M., Hashimoto S., Yonemura S., Sabe H., Aizawa S.
  • Journal Title: J Cell Biol. 182 Pages: 1217-1230
  • Peer Reviewed
• [Journal Article] Fbx8 makes Arf6 refractory to function via ubiquitination (2008)
  • Author(s): Yano H., obayashi I., Onodera Y., Luton F., Franco M., Mazaki Y., Hashimoto S., Iwai K., Ronai Z., Sabe H.
  • Journal Title: Mol Biol Cell. 19 Pages: 822-832
  • Peer Reviewed
• [Journal Article] GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion (2008)
  • Author(s): Morishige M., Hashimoto S., Ogawa E., Toda Y., Kotani H., Hirose M., Wei S., Hashimoto A., Yamada A., Yano H., Mazaki Y., Kodama H., Nio Y., Manabe T., Wada H., Kobayashi H., Sabe H.
  • Journal Title: Nat Cell Biol. 10 Pages: 85-92
  • Peer Reviewed
• [Journal Article] GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion (2008)
  • Author(s): Masaki Morishige
  • Journal Title: Nature Cell Biology 10 Pages: 85-92
  • Peer Reviewed
• [Journal Article] Fbx8 Makes Arf6 Refractory to Function via Ubiquitination (2008)
  • Author(s): Hajime Yano
  • Journal Title: Molecular Biology of the Cell 19 Pages: 822-832
  • Peer Reviewed
• [Journal Article] EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition (2008)
  • Author(s): Mariko Hirano
  • Journal Title: Journal of Cell Biology 182 Pages: 1217-1230
  • Peer Reviewed
• [Journal Article] IRES-mediated translational control of AMAP1 expression during differentiation of monocyte U937 cells (2008)
  • Author(s): Mariko Miyata
  • Journal Title: Cell Cycle 7 Pages: 162-170
  • Peer Reviewed
• [Journal Article] The EGFR-GEP100-Arf6 pathway in breast cancer : Full invasiveness is not from the inside (2008)
  • Author(s): Hisataka Sabe
  • Journal Title: Cell adhesion & migration 2 Pages: 71-73
  • Peer Reviewed
• [Presentation] p53 mutation and TGFβ signaling culminate in cancer invasiveness via GEP100-Arf6-AMAP1 pathway (2012)
  • Author(s): 佐邊壽孝
  • Organizer: 平成23年度ライフサイエンスイノベージョン推進機構セミナー第371回学内セミナー
  • Place of Presentation: 福井大学(福井県)(招待講演)
  • Year and Date: 2012-02-03
• [Presentation] p53 mutation and TGFβ signaling culminate in cancer invasiveness via GEP100-Arf6-AMAP1 pathway (2012)
  • Author(s): 佐邊壽孝
  • Organizer: Cell Migration in Biology and Medicine
  • Place of Presentation: 九州大学(福岡県)
  • Year and Date: 2012-01-23
• [Presentation] p53 mutation and TGFβ signaling culminate in cancer invasiveness via GEP100-Arf6-AMAP1 pathway (2012)
  • Author(s): 佐邊壽孝
  • Organizer: Cell Migration in Biology and Medicine
  • Place of Presentation: 九州大学(福岡県)(招待講演)
  • Year and Date: 2012-01-23
• [Presentation] p53 mutation and TGFβ signaling culminate in cancer invasiveness via GEP100-Arf6-AMAP1 pathway (2011)
  • Author(s): 佐邊壽孝
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-12-15
• [Presentation] Mutant p53 is essential for TGFβ1-induced breast cancer cellinvasion (2011)
  • Author(s): 橋本あり
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-12-15
• [Presentation] Mutant p53 is essential for TGFβ1-induced breast cancer cell invasion (2011)
  • Author(s): 橋本あり
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-12-15
• [Presentation] p53 mutation and TGFβ signaling culminate in cancer invasiveness via GEP100-Arf6-AMAP1 pathway (2011)
  • Author(s): 佐邊壽孝
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)(招待講演)
  • Year and Date: 2011-12-15
• [Presentation] EZH2 regulates Arf6 activity necessary for invasiveness of some breast cancer cells under normoxia and hypoxia (2011)
  • Author(s): 橋本茂
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-12-14
• [Presentation] AMAP1 promotes β1 integrin recycling via PRKD2 and Rab5c in EGF-induced invasion of breast cancer cells (104/120) (2011)
  • Author(s): 小野寺康仁
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-03
• [Presentation] Mutant p53 is essential for TGFβ1-induced breast cancer cell invasiveness (2011)
  • Author(s): 橋本あり
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-03
• [Presentation] EZH2 is essential to Arf6 activation necessary for TGFβ1-and hypoxia-induced invasiveness of breast cancer cells (2011)
  • Author(s): 橋本茂
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-03
• [Presentation] EZH2 is essential to Arf6 activation necessary for TGFβ1- and hypoxia-induced invasiveness of breast cancer cells (2011)
  • Author(s): 橋本茂
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-03
• [Presentation] HGFR/c-Met-mediated activation of GEP100-Arf6-AMAP1 pathway is an integral part for TGFβ-induced cancerous EMT and invasiveness (2011)
  • Author(s): 橋本あり
  • Organizer: 第63回日本細胞生物学会大会
  • Place of Presentation: 北海道大学(北海道)
  • Year and Date: 2011-06-28
• [Presentation] Glucose metabolism and intracellular trafficking in tumor malignancy (2011)
  • Author(s): 小野寺康仁
  • Organizer: 第63回日本細胞生物学会大会
  • Place of Presentation: 北海道大学(北海道)
  • Year and Date: 2011-06-27
• [Presentation] Intracellular trafficking and glucose metabolism in tumor malignancy (2010)
  • Author(s): 小野寺康仁
  • Organizer: 第33回日本分子生物学会年会、第83回日本生化学会合同大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
  • Year and Date: 2010-12-09
• [Presentation] Intracellular trafficking and glucose metabolism in tumor malignancy (2010)
  • Author(s): 小野寺康仁
  • Organizer: BMB2010
  • Place of Presentation: 神戸ポートアイランド(神戸市)
  • Year and Date: 2010-12-09
• [Presentation] Arf6 activation under hypoxia and its relationship to invasion, EMT conversion and stemness of breast cancer cells (2010)
  • Author(s): 橋本茂
  • Organizer: BMB2010
  • Place of Presentation: 神戸ポートアイランド(神戸市)
  • Year and Date: 2010-12-09
• [Presentation] TGFβ1 activates GEP100-Arf6-AMAP1 pathway to induce EMT, and possible relationship of this activation to cancer (2010)
  • Author(s): 橋本あり
  • Organizer: 第33回日本分子生物学会年会、第83回日本生化学会合同大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
  • Year and Date: 2010-12-08
• [Presentation] TGFβ1 activates GEP100-Arf6-AMAP1 pathway to induce EMT, and possible relationship of this activation to cancer (2010)
  • Author(s): 橋本あり
  • Organizer: BMB2010
  • Place of Presentation: 神戸ポートアイランド(神戸市)
  • Year and Date: 2010-12-08
• [Presentation] 癌の初期播種と転移部における癌の休眠と再発:癌的EMTから考える (2010)
  • Author(s): 佐邊壽孝
  • Organizer: JSTさきがけ研究同窓会発表会
  • Place of Presentation: 長崎大学(長崎市) 招待講演
  • Year and Date: 2010-10-30
• [Presentation] Arf6 activation under hypoxia and its relationship to invasion, EMT conversion and stemness of breast cancer cells (2010)
  • Author(s): 橋本茂
  • Organizer: 第33回日本分子生物学会年会、第83 回日本生化学会合同大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
  • Year and Date: 2010-10-09
• [Presentation] Hypoxia-induced invasive activity of breast cancer cells involves Arf6 activation (2010)
  • Author(s): 橋本茂
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2010-09-24
• [Presentation] HGFR-mediated GEP100-Arf6-AMAP1 pathway is an integral part for TGFβ-induced cancerous EMT and invasiveness (2010)
  • Author(s): 橋本あり
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2010-09-24
• [Presentation] HGFR-mediated GEP100-Arf6-AMAP1 pathway is an integral part for T GFβ-induced cancerous EMT and invasiveness (2010)
  • Author(s): 橋本あり
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場(大阪市)
  • Year and Date: 2010-09-24
• [Presentation] Hypoxia-induced invasive activity of breast cancer cells involves Arf6 activation (2010)
  • Author(s): 橋本茂
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場(大阪市)
  • Year and Date: 2010-09-24
• [Presentation] The Arf6-AMAP1 Pathway Contributes to Cancerous EMT (2010)
  • Author(s): 佐邊壽孝
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2010-09-23
• [Presentation] The Arf6-AMAP1 Pathway Contributes to Cancerous EMT (2010)
  • Author(s): Sabe H
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-23
• [Presentation] The Arf6-AMAP1 Pathway Contributes to Cancerous EMT (2010)
  • Author(s): 佐邊壽孝
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場(大阪市) 招待講演
  • Year and Date: 2010-09-23
• [Presentation] Roles of intracellular trafficking and glucose metabolism in tumor malignancy (2010)
  • Author(s): 小野寺康仁
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2010-09-22
• [Presentation] Roles of intracellular trafficking and glucose metabolism in tumor malignancy (2010)
  • Author(s): 小野寺康仁
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場(大阪市)
  • Year and Date: 2010-09-22
• [Presentation] The Arf6-AMAP1 Pathway Contributes to Cancerous EMT (2010)
  • Author(s): 佐邊壽孝
  • Organizer: 第30回札幌国際がんシンポジウム
  • Place of Presentation: 北海道大学(北海道)
  • Year and Date: 2010-06-29
• [Presentation] The Arf6-AMAP1 Pathway Contributes to Cancerous EMT (2010)
  • Author(s): 佐邊壽孝
  • Organizer: 第30回札幌国際がんシンポジウム
  • Place of Presentation: 北海道大学(札幌市) 招待講演
  • Year and Date: 2010-06-29
• [Presentation] GEP100-Arf6-AMAP1経路は癌浸潤と血管新生に対する共通の分子標的である (2010)
  • Author(s): 橋本あり
  • Organizer: 第62回日本細胞生物学会大会
  • Place of Presentation: 大阪国際会議場(大阪市)
  • Year and Date: 2010-05-29
• [Presentation] GEP100-Arf6-AMAP1経路は癌浸潤と血管新生に対する共通の分子標的である (2010)
  • Author(s): 橋本あり
  • Organizer: 第62回本細胞生物学会大会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2010-05-20
• [Presentation] Intracellular traffic and glucose metabolism in tumor malignancy (2010)
  • Author(s): 小野寺康仁
  • Organizer: 第62回本細胞生物学会大会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2010-05-20
• [Presentation] Intracellular traffic and glucose metabolism in tumor malignancy (2010)
  • Author(s): 小野寺康仁
  • Organizer: 第62回日本細胞物学会大会
  • Place of Presentation: 大阪国際会議場(大阪市)
  • Year and Date: 2010-05-20
• [Presentation] 転移部における癌の休眠と再発:癌的EMTから考える (2010)
  • Author(s): 佐邊壽孝
  • Organizer: 第62回日本細胞生物学会大会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2010-05-19
• [Presentation] 転移部における癌の休眠と再発:癌的EMTから考える (2010)
  • Author(s): 佐邊壽孝
  • Organizer: 第62回日本細胞生物学会大会
  • Place of Presentation: 大阪国際会議場(大阪市) 招待講演
  • Year and Date: 2010-05-19
• [Presentation] 癌細胞の休眠と再活性化:糖代謝と小胞輸送の関与 (2010)
  • Author(s): 小野寺康仁
  • Organizer: 第2回シグナルネットワーク研究会
  • Place of Presentation: 千里ライフサイエンスセンター(大阪府)
  • Year and Date: 2010-05-14
• [Presentation] 癌細胞の休眠と再活性化:糖代謝と小胞輸送の関与 (2010)
  • Author(s): 小野寺康仁
  • Organizer: 第2回シグナルネットワーク研究会
  • Place of Presentation: 千里ライフサイエンスセンター(吹田市)
  • Year and Date: 2010-05-14
• [Presentation] Integrin activation and E-cadherin inactivation by the Arf6 pathway specific to breast cancer invasion and metastasis (2010)
  • Author(s): 佐邊壽孝
  • Organizer: 第6回OOTR年次学会
  • Place of Presentation: ウェスティン都ホテル京都(京都府)
  • Year and Date: 2010-02-25
• [Presentation] Integrin activation and E-cadherin inactivation by the Arf6 pathway specific to breast cancer invasion and metastasis (2010)
  • Author(s): Sabe H
  • Organizer: 第6回OOTR年次学会
  • Place of Presentation: 京都
  • Year and Date: 2010-02-25
• [Presentation] Integrin activation and E-cadherin inactivation by the Arf6 pathway specific to breast cancer invasion and metastasis. (2010)
  • Author(s): Sabe H
  • Organizer: 第6回OOTR年次学会
  • Place of Presentation: ウェスティン都ホテル京都(京都市)
  • Year and Date: 2010-02-25
• [Presentation] Both GBF1 and PI3-kinaseY are essential for Arf1 activation necessary for neutrophil directional migration (2009)
  • Author(s): 真崎雄一
  • Organizer: 第39回日本免疫学会学術集会
  • Place of Presentation: ウェスティン都ホテル京都(京都府)
  • Year and Date: 2009-12-02
• [Presentation] Both GBF1 and PI3-kinaseγ are essential for Arf1 activation necessary for neutrophil directional migration (2009)
  • Author(s): Masaki Y
  • Organizer: 第39回日本免疫学会学術集会
  • Place of Presentation: ウェスティン都ホテル京都(京都市)
  • Year and Date: 2009-12-02
• [Presentation] 腫瘍血管における透過性亢進に関与する分子輸送のメカニズム及び病態の解明 (2009)
  • Author(s): 橋本あり
  • Organizer: 細胞内ロジスティックス斑会議
  • Place of Presentation: 万座ビーチリゾート会議場(沖縄県)
  • Year and Date: 2009-11-11
• [Presentation] 腫瘍血管における透過性亢進に関与する分子輪送のメカニズム及び病態の解明 (2009)
  • Author(s): Hashimoto A
  • Organizer: 細胞内ロジスティックス斑会議
  • Place of Presentation: 万座ビーチリゾート会議場(恩納村)
  • Year and Date: 2009-11-11
• [Presentation] メンブレントラフィックと癌浸潤形質獲得機序 (2009)
  • Author(s): 佐邊壽孝
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
  • Year and Date: 2009-10-21
• [Presentation] EphA2 engages Git1 to suppress Arf6 activity modulating epithelial cell-cell contacts (2009)
  • Author(s): 三浦浩一
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
  • Year and Date: 2009-10-21
• [Presentation] メンブレントラフィックと癌浸潤形質獲得機序 (2009)
  • Author(s): Sabe H
  • Organizer: 第82回日本生化学会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-21
• [Presentation] EphA2 engages Git1 to suppress Arf6 activity modulating epithelial cell-cell contacts (2009)
  • Author(s): Miura M
  • Organizer: 第82回日本生化学会
  • Place of Presentation: 神戸ポートアイランド(神戸市)
  • Year and Date: 2009-10-21
• [Presentation] メンブレントラフィックと癌浸潤形質獲得機序 (2009)
  • Author(s): Sabe H
  • Organizer: 第82回日本生化学会
  • Place of Presentation: 神戸ポートアイランド(神戸市)
  • Year and Date: 2009-10-21
• [Presentation] 微小環境の変化に連動した癌の浸潤形質獲得の分子機序 (2009)
  • Author(s): Hashimoto S
  • Organizer: 特別学術講演会
  • Place of Presentation: 北海道大学薬学部臨床薬学講義室(札幌市)
  • Year and Date: 2009-09-25
• [Presentation] Integrin activation and E-cadherin inactivation by the Arf6 pathway specific to breast cancer invasion and metastasis (2009)
  • Author(s): 佐邊壽孝
  • Organizer: 2009 FEBS workshop
  • Place of Presentation: Hotel Veronika(Seefeld)
  • Year and Date: 2009-09-06
• [Presentation] Integrin activation and E-cadherin inactivation by the Arf6 pathway specific to breast cancer invasion and metastasis. (2009)
  • Author(s): Sabe H
  • Organizer: 2009 FEBS workshop
  • Place of Presentation: Seefeld
  • Year and Date: 2009-09-06
• [Presentation] Integrin activation and E-cadherin inactivation by the Arf6 pathway specific to breast cancer invasion and metastasis. (2009)
  • Author(s): Sabe H
  • Organizer: 2009 FEBS workshop
  • Place of Presentation: Hotel Veronika(ミュンヘン)
  • Year and Date: 2009-09-06
• [Presentation] 癌の浸潤形質獲得機序:その組織特異性についての考察 (2009)
  • Author(s): Sabe H
  • Organizer: 生化学会支部例会
  • Place of Presentation: 旭川医科大学(旭川市)
  • Year and Date: 2009-07-17
• [Presentation] 乳がん浸潤形質獲得の分子機序 (2009)
  • Author(s): Hashimoto S
  • Organizer: 平成21年度大学院「先端医療トピックス」
  • Place of Presentation: 神戸大学医学部B講義室(神戸市)
  • Year and Date: 2009-06-12
• [Presentation] Roles of GBF1 in neutrophil chemotaxis (2009)
  • Author(s): 真崎雄一
  • Organizer: 第61回日本細胞生物学会大会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2009-06-02
• [Presentation] EphA2 engages Git1 to suppress Arf6 activity modulating epithelial cell-cell contacts (2009)
  • Author(s): 三浦浩一
  • Organizer: 第61回日本細胞生物学会大会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2009-06-02
• [Presentation] EphA2 engages Git1 to suppress Arf6 activity modulating epithelial cell-cell contacts (2009)
  • Author(s): Miura M
  • Organizer: 第61回日本細胞生物学会
  • Place of Presentation: 名古屋国際会議場(名古屋市)
  • Year and Date: 2009-06-02
• [Presentation] Roles of GBF1 in neutrophil chemotaxis (2009)
  • Author(s): Masaki Y
  • Organizer: 第61回日本細胞生物学会
  • Place of Presentation: 名古屋国際会議場(名古屋市)
  • Year and Date: 2009-06-02
• [Presentation] Arf6-AMAP1 pathway in invasion of lung cancer and malignant mesothelioma cell lines (2008)
  • Author(s): 毛受暁史
  • Organizer: 20th EORTC.NCL-AACR Symposium on Molecular Targets and Cancer Therapeutics
  • Place of Presentation: Geneva palexpo(Switzerlamd)
  • Year and Date: 2008-10-22
• [Presentation] Arf6-AMAP1 pathway in invasion of lung cancer and malignant mesothelioma cell lines (2008)
  • Author(s): Toshi Menju
  • Organizer: 20th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
  • Place of Presentation: Geneva Palexpo, Geneva, Switzerland
  • Year and Date: 2008-10-22
• [Book] 乳癌レビュー2012 EMT-基礎的観点から (2011)
  • Author(s): 橋本あり、杉野弘和、橋本茂、佐邊壽孝
  • Publisher: メディカルレビュー社
• [Remarks]
  • URL: http://www.hucc.hokudai.ac.jp/~g21001/index.html
• [Remarks]
  • URL: http://info.coop.hokudai.ac.jp/bunsei/index.html
• [Remarks]
  • URL: http://www.obi.or.jp/japanese/introduction/set_introduction.html