| Budget Amount *help |
¥44,980,000 (Direct Cost: ¥34,600,000、Indirect Cost: ¥10,380,000)
Fiscal Year 2011: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2010: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2009: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2008: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
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| Research Abstract |
This study was conducted to elucidate the role of sex steroid/growth factor systems in sexual differentiation of the brain during perinatal period and neuroprotection as well as neurogenesis after maturation. By the studies using progranulin(PGRN)-deficient mice we have generated, we found that PGRN mediates the brain actions of estrogens and modulates brain sexual differentiation, neurogenesis in the dentate gyrus of the hippocampus and neurodegeneration. It is also demonstrated that PGRN plays a role in regulating the activation of microglia after traumatic brain injury. In addition, it is suggested that the actions of PGRN in the brain is transduced through glycogen synthase kinase 3βphosphorylation, and mediated by genes/proteins containing LIM domain.
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