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Asymmetric Addition of carbon, nitrogen, oxygen and sulfur nucleophiles and its application to the synthesis of biologically active compounds

Research Project

Project/Area Number 20249002
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Chemical pharmacy
Research InstitutionDoshisha Women's College of Liberal Arts (2011)
Kyoto University (2008-2010)

Principal Investigator

TOMIOKA Kiyoshi  同志社女子大学, 薬学部, 教授 (50114575)

Co-Investigator(Renkei-kenkyūsha) YAMADA Ken-ichi  京都大学, 薬学研究科, 准教授 (00335184)
YAMAMOTO Yasutomo  同志社女子大学, 薬学部, 助教 (10452278)
Project Period (FY) 2008 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥37,960,000 (Direct Cost: ¥29,200,000、Indirect Cost: ¥8,760,000)
Fiscal Year 2011: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2010: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2009: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Keywords四大元素 / キラル配位子 / 不斉触媒 / 天然物合成 / 連続反応
Research Abstract

Most chiral carbon centers of biologically active compound directly connect to representative 4 atoms, carbon, nitrogen, oxygen, and sulfur atoms. Asymmetric addition reaction of these 4 atoms develops the methodology for the efficient synthesis of useful medicines and biologically active molecules. We achieved asymmetric addition of organolithiums, lithium enolates, lithium amides, organoboranes, organomagnesiums, and organozincs. Asymmetric total synthesis of some natural products was also achieved by using our developed asymmetric reaction as a key step.

Report

(6 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (56 results)

All 2012 2011 2010 2009 2008

All Journal Article (43 results) (of which Peer Reviewed: 36 results) Presentation (12 results) Book (1 results)

  • [Journal Article] High Performance of N-Alkoxycarbonyl-Imines in Triethylborane-Mediated Tin-Free Radical Addition2012

    • Author(s)
      Kiyoshi Tomioka
    • Journal Title

      J.Org.Chem.

      Volume: 77巻 Issue: 3 Pages: 1547-1553

    • DOI

      10.1021/jo2025042

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Steric Influence of N-Phosphorus-arylimines on the Rhodium-Catalyzed Asymmetric Arylation2011

    • Author(s)
      Hao, X.; Chen, Q.; Yamada, K.; Yamamoto, Y.; Tomioka, K
    • Journal Title

      Tetrahedron

      Volume: 67(35) Issue: 22 Pages: 6469-6473

    • DOI

      10.1016/j.tet.2012.03.107

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chiral N-Heterocyclic Carbene. Copper(I)-Catalyzed Asymmetric Allylic Arylation of Aliphatic Allylic Bromides : Steric and Electronic Effects on γ-Selectivity2011

    • Author(s)
      Selim, K. B.; Nakanishi, H.; Matsumoto, Y.; Yamamoto, Y.; Yamada, K.; Tomioka, K
    • Journal Title

      J. Org. Chem

      Volume: 76(5) Issue: 5 Pages: 1398-1408

    • DOI

      10.1021/jo102386s

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rhodium-Catalyzed Asymmetric Phenylation of N-Phosphinoylarylimines with Triphenylborane2011

    • Author(s)
      Hao, X.; Chen, Q.; Kuriyama, M.; Yamada, K.; Yamamoto, Y.; Tomioka, K
    • Journal Title

      Catal. Sci. Tech

      Volume: 1(1) Issue: 1 Pages: 62-64

    • DOI

      10.1039/c0cy00083c

    • NAID

      120004205184

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Steric Influence of N-Phosphorus-arylimines on the Rhodium-Catalyzed Asymmetric Arylation2011

    • Author(s)
      Kiyoshi Tomioka
    • Journal Title

      Tetrahedron

      Volume: 67巻 Issue: 35 Pages: 6469-6473

    • DOI

      10.1016/j.tet.2011.06.033

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rhodium-Catalyzed Asymmetric Phenylation of N-Phosphinoylarylimines with Triphenylborane.2011

    • Author(s)
      Kiyoshi Tomioka
    • Journal Title

      Catal.Sci.Tech.

      Volume: 1 Pages: 62-64

    • NAID

      120004205184

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stereoselective Formal Synthesis of (+)-Allokainic Acid <i>via</i> Thiol-Mediated Acyl Radical Cyclization2010

    • Author(s)
      Yamada, K.; Sato, T.; Hosoi, M.; Yamamoto, Y.; Tomioka, K
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 58 Issue: 11 Pages: 1511-1516

    • DOI

      10.1248/cpb.58.1511

    • NAID

      130000405667

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stereoselective Radical Addition of an Acetal to Sterically Tuned Enantiomerically Pure N-Sulfinyl Imines2010

    • Author(s)
      Akindele, T.; Yamada, K.; Sejima, T.; Maekawa, M.; Yamamoto, Y.; Nakano, M.; Tomioka, K
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 58 Issue: 2 Pages: 265-269

    • DOI

      10.1248/cpb.58.265

    • NAID

      130000161607

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chiral Carbene Approach to Gold-Catalyzed Asymmetric Cyclization of 1, 6-Enynes2010

    • Author(s)
      Matsumoto, Y.; Selim, K. B.; Nakanishi, H.; Yamada, K.; Yamamoto, Y.; Tomioka, K
    • Journal Title

      Tetrahedron Lett

      Volume: 51(2) Issue: 2 Pages: 404-406

    • DOI

      10.1016/j.tetlet.2009.11.039

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chiral Carbene Approach to Gold-Catalyzed Asymmetric Cyclization of 1,6-Enynes.2010

    • Author(s)
      Kiyoshi Tomioka
    • Journal Title

      Tetrahedron Lett.

      Volume: 51 Pages: 404-406

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stereoselective Radical Addition of an Acetal to Sterically Tuned Enantiomerically Pure N-Sulfinyl Imines.2010

    • Author(s)
      Kiyoshi Tomioka
    • Journal Title

      Chem.Pharm.Bull.

      Volume: 58 Pages: 265-269

    • NAID

      130000161607

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stereoselective Formal Synthesis of (+)-Allokainic Acid via Thiol-mediated Acyl Radical Cyclization.2010

    • Author(s)
      Kiyoshi Tomioka
    • Journal Title

      Chem.Pharm.Bull.

      Volume: 58 Pages: 1511-1516

    • NAID

      130000405667

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient Chiral N-Heterocyclic Carbene/Copper(I)-Catalyzed Asymmetric Allylic Arylation with Aryl Grignard Reagents2009

    • Author(s)
      Selim, K. B, Matsumoto, Y.; Yamada, K.; Tomioka, K
    • Journal Title

      Angew. Chem. Int. Ed

      Volume: 48(46) Issue: 46 Pages: 8733-8735

    • DOI

      10.1002/anie.200904676

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Steric Tuning of the Amidomonophosphane-Rhodium(I) Catalyst in Asymmetric Addition of Arylboroxines to N-Phosphinoyl Aldimines2009

    • Author(s)
      Hao, X.; Kuriyama, M.; Chen, Q.; Yamamoto, Y.; Yamada, K.; Tomioka, K
    • Journal Title

      Org. Lett.

      Volume: 11(19) Issue: 19 Pages: 4470-4473

    • DOI

      10.1021/ol901866y

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Iron Chloride Enhancement of Dimethylzinc-Mediated Radical Conjugate Addition of Ethers and an Amine to Alkylidenemalonates2009

    • Author(s)
      Yamada, K.; Maekawa, M.; Yamamoto, Y.; Nakano, M.; Akindele, T.; Tomioka, K
    • Journal Title

      Tetrahedron Lett

      Volume: 50(44) Issue: 44 Pages: 6040-6043

    • DOI

      10.1016/j.tetlet.2009.08.034

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chiral Amidophosphane-Rhodium(I)-Catalyzed Asymmetric Conjugate Arylation of Acyclic Enones with Arylboronic Acids2009

    • Author(s)
      Chen, Q.; Kuriyama, M.; Hao, X.; Soeta, T.; Yamamoto, Y.; Yamada, K.; Tomioka, K
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 57 Issue: 9 Pages: 1024-1027

    • DOI

      10.1248/cpb.57.1024

    • NAID

      130000124206

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Asymmetric Construction of Three Contiguous Stereogenic Centers by Conjugate Addition-Alkylation of Lithium Ester Enolate2009

    • Author(s)
      Yamamoto, Y.; Yasuda, Y.; Nasu, H.; Tomioka, K
    • Journal Title

      Org. Lett

      Volume: 11(9) Issue: 9 Pages: 2007-2009

    • DOI

      10.1021/ol900447n

    • Related Report
      2011 Final Research Report
  • [Journal Article] Accessing the Amide Functionality by the Mild and Low-Cost Oxidation of Imine2009

    • Author(s)
      Mohamed, M. A, Yamada, K.; Tomioka, K
    • Journal Title

      Tetrahedron Lett

      Volume: 50(26) Issue: 26 Pages: 3436-3438

    • DOI

      10.1016/j.tetlet.2009.02.174

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Total Synthesis of(-)-Lycorine and (-)-2-epi-Lycorine by Asymmetric Conjugate Addition Cascade2009

    • Author(s)
      Yamada, K.; Yamashita, M.; Sumiyoshi, T.; Nishimura, K.; Tomioka, K
    • Journal Title

      Org. Lett

      Volume: 11(7) Issue: 7 Pages: 1631-1633

    • DOI

      10.1021/ol9003564

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dimethylzinc Initiated Radical Reactions2009

    • Author(s)
      Akindele, T, Yamada, K.; Tomioka, K
    • Journal Title

      Acc. Chem. Res

      Volume: 42(2) Issue: 2 Pages: 345-355

    • DOI

      10.1021/ar800166q

    • Related Report
      2011 Final Research Report
  • [Journal Article] Carbon Centers by Sequential Conjugate Addition of Lithium Amide and in situ Alkylation : Utility in the Synthesis of(-)-Aspidospermidine2009

    • Author(s)
      Suzuki, M, Kawamoto, Y.; Sakai, T.; Yamamoto, Y.; Tomioka, K
    • Journal Title

      Org. Lett

      Volume: 11(3) Issue: 3 Pages: 653-655

    • DOI

      10.1021/ol802759j

    • Related Report
      2011 Final Research Report
  • [Journal Article] Tandem Conjugate Addition-Aldol Cyclization of 2-Formylbenzylidenemalonate with Ether Radicals by the Mediation of Dimethylzinc2009

    • Author(s)
      Yamada, K.; Maekawa, M.; Akindele, T.; Yamamoto, Y.; Nakano, M.; Tomioka, K
    • Journal Title

      Tetrahedron

      Volume: 65(4) Issue: 4 Pages: 903-908

    • DOI

      10.1016/j.tet.2008.11.009

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficient Chiral N-Heterocyclic Carbene/Copper(I)-Catalyzed Asymmetric Allylic Arylation with Aryl Grignard Reagents.2009

    • Author(s)
      Khalid B.Selim, Yasumasa Matsumoto, Ken-ichi Yamada, Kiyoshi Tomioka
    • Journal Title

      Angew.Chem.Int.Ed. 48(46)

      Pages: 8733-8735

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Steric Tuning of the Amidomonophosphane-Rhodium(I) Catalyst in Asymmetric Addition of Arylboroxines to N-Phosphinoyl Aldimines.2009

    • Author(s)
      Xinyu Hao, Masami Kuriyama, Qian Chen, Yasutomo Yamamoto, Ken-ichi Yamada, Kiyoshi Tomioka
    • Journal Title

      Org.Lett. 11(19)

      Pages: 4470-4473

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Total Synthesis of (-)-Lycorine and(-)-2-epi-Lycorine by Asymmetric Conjugate Addition Cascade.2009

    • Author(s)
      Ken-ichi Yamada, Mitsuaki Yamashita, Takaaki Sumiyoshi, Katsumi Nishimura, Kiyoshi Tomioka
    • Journal Title

      Org.Lett. 11(7)

      Pages: 1631-1633

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Asymmetric Construction of Quaternary Carbon Centers by Sequential Conjugate Addition of Lithium Amide and in situ Alkylation : Utility in the Synthesis of (-)-Aspidospermidine.2009

    • Author(s)
      Mayuko Suzuki, Yoshito Kawamoto, Takeo Sakai, Yasutomo Yamamoto, Kiyoshi Tomioka
    • Journal Title

      Org.Lett. 11(3)

      Pages: 653-655

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Tandem Conjugate Addition-Aldol Cyclization of 2-Formylbenzylidenemalonate with Ether Radicals by the Mediation of Dimethylzinc2009

    • Author(s)
      K.Tomioka
    • Journal Title

      Tetrabedron 65

      Pages: 903-908

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asymmetric Construction of Quaternary Carbon Centers by Sequential Conjugate Addition of Lithium Amide and in situ Alkylation : Utility in the Synthesis of (-) -Aspidospermidine2009

    • Author(s)
      K.Tomioka
    • Journal Title

      Organic Letters 11

      Pages: 653-655

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Total Synthesis of (-) -Lycorine and (-) -2-epi-Lycorine by Asymmetric Conjugate Ad2009

    • Author(s)
      K.Tomioka
    • Journal Title

      Organic Letters 11

      Pages: 1631-1633

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Accessing the Amide Functionality by the Mild and Low-Cost Oxidation of Imine2009

    • Author(s)
      K.Tomioka
    • Journal Title

      Tetrabedron Letters 50

      Pages: 3436-3438

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Steric Tuning of the Amidomonophosphane-Rhodium (I) Catalyst in Asymmetric Addition of Arylboroxines to N-Phosphinoyl Aldimines2009

    • Author(s)
      K.Tomioka
    • Journal Title

      Organic Letters 11

      Pages: 4470-4473

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient Chiral N-Heterocycli Carbene/Copper (I) -Catalyzed Asymmetric Allylic Arylation with Aryl Grignard Reagents2009

    • Author(s)
      K.Tomioka
    • Journal Title

      Angewandte Chemie International Edition 48

      Pages: 8733-8735

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemoselective Conjugate Addition of Dimethylzinc-Mediated Ether and Acetal Radicals to Alkylidenemalonates and Asymmetric Reactions2008

    • Author(s)
      Yamada, K.; Maekawa, M.; Akindele, T.; Nakano, M.; Yamamoto, Y.; Tomioka, K
    • Journal Title

      Org. Chem

      Volume: 73(24) Issue: 24 Pages: 9535-9538

    • DOI

      10.1021/jo801541m

    • Related Report
      2011 Final Research Report
  • [Journal Article] Copper-Catalyzed Asymmetric Allylic Substitution with Aryl and Ethyl Grignard Reagents2008

    • Author(s)
      Selim, K. B.; Yamada, K.; Tomioka, K.
    • Journal Title

      Chem. Commun

      Volume: (41) Issue: 41 Pages: 5140-5142

    • DOI

      10.1039/b809140d

    • Related Report
      2011 Final Research Report
  • [Journal Article] A Ternary Complex Reagent for An Asymmetric Michael Reaction of Lithium Ester Enolates with Enoates2008

    • Author(s)
      Yamamoto, Y.; Suzuki, H.; Yasuda, Y.; Iida, A.; Tomioka, K
    • Journal Title

      Tetrahedron Lett

      Volume: 49(31) Issue: 31 Pages: 4582-4584

    • DOI

      10.1016/j.tetlet.2008.05.101

    • Related Report
      2011 Final Research Report
  • [Journal Article] Consecutive Cyclization of Allylaminoalkene by Intramolecular Aminolithiation-Carbolithiation2008

    • Author(s)
      Tsuchida, S.; Kaneshige, A.; Ogata, T.; Baba, H.; Yamamoto, Y.; Tomioka, K
    • Journal Title

      Org. Lett

      Volume: 10(16) Issue: 16 Pages: 3635-3638

    • DOI

      10.1021/ol801397v

    • Related Report
      2011 Final Research Report
  • [Journal Article] Consecutive Cyclization of Allylaminoalkene by Intramolecular Aminolithiation-Carbolithiation.2008

    • Author(s)
      Susumu Tsuchida, Atsunori Kaneshige, Tokutaro Ogata, Hiromi Baba, Yasutomo Yamamoto, Kiyoshi Tomioka
    • Journal Title

      Org.Lett. 10(16)

      Pages: 3635-3638

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] A Ternary Complex Reagent for An Asymmetric Michael Reaction of Lithium Ester Enolates with Enoates2008

    • Author(s)
      K.Tomioka
    • Journal Title

      Tetrahedron Letters 49

      Pages: 4582-4584

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C2 Symmetric Chiral NHC Ligand for Asymmetric Quaternary Carbon Constructing Copper-Catalyzed Conjugate Addition of Grignard Reagents to 3-Substituted Cyclohexenones2008

    • Author(s)
      K.Tomioka
    • Journal Title

      The Journal of Organic Chemistry 731

      Pages: 4578-4581

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Consecutive Cyclization of Allylaminoalkene by Intramolecular Aminolithiation-Carbolithiation2008

    • Author(s)
      K.Tomioka
    • Journal Title

      Organic Letters 10

      Pages: 3635-3638

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Copper-Catalyzed Asymmetric Allylic Substitution with Aryl and Ethyl Grignard Reagents2008

    • Author(s)
      K.Tomioka
    • Journal Title

      Chemical Communications

      Pages: 5140-5142

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conjugate Addition of THF-2-yl Radical with α,β-Unsaturated N-Tosyl Imines Using a Dimethylzinc-Air Initiator2008

    • Author(s)
      K.Tomioka
    • Journal Title

      Tetrahedron 64

      Pages: 7258-7265

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemoselective Conjugate Addition of Dimethylzinc-Mediated Ether and Acetal Radicals to Alkylidenemalonates and Asymmetric Reactions2008

    • Author(s)
      K.Tomioka
    • Journal Title

      The Journal of Organic Chemistry 73

      Pages: 9535-9538

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Catalytic Asymmetric Reactions Mediated by Chiral Molecule and Metal2012

    • Author(s)
      Tomioka, K.
    • Organizer
      The 4th Novel Chiral Chemistries Japan
    • Place of Presentation
      東京工業大学くらまえホール(東京都)
    • Year and Date
      2012-03-15
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Aminolithiation. Carbolithiation Conjugate Process2011

    • Author(s)
      Tomioka, K.
    • Organizer
      ISOR-10
    • Place of Presentation
      慶應大学(神奈川県)
    • Year and Date
      2011-11-23
    • Related Report
      2011 Final Research Report
  • [Presentation] Aminolithiation-Carbolithiation Conjugate Process2011

    • Author(s)
      富岡清
    • Organizer
      The 10th International Symposium on Organic Reactions
    • Place of Presentation
      慶應大学(神奈川県)
    • Year and Date
      2011-11-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Consecutive aminolithiation. carbolithiation of olefins2010

    • Author(s)
      Tomioka, K.
    • Organizer
      PACIFICHEM2010
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2010-12-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Consecutive aminolithiation.2010

    • Author(s)
      富岡清
    • Organizer
      carbolithiation of olefins, PACIFICHEM2010
    • Place of Presentation
      Honolulu, Hawaii.
    • Year and Date
      2010-12-16
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Consecutive aminolithiation-carbolithiation of olefins2010

    • Author(s)
      富岡清
    • Organizer
      PACIFICHEM2010
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2010-12-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] リチウムアミドの不斉共役付加-アルキル化反応の効率化を鍵とするアスピドスペルマアルカロイドの合成研究2010

    • Author(s)
      富岡清
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山大学
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Recent Progress in Dimethylzinc-Initiated Radical Reactions2009

    • Author(s)
      Tomioka, K.
    • Organizer
      The 4th Pacific Symposium on Radical Chemistry
    • Place of Presentation
      Shanghai, China
    • Year and Date
      2009-11-21
    • Related Report
      2011 Final Research Report 2010 Self-evaluation Report
  • [Presentation] 二重結合のヒドロアミノ化反応を基軸とする含窒素複素環の合成2008

    • Author(s)
      富岡清
    • Organizer
      有機合成夏期セミナー「明日の有機合成化学」
    • Place of Presentation
      大阪
    • Year and Date
      2008-09-25
    • Related Report
      2011 Final Research Report 2010 Self-evaluation Report 2008 Annual Research Report
  • [Presentation] Hydroamination of Carbon-Carbon Double Bond for Nitrogen-Containing Heterocycles2008

    • Author(s)
      Tomioka, K.
    • Organizer
      ICOS-17
    • Place of Presentation
      Daejeon, Korea
    • Year and Date
      2008-06-25
    • Related Report
      2011 Final Research Report
  • [Presentation] Hydroamination of Carbon-Carbon Double Bond for Nitrogen-Containing Heterocycles2008

    • Author(s)
      富岡清
    • Organizer
      The 17th International Conference on Organic Synthesis (ICOS-17)
    • Place of Presentation
      Daejeon, Korea.
    • Year and Date
      2008-06-25
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Hydroamination of Carbon-Carbon Double Bond for Nitrogen-Containing Heterocycle2008

    • Author(s)
      K.Tomioka
    • Organizer
      The 17th International Conference on Organic Synthesis(ICOS-17)
    • Place of Presentation
      Daejeon, Korea
    • Year and Date
      2008-06-25
    • Related Report
      2008 Annual Research Report
  • [Book] 化学同人,使える!有機合成反応241実践ガイド2010

    • Author(s)
      富岡清
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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