| Budget Amount *help |
¥50,050,000 (Direct Cost: ¥38,500,000、Indirect Cost: ¥11,550,000)
Fiscal Year 2010: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2009: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2008: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
|
|---|
| Research Abstract |
Boron neutron capture therapy (BNCT) is a novel cancer treatment modality that can selectively target the tumor without causing excessive radiation damage to the normal tissues. In this project, we developed 2 types of new therapeutic agents for BNCT : cell-penetrating peptides using the protein therapy or nanoparticles, which are effective of delivering cargo into cells, to deliver ^<10>B into the tumor cells as BNCT agents. In both in-vitro studies using the cultured tumor cells and in-vivo studies using tumor-bearing mice, these agents were only observed in the tumor. The results suggest that our systems utilizing peptides or nanoparticles provide an effective means of delivering ^<10>B into tumor cells selectively in BNCT.
|
