| Budget Amount *help |
¥50,700,000 (Direct Cost: ¥39,000,000、Indirect Cost: ¥11,700,000)
Fiscal Year 2010: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Fiscal Year 2009: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2008: ¥21,450,000 (Direct Cost: ¥16,500,000、Indirect Cost: ¥4,950,000)
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| Research Abstract |
Ion channel functions are modulated by the drugs. However, the mechanisms underling drug actions are often not well understood. In this study, we examined the mechanisms of drug actions in inward-rectifier potassium channels and voltage-dependent potassium channel. Our studies reveal structural bases of drug-channel interactions and their functional alterations in potassium channel. Moreover, our results provide better understandings of their clinical efficacy or undesirable side effects, and shed light on the rational development of pharmacological agents.
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