Studies on the structure-activity relationship on pharmacological modulations of potassium channels
| Project/Area Number |
20249012
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Osaka University |
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Principal Investigator |
KURACHI Yoshihisa Osaka University, 大学院・医学系研究科, 教授 (30142011)
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| Co-Investigator(Kenkyū-buntansha) |
INANOBE Atsushi 大阪大学, 医学系研究科, 准教授 (00270851)
HIBINO Hiroshi 新潟大学, 医歯学系, 教授 (70314317)
MURAKAMI Shingo 大阪大学, 医学系研究科, 助教 (40437314)
FURUTANI Kazuharu 大阪大学, 医学系研究科, 助教 (40452437)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥50,700,000 (Direct Cost: ¥39,000,000、Indirect Cost: ¥11,700,000)
Fiscal Year 2010: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Fiscal Year 2009: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2008: ¥21,450,000 (Direct Cost: ¥16,500,000、Indirect Cost: ¥4,950,000)
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| Keywords | イオンチャネル / 内向き整流性カリウムチャネル / 電位依存性カリウムチャネル / 薬物-チャネル相互作用 / 構造活性相関 / 薬理学 / 生物物理学 / カリウムイオンチャネル / 電気生理学的解析 / 抗鬱薬 / 抗不整脈薬 |
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| Research Abstract |
Ion channel functions are modulated by the drugs. However, the mechanisms underling drug actions are often not well understood. In this study, we examined the mechanisms of drug actions in inward-rectifier potassium channels and voltage-dependent potassium channel. Our studies reveal structural bases of drug-channel interactions and their functional alterations in potassium channel. Moreover, our results provide better understandings of their clinical efficacy or undesirable side effects, and shed light on the rational development of pharmacological agents.
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Report
(4 results)
Research Products
(77 results)
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[Journal Article] on behalf of the J-RHYTHM II Investigators. Randomized trial of angiotensin II-receptor blocker vs. dihydropiridine calcium channel blocker in the treatment of paroxysmal atrial fibrillation with hypertension (J-RHYTHM II Study).2011
Author(s)
Yamashita T, Inoue H, Okumura K, Kodama I, Aizawa Y, Atarashi H, Ohe T, Ohtsu H, Kato T, Kamakura S, Kumagai K, Kurachi Y, Koretsune Y, Saikawa T, Sakurai M, Sato T, Sugi K, Nakaya H, Hirai M, Hirayama A, Fukatani M, Mitamura H, Yamazaki T, Watanabe E, Ogawa S
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Journal Title
Europace 13(4)
Pages: 473-479
Related Report
Peer Reviewed
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[Journal Article] A platform for in silico modeling of physiological systems III.2009
Author(s)
Suzuki Y, Asai Y, Oka H, Heien E, Urai T, Okamoto T, Yumikura Y, Tominaga K, Kido Y, Nakanishi M, Hagihara K, Kurachi Y, Nomura T.
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Journal Title
Conf Proc IEEE Eng Med Biol Soc. 2009
Pages: 2803-2806
Related Report
Peer Reviewed
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[Journal Article] Optimal treatment strategy for patients with paroxysmal atrial fibrillation : J-RHYTHM Study.2009
Author(s)
Ogawa S, Yamashita T, Yamazaki T, Aizawa Y, Atarashi H, Inoue H, Ohe T, Ohtsu H, Okumura K, Katoh T, Kamakura S, Kumagai K, Kurachi Y, Kodama I, Koretsune Y, Saikawa T, Sakurai M, Sugi K, Tabuchi T, Nakaya H, Nakayama T, Hirai M, Fukatani M, Mitamura H.
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Journal Title
Circ J 73(2)
Pages: 242-248
NAID
Related Report
Peer Reviewed
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[Presentation] 薬物のhERGチャネル機能制御2010
Author(s)
古谷和春、稲野辺厚、山川祐子、岩田美紀、倉智嘉久
Organizer
平成22年度筋生理の集い
Place of Presentation
東京慈恵会医科大学高木会館、東京(招待講演)
Year and Date
2010-12-04
Related Report
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[Presentation] 心筋細胞のL型Ca2+チャネルの不活性化モデル2010
Author(s)
村上慎吾、河津俊宏、イアンフィンドレイ、鈴木慎吾、赤羽悟美、野村泰伸、倉智嘉久
Organizer
生理研研究会「シグナル伝達の動的理解を目指す新戦略」
Place of Presentation
自然科学研究機構岡崎コンファレンスセンター、岡崎(招待講演)
Year and Date
2010-09-30
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