| Budget Amount *help |
¥49,920,000 (Direct Cost: ¥38,400,000、Indirect Cost: ¥11,520,000)
Fiscal Year 2011: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2010: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Fiscal Year 2009: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Fiscal Year 2008: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
|
|---|
| Research Abstract |
We generated various tissuespecific PTENdeficient mice and found the novel functions of PTEN in vivo.(2) We found PICT1 binds and stabilizes PTEN protein. Moreover, we found PICT1 is a potent regulator of the MDM2-P53 pathway and promotes tumor progression by retaining RPL11 in the nucleolus.(3) We found PBP1 binds and activates lipid phosphatase activity of PTEN, and strongly represss the Akt activation in vitro. Thus, we found the novel functions of PTEN and the mechanism of its regulation.
|
