| Co-Investigator(Renkei-kenkyūsha) |
UOZAKI Hiroshi 東京大学, 大学院・医学系研究科, 講師(H23より准教授) (10296246)
SAKATANI Takashi 東京大学, 大学院・医学系研究科, 助教 (50431903)
HINO Rumi 東京大学, 大学院・医学系研究科, 助教 (60451770)
USHIKU Tetsuo 東京大学, 医学部附属病院, 助教 (60376415)
MORIKAWA Teppei 東京大学, 医学部附属病院, 助教 (80451772)
KIKUCHI Yoshinao 東京大学, 医学部附属病院, 助教 (90512260)
NAKAYA Takeo 東京大学, 大学院・医学系研究科, 特任助教 (80512277)
SHINOZAKI Aya 東京大学, 大学院・医学系研究科, 助教 (60581824)
KUNITA Akiko 東京大学, 大学院・医学系研究科, 助教 (50608768)
MATSUSAKA Keisuke 東京大学, 医学部附属病院, 助教 (40610150)
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| Budget Amount *help |
¥50,310,000 (Direct Cost: ¥38,700,000、Indirect Cost: ¥11,610,000)
Fiscal Year 2012: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2011: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2010: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2009: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2008: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
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| Research Abstract |
Methylation array analyses demonstrated that EBV-associated GC showed genome-wide hypermethylation at CpG sites of promoter regions. We succeeded in reproducing this genome-wide methylation by EBV infection of the gastric cancer cell line, MKN7, which serves as an important experimental system to investigate the molecular mechanisms. We demonstrated that a viral latent protein, LMP2A, partially contributed to the DNA hypermethylation. A possible virus-reactivating therapy was evaluated with inhibitors of DNA methylation and proteosome.
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