| Budget Amount *help |
¥50,050,000 (Direct Cost: ¥38,500,000、Indirect Cost: ¥11,550,000)
Fiscal Year 2010: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2009: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2008: ¥21,190,000 (Direct Cost: ¥16,300,000、Indirect Cost: ¥4,890,000)
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| Research Abstract |
Drug response is likely altered in the patient with metabolic syndrome. The present results indicated that the expression levels of drug transporters were varied, and pharmacokinetics was changed in several diseases. Especially, we clearly revealed that an efflux transporter MATE1 could influence the sensitivities of anti-diabetic drug metformin and anti-cancer drug cisplatin. These outcomes can lead to the optimized pharmacotherapy in metabolic syndrome patients.
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