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Lung effects of indium compounds on indium-exposed workers : A cohort study

Research Project

Project/Area Number 20249039
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionKeio University

Principal Investigator

OMAE Kazuyuki  Keio University, 医学部, 教授 (60118924)

Co-Investigator(Kenkyū-buntansha) TANAKA Akiyo  九州大学, 大学院・医学研究院, 講師 (10136484)
Co-Investigator(Renkei-kenkyūsha) HIRATA Miyuki  九州大学, 大学院・医学研究院, 助教 (30156674)
Research Collaborator NAKANO MAKIKO  慶應義塾大学, 医学部, 助教 (70384906)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥36,400,000 (Direct Cost: ¥28,000,000、Indirect Cost: ¥8,400,000)
Fiscal Year 2010: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2009: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2008: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Keywordsインジウム / 呼吸器影響 / コホート研究 / 間質性肺障害 / KL-6高精度胸部CT(HRCT) / スパイロメトリー / リスクコミュニケーション / 肺間質性障害 / 産業疫学 / 量反応関係 / 量影響関係 / 生物学的モニタリング / 肺間質件障害
Research Abstract

Up to 2007, our study team established the causal relationship between exposure to hardly soluble indium compound particles and lung disease called "indium lung". From 2008 through 2010, we re-visited total of 50 times of 17 indium factories and 4 head-quarters, and carried out the follow-up survey on approximately 700 indium-exposed and referent workers. Both exposure and outcome parameters were gradually improving in indium-exposed workers. Industrial hygiene managements such as job transfer, improvement of working conditions and use of respiratory protective masks may be functioned adequately.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (53 results)

All 2011 2010 2009 2008 Other

All Journal Article (16 results) (of which Peer Reviewed: 14 results) Presentation (32 results) Book (4 results) Remarks (1 results)

  • [Journal Article] Indium lung-Case reports and epidemiology.2010

    • Author(s)
      大前和幸, 中野真規子, 田中昭代, 平田美由紀, et al.
    • Journal Title

      Int Arch Occup Environ Health (Published online)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chronic pulmonary toxicity study of indium-tin oxide and indium oxide following intratracheal instillations into the lungs of hamsters.2010

    • Author(s)
      田中昭代, 平田美由紀, et al.
    • Journal Title

      J Occup Health 52

      Pages: 14-22

    • NAID

      10025966537

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Review of pulmonary toxicity of indium compounds to animals and humans.2010

    • Author(s)
      Tanaka A, Hirata M, Kiyohara Y, Nakano M, Omae K, et al.
    • Journal Title

      Thin Solid Films 518

      Pages: 2934-2936

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] インジウム肺2010

    • Author(s)
      中野真規子、田中昭代、平田美由紀、大前和幸
    • Journal Title

      産業医学レビュー 23

      Pages: 1-15

    • NAID

      40017131944

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Indium lung-Case reports and epidemiology.2010

    • Author(s)
      Omae K, Nakano M, Tanaka A, Hirata M, Hamaguchi T, Chonan T.
    • Journal Title

      Int Arch Occup Environ Health

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] インジウム肺2010

    • Author(s)
      中野真規子、大前和幸
    • Journal Title

      産業医学レどユー

      Volume: 23 Pages: 1-15

    • NAID

      40017131944

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Review of pulmonary toxicity of indium compounds to animals and humans2010

    • Author(s)
      Tanaka A, Hirata M, Kiyehara Y, Nakano M, Omae K, Shiratani M, Koga K
    • Journal Title

      Thin Solid Films 518

      Pages: 2934-2936

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genotoxicity studies on heavy metals : Lead, bismuth, indium, silver and antimony.2009

    • Author(s)
      Asakura K, Nakano M, Omae K
    • Journal Title

      J Occup Health 51

      Pages: 498-512

    • NAID

      10025966383

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Causal relationship between indium compound inhalation and effects on the lungs.2009

    • Author(s)
      中野真規子, 大前和幸, 田中昭代, 平田美由紀, et al.
    • Journal Title

      J Occup Health 51

      Pages: 513-521

    • NAID

      10025966413

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Causal relationship between indium compound inhalation and effects on the lungs2009

    • Author(s)
      Nakano M, Omae K, Tanaka A, Hirata M, Kikuchi Y, Yoshioka N, Nishiwaki Y, Chonan T
    • Journal Title

      Journal of Occupational Health 51

      Pages: 513-521

    • NAID

      10025966413

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oral toxicity of indium in rats : Single and 28-day repeated administration studies.2008

    • Author(s)
      Asakura K, Nakano M, Omae K
    • Journal Title

      J Occup Health 50

      Pages: 471-479

    • NAID

      110007007855

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exposure to hardly soluble indium compounds in the ITO producing and recycling plants is a new potent risk of interstitial lung damage.2008

    • Author(s)
      Hamaguchi T, Omae K, Tanaka A, Hirata M, et al.
    • Journal Title

      Occup Environ Med 65

      Pages: 51-55

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 化学物質と産業中毒「インジウム」2008

    • Author(s)
      大前和幸、中野真規子、田中昭代、平田美由紀
    • Journal Title

      労働の科学 63

      Pages: 286-289

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exposure to hardly soluble indium compounds in the ITO producing and recycling plants is a new potent risk of interstitial lung damage.2008

    • Author(s)
      Hamaguchi T, Omae K, Tanaka A, Hirata M, Takebayashi T, Kikuchi Y, Yoshioka N, Taguchi O, Chonan T.
    • Journal Title

      Occupational and Environmental Medicine 65

      Pages: 51-55

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oral toxicity of indium in rats : Single and 28-day repeated administration studies2008

    • Author(s)
      Asakura K, Satoh H, Chiba M, Okamoto M, Serizawa K, Nakano M, Omae K
    • Journal Title

      Journal of Occupational Health 50

      Pages: 471-479

    • NAID

      110007007855

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 化学物質と産業中毒「インジウム」2008

    • Author(s)
      大前和幸, 中野真規子, 田中昭代, 平田美由紀
    • Journal Title

      労働の科学 63

      Pages: 286-289

    • Related Report
      2008 Annual Research Report
  • [Presentation] 肺障害を惹起するインジウムの吸収、代謝、排泄2010

    • Author(s)
      平田美由紀、田中昭代、清原裕、中野真規子、大前和幸
    • Organizer
      第21回微量元素学会学術集会 シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2010-07-03
    • Related Report
      2010 Final Research Report
  • [Presentation] 肺炎症惹起金属インジウムの代謝研究-塩化インジウムの吸収と排泄-2010

    • Author(s)
      野中美希、平田美由紀、田中昭代、清原裕
    • Organizer
      平成22年度日本産業衛生学会九州地方会
    • Place of Presentation
      北九州
    • Year and Date
      2010-06-10
    • Related Report
      2010 Final Research Report
  • [Presentation] Indium Workshop. Indium-Related Lung Disease in Japan. Overview of the Japanese Experience. National Institute for Occupational Safety and Health2010

    • Author(s)
      大前和幸
    • Organizer
      Center for Disease Control and Prevention.
    • Place of Presentation
      Morgantown, West Virginia
    • Related Report
      2010 Final Research Report
  • [Presentation] Indium Workshop. Indium-Related Lung Disease in Japan. Outcomes of Epidemiologic Investigations in Japan. National Institute for Occupational Safety and Health2010

    • Author(s)
      大前和幸
    • Organizer
      Center for Disease Control and Prevention.
    • Place of Presentation
      Morgantown, West Virginia.
    • Related Report
      2010 Final Research Report
  • [Presentation] Indium Workshop. Indium-Related Lung Disease in Japan. Planned Response of the Japanese Ministry of Health, Labor, andWelfare. National Institute for Occupational Safety and Health2010

    • Author(s)
      大前和幸
    • Organizer
      Center for Disease Control and Prevention.
    • Place of Presentation
      Morgantown, West Virginia.
    • Related Report
      2010 Final Research Report
  • [Presentation] Indium Workshop. Clinical features of indium lung in Japan. National Institute for Occupational Safety and Health2010

    • Author(s)
      中野真規子
    • Organizer
      Center for Disease Control and Prevention.
    • Place of Presentation
      Morgantown, West Virginia.
    • Related Report
      2010 Final Research Report
  • [Presentation] インジウムナノ粒子の生体影響2010

    • Author(s)
      田中昭代、平田美由紀
    • Organizer
      第51回大気環境学会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] 塩化インジウム気管内単回投与による代謝および生体への影響2010

    • Author(s)
      野中美希、平田美由紀、田中昭代、清原裕
    • Organizer
      第21回微量元素学会
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report
  • [Presentation] インジウム化合物の気管内投与後の血清インジウム濃度推移2010

    • Author(s)
      田中昭代、平田美由紀、他
    • Organizer
      第83回日本産業衛生学会総会
    • Place of Presentation
      福井
    • Related Report
      2010 Final Research Report
  • [Presentation] インジウム化合物曝露による肺影響-曝露形態別の量影響関係2010

    • Author(s)
      平田美由紀、田中昭代、清原裕、中野真規子、大前和幸、他
    • Organizer
      第83回日本産業衛生学会総会
    • Place of Presentation
      福井
    • Related Report
      2010 Final Research Report
  • [Presentation] インジウム化合物曝露による肺影響-日本のインジウムコホート研究-2010

    • Author(s)
      中野真規子、田中昭代、平田美由紀、大前和幸
    • Organizer
      第80回日本衛生学会総会
    • Place of Presentation
      仙台
    • Related Report
      2010 Final Research Report
  • [Presentation] Five-year changes of effects of indium exposure on the lungs?2010

    • Author(s)
      中野真規子, 田中昭代, 平田美由紀, 大前和幸
    • Organizer
      a Japanese indium cohort study-EPICOHMEDICHEM 2010
    • Place of Presentation
      Taipei
    • Related Report
      2010 Final Research Report
  • [Presentation] Indium-Related Lung Disease in Japan.Overview of the Japanese Experience.2010

    • Author(s)
      Omae K.
    • Organizer
      Indium Workshop.NIOSH, CDC
    • Place of Presentation
      Morgantown, West Virginia.
    • Related Report
      2010 Annual Research Report
  • [Presentation] Indium-Related Lung Disease in Japan.Outcomes of Epidemiologic Investigations in Japan.2010

    • Author(s)
      Omae K.
    • Organizer
      Indium Workshop.NIOSH, CDC
    • Place of Presentation
      Morgantown, West Virginia.
    • Related Report
      2010 Annual Research Report
  • [Presentation] Indium-Related Lung Disease in Japan.Planned Response of the Japanese Ministry of Health, Labor, and Welfare.2010

    • Author(s)
      Omae K.
    • Organizer
      Indium Workshop.NIOSH, CDC
    • Place of Presentation
      Morgantown, West Virginia.
    • Related Report
      2010 Annual Research Report
  • [Presentation] シンポジウム。インジウム肺:基礎・臨床・疫学研究の協同による因果関連の確立-疫学研究の結果-2009

    • Author(s)
      大前和幸
    • Organizer
      第82回日本産業衛生学会総会
    • Place of Presentation
      福岡
    • Related Report
      2010 Final Research Report
  • [Presentation] シンポジウム。インジウム肺:基礎・臨床・疫学研究の協同による因果関連の確立-動物実験による知見-2009

    • Author(s)
      田中昭代
    • Organizer
      第82回日本産業衛生学会総会
    • Place of Presentation
      福岡
    • Related Report
      2010 Final Research Report
  • [Presentation] シンポジウム.インジウム肺:基礎・臨床・疫学研究の協同による因果関連の確立-臨床の立場から-2009

    • Author(s)
      中野真規子
    • Organizer
      第82回日本産業衛生学会総会
    • Place of Presentation
      福岡
    • Related Report
      2010 Final Research Report
  • [Presentation] Indium lung : Specificity of association between exposure to indium and lung interstitial damage.2009

    • Author(s)
      中野真規子, 田中昭代, 平田美由紀, 大前和幸
    • Organizer
      21^<st> Conference of International Society for Environmental Epidemiology 2009
    • Place of Presentation
      Dublin
    • Related Report
      2010 Final Research Report
  • [Presentation] 肺障害性インジウムの職業性曝露と尿インジウム:吸入曝露指標としての尿インジウムの有効性2009

    • Author(s)
      平田美由紀、田中昭代
    • Organizer
      第20回微量元素学会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] インジウム曝露者における胸部CT所見2009

    • Author(s)
      中野真規子、大前和幸、平田美由紀、田中昭代、他
    • Organizer
      第49回日本呼吸器学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] インジウム作業者の尿中インジウム濃度と腎への影響2009

    • Author(s)
      平田美由紀、田中昭代、清原裕、大前和幸、中野真規子
    • Organizer
      第82回日本産業衛生学会総会
    • Place of Presentation
      福井
    • Related Report
      2010 Final Research Report
  • [Presentation] Health effects of indium compounds : Outcomes of animal and epidemiological studies, and prevention of indium lung.2009

    • Author(s)
      Tanaka A, Hirata M, Kiyohara Y, Nakano M, Omae K, et al.
    • Organizer
      6th International Symposium on Transparent Oxide Thin Films for Electronics and Optics.
    • Place of Presentation
      Tokyo
    • Related Report
      2010 Final Research Report
  • [Presentation] インジウム曝露者における呼気一酸化窒素濃度(FENO)との関連性2009

    • Author(s)
      中野真規子,大前和幸、平田美由紀、田中昭代
    • Organizer
      第79回日本衛生学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] Indium lung : Specificity of association between exposure to indium and lung interstitial damage2009

    • Author(s)
      Nakano M, Tanaka A, Hirata M, Nishiwaki Y, Yoshioka N, Michikawa T, Kikuchi Y, Omae K.
    • Organizer
      21th Conference of International Society for Environmental Epidemiology
    • Place of Presentation
      Dublin, Ireland
    • Related Report
      2009 Annual Research Report
  • [Presentation] インジウム製錬作業者の職場改善による血中指標の変化-インジウム濃度と呼吸器影響-2008

    • Author(s)
      平田美由紀、田中昭代、清原裕、大前和幸、中野真規子、他
    • Organizer
      第41回生物学的モニタリング・バイオマーカー研究会
    • Place of Presentation
      佐賀
    • Year and Date
      2008-11-10
    • Related Report
      2010 Final Research Report
  • [Presentation] インジウム曝露による肺間質性変化 : 作業環境改善による肺影響の軽減2008

    • Author(s)
      中野真規子, 菊池有利子, 吉岡範行, 佐野有理, 田中昭代, 平田美由紀, 大前和幸
    • Organizer
      第48回日本呼吸器学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2008-06-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] シンポジウム。化学物質による障害を見逃さないために-インジウム肺を例として-2008

    • Author(s)
      大前和幸
    • Organizer
      第81回日本産業衛生学会総会
    • Place of Presentation
      札幌
    • Related Report
      2010 Final Research Report
  • [Presentation] Effect of workplace environment improvement on serumindiumlevel and respiratory influence among indium refinement workers.2008

    • Author(s)
      Hirata M, Tanaka A, Kiyohara Y, Omae K, Nakano M, et al.
    • Place of Presentation
      Porto Alegre
    • Related Report
      2010 Final Research Report
  • [Presentation] インジウム曝露による肺間質性変化:作業環境改善による肺影響の軽減2008

    • Author(s)
      中野規子、田中昭代、平田美由紀、大前和幸
    • Organizer
      第81回日本産業衛生学会総会
    • Place of Presentation
      札幌
    • Related Report
      2010 Final Research Report
  • [Presentation] インジウム曝露による肺間質性変化:作業環境改善による肺影響の軽減2008

    • Author(s)
      中野真規子、田中昭代、平田美由紀、大前和幸
    • Organizer
      第48回日本呼吸器学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] インジウムによる間質性肺障害2008

    • Author(s)
      中野真規子、田中昭代、平田美由紀、道川武紘、大前和幸
    • Organizer
      第78回日本衛生学会総会
    • Place of Presentation
      熊本
    • Related Report
      2010 Final Research Report
  • [Book] レアメタル便覧(足立吟也監修)(第33章レアメタルと生態系・健康 インジウム(In) 東京)2011

    • Author(s)
      田中昭代
    • Related Report
      2010 Final Research Report
  • [Book] ナノ材料のリスク評価と安全性対策-生体・環境への影響、安全性対策・国内動向-(亘理文夫監修)(第3章代表的ナノマテリアルのリスク評価と生体影響、ITOの健康影響 東京)2010

    • Author(s)
      田中昭代、平田美由紀
    • Publisher
      フロンティア出版
    • Related Report
      2010 Final Research Report
  • [Book] 透明導電膜の新展開III-ITOとその代替材料開発の現状-(南内嗣監修)(第2編インジウムベース透明電極の現状とITO取扱上の問題点。第2章インジウム化合物の毒性とITO取り扱い上の注意 東京)2008

    • Author(s)
      田中昭代、平田美由紀、大前和幸
    • Publisher
      シーエムシー出版
    • Related Report
      2010 Final Research Report
  • [Book] 南 内嗣監修。透明導電膜の新展開III -ITOとその代替材料開発の現状-。第2編インジウムベース透明電極の現状とITO取扱上の問題点。第2章インジウム化合物の毒性とITO取り扱い上の注意。2008

    • Author(s)
      田中昭代, 平田美由紀, 大前和幸
    • Publisher
      シーエムシー出版。東京
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://www.keiopublichealth.jp/

    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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