| Project/Area Number |
20249043
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Osaka University |
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Principal Investigator |
MOCHIZUKI Kiyoshi (2010) Osaka University, 医学系研究科, 助教 (50467578)
林 紀夫 (2008-2009) Osaka University, 医学系研究科, 教授 (00144478)
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| Co-Investigator(Kenkyū-buntansha) |
HAYASHI Norio 大阪大学, 医学系研究科, 教授 (00144478)
TAKEHARA Tetsuo 大阪大学, 医学系研究科, 教授 (70335355)
KANTO Tatsuya 大阪大学, 医学系研究科, 寄附講座准教授 (80372613)
望月 圭 大阪大学, 医学系研究科, 助教 (50467578)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥31,070,000 (Direct Cost: ¥23,900,000、Indirect Cost: ¥7,170,000)
Fiscal Year 2010: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2009: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
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| Keywords | ウイルス肝炎 / NK細胞 / 樹状細胞 / ノックアウト / 制御性T細胞 / C型肝炎 / インターフェロン / T細胞 / HCV / 免疫 / ELISPOT / 肝細胞癌 / Trl / 血小板 / 線維化 / 肝癌 / 自然免疫 / 獲得免疫 |
|---|
| Research Abstract |
The aim of this study is to analyze the immunological pathogenesis of chronic hepatitis C (CHC). The innate immune system recognizing hepatitis C virus (HCV) in myeloid dendritic cells was impaired in CHC patients. The IFN-α signaling in NK cells altered in CHC patients and this was associated with the outcome of the peg-IFN-α/ribavirin combination therapy. The early induction of HCV-specific CTL responses plays an important role in the eradication of HCV by this combination therapy. The impairment of activation of NKT cells could be occurred in tumor-bearing host and the generation of regulatory T cells could also be occurred in the presence of dendritic cells and HCC cells. These results might contribute to the development of future immunotherapy against CHC and HCC.
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