| Project/Area Number |
20249045
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
MUROHARA Toyoaki Nagoya University, 医学系研究科, 教授 (90299503)
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| Co-Investigator(Kenkyū-buntansha) |
SHINTANI Satoshi 名古屋大学, 大学院・医学研究科, 講師 (20309777)
BANDO Yasuko 名古屋大学, 大学院・医学研究科, 助教 (60452190)
MAEDA Kengo 名古屋大学, 医学部付属病院, 助教 (80456673)
SHIBATA Rei 名古屋大学, 大学院・医学研究科, 特任講師 (70343689)
TAKESHITA Kyosuke 名古屋大学, 医学部付属病院, 講師 (70444403)
沼口 靖 名古屋大学, 医学部, 寄附講座准教授 (90378224)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥46,410,000 (Direct Cost: ¥35,700,000、Indirect Cost: ¥10,710,000)
Fiscal Year 2010: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2009: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2008: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
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| Keywords | 糖尿病 / 糖尿病性心筋症 / 血管新生 / 再生医学 / 血管再生 / 心不全 / 細胞内シグナル / 蛋白分解酵素 / インスリン抵抗性 / 心筋繊維化 / ミトコンドリア / 心筋リモデリング / 高血糖 / 糖尿病性毛細血管傷害 / 心筋症 / 高インスリン血症 |
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| Research Abstract |
Mismatch between cardiomyocyte growth and reduced coronary angiogenesis promotes maladaptive cardiac remodeling including diabetic cardiomyopathy. Diabetes enhances cardiac aminopeptidase activity which promotes degradation in angiogenic chemokine SDF1-α, leading to reduced coronary angiogenesis and resultant cardiac remodeling. Our data suggest that regulation of cardiac aminopepetidase activity may be essential for therapeutic strategy of maladaptive cardiac remodeling in diabetes.
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