| Budget Amount *help |
¥47,710,000 (Direct Cost: ¥36,700,000、Indirect Cost: ¥11,010,000)
Fiscal Year 2012: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2011: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2010: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2009: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2008: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
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| Research Abstract |
In 2007, we discovered a novel signal cascade of WNK kinases, and clarified that its constitutive activation causes human hypertension in pseudohypoaldosteronism type II (PHAII). This study was conducted to further clarify the roles of WNK signal cascade in vivo other than PHAII by using the genetically engineered mice. As a result, we were able to identify several hormonal factors that regulate WNK kinases and new downstream targets, and could provide a whole picture of WNK kinase signaling in the body, especially in kidney.
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