| Project/Area Number |
20249050
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MATSUMOTO Toshio The University of Tokushima, 大学院・ヘルスバイオサエン研究部, 教授 (20157374)
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| Co-Investigator(Kenkyū-buntansha) |
ABE Masahiro 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (80263812)
AIHARA Kenichi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (70372711)
FUJINAKA Yuichi 徳島大学, 病院, 講師 (30432751)
ENDO Itsuro 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (10432759)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥47,970,000 (Direct Cost: ¥36,900,000、Indirect Cost: ¥11,070,000)
Fiscal Year 2010: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2009: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2008: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
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| Keywords | 内科 / 老化 / 多発性骨髄腫 / 骨粗鬆症 / 糖尿病 / 動脈硬化 / interleukin-11 / Wntシグナル / アンドロゲン |
|---|
| Research Abstract |
IL-11 gene transcription is enhanced by mechanical stress to bone, and IL-11 stimulates osteoblast differentiation and bone formation via activation of canonical Wnt signaling. TGF-・inhibitor enhances osteoblast differentiation, and mature osteoblasts inhibit myeloma cell proliferation. Thus, TGF-・inhibition can become a new therapeutic approach against multiple myeloma. Pitavastatin ameliorates left ventricular diastolic function and microalbumiuria via suppression of oxidative stress. A thrombin inhibitor, heparin cofactor II, inhibits migration and proliferation of vascular smooth muscle cells, and protects against atherosclerotic changes.
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