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Study on the pathogenesis of acute encephalitis and encephalopathy for the effective treatment and prevention

Research Project

Project/Area Number 20249053
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionOkayama University

Principal Investigator

MORISHIMA Tsuneo  Okayama University, 大学院・医歯薬学総合研究科, 教授 (90157892)

Co-Investigator(Kenkyū-buntansha) OKABE Nobuhiko  国立感染症研究所, 感染症情報センター, センター長 (10057028)
NAKAGOMI Osamu  長崎大学, 大学院・医歯薬学総合研究科, 教授 (70143047)
NUNOI Hiroyuki  宮崎大学, 医学部, 教授 (50218260)
KONDOU Kazuhiro  東京慈恵会医科大学, 医学部, 教授 (70234929)
HOSOYA Mitsuaki  福井県立医科大学, 医学部, 教授 (80192318)
MATSUKAWA Akihiro  岡山大学, 大学院・医歯薬学総合研究科, 教授 (90264283)
KIMURA Hioroshi  名古屋大学, 大学院・医学系研究科, 准教授 (30303621)
YOSHIKAWA Tetsushi  藤田保健衛生大学, 医学部, 准教授 (80288472)
ICHIYAMA Takashi  山口大学, 大学院・医学系研究科, 教授 (20263767)
OKUMURA Akihisa  順天堂大学, 医学部, 准教授 (60303624)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥49,400,000 (Direct Cost: ¥38,000,000、Indirect Cost: ¥11,400,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2008: ¥28,860,000 (Direct Cost: ¥22,200,000、Indirect Cost: ¥6,660,000)
Keywords急性脳症 / 小児感染症学 / 急性脳炎 / サイトカイン / ロタウィルス / HHV-6 / インフルエンザ / チオレドキシン(TRX) / 酸化ストレス / インフルエンザ脳症 / 新型インフルエンザ / ロタウイルス / チトクロームC / DNAマイクロアレイ / 炎症性サイトカイン / 単純ヘルペス / ロタウイルス脳炎・脳症
Research Abstract

We have studied on the clinical features and pathogenesis of acute encephalitis/encephalopathy caused by viruses among children. As an causative agent, Influenza virus was a most common virus, followed by HHV-6 and rotavirus, and overall mortality was 7.7%. In terms of the pathogenesis of CNS damage caused by HHV-6 primary infection (E. subitum), virus growth has not been found in the brain tissue, showing encephalopathy not encephalitis. For treatment of this illness, TRX could be an important target in the near future.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (63 results)

All 2011 2010 2009 2008

All Journal Article (41 results) (of which Peer Reviewed: 39 results) Presentation (22 results)

  • [Journal Article] Serum concentrations of complement anaphylatoxins and proinflammatory mediators in patients with 2009 H1N1 influenza.2011

    • Author(s)
      Ohta R, Torii Y, Imai M, Kimura H, Okada N, Ito Y.
    • Journal Title

      Microbiol Immunol 55

      Pages: 191-8

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serum concentrations of complement anaphylatoxins and proinflammatory mediators in patients with 2009 H1N1 influenza.2011

    • Author(s)
      Ohta R, Torii Y, Imai M, Kimura H, Okada N, Ito Y.
    • Journal Title

      Microbiol Immunol

      Volume: 55 Pages: 191-8

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of the cerebrospinal fluid levels and serum concentrations of human herpesvirus 6 (HHV-6) DNA and cytokines in children with HHV-6 encephalopathy.2010

    • Author(s)
      Kawabe S, Ito Y, Ohta R, Sofue A, Gotoh K, Morishima T, Kimura H.
    • Journal Title

      J Med Virol 82

      Pages: 1410-1415

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Autoimmune focal encephalitis shows marked hypermetabolism on positron emission tomography.2010

    • Author(s)
      Sekigawa M, Okumura A, Niijima S, Hayashi M, Tanaka K, Shimizu T.
    • Journal Title

      J Pediatr 156

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increase of tumor necrosis factor-alpha in the blood induces early activationofmatrix metalloproteinase-9 in the brain.2010

    • Author(s)
      Tsuge M, Yasui K, Ichiyama T, Saito Y, Nagaoka Y, Yashiro M, Yamashita N, Morishima T.
    • Journal Title

      Microbiol Immunol 54

      Pages: 417-424

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic seizure susceptibility underlying acute encephalopathies in childhood.2010

    • Author(s)
      Kobayashi K, Ouchida M, Okumura A, Maegaki Y, Nishiyama I, Matsui H, Ohtsuka Y, Ohmori I.
    • Journal Title

      Epilepsy Res 91

      Pages: 143-152

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Norovirus encephalopathy in a previously healthy child.2010

    • Author(s)
      Obinata K, Okumura A, Nakazawa T, Kamata A, Niizuma T, Kinoshita K, Shimizu T.
    • Journal Title

      Pediatr Infect Dis J 29

      Pages: 1057-1059

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of the cerebrospinal fluid levels and serum concentrations of human herpesvirus 6 (HHV-6) DNA and cytokines in children with HHV-6 encephalopathy.2010

    • Author(s)
      Kawabe S., Ito Y., Ohta R., Sofue A., Gotoh K., Morishima T., Kimura H.
    • Journal Title

      J Med Virol

      Volume: 82 Pages: 1410-1415

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute encephalopathy/encephalitis in childhood : a relatively common and potentially devastating clinical syndrome.2010

    • Author(s)
      Ichiyama T.
    • Journal Title

      Brain Dev

      Volume: 32 Pages: 433-434

    • NAID

      10027491585

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Increase of tumor necrosis factor-alpha in the blood induces early activation of matrix metalloproteinase-9 in the brain.2010

    • Author(s)
      Tsuge M., Yasui K., Ichiyama T., Saito Y., Nagaoka Y., Yashiro M., Yamashita N., Morishima T.
    • Journal Title

      Microbiol Immunol

      Volume: 54 Pages: 417-424

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rotavirus infections with multiple emerging genotypes to Sri Lanka.2010

    • Author(s)
      Ahmed K., Batuwanthudawe R., Chandrasena TG., Mitui MT., Rajindrajith S., Galagoda G., Pun SB, Uchida R., Kunii O., Moji K., Abeysinghe N., Nishizono A.
    • Journal Title

      Arch Virol

      Volume: 155 Pages: 71-75

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum and cerebrospinal fluid cytokine concentrations in subacute selerosing panencephalitis.2010

    • Author(s)
      Aydin OF, Ichiyama T, Anlar B.
    • Journal Title

      Brain Dev

      Volume: 32 Pages: 463-466

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin E2 suppresses β1-integrin expression via E-prostanoid receptor in human monocytes/macrophages.2010

    • Author(s)
      Hasegawa S, Ichiyama T, Kohno F, Korenaga Y, Ohsaki A, Hirano R, Haneda Y, Fukano R, Furukawa S.
    • Journal Title

      Cell Immunol

      Volume: 263 Pages: 161-165

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autoimmune focal encephalitis shows marked hypermetabolism on positron emission tomography.2010

    • Author(s)
      Sekigawa M, Okumura A, Niijima S, Hayashi M, Tanaka K, Shimizu T.
    • Journal Title

      J Pediatr

      Volume: 156 Pages: 158-160

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute encephalopathy with biphasic seizures and late reduced diffusion associated with hemophagocytic syndrome.2010

    • Author(s)
      Tadokoro R., Okumura A., Nakazawa T., Hara S., Yamakawa Y., Kamata A., Kinoshita K., Obinata K., Shimizu T.
    • Journal Title

      Brain Dav

      Volume: 32 Pages: 477-481

    • NAID

      10027491741

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gaelectin-9 expands immunosuppressive macrophages to ameliorate Tcell-mediated lung inflammation.2010

    • Author(s)
      Arikawa T, Saita N, Oomizu S, Ueno M, Matsukawa A, Katoh S, Kojima K, Nagahara K, Miyake M, Yamauchi A.
    • Journal Title

      Eur J Immunol.

      Volume: 40 Pages: 548-558

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxidative stress enhances granulocytic differentiation in HL 60 cells, an acute promyelocytic leukemia cell line. Free Radic Res.2010

    • Author(s)
      Ogino T, Ozaki M, Matsukawa A.
    • Journal Title

      PubMed PMID

      Volume: 44 Pages: 1328-37

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Localization of viral DNA and cytokines in children with human herpes virus 6 encephalopathy.2009

    • Author(s)
      Kawabe S, Ito Y, Ohta R, Iwata S, Nishiyama Y, Kimura.
    • Journal Title

      The 14th International Conference on Immunobiology and Prophylaxis of Human Herpesvirus Infections. Kobe, Japan

    • Related Report
      2010 Final Research Report
  • [Journal Article] Nationwide survey of exanthem subitum-associated encephalitis in Japan.2009

    • Author(s)
      Yoshikawa T, Ohashi M, Miyake F, Funjita A, Usui C, Sugata K, Suga S, Hashimoto S, Asano Y.
    • Journal Title

      Pediatr Neurol 41

      Pages: 353-358

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differences of clinical manifestations according to the patterns of brain lesions in acute encephalopathy with reduced diffusion in the bilateral hemispheres.2009

    • Author(s)
      Okumura A, Kidokoro H, Tsuji T, Suzuki M, Kubota T, Kato T, Komatsu M, Shono T, Hayakawa F, Shimizu T, Morishima T.
    • Journal Title

      Am J Neuroradiol 30

      Pages: 825-830

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The spectrum of acute encephalopathy with reduced diffusion in the unilateral hemisphere.2009

    • Author(s)
      Okumura A, Suzuki M, Kidokoro H, Komatsu M, Shono T, Hayakawa F, Shimizu T.
    • Journal Title

      Eur J Paediatr Neurol 13

      Pages: 154-159

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differences in clinicalmanifestations of influenza-associated encephalopathy by age.2009

    • Author(s)
      Wada T, Morishima T, Okumura A, Tashiro M, Hosoya M, Shiomi M, Okuno Y.
    • Journal Title

      Microbiol Immunol 53

      Pages: 83-88

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sudden unexpected cardiopulmonary arrest associated with influenza infection.2009

    • Author(s)
      Kidokoro H, Okumura A, Suzuki M, Kubota T, Kato T, Hayakawa F, Watanabe K, Morishima T.
    • Journal Title

      Pediatr Int 51

      Pages: 742-744

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Outcome of acute necrotizing encephalopathy in relation to treatment with corticosteroids and gammaglobulin.2009

    • Author(s)
      Okumura A, Mizuguchi M, Kidokoro H, Tanaka M, Abe S, Hosoya M, Aiba H, Maegaki Y, Yamamoto H, Tanabe T, Noda E, Imataka G, Kurahashi H.
    • Journal Title

      Brain Dev 31

      Pages: 221-227

    • NAID

      10025579183

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serum and cerebrospinal fluid levels of cytokines in human herpesvirus-6 encephalopathy.2009

    • Author(s)
      Ichiyama T, Ito Y, Kubota M, Yamazaki T, Nakamura K, Susumu F.
    • Journal Title

      Brain Dev 31

      Pages: 731-738

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serum matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 levels in non-herpetic acute limbic encephalitis.2009

    • Author(s)
      Ichiyama T, Takahashi Y, Matsushige T, Kajimoto M, Fukunaga S, Furukawa S.
    • Journal Title

      J Neurol 256

      Pages: 1846-1850

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multiplex real-time PCR for the simultaneous detection of herpes simplex virus, human herpesvirus 6, and human herpesvirus 7.2009

    • Author(s)
      Wada K, Mizoguchi S, Ito Y, Kawada J, Yamauchi Y, Morishima T, Nishiyama Y, Kimura H.
    • Journal Title

      Microbiol Immunol 53

      Pages: 22-29

    • NAID

      10026403953

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differences in clinical manifestations of influenza-associated encephalopathy by age.2009

    • Author(s)
      Wada T, Morishima T, Okumura A, Tashiro M, Hosoya M, Shiomi M, Okuno Y.
    • Journal Title

      Microbiol Immunol 53

      Pages: 83-88

    • NAID

      10027685683

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Callosal lesions and delirious behavior during febrile illness.2009

    • Author(s)
      Okumura A, Hayakawa F, Kato T, Suzuki M, Tsuji T, Fukumoto Y, Nakata T, Watanabe K, Morishima T.
    • Journal Title

      Brain Dev 31

      Pages: 158-162

    • NAID

      10025578929

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Outcome of acute necrotizing encephalopathy in relation to treatment with corticosteroids and gammaglobulin.2009

    • Author(s)
      Okumura A, Mizuguchi M, Kidokoro H, Tanaka M, Abe S, Hosoya M, Aiba H, Maegaki Y, Yamamoto H, Tanabe T, Noda E, Imataka G.
    • Journal Title

      Brain Dev 31

      Pages: 221-227

    • NAID

      10025579183

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Primary infection of human herpesvirus-6 in an infant who received cord blood SCT.2009

    • Author(s)
      Muramatsu H, Watanabe N, Matsumoto K, Ito M, Yoshikawa T, Kato K, Kojima S
    • Journal Title

      Bone Marrow Transplant. 43

      Pages: 83-84

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Epstein-Barr virus(EBV)-infected lymphocyte subtypes by flow cytometric in situhybridization in EBV-associated lymphoproliferative diseases.2009

    • Author(s)
      Kimura H, Miyake K, Yamauchi Y, Nishiyama K, Iwata S, Iwatsuki K, Gotoh K, Kojima S, Ito Y, Nishiyama Y.
    • Journal Title

      J Infect Dis 200

      Pages: 1078-1087

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum and cerebrospinal fluid levels of cytokines in acute encephalopathy associated with human herpesvirus-6 infection.2009

    • Author(s)
      Ichiyama T. Ito Y, Kubota M. Yamazaki T, Nakamura K, Furukawa s.
    • Journal Title

      Brain Dev. (In press. )

    • NAID

      10026412963

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiplex real-time PCR for the simultaneous detecion of herpes simplexvirus, human herpesvirus 6, and human herpesvirus 7.2009

    • Author(s)
      Wada K. Mizoguchi S, Ito Y, Kawada J. Yamauchi Y, Morishima T, Nishiyama Y, Kimura H.
    • Journal Title

      Microbiol Immunol. 53(1)

      Pages: 22-29

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Subacute encephalopathy : Clinical features, laboratory data, neuroimaging, and outcomes.2008

    • Author(s)
      Okumura A, Kidokoro H, Itomi K, Maruyama K, Kubota T, Kondo Y, Itomi S, Uemura N, Natsume J, Watanabe K, Morishima T.
    • Journal Title

      Pediatr Neurol 38

      Pages: 111-117

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diffusion tensor imaging in infants with basal ganglia-thalamic lesions.2008

    • Author(s)
      Okumura A, Hayakawa M, Tsuji T, Naganawa S, Watanabe K.
    • Journal Title

      Eur J Paediatr Neurol 12

      Pages: 412-416

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cerebrospinal fluid levels of cytokines in non-herpetic acute limbic encephalitis : comparison with herpes simplex encephalitis.2008

    • Author(s)
      Ichiyama T, Shoji H. Takahashi Y, Matsushige T, Kajimoto M, Inuzuka T, Furukawa S.
    • Journal Title

      Cytokine 44

      Pages: 149-153

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic Factors in Influenza-Associated Encephalopathy2008

    • Author(s)
      Nagao T, Morishima T, Kimura H, Yokota S, Yamashita N, Ichiyama T, Kurihara M, Miyazaki C, Okabe N.
    • Journal Title

      Pediat Infect Dis J 27

      Pages: 384-389

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cerebrospinal fluid levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in subacute sclerosing panencephalitis.2008

    • Author(s)
      Ichiyama T, Matsushige T, Siba P, Suarkia D, Takasu T, Miki K, Furukawa S.
    • Journal Title

      J Infect 56

      Pages: 376-380

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] CSF neurofilament and soluble TNF receptor l levels in subacute sclerosing panenphalitis.2008

    • Author(s)
      Matsushige T, Ichiyama T, Anlar B, Tohyama J. Somura K. Yamashita Y. Furukawa S.
    • Journal Title

      J Neuroimmunol. 205(1-2)

      Pages: 155-159

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Subacute encephalopathy : clinical features, laboratory data, neuroimaging, and outcomes.2008

    • Author(s)
      Okumura A. Kidokuro H. Itomi K. Maruyama K, Kubota T, Kondo Y. Itomi S. Uemura S, Satsume J, Watanabe K, Morishima T.
    • Journal Title

      Pediatr Neurol. 38(2)

      Pages: 111-117

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] HHV-6と神経疾患2011

    • Author(s)
      吉川哲史
    • Organizer
      第14回神経感染症学会シンポジウム2-ウイルス感染と神経疾患
    • Place of Presentation
      福島
    • Related Report
      2010 Final Research Report
  • [Presentation] Increased levels of cytokines and high-mobility group box 1 are associated with the development of severe pneumonia, but not acute encephalopathy, in 2009 H1N1 influenza-infected children.2010

    • Author(s)
      Ito Y, Torii Y, Ohta R, Imai M, Kimura H
    • Organizer
      Cell Symposia Influenza : Translating basic insights.
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2010-12-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 先天性・周産期感染症(TORCH)の実態に関する全国アンケート調査2010

    • Author(s)
      木村宏
    • Organizer
      第42回日本小児感染症学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2010-11-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 急性脳炎・脳症-病態解析から治療へ-2010

    • Author(s)
      森島恒雄
    • Organizer
      第80回西日本感染症学会
    • Place of Presentation
      松山市(特別講演)
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新型インフルエンザ-病態解明から治療へ-2010

    • Author(s)
      森島恒雄
    • Organizer
      第53回日本感染症学会中日本地方会
    • Place of Presentation
      京都市(特別講演)
    • Year and Date
      2010-11-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 急性脳症の病態解析と治療戦略2010

    • Author(s)
      市山高志
    • Organizer
      第86回山陰小児科学会
    • Place of Presentation
      米子(特別講演)
    • Year and Date
      2010-09-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Noninvasive identification of EBV-infected lymphocyte subtypes in EBV-associated T/NK lymphoproliferative diseases.2010

    • Author(s)
      Kimura H, Ito Y, Kawabe S, Gotoh K, Iwata S, Nishiyama Y
    • Organizer
      The 14th Biennial Conference of the International Association for Research on Epstein-Barr virus & Associated Diseases
    • Place of Presentation
      Birmingham, UK
    • Year and Date
      2010-09-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Brain Science on Fatigue, Identification of a novel HHV-6 latent-protein associated with CFS and mood disorders. K.Kondo2010

    • Author(s)
      K.Kondo
    • Organizer
      Neuro 2010
    • Place of Presentation
      Kobe(Symposium)
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脳炎・脳症、髄膜炎トピックス2010

    • Author(s)
      市山高志
    • Organizer
      第134回日本小児科学会徳島地方会
    • Place of Presentation
      徳島(特別講演)
    • Year and Date
      2010-06-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 幼児期にepileptic spasmaを認める多小脳回の1例2010

    • Author(s)
      奥村彰久、安部信平、池野充、斎藤雅子、清水俊明
    • Organizer
      第4回日本てんかん学会関東甲信越地方会
    • Place of Presentation
      東京
    • Year and Date
      2010-06-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 急性脳症における脳波2010

    • Author(s)
      奥村彰久
    • Organizer
      第52回日本小児神経学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2010-05-22
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 新型インフルエンザ関連脳症の臨床像2010

    • Author(s)
      奥村彰久、清水俊明、辻健史、久保田哲夫、山下進太郎、新島新一、平岩朋子
    • Organizer
      第52回日本小児神経学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 急性脳炎・脳症の臨床症状と治療法2010

    • Author(s)
      奥村彰久
    • Organizer
      第27回神経研都民講座
    • Place of Presentation
      国分寺
    • Year and Date
      2010-04-13
    • Related Report
      2010 Final Research Report
  • [Presentation] 急性脳炎・脳症の臨床症状と治療法2010

    • Author(s)
      奥村彰久
    • Organizer
      第27回神経研都民講座
    • Place of Presentation
      国分寺(招待講演)
    • Year and Date
      2010-04-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] インフルエンザ感染におけるレドックス制御蛋白チオレドキシン(TRX)の役割2010

    • Author(s)
      八代将登、藤井洋輔、斎藤有希恵、長岡義晴、津下充、山下信子、塚原宏一、松川昭博、森島恒雄
    • Organizer
      日本ウイルス学会学術集会
    • Place of Presentation
      徳島県
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒトヘルペスウイルス6(HHV-6)の細胞特異性とスプライシング関連因子SART3の発現量に関する解析2010

    • Author(s)
      嶋田和也、近藤一博
    • Organizer
      第58回日本ウイルス学会
    • Place of Presentation
      徳島
    • Related Report
      2010 Annual Research Report
  • [Presentation] 「急性脳症の診療・研究最前線」、病態解析と治療戦略2010

    • Author(s)
      市山高志
    • Organizer
      第52回日本小児神経学会
    • Place of Presentation
      福岡(シンポジウム)
    • Related Report
      2010 Annual Research Report
  • [Presentation] HHV-6脳症における髄液・血清中のウイルスDNA・サイトカインの局在2009

    • Author(s)
      河邉慎司、伊藤嘉規、太田里永子、後藤研誠、川田潤一、木村宏
    • Organizer
      第57回日本ウイルス学会学術集会、東京
    • Place of Presentation
      東京
    • Year and Date
      2009-10-26
    • Related Report
      2010 Final Research Report
  • [Presentation] Identification of a novel molecular mechanism and a major cause of fatigue.2009

    • Author(s)
      Kondo N.
    • Organizer
      36th International Congress of Physiological Sciences. Late-breaking symposium
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2009-08-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Neuropsychiatric aspects of influenza.2009

    • Author(s)
      Morishima T.
    • Organizer
      47th AnnualMeeting of Infectious Diseases Society of America
    • Place of Presentation
      Philadelphia, U.S.A.
    • Related Report
      2009 Annual Research Report
  • [Presentation] インフルエンザと意識障害・異常言動2008

    • Author(s)
      奥村彰久
    • Organizer
      第559回日本小児科学会東京都地方会講話会
    • Place of Presentation
      東京
    • Year and Date
      2008-09-13
    • Related Report
      2010 Final Research Report
  • [Presentation] 急性壊死性脳症の臨床像と予後2008

    • Author(s)
      奥村彰久
    • Organizer
      第111回日本小児科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2008-04-26
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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