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Study on pathophysiology of schizophrenia started from a rare case.

Research Project

Project/Area Number 20249054
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research Institution財団法人東京都医学総合研究所 (2011)
Tokyo Metropolitan Organization for Medical Research (2008-2010)

Principal Investigator

ITOKAWA Masanari  財団法人東京都医学総合研究所, 精神行動医学研究分野, 参事研究員 (40332324)

Co-Investigator(Kenkyū-buntansha) YOSHIKAWA Takeo  独立行政法人理化学研究所, 分子精神科学研究チーム, チームリーダー (30249958)
TAKIZAWA Tosiya  東海大学, 医学部, 医学部 (70197234)
Project Period (FY) 2008 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥47,580,000 (Direct Cost: ¥36,600,000、Indirect Cost: ¥10,980,000)
Fiscal Year 2011: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2010: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2009: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Fiscal Year 2008: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Keywords精神薬理学 / 分子生物学 / 統合失調症 / カルボニルストレス / 週末糖化産物 / ビタミンB6 / glyoxalasel / 終末糖化産物 / esRAGE(Receptor for AGEs) / 染色体転座 / 転写因子 / Common disease rare variant仮説 / 神経発達異常仮説 / 遺伝子多型 / resequence / ノックアウトマウス / common disease rare variant仮説 / yeast two-hyhrid法
Research Abstract

We detected a novel frameshif mutation in GLO1 gene of a case with schizophrenia. He showed elevated plasma AGEs and depletion of vitamin B6.We measured AGEs and vitamin B6 using 45 schizophrenia and 61 controls that showed significant high AGEs and low vitamin B6 in schizophrenia compared with that of controls. We started phase II clinical trial to carbonyl stress related schizophrenia by piridoxamine.

Report

(6 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (122 results)

All 2011 2010 2009 2008 Other

All Journal Article (63 results) (of which Peer Reviewed: 54 results) Presentation (51 results) Book (5 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Positive association of phencyclidine-responsive genes, PDE4A and PLAT, with schizophrenia2011

    • Author(s)
      Deng X, Takaki H, Wang L, Kuroki T, Nakahara T, Hashimoto K, Ninomiya H, Arinami T, Inada T, Ujike H, Itokawa M, Tochigi M, Watanabe Y, Someya T, Kunugi H, Iwata N, Ozaki N, Shibata H, Fukumaki Y
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet

      Volume: 156B(7) Pages: 850-858

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] yoxalase I retards renal senescence2011

    • Author(s)
      Ikeda Y, Inagi R, Miyata T, Nagai R, Arai M, Miyashita M, Itokawa M, Fujita T, Nangaku M
    • Journal Title

      Am J Pathol

      Volume: 179(6) Pages: 2810-2821

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] iopathic carbonyl stress in a drug-naive case of at-risk mental state2011

    • Author(s)
      Arai M, Koike S, Oshima N, Takizawa R, Araki T, Miyashita M, Nishida A, Miyata T, Kasai K, Itokawa M
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 65 Pages: 604-607

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Positive association of Phencyclidine-responsive genes, PDE4A and PLAT, with schizophrenia2011

    • Author(s)
      Deng X, Takaki H, Wang L, Kuroki T, Nakahara T, Hashimoto K, Ninomiya H, Arinami T, Inada at, Ujike H, Itokawa M, chigi M, Watanabe Y, Someya T, Kunugi H, Iwata N, Ozaki N, Shibata H, Fukumaki Y
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet

      Volume: 156(7) Pages: 850-858

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] sociation analysis of the tryptophan hydroxylase 2 gene polymorphisms in patients with methamphetamine dependence/psychosis2011

    • Author(s)
      Kobayashi H, Ujike H, Iwata N, Inada T, Yamada M, Sekine Y, Uchimura N, Iyo M, Ozaki N, Itokawa M, Sora I
    • Journal Title

      Curr Neuropharmacol

      Volume: 9(1) Pages: 137-142

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] hizophrenia with the 22q11.2 deletion and additional genetic defects : case history2011

    • Author(s)
      Toyosima M, Maekawa M, Toyota T, Iwayama Y, Arai M, Ichikawa T, Miyashita M, Arinami T, Itokawa M, Yoshikawa T
    • Journal Title

      The British Journal of Psychiatry

      Volume: 199 Pages: 245-246

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] lassification of First-Episode Schizophrenia Patients and Healthy Subjects by Automated MRI Measures of Regional Brain Volume and Cortical Thickness2011

    • Author(s)
      Takayanagi Y, Takahashi T, Orikabe L, Mozue Y, Kawasaki Y, Nakamura K, Sato Y, Itokawa M, Yamasue H, Kasai K, Kurachi M, Okazaki Y, Suzuki M
    • Journal Title

      PLoS One

      Volume: 6(6)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 学研究から見えてきた統合失調症の病態および治療と予防の展開2011

    • Author(s)
      糸川昌成,新井誠,小池進介,滝沢龍,市川智恵,宮下光弘,吉川武男,宮田敏男,笠井清登,岡崎祐士
    • Journal Title

      精神医学

      Volume: 53(12) Pages: 1195-1200

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glyoxalase I retards renal senescence2011

    • Author(s)
      Ikeda Y, Inagi R, Miyata T, Nagai R, Arai M, Miyashita M, Itokawa M, Fujita T, Nangaku M
    • Journal Title

      Am J Pathol

      Volume: 179(6) Pages: 2810-2821

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 脳科学研究から見えてきた統合失調症の病態および治療と予防の展開2011

    • Author(s)
      糸川昌成, 新井誠, 小池進介, 滝沢龍, 市川智恵, 宮下光弘, 吉川武男, 宮田敏男, 笠井清登, 岡崎祐士
    • Journal Title

      精神医学

      Volume: 53(12) Pages: 1195-1200

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 稀な遺伝子変異を手がかりとする統合失調症の病態研究2011

    • Author(s)
      糸川昌成, 新井誠, 市川智恵, 宮下光弘, 岡崎祐士
    • Journal Title

      BRAIN and NERVE

      Volume: 63(3) Pages: 223-231

    • NAID

      40018741200

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 統合失調症の分子病態と思春期までの予防戦略2011

    • Author(s)
      糸川昌成, 新井誠, 市川智恵, 宮下光弘, 菊地克史, 吉川武男, 岡崎祐士, 宮田敏男
    • Journal Title

      精神神経誌

      Volume: 印刷中

    • NAID

      10029576451

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Supportive evidence for reduced expression of GNB1L in schizophrenia2010

    • Author(s)
      Ishiguro H, Koga M, Horiuchi Y, Noguchi E, Morikawa M, Suzuki Y, Arai M, Niizato K, Iritani S, Itokawa M, Inada T, Iwata N, Ozaki N, Ujike H, Kunugi H, Sasaki T, Takahashi M, Watanabe Y, Someya T, Kakita A, Takahashi H, Nawa H, Arinami T
    • Journal Title

      Schizophr Bull

      Volume: 36 Pages: 756-765

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced Carbonyl Stress in a Subpopulation of Schizophrenia2010

    • Author(s)
      Arai M, Yuzawa H, Nohara I, Ohnishi T, Obata N, Iwayama Y, Haga S, Toyota T, Ujike H, Arai M, Ichikawa T, Nishida A, Tanaka Y, Furukawa A, Aikawa Y, Kuroda O, Niizato K, Izawa R, Nakamura K, Mori N, Matsuzawa D, Hashimoto K, Iyo M, Sora I, Matsushita M, Okazaki Y, Yoshikawa T, Miyata T, Itokawa M
    • Journal Title

      Arch Gene Psychiatry

      Volume: 67 Pages: 589-597

    • NAID

      130005395360

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Advanced Research on Dopamine Signaling to Develop Drugs for the Treatment of Mental Disorders : Ser311Cys Polymorphisms of the Dopamine D(2)-Receptor Gene and Schizophrenia2010

    • Author(s)
      Itokawa M, Arinami T, Toru M
    • Journal Title

      J Pharmacol Sci

      Volume: 114 Pages: 1-5

    • NAID

      130000302180

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The adenosine A2A receptor is associated with methamphetamine dependence/psychosis in the Japanese population2010

    • Author(s)
      Kobayashi H, Ujike H, Iwata N, Inada T, Yamada M, Sekine Y, Uchimura N, Iyo M, Ozaki N, Itokawa M, Sora I
    • Journal Title

      Behav Brain Funct

      Volume: 6 Pages: 50-50

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A hard road in psychiatric genetics : schizophrenia and DPYSL22010

    • Author(s)
      Arai M, Itokawa M
    • Journal Title

      J Hum Genet

      Volume: 55 Pages: 397-399

    • NAID

      10030735596

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] An association study between the dymeclin gene and schizophrenia in the Japanese population2010

    • Author(s)
      Yazaki S, Koga M, Ishiguro H, Inada T, Ujike H, Itokawa M, Otowa T, Watanabe Y, Someya T, Iwata N, Kunugi H, Ozaki N, Arinami T
    • Journal Title

      J Hum Genet

      Volume: 55 Pages: 631-634

    • NAID

      10030736885

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Brain cannabinoid CB2 receptor in schizophrenia2010

    • Author(s)
      Ishiguro H, Horiuchi Y, Ishikawa M, Koga M, Imai K, Suzuki Y, Morikawa M, Inada T, Watanabe Y, Takahashi M, Someya T, Ujike H, Iwata N, Ozaki N, Onaivi ES, Kunugi H, Sasaki T, Itokawa M, Arai M, Niizato K, Iritani S, Naka I, Ohashi J, Kakita A, Takahashi H, Nawa H, Arinami T
    • Journal Title

      Biol Psychiatry

      Volume: 67 Pages: 974-982

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differentiation of first-episode schizophrenia patients from healthy controls using ROI-based multiple structural brain variables2010

    • Author(s)
      Takayanagi Y, Kawasaki Y, Nakamura K, Takahashi T, Orikabe L, Toyoda E, Mozue Y, Sato Y, Itokawa M, Yamasue H, Kasai K, Kurachi M, Okazaki Y, Matsushita M, Suzuki M
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry

      Volume: 34 Pages: 10-17

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of the HSPG2 gene with neuroleptic-induced tardive dyskinesia2010

    • Author(s)
      Syu A, Ishiguro H, Inada T, Horiuchi Y, Tanaka S, Ishikawa M, Arai M, Itokawa M, Niizato K, Iritani S, Ozaki N, Takahashi M, Kakita A, Takahashi H, Nawa H, Keino-Masu K, Arikawa-Hirasawa E, Arinami T
    • Journal Title

      Neuropsychopharmacology

      Volume: 35 Pages: 1155-1164

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Volume reduction and altered sulco-gyral pattern of the orbitofrontal cortex in first-episode schizophrenia2010

    • Author(s)
      Takayanagi Y, Takahashi T, Orikabe L, Masuda N, Mozue Y, Nakamura K, Kawasaki Y, Itokawa M, Sato Y, Yamasue H, Kasai K, Okazaki Y, Suzuki M
    • Journal Title

      Schizophr Res

      Volume: 121 Pages: 55-65

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Familial ALS with G298S mutation in TARDBP : A comparison of CSF tau protein levels with those in sporadic ALS2010

    • Author(s)
      Nozaki I, Arai M, Takahashi K, Hamaguchi T, Yoshikawa H, Muroishi T, Noguchi-Shinohara M, Ito H, Itokawa M, Akiyama H, Kawata A, Yamada M
    • Journal Title

      Inter Med

      Volume: 49 Pages: 1209-1212

    • NAID

      130000251656

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Replication study of association between ADCYAP1 gene polymorphisms and schizophrenia2010

    • Author(s)
      Koga M, Ishiguro H, Horiuchi Y, Inada T, Ujike H, Itokawa M, Otowa T, Watanabe Y, Someya T, Arinami T
    • Journal Title

      Psychiatr Genet

      Volume: 20 Pages: 123-125

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Failure to find an association between myosin heavy chain 9, non-muscle(MYH9) and schizophrenia : a three-stage case-control association study2010

    • Author(s)
      Amagane H, Watanabe Y, Kaneko N, Nunokawa A, Muratake T, Ishiguro H, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Sasaki T, Hashimoto R, Itokawa M, Ozaki N, Someya T
    • Journal Title

      Schizophr Res

      Volume: 118 Pages: 106-112

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] TDP-43 M337V Mutation in Familial Amyotrophic Lateral Sclerosis in Japan2010

    • Author(s)
      Tamaoka A, Arai M, Itokawa M, Arai T, Hasegawa M, Tsuchiya K, Takuma H, Tsuji H, Ishii A, Watanabe M, Takahashi Y, Goto J, Tsuji S, Akiyama H
    • Journal Title

      Intern Med

      Volume: 49 Pages: 331-334

    • NAID

      130000152618

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The dopamine D3 receptor(DRD3) gene and risk of schizophrenia : Case-control studies and an updated meta-analysis2010

    • Author(s)
      Nunokawa A, Watanabe Y, Kaneko N, Sugai T, Yazaki S, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Sasaki T, Itokawa M, Ozaki N, Hashimoto R, Someya T
    • Journal Title

      Schizophr Res

      Volume: 116 Pages: 61-67

    • Related Report
      2011 Final Research Report
  • [Journal Article] Psychotic-like experiences are associated with suicidal feelings and deliberate self-harm behaviors in adolescents aged 12-15 years2010

    • Author(s)
      Nishida A, Sasaki T, Nishimura Y, Tanii H, Hara N, Inoue K, Yamada T, Takami T, Shimodera S, Itokawa M, Asukai N, Okazaki Y
    • Journal Title

      Acta Psychiatr Scand

      Volume: 121 Pages: 301-307

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced Carbonyl Stress in a Subpopulation of Schizophrenia.2010

    • Author(s)
      Arai M, et al.
    • Journal Title

      Arch Gene Psychiatry 67

      Pages: 589-597

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Advanced Research on Dopamine Signaling to Develop Drugs for the Treatment of Mental Disorders : Ser311Cys Polymorphisms of the Dopamine D(2)-Receptor Gene and Schizophrenia.2010

    • Author(s)
      Itokawa M, et al.
    • Journal Title

      J Pharmacol Sci 114

      Pages: 1-5

    • NAID

      130000302180

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Advanced Research on Dopamine Signaling to Develop Drugs for the Treatment of Mental Disorders : Ser311Cys Polymorphisms of the Dopamine D(2)-Receptor Gene and Schizophrenia.2010

    • Author(s)
      Itokawa M, Arinami T, Yoru M.
    • Journal Title

      J Pharmacol Sci

      Volume: 114 Pages: 1-5

    • NAID

      130000302180

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A hard road in psychiatric genetics : schizophrenia and DPYSL2.2010

    • Author(s)
      Arai M, Itokawa M.
    • Journal Title

      J Hum Genet

      Volume: 55 Pages: 397-399

    • NAID

      10030735596

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brain cannabinoid CB2 receptor in schizophrenia.2010

    • Author(s)
      Ishiguro H, Horiuchi Y, Ishikawa M, Koga M, Imai K, Suzuki Y, Morikawa M, Inada T, Watanabe Y, Takahashi M, Someya T, Ujike H, Iwata N, Ozaki N, Onaivi ES, Kunugi H, Sasaki T, Itokawa M, Arai M, Niizato K, Iritani S, Naka I, Ohashi J, Kakita A, Takahashi H, Nawa H, Arinami T.
    • Journal Title

      Biol Psychiatry

      Volume: 67 Pages: 974-982

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of the HSPG2 gene with neuroleptic-induced tardive dyskinesia.2010

    • Author(s)
      Syu A, Ishiguro H, Inada T, Horiuchi Y, Tanaka S, Ishikawa M, Arai M, Itokawa M, Niizato K, Iritani S, Ozaki N, Takahashi M, Kakita A, Takahashi H, Nawa H, Keino-Masu K, Arikawa-Hirasawa E, Arinami T.
    • Journal Title

      Neurop sychop harmacology

      Volume: 35 Pages: 1155-1164

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Familial ALS with G298S mutation in TARDBP: A comparison of CSF tau protein levels with those in sporadic ALS.2010

    • Author(s)
      Nozaki I, Arai M, Takahashi K, Hamaguchi T, Yoshikawa H, Muroishi T, Noguchi-Shinohara M, Ito H, Itokawa M, Akiyama H, Kawata A, Yamada M.
    • Journal Title

      Inter Med

      Volume: 49 Pages: 1209-1212

    • NAID

      130000251656

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The dopamine D3 receptor(DRD3)gene and risk of schizophrenia : Case-control studies and an updated meta-analysis.2010

    • Author(s)
      Nunokawa A, Watanabe Y, Kaneko N, Sugai T, Yazaki S, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Sasaki T, Itokawa M, Ozaki N, Hashimoto R, Someya T.
    • Journal Title

      Schizophr Res

      Volume: 116 Pages: 61-67

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Psychotic-like experiences are associated with suicidal feelings and deliberate self-harm behaviors in adolescents aged 12-15 years.2010

    • Author(s)
      Nishida A, Sasaki T, Nishimura Y, Tanii H, Hara N, Inoue K, Yamada T, Takami T, Shimodera S, Itokawa M, Asukai N, Okazaki Y.
    • Journal Title

      Acta Psychiatr Scand

      Volume: 121 Pages: 301-307

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differentiation of first-episode schizophrenia patients from healthy controls using ROI-based multiple structural brain variables2010

    • Author(s)
      Takayanagi Y, Kawasaki Y, Nakamura K, Takahashi T, Orikabe L, Toyoda E, Mozue Y, Sato Y, Itokawa M, Yamasue H, Kasai K, Kurachi M, Okazaki Y, Matsushita M, Suzuki M.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry. 34(1)

      Pages: 10-17

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 網膜色素変性症と統合失調症を合併した兄弟例2010

    • Author(s)
      河上緒、梅津寛、大澤達哉、石川陽一、小椋哲、合川勇三、糸川昌成、岡崎祐士
    • Journal Title

      東京精神医学会誌 27

      Pages: 21-25

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 脳と心の分子メカニズム:発見の瞬間はどのようにして訪れるのか2010

    • Author(s)
      糸川昌成
    • Journal Title

      こころの働きと病・覚醒剤(NPO法人脳の世紀推進会議編)

      Pages: 45-74

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Persistence criteria for susceptibility genes for schizophrenia : a discussion from an evolutionary viewpoint2009

    • Author(s)
      Doi N, Hoshi Y, Itokawa M, Usui C, Yoshikawa T, Tachikawa H
    • Journal Title

      PLoS One

      Volume: 4(11)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of SMARCA2/BRM in the SWI/SNF chromatin-remodeling complex in schizophrenia2009

    • Author(s)
      Koga M, Ishiguro H, Yazaki S, Horiuchi Y, Arai M, Niizato K, Iritani S, Itokawa M, Inada T, Iwata N, Ozaki N, Ujike H, Kunugi H, Sasaki T, Takahashi M, Watanabe Y, Someya T, Kakita A, Takahashi H, Nawa H, Muchardt C, Yaniv M, Arinami T
    • Journal Title

      Hum Mol Genet

      Pages: 2483-2494

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Two-stage case-control association study of PADI2 with schizophrenia2009

    • Author(s)
      Watanabe Y, Nunokawa A, Kaneko N, Arinami T, Ujike, Inada T, Iwata N, Kunugi H, Itokawa M, Otowa T, Ozaki N, Someya T
    • Journal Title

      J Hum Genet

      Volume: 54 Pages: 430-432

    • NAID

      10030731190

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preliminary Genome-wide Association Study of Bipolar Disorder in the Japanese Population2009

    • Author(s)
      Hattori E, Toyota T, Ishitsuka Y, Iwayama Y, Yamada K, Ujike H, Morita Y, Kodama M, Nakata K, Minabe Y, Nakamura K, Iwata Y, Takei N, Mori N, Naitoh H, Yamanouchi Y, Iwata N, Ozaki N, Kato T, Nishikawa T, Kashiwa A, Suzuki M, Shioe K, Shinohara M, Hirano M, Nanko S, Akahane A, Ueno M, Kaneko N, Watanabe Y, Someya T, Hashimoto K, Iyo M, Itokawa M, Arai M, Nankai M, Inada T, Yoshida S, Kunugi H, Nakamura M, Iijima Y, Okazaki Y, Higuchi T, Yoshikawa T
    • Journal Title

      Am J Med Genet

      Volume: 150B Pages: 1110-1117

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 統合失調症の遺伝子研究による病態解明:稀な症例を出発点とするこころみ2009

    • Author(s)
      糸川昌成,数藤由美子,新井誠,本多真
    • Journal Title

      精神医学

      Volume: 51 Pages: 185-193

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 網膜色素変性症と統合失調症を合併した兄弟例2009

    • Author(s)
      河上緒、梅津寛、大澤達哉、石川陽一、小椋哲、合川勇三、糸川昌成、岡崎祐士
    • Journal Title

      東京精神医学会誌

      Volume: 27 Pages: 21-25

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Two-stage case-control association study of polymorphisms in rheumatoid arthritis susceptibility genes with schizophrenia2009

    • Author(s)
      Watanabe Y, Nunokawa A, Kaneko N, Muratake T, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Itokawa M, Otowa T, Ozaki N, Someya T
    • Journal Title

      J Hum Genet

      Volume: 54 Pages: 62-65

    • NAID

      10030728996

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Two-stage case-control association study of polymorphisms in rheumatoid arthritis susceptibility genes with schizophrenia2009

    • Author(s)
      Watanabe Y, Nunokawa A, Kaneko N, Muratake T, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Itokawa M, Otowa T, Ozaki N, Someya T.
    • Journal Title

      J Hum Genet 54

      Pages: 62-65

    • NAID

      10030728996

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 統合失調症の遺伝子研究による病態解明:稀な症例を出発点とするこころみ2009

    • Author(s)
      糸川昌成, 数藤由美子, 新井誠, 本多真
    • Journal Title

      精神医学 51

      Pages: 185-193

    • Related Report
      2009 Annual Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 論文投稿の仕方:精神医学研究マニュアル2009

    • Author(s)
      糸川昌成
    • Journal Title

      臨床精神医学 38[増刊号]

      Pages: 77-80

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TDP-43 G298S変異示す認知症を伴う家族性ALS2009

    • Author(s)
      吉田眞理, 櫻井信夫, 三室マヤ, 橋詰良夫, 新井哲明, 長谷川成人, 新井誠, 糸川昌成, 秋山治彦
    • Journal Title

      Dementia Japan 23

      Pages: 218-218

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 脳神経分野2009

    • Author(s)
      糸川昌成
    • Journal Title

      ライフサイエンス分野科学技術・研究開発の国際比較(JST研究開発戦略センター) 2009年度版

      Pages: 255-260

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 神経系の疾患2009

    • Author(s)
      糸川昌成
    • Journal Title

      ライフサイエンス分野科学技術・研究開発の国際比較(JST研究開発戦略センター) 2009年度版

      Pages: 68-72

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Replication study for associations between polymorphisms in the CLDN5 and DGCR2 genes in the 22q11 deletion syndrome region and schizophrenia2008

    • Author(s)
      Ishiguro H, Imai K, Koga M, Horiuchi Y, Inada T, Iwata N, Ozaki N, Ujike H, Itokawa M, Kunugi H, Sasaki T, Watanabe Y, Someya T, Arinami T
    • Journal Title

      Psychiatr Genet

      Volume: 18 Pages: 255-256

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Microarray comparative genomic hybridization analysis of 59 patients with schizophrenia2008

    • Author(s)
      Mizuguchi T, Hashimoto R, Itokawa M, Sano A, Shimokawa O, Yoshimura Y, Harada N, Miyake N, Nishimura A, Saitsu H, Sosonkina N, Niikawa N, Kunugi H, Matsumoto N
    • Journal Title

      J Hum Genet

      Volume: 53 Pages: 914-919

    • NAID

      10022603067

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Large-scale case-control study of a functional polymorphism in the glutamate receptor, metabotropic 3 gene in patients with schizophrenia2008

    • Author(s)
      Nunokawa A, Watanabe Y, Kitamura H, Kaneko N, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Itokawa M, Ozaki N, Someya T
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 62 Pages: 239-240

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A polymorphism of the metabotropic glutamate receptor mGluR7(GRM7) gene is associated with schizophrenia2008

    • Author(s)
      Ohtsuki T, Koga M, Ishiguro H, Horiuchi Y, Arai M, Niizato K, Itokawa M, Inada T, Iwata N, Iritani S, Ozaki N, Kunugi H, Ujike H, Watanabe Y, Someya T, Arinami T
    • Journal Title

      Schizophr Res

      Volume: 101 Pages: 9-16

    • NAID

      120007138788

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Microarray comparative genomic hybridization analysis of 59 patients with schizophrenia2008

    • Author(s)
      Mizuguchi T, Hashimoto R, Itokawa M, Sano A, Shimokawa O, Yishimura Y, Harada N, Miyake N, Nishimura A, Saitsu H, Sosonkina N, Niikawa N, Kunugi H, Matsumoto N.
    • Journal Title

      J Hum Genet 53

      Pages: 914-919

    • NAID

      10022603067

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Arinami T. A polymorphism of the metabotropic glutamate receptor mGluR7 (GRM7) gene is associated with schizophrenia2008

    • Author(s)
      Ohtsuki T, Koga M, Ishiguro H, Horiuchi Y, Arai M, Niizato K, Itokawa M, Inada T, Iwata N, Iritani S, Ozaki N, Kunugi H, Ujike H, Watanabe Y, Someya T.
    • Journal Title

      Schizophr Res 101

      Pages: 9-16

    • Related Report
      2008 Annual Research Report
  • [Journal Article]2008

    • Author(s)
      糸川昌成
    • Journal Title

      臨床で発見する統合失調症研究.In:松沢臨床精神医学セミナー(松下正明監修, 岡崎祐士編)(東京 日本評論社) 1

      Pages: 253-263

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Psychotic-like experiences are associated with suicidal feelings and deliberate self-harm behaviors in adolescents aged 12-15 years

    • Author(s)
      Nishida A, Sasaki T, Nishimura Y, Tanii H, Hara N, Inoue K, Yamada T, Takami T, Shimodera S, Itokawa M, Asukai N, Okazaki Y.
    • Journal Title

      Acta Psychiatr Scand (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of SMARCA2/BRM in the SWI/SNF chromatin-remodeling complex in schizophrenia

    • Author(s)
      Koga M, Ishiguro H, Yazaki S, Horiuchi Y, Arai M, Niizato K, Iritani S, Itokawa M, Inada T, Iwata N, Ozaki N, Ujike H, Kunugi H, Sasaki T, Takahashi M, Watanabe Y, Someya T, Kakita A, Takahashi H, Nawa H, Muchardt C, Yaniv M, Arinami T.
    • Journal Title

      Hum Mol Genet (in press)

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Two-stage case-control association study of polymorphisms in rheumatoid arthritis susceptibility genes with schizophrenia

    • Author(s)
      Watanabe Y, Nunokawa A, Kaneko N, Muratake T, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Itokawa M, Otowa T, Ozaki N, Someya T.
    • Journal Title

      J Hum Genet (in press)

    • NAID

      10030728996

    • Related Report
      2008 Annual Research Report
  • [Presentation] カルボニルストレスと早期診断・治療・予防2011

    • Author(s)
      新井誠,宮下光弘,市川智恵,豊田倫子,大西哲生,吉川武男,有波忠雄,岡崎祐士,久島周,尾崎紀夫,福本素由乙,橋本亮太,武田雅俊,小池進介,滝沢龍,笠井清登,山本博,渡邉琢夫,宮田敏男,糸川昌成
    • Organizer
      第15階日本精神保健・予防学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-12-04
    • Related Report
      2011 Final Research Report
  • [Presentation] カルボニルストレス代謝制御の解明と統合失調症の診断・治療・予防法の創出2011

    • Author(s)
      新井誠,宮下光弘,市川智恵,豊田倫子,大西哲生,吉川武男,有波忠雄,岡崎祐士,久島周,尾崎紀夫,福本素由乙,橋本亮太,武田雅俊,小池進介,滝沢龍,笠井清登,山本博,渡邉琢夫,宮田敏男,糸川昌成
    • Organizer
      第44回精神神経系薬物治療研究報告会
    • Place of Presentation
      豊中
    • Year and Date
      2011-12-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 統合失調症の病態生理に関連するカルボニルストレス2011

    • Author(s)
      宮下光弘,新井誠,市川智恵,新井麻友美,小幡菜々子,野原泉,岡崎祐士,吉川武男,糸川昌成
    • Organizer
      第31回日本精神科診断学会
    • Place of Presentation
      長野
    • Year and Date
      2011-11-19
    • Related Report
      2011 Final Research Report
  • [Presentation] 統合失調症多発大家系における表現型の違い2011

    • Author(s)
      糸川昌成,新井誠,宮下光弘,市川智恵,小幡菜々子,野原泉,新井麻友美,長瀬輝誼
    • Organizer
      第31回日本精神科診断学会
    • Place of Presentation
      長野
    • Year and Date
      2011-11-19
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] カルボニルストレス性統合失調症の病態解明と治療法の研究2011

    • Author(s)
      糸川昌成,新井誠,宮下光弘,市川智恵,岡崎祐士,小池進介,滝沢龍,笠井清登,山本博,渡邉琢夫,段孝,宮田敏男
    • Organizer
      第21回日本メイラード学会年会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-28
    • Related Report
      2011 Final Research Report
  • [Presentation] 統合失調症のカルボニルストレス回避に向けた研究2011

    • Author(s)
      新井誠,宮下光弘,市川智恵,岡崎祐士,吉川武男,橋本亮太,尾崎紀夫,笠井清登,渡邉琢夫,山本博,宮田敏男,糸川昌成
    • Organizer
      第21回日本メイラード学会年会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-28
    • Related Report
      2011 Final Research Report
  • [Presentation] S37-1カルボニルストレスと統合失調症2011

    • Author(s)
      新井誠,宮下光弘,市川智恵,岡崎祐士,糸川昌成
    • Organizer
      第107回日本精神神経学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-27
    • Related Report
      2011 Final Research Report
  • [Presentation] 研修2日常臨床から研究テーマをどのように得るのか2011

    • Author(s)
      糸川昌成
    • Organizer
      第107回日本精神神経学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-26
    • Related Report
      2011 Final Research Report
  • [Presentation] Pyridoxamine ; a new medication for psychiatric disorders2011

    • Author(s)
      Itokawa M, Arai M, Miyashita M, Ichikawa T, Okazaki Y
    • Organizer
      The 32nd NAITO CONFERENCE ON Biological Basis of Mental Functions and Disorders Yatsugatake Royal Hotel
    • Place of Presentation
      Japan
    • Year and Date
      2011-10-19
    • Related Report
      2011 Final Research Report
  • [Presentation] 統合失調症におけるAGER遺伝子多型とesRAGE血中濃度との関連2011

    • Author(s)
      宮下光弘,新井誠,市川智恵,新井麻友美,小幡菜々子,野原泉,岡崎祐士,吉川武男,天野直二,渡邉琢夫,山本博,糸川昌成
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 統合失調症のカルボニルストレス病態回避に向けた研究2011

    • Author(s)
      新井誠,宮下光弘,市川智恵,岡崎祐士,吉川武男,橋本亮太,尾崎紀夫,笠井清登,宮田敏男,糸川昌成
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-22
    • Related Report
      2011 Final Research Report
  • [Presentation] カルボニルストレス性統合失調症の病態解明2011

    • Author(s)
      糸川昌成(Chairpersons),新井誠,宮下光弘,市川智恵,岡崎祐士,宮田敏男
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-17
    • Related Report
      2011 Final Research Report
  • [Presentation] 統合失調症患者におけるミトコンドリアDNAの遺伝子解析2011

    • Author(s)
      市川智恵,新井誠,宮下光弘,野原泉,小幡菜々子,新井麻友美,田中陽子,大島健一,新里和弘,岡崎祐士,土井永史,糸川昌成
    • Organizer
      第33回日本生物学的精神医学会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-22
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] カルボニルストレス性統合失調症のオミックス解析2011

    • Author(s)
      小幡菜々子,新井麻友美,野原泉,新井誠,市川智恵,宮下光弘,岡崎祐士,糸川昌成
    • Organizer
      第33回日本生物学的精神医学会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 統合失調症にけるAGER遺伝子多型とカルボニルストレスとの関連2011

    • Author(s)
      宮下光弘,新井誠,市川智恵,新井麻友美,小幡菜々子,野原泉,杉岡大輝,岡崎祐士,吉川武男,天野直二,渡邉琢夫,山本博,糸川昌成
    • Organizer
      第33回日本生物学的精神医学会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-22
    • Related Report
      2011 Final Research Report
  • [Presentation] カルボニルストレス性統合失調症の病態に関する研究2011

    • Author(s)
      新井誠,市川智恵,宮下光弘,新井麻友美,小幡菜々子,野原泉,岡崎祐士,吉川武男,有波忠雄,久島周,尾崎紀夫,福本素由乙,橋本亮太,小池進介,滝沢龍,笠井清登,宮田敏男,渡邉琢夫,山本博,糸川昌成
    • Organizer
      第33回日本生物学的精神医学会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-22
    • Related Report
      2011 Final Research Report
  • [Presentation] イブニングセミナー2臨床家がなぜ研究をするのか-日本人だからこそ発見できる統合失調症研究-2011

    • Author(s)
      糸川昌成
    • Organizer
      第33回日本生物学的精神医学会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-21
    • Related Report
      2011 Final Research Report
  • [Presentation] 統合失調症におけるカルボニルストレス回避機構の研究2011

    • Author(s)
      新井誠,市川智恵,宮下光弘,新麻友美,小幡菜々子,野原泉,杉岡大輝,岡崎祐士,吉川武男,有波忠雄,久島周,尾崎紀夫,福本素由乙,橋本亮太,小池進介,滝沢龍,笠井清登,宮田敏男,湯澤公子,糸川昌成
    • Organizer
      第6回日本統合失調症学会
    • Place of Presentation
      福島
    • Year and Date
      2011-03-25
    • Related Report
      2011 Final Research Report
  • [Presentation] 統合失調症におけるAGE受容体の遺伝子解析2011

    • Author(s)
      宮下光弘,新井誠,市川智恵,新井麻友美,小幡菜々子,野原泉,杉岡大輝,岡崎祐士,吉川武男,天野直二,糸川昌成
    • Organizer
      第6回日本統合失調症学会
    • Place of Presentation
      福島
    • Year and Date
      2011-03-25
    • Related Report
      2011 Final Research Report
  • [Presentation] カルボニルストレス性統合失調症の病態および治療法の解明2011

    • Author(s)
      糸川昌成
    • Organizer
      第7回統合失調症研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-02-05
    • Related Report
      2011 Final Research Report
  • [Presentation] 統合失調症の病因と病態に関する代謝カスケード分子群の研究2010

    • Author(s)
      新井誠, 市川智恵, 宮下光弘, 新井麻友美, 小幡菜々子, 野原泉, 湯澤公子, 大西哲生, 豊田倫子, 氏家寛, 有波忠雄, 久島周, 尾崎紀夫, 福本素由乙, 橋本亮太, 小池進介, 滝沢龍, 笠井清登, 橋本謙二, 山本博, 渡邉琢夫, 宮田敏男, 吉川武男, 岡崎祐士, 糸川昌成
    • Organizer
      第43回精神神経系薬物治療研究報告会
    • Place of Presentation
      豊中(大阪府)
    • Year and Date
      2010-12-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 統合失調症患者剖検脳および末梢血におけるミトコンドリアDNAの遺伝子解析2010

    • Author(s)
      市川智恵, 新井誠, 宮下光弘, 野原泉, 小幡菜々子, 新井麻友美, 田中陽子, 大島健一, 新里和弘, 岡崎祐士, 土井永史, 糸川昌成
    • Organizer
      第32回日本生物学的精神医学会
    • Place of Presentation
      北九州(福岡県)
    • Year and Date
      2010-10-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 統合失調症におけるAGE受容体の遺伝子解析2010

    • Author(s)
      宮下光弘, 新井誠, 市川智恵, 新井麻友美, 小幡菜々子, 野原泉, 杉岡大輝, 岡崎祐士, 吉川武男, 天野直二, 糸川昌成
    • Organizer
      第32回日本生物学的精神医学会
    • Place of Presentation
      北九州(福岡県)
    • Year and Date
      2010-10-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] ドパミンD3受容体遺伝子と統合失調症のリスク2010

    • Author(s)
      布川綾子, 渡部雄一郎, 金子尚史, 須貝拓朗, 矢崎沙織, 有波忠雄, 氏家寛, 稲田俊也, 岩田仲生, 功刀浩, 佐々木司, 糸川昌成, 尾崎紀夫, 橋本亮太, 染矢俊幸
    • Organizer
      第32回日本生物学的精神医学会
    • Place of Presentation
      北九州(福岡県)
    • Year and Date
      2010-10-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] ミオシン重鎖9遺伝子は統合失調症と関連しない2010

    • Author(s)
      渡部雄一郎, 天金秀樹, 金子尚史, 布川綾子, 村竹辰之, 石黒浩毅, 有波忠雄, 氏家寛, 稲田俊也, 岩田仲生, 功刀浩, 佐々木司, 橋本亮太, 糸川昌成, 尾崎紀夫, 染矢俊幸
    • Organizer
      第32回日本生物学的精神医学会
    • Place of Presentation
      北九州(福岡県)
    • Year and Date
      2010-10-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 代謝カスケード障害としての統合失調症の病態解明2010

    • Author(s)
      糸川昌成, 新井誠, 市川智恵, 宮下光弘, 渡辺琢夫, 橋本亮太, 尾崎紀夫, 氏家寛, 岩田仲生, 稲田俊也, 笠井清登, 吉川武男, 岡崎祐士, 有波忠, 山本博, 宮田敏男
    • Organizer
      第18回日本精神・行動遺伝医学会
    • Place of Presentation
      仙台(宮城県)
    • Year and Date
      2010-09-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 初回エピソード統合失調症における眼窩前頭皮質の形態研究2010

    • Author(s)
      高柳陽一郎, 高橋努, 増田尚久, 川崎康弘, 中村主計, 織壁里名, 茂末諭理子, 糸州昌成, 岡崎祐士, 鈴木道雄
    • Organizer
      第5回日本統合失調症学会
    • Place of Presentation
      福岡
    • Year and Date
      2010-03-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 臨床家だからできる統合失調症研究2010

    • Author(s)
      糸川昌成
    • Organizer
      第6回統合失調症研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-02-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 稀な遺伝子変異症例の分子基盤に基づく統合失調症の診断・治療法の開発2009

    • Author(s)
      新井誠, 湯澤公子, 小幡菜々子, 新井麻友美, 野原泉, 市川智恵, 西田淳志, 大西哲生, 豊田倫子, 曽良一郎, 氏家寛, 松下正明, 岡崎祐士, 吉川武男, 宮田敏男, 糸川昌成
    • Organizer
      第42回精神神経系薬物治療研究報告会
    • Place of Presentation
      豊中
    • Year and Date
      2009-12-04
    • Related Report
      2009 Annual Research Report
  • [Presentation]2009

    • Author(s)
      糸川昌成, ほか
    • Organizer
      第19回日本メイラード学会学術総会
    • Place of Presentation
      金沢
    • Year and Date
      2009-11-20
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Association study for neuropathological findings and schizophrenia-related genes polymorphisms2009

    • Author(s)
      Niizato K, Oshima K, Nonaka T, Togi M, Nakamura R, Arai T, Okazaki Y, Arai M, Itokawa M.
    • Organizer
      Society for Neuroscience 39th Annual Meeting
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2009-10-19
    • Related Report
      2009 Annual Research Report
  • [Presentation]2009

    • Author(s)
      Itokawa M
    • Organizer
      10th International Symposium on the Maillard Reaction
    • Place of Presentation
      Cairns, Australia
    • Year and Date
      2009-08-31
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] 変異示す認知症を伴う家族性ALS2009

    • Author(s)
      吉田眞理, 櫻井信夫, 三室マヤ, 橋詰良夫, 新井哲明, 長谷川成人, 新井誠, 糸川昌成, 秋山治彦
    • Organizer
      日本神経病理学会
    • Place of Presentation
      高松
    • Year and Date
      2009-06-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 関心領域法を用いた脳構造による初回エピソード統合失調症患者と健常者の判別2009

    • Author(s)
      高柳陽一郎, 中村主計, 川崎康弘, 高橋努, 織壁里名, 豊田英真, 茂末諭理子, 糸川昌成, 佐藤洋子, 山末英典, 笠井清登, 倉知正佳, 岡崎祐士, 鈴木道雄
    • Organizer
      第31回日本生物学的精神医学会
    • Place of Presentation
      京都
    • Year and Date
      2009-04-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 二段階サンプルによる関節リウマチ感受性遺伝子と統合失調症との関連研究2009

    • Author(s)
      金子尚史, 渡部雄一郎, 布川綾子, 村竹辰之, 有波忠雄, 氏家寛, 稲田俊也, 岩田仲生, 功刀浩, 糸川昌成, 音羽健司, 尾崎紀夫, 染矢俊幸
    • Organizer
      第31回日本生物学的精神医学会
    • Place of Presentation
      京都
    • Year and Date
      2009-04-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Genetic study on schizophrenia started from a rare case2009

    • Author(s)
      Itokawa M.
    • Organizer
      The 1st Asian Workshop on Schizophrenia Research
    • Place of Presentation
      吹田
    • Year and Date
      2009-01-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] 染色体均衡転座を持つ男性統合失調症から同定されたDISC-Mの resequence 解析2009

    • Author(s)
      前田直彦, 羽賀誠一, 小幡菜々子, 野原泉, 田中陽子, 新井麻友美, 新井誠, 高橋哲夫, 糸川昌成
    • Organizer
      第4回日本統合失調症学会
    • Place of Presentation
      吹田
    • Year and Date
      2009-01-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] 関心領域法を用いた脳MRI画像による、初回エピソード統合失調症患者と健常者の判別分析2009

    • Author(s)
      高柳陽一郎, 中村主計, 高橋努, 川崎康弘, 織壁里名, 豊田英真, 糸川昌成, 山末英典, 笠井清登, 岡崎祐士, 松下正明, 鈴木道雄, 倉知正佳
    • Organizer
      第4回日本統合失調症学会
    • Place of Presentation
      吹田
    • Year and Date
      2009-01-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] 遺伝子変異症例からの統合失調症感受性遺伝子の同定2008

    • Author(s)
      新井誠, 野原泉, 小幡菜々子, 湯澤公子, 羽賀誠一, 大西哲生, 豊田倫子, 曽良一郎, 氏家寛, 松下正明, 岡崎祐士, 吉川武男, 宮田敏男, 糸川昌成
    • Organizer
      第81回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] 染色体異常をともなった統合失調症を利用した病態解明の研究2008

    • Author(s)
      羽賀誠一, 糸川昌成, 新井誠, 数藤由美子, 前田直彦, 小幡菜々子, 野原泉, 新井麻友美, 田中陽子, 大西哲生, 松下正明, 岡崎祐士, 吉川武男
    • Organizer
      第41回精神神経系薬物治療研究報告会
    • Place of Presentation
      豊中
    • Year and Date
      2008-12-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] 稀な遺伝子変異をもつ症例を出発点とした統合失調症感受性遺伝子の同定2008

    • Author(s)
      新井誠, 野原泉, 小幡菜々子, 湯澤公子, 羽賀誠一, 大西哲生, 豊田倫子, 曽良一郎, 氏家寛, 松下正明, 岡崎祐士, 吉川武男, 宮田敏男, 系川昌成
    • Organizer
      第41回精神神経系薬物治療研究報告会
    • Place of Presentation
      豊中
    • Year and Date
      2008-12-05
    • Related Report
      2008 Annual Research Report
  • [Presentation]2008

    • Author(s)
      Arai M, et al.
    • Organizer
      Society for Neuroscience 38th Annual Meeting
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2008-11-18
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] A search for schizophrenia associated genes regulated by epigenetical gene expression2008

    • Author(s)
      Koga M, Ishiguro H, Yuzaki S, Arai M, Inada T, Itokawam, Arinami T.
    • Organizer
      Society for Neuroscience 38th Annual Meeting
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2008-11-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] 網膜色素変性症と統合失調症を合併した兄弟の弟例2008

    • Author(s)
      河上緒, 梅津寛, 大澤達哉, 石川陽一, 小椋哲, 糸川昌成, 岡崎祐士
    • Organizer
      東京精神医学会第84回学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] A gene disrupted by a chromosomal translocation in 4p 15. 2 was associated with schizophrenia2008

    • Author(s)
      Itokawam, Arai M, Suto Y, Haga S, Obata N, Nohara I, Arai M, Maeda N, Tanaka Y, Yamada K, Toyota T, Matsushita M, Okazaki Y, Yoshikawa T.
    • Organizer
      XVIth World Congress on Psychiatric Genetics
    • Place of Presentation
      Osaka
    • Year and Date
      2008-10-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] Testing genetic models and candidate genes for schizophrenia from an evolutionary viewpoint2008

    • Author(s)
      Doi N, Hoshi Y, Itokawam, Usui C, Yoshikawa T.
    • Organizer
      XVIth World Congress on Psychiatric Genetics
    • Place of Presentation
      Osaka
    • Year and Date
      2008-10-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] A search for Schizophrenia associated genes regulated by epigenetical gene expression2008

    • Author(s)
      Koga M, Ishiguro H, Yazaki S, Arai M, Inada T, Itokawam, Arinami T.
    • Organizer
      XVIth World Congress on Psychiatric Genetics
    • Place of Presentation
      Osaka
    • Year and Date
      2008-10-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] 稀な遺伝子変異をもつ症例からの統合失調症感受性遺伝子の同定2008

    • Author(s)
      新井誠, 野原泉, 小幡菜々子, 湯沢公子, 羽賀誠一, 大西哲生, 豊田倫子, 曽良一郎, 氏家寛, 松下正明, 岡崎祐士, 吉川武男, 宮田敏男, 糸川昌成
    • Organizer
      第30回日本生物学的精神医学会
    • Place of Presentation
      富山
    • Year and Date
      2008-09-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] 統合失調症の de novo 均衡転座を伴う1症例から見出したDISC-Mの binding partners の単離2008

    • Author(s)
      羽賀誠一, 前田直彦, 新井誠, 小幡菜々子, 野原泉, 田中陽子, 系川昌成
    • Organizer
      第30回日本生物学的精神医学会
    • Place of Presentation
      富山
    • Year and Date
      2008-09-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 覚醒剤精神病患者における統合失調症と共通または特異的な脳形態異常部位の同定2008

    • Author(s)
      豊田英真, 山末英典, 織壁里名, 石井竜二, 井上秀之, 高柳陽一郎, 糸川昌成, 鈴木道雄, 倉知正佳, 岡崎祐士, 笠井清登
    • Organizer
      第30回日本生物学的精神医学会
    • Place of Presentation
      富山
    • Year and Date
      2008-09-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] 大きな遺伝子効果を利用した統合失調症の病因研究2008

    • Author(s)
      糸川昌成
    • Organizer
      平成20年度特定領域研究「統合脳」夏のワークショップ,合同班会議,統合シンポジウム
    • Place of Presentation
      札幌
    • Year and Date
      2008-08-09
    • Related Report
      2008 Annual Research Report
  • [Book] 脳と心の分子メカニズム:発見の瞬間はどのようにして訪れるのか.こころの働きと病・覚醒剤2010

    • Author(s)
      糸川昌成
    • Related Report
      2011 Final Research Report
  • [Book] こころの働きと病・覚醒剤(NPO法人脳の世紀推進会議編)(脳と心の分子メカニズム:発見の瞬間はどのようにして訪れるのか)2010

    • Author(s)
      糸川昌成
    • Publisher
      クバプロ
    • Related Report
      2010 Self-evaluation Report
  • [Book] グルタミン酸関連遺伝子と統合失調症(In:専門医のための精神科臨床リュミエール16, 脳科学エッセンシャル(神庭重信)(加藤忠史責任編集)2010

    • Author(s)
      糸川昌成, 市川智恵, 新井誠
    • Publisher
      東京中山書店
    • Related Report
      2010 Annual Research Report
  • [Book] 臨床で発見する統合失調症研究.松沢臨床精神医学セミナー2008

    • Author(s)
      糸川昌成
    • Publisher
      日本評論社
    • Related Report
      2011 Final Research Report
  • [Book] 統合失調症の遺伝子異常(In:キーワード279で読み解く精神医学)(松下正明総編集)

    • Author(s)
      新井誠, 糸川昌成
    • Publisher
      東京中山書店
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.igakuken.or.jp/schizo-dep/

    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 精神疾患の診断方法2009

    • Inventor(s)
      糸川昌成, 東原和成, 白須未香
    • Industrial Property Rights Holder
      糸川昌成, 東原和成, 白須未香
    • Industrial Property Number
      2009-256133
    • Filing Date
      2009-11-09
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 遺伝子変異を用いた筋萎縮性側索硬化症の予測法2008

    • Inventor(s)
      糸川昌成,新井誠,長谷川成人,野中隆,秋山治彦,新井哲明
    • Industrial Property Rights Holder
      糸川昌成,新井誠,長谷川成人,野中隆,秋山治彦,新井哲明
    • Filing Date
      2008-04-01
    • Related Report
      2011 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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