| Co-Investigator(Kenkyū-buntansha) |
ISHIDA Yasushi 宮崎大学, 医学部, 教授 (20212897)
MAGATA Yasuhiro 浜松医科大学, メディカルフォトニクス研究センター, 教授 (20209399)
OKAZAWA Hidehiko 福井大学, 高エネルギー医学研究センター, 教授 (50360813)
TENMA Takashi 京都大学, 薬学研究科, 助教 (90378787)
YOSHIMOTO Mitsuyoshi 国立がん研究センター研究所, 発がんシステム研究分野, 主任研究員 (00345638)
KOBAYASHI Masato 金沢大学, 保健学系, 助教 (30444235)
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| Budget Amount *help |
¥33,150,000 (Direct Cost: ¥25,500,000、Indirect Cost: ¥7,650,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
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| Research Abstract |
As a result of analyzing by PET tracers relevant to function analysis of cerebral dopaminergic neuron using the transplant group which was transplanted the rat intrastriatal grafts of fetal ventral mesencephalon of a Parkinson's disease model rat aiming at the diagnostic application to the regeneration effect of medicine, the individual specificity in a transplant group was large, but the significant correlation was acquired between the functional recovery by the degree of methamphetamine-induced rotation test and immunity dyeing analysis. Furthermore, functional change of cerebral dopaminergic neuron in a psychiatry drug administration model rat was also evaluated, the gene expression level of the functional molecule relevant to the nervous function in the pathological part after a transplant or drug administration was analyzed comprehensively, and comparison examination was carried out with functional change of cerebral dopaminergic neuron.
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