|Budget Amount *help
¥48,100,000 (Direct Cost: ¥37,000,000、Indirect Cost: ¥11,100,000)
Fiscal Year 2011: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2010: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2009: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2008: ¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
By applying variety of experimental stroke models for the basic research, we have exerted the comprehensive analysis of neuronal regeneration, inflammation and ischemic tolerance after ischemic insult. For the possibility of axonal regeneration treated by the cell transplantion, the small number of the transplanted cells remain in the lesion, appearing just homing, neither proliferation nor rewiring. In terms of the immunoreactions to ischemic insult of the brain, Cyclophilin C-associated protein(CyCAP), via stimulating calcineurin phosphatase activity, plays a pivotal role for activation of macrophage. The phenomenon of ischemic tolerance may link hypoxic preconditioning with vascular remodeling.