Elucidation and regulation of the mechanism underlying female reproductive tract diseases by targeting adult stem cells
| Project/Area Number |
20249067
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MARUYAMA Tetsuo 慶應義塾大学, 医学部, 講師 (10209702)
UCHIDA Hiroshi 慶應義塾大学, 医学部, 助教 (90286534)
梶谷 宇 慶應義塾大学, 医学部, 助教 (60407111)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥50,180,000 (Direct Cost: ¥38,600,000、Indirect Cost: ¥11,580,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2008: ¥37,050,000 (Direct Cost: ¥28,500,000、Indirect Cost: ¥8,550,000)
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| Keywords | 再生医学 / 移植・再生医療 / 応用動物 / 細胞・組織 / マイクロアレイ / 幹細胞 |
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| Research Abstract |
The aim of this research project was to elucidate the mechanism underlying the female reproductive tract diseases and to develop novel therapeutic strategies by targeting adult stem cells. We have developed a novel method to isolate and characterize human myometrial stem cells and demonstrated their involvement in the pregnancy-induced uterine remodeling. We also have isolated and characterized human endometrial stem cells thereby proposing stem cell theory not only for the mechanism underlying physiological endometrial regeneration but also for the pathogenesis of endometriosis.
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Report
(4 results)
Research Products
(67 results)
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[Journal Article] Stem Cell-Like Properties of the Endometrial Side Population : Implication in Endometrial Regeneration.2010
Author(s)
Masuda H, Matsuzaki Y, Hiratsu E, Ono M, Nagashima T, Kajitani T, Arase T, Oda H, Uchida H, Asada H, Ito M, Yoshimura Y, Maruyama T, Okano H
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Xenografted human amniotic membrane-derived mesenchymal stem cells are immunologically tolerated and transdifferentiated into cardiomyocytes.2010
Author(s)
Tsuji H, Miyoshi S, Ikegami Y, Hida N, Asada H, Togashi I, Suzuki J, Satake M, Nakamizo H, Tanaka M, Mori T, Segawa K, Nishiyama N, Inoue J, Makino H, Miyado K, Ozawa S, Yoshimura Y, Umezawa A
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Journal Title
Circ Res. 106
Pages: 1613-1623
Related Report
Peer Reviewed
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[Journal Article] Stem cell-like properties of the endometrial side population : implication in endometrial regeneration2010
Author(s)
Masuda H, Matsuzaki Y, Hiratsu E, Ono M, Nagashima T, Kajitani T, Arase T, Oda H, Uchida H, Asada H, Ito M, Yoshimura Y, Maruyama T, Okano H
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] The UDP-glucose recepter P2RY14 triggers innate mucosal immunity in the female reproductive tract by inducing IL-8.2009
Author(s)
Arase T, Uchida H, Kajitani T, Ono M, TamakiK, Oda H, Nishikawa S, Kagami M, Nagashima T, Masuda H, Asada H, Yoshimura Y, Maruyama T
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Journal Title
J Immunol.(平成21年度日本産科婦人科学会優秀論文賞) 182(11)
Pages: 7074-7084
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Peer Reviewed
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[Journal Article] The UDP-glucose recepter P2RY14 triggers innate mucosal immunity in the female reproductive tract by inducing IL-82009
Author(s)
Arase T, Uchida H, Kajitani T, Ono M, Tamaki K, Oda H, Nishikawa S, Kagami M, Nagashima T, Masuda H, Asada H, Yoshimura Y, Maruyama T
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Journal Title
J Immunol. 182
Pages: 7074-7084
Related Report
Peer Reviewed
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[Journal Article] The UDP-glucose receptor P2RY14 triggers innate mucosalimmunity in the female reproductive tract by inducing IL-8.2009
Author(s)
Arase T, Uchida H, Kajitani T, Ono M, Tamaki K, Oda H, Nishikawa S, Kagami M, Nagashima T, Masuda H, Asada H, Yoshimura Y, Maruyama T
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Journal Title
The Journal of Immunology (In press)
Related Report
Peer Reviewed
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[Journal Article] Activation of SRC kinase and phosphorylation of STAT5 are required for decidual transformation of human endometrial stromal cells.2008
Author(s)
Nagashima T, Maruyama T, Uchida H, Kajitani T, Arase T, Ono M, Oda H, Kagami M, Masuda H, Nishikawa S, Asada H, Yoshimura Y
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Journal Title
Endocrinology.(平成22年度日本生殖学会学術奨励賞) 149(3)
Pages: 1227-1234
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Peer Reviewed
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[Journal Article] Activation of SRC kinase and phosphorylation of STAT5 are required for decidual transformation of human endometrial stromal cells.2008
Author(s)
Nagashima T, Maruyama T, Uchida H, Kajitani T, Arase T, Ono M, Oda H, Kagami M, Masuda H, Nishikawa S, Arase H, Yoshimura Y
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Journal Title
Endocrinology 149
Pages: 1227-1234
Related Report
Peer Reviewed
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[Presentation] Possible involvement of endometrial stem/progenitor cells in the pathogenesis of endocetriosis.2010
Author(s)
Tetsuo Maruyama, Hirotaka Masuda, Takashi Nagashima, Takashi Kajitani, Masanori Ono, Sayaka Nishikawa-Uchida Hideyuki Oda, Kaoru Miyazaki, Toru Arase, Maki Kagami, Hiroshi Uchida Hironori Asada, Yasunori Yoshimura
Organizer
The First Asian Conference on Endometriosis(ACE).
Place of Presentation
Shanghai, China(招請講演)
Related Report
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[Presentation] The role of uterine smooth muscle stem cells, isolated based on cell surface markers, in myometrial remodeling in the pregnantuterus.2009
Author(s)
Ono M, Maruyama T, Kajitani T, Uchida H, Oda H, Nishikawa S, Kagami M, Arase T, Nagashima T, Masuda H, Morikawa S, Mabuchi Y, Okano H, Matsuzaki Y, Yoshimura Y
Organizer
Society for Gynecologic Investigation 56^<th> Annual Meeting
Place of Presentation
Glasgow, Scotland
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