| Project/Area Number |
20249073
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
NAKAYAMA Koji Nagasaki University, 大学院医・歯薬学総合研究科, 教授 (80150473)
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| Co-Investigator(Renkei-kenkyūsha) |
NAITO Mariko 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (20244072)
SHOJI Mikio 長崎大学, 大学院・医歯薬学総合研究科, 助教 (10336175)
SATO Keiko 長崎大学, 大学院・医歯薬学総合研究科, 助教 (70410579)
YUKITAKE Hideharu 長崎大学, 大学院・医歯薬学総合研究科, 技術職員 (30380984)
HIRAKAWA Hideki かずさDNA研究所, 植物ゲノム情報研究室, 研究員 (80372746)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥48,490,000 (Direct Cost: ¥37,300,000、Indirect Cost: ¥11,190,000)
Fiscal Year 2010: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Fiscal Year 2009: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2008: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
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| Keywords | 歯周病 / Porphyromonas gingivalis / gingipain / タンパク分泌機構 / Flavobacterium johnsoniae / 滑走運動 |
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| Research Abstract |
Porphyromonas gingivalis secretes strong proteases called gingipains that are implicated in periodontal pathogenesis. Comparative genome analysis and genetic experiments revealed proteins involved in gingipain secretion. These proteins were similar in sequence to Flavobacterium johnsoniae gliding motility proteins. Disruption of the F. johnsoniae porT ortholog resulted in defects in motility and chitinase secretion, providing a link between a unique protein translocation system and a motility apparatus in members of the Bacteroidetes phylum.
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