| Budget Amount *help |
¥48,490,000 (Direct Cost: ¥37,300,000、Indirect Cost: ¥11,190,000)
Fiscal Year 2010: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Fiscal Year 2009: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2008: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
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| Research Abstract |
Migrating dendritic cells (DC) from oral mucosa into regional lymph nodes were divided into four subsets similar to cutaneous migrating DCs. CD207-CD11c^<hi> F1-DCs that migrated quickly, expressed the highest levels of co-signal molecules, whereas CD207+CD11c^<int/lo> F3-DCs that migrated at the later time point were further divided into both CD103+CD207+ submucosal DCs and CD103- Langerhans cells (LCs) and the latter expressed the lowest co-signal molecules, suggest tolerogenic properties. We demonstrated that using mouse skin allergic models, silencing of CD86 co-signal molecule in skin DCs by RNA interference efficiently inhibited both early innate immune responses at the local site and adaptive immune responses in the secondary lymphoid tissues.
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