Development of the basic technology for tooth regenerative therapy system
| Project/Area Number |
20249078
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (A)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Dental engineering/Regenerative dentistry
|
|---|
| Research Institution | Tokyo University of Science |
|---|
Principal Investigator |
TSUJI Takashi Tokyo University of Science, 総合研究機構, 助教 (50339131)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KUBOLKI Takuo 岡山大, 院・医歯薬学, 教授 (00225195)
KASUGAI Shohei 東京医歯大, 院・医歯薬学, 教授 (70161049)
TOMOOKA Yasuhiro 東京理科大, 基礎工学部, 教授 (10197949)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
YAMAMOTO Teruko 東北大, 院・歯学, 教授 (00127250)
SONOYAMA Wataru 岡山大, 医・歯学部附属病院, 助教 (40325121)
SAITO Masahiro 東京理科大, 基礎工学部, 准教授 (40215562)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥48,620,000 (Direct Cost: ¥37,400,000、Indirect Cost: ¥11,220,000)
Fiscal Year 2010: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2009: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2008: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
|
|---|
| Keywords | 再生 / 歯 / 再生医療 / 幹細胞 / 歯胚 |
|---|
| Research Abstract |
In current research on whole-tooth regenerative therapy, a basic strategy is being pursued in which a bioengineered tooth germ is induced to develop into a fully functional tooth. We developed a three-dimensional organ-germ culture method for the reconstitution a bioengineered organ germ. We successfully demonstrated that our bioengineered tooth germ could develop a fully functioning tooth, which has hardness for masticatory potential, the functional responsibility against a mechanical stress, and perceptive potentials of neural fibers. Furthermore, we demonstrated a further development in this regard in which a bioengineered tooth unit comprising mature tooth, periodontal ligament and alveolar bone, was successfully transplanted into a properly-sized bony hole in the alveolar bone through bone integration by recipient bone remodeling in a murine transplantation model system. These results showed that the bioengineered tooth germ and mature tooth unit could regenerate a fully functioning tooth and an organ replacement regenerative therapy might be feasible.
|
Report
(4 results)
Research Products
(254 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Simvastatin induces the odontogenic differentiation of human dental pulp stem cells in vitro and in vivo2009
Author(s)
Okamoto Y, Sonoyama W, Ono M, Akiyama K, Fujisawa T, Oshima M, Tsuchimoto Y, Matsuka Y, Yasuda T, Shi S, Kuboki T.
-
Journal Title
Journal of Endodontics 35
Pages: 367-372
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Early bone regeneration by novel nanogel cross linking membrane.2010
Author(s)
Miyahara T, Nyan M, Shimoda A, Hao J, Rodoriguez R, Kobayashi H, Kuroda S, Shiota M, Akiyoshi K, Kasugai K.
Organizer
19^<th> annual Scientific Meeting of European Association for Osseointegration
Place of Presentation
Glasgow Convention Center, Glasgow, UK
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Novel GBR membrane consisting of cholesterol-bearing pullulan nanogel.2010
Author(s)
Miyahara T, Nyan M, Nagayama T, Hao J, Rodoriguez R, Yamamoto Y, Shimoda A, Kuroda S, Tachikawa N, Shiota M, Akiyoshi K, Kasugai S.
Organizer
The 25^<th> Annual Meeting of Academy of Osseointegration
Place of Presentation
アメリカ、オーランド
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 再生歯の顎連携機能と侵害刺激応答能の解析2009
Author(s)
森田梨津子, 池田悦子, 中尾一久, 石田研太郎, 仲村 崇, 小川美穂, 室伏真由美, 水野光政, 山本照子, 辻 孝
Organizer
第31回日本再生医療学会総会
Place of Presentation
東京国際フォーラム
Year and Date
2009-03-05
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
