| Project/Area Number |
20249078
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
TSUJI Takashi Tokyo University of Science, 総合研究機構, 助教 (50339131)
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| Co-Investigator(Kenkyū-buntansha) |
KUBOLKI Takuo 岡山大, 院・医歯薬学, 教授 (00225195)
KASUGAI Shohei 東京医歯大, 院・医歯薬学, 教授 (70161049)
TOMOOKA Yasuhiro 東京理科大, 基礎工学部, 教授 (10197949)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAMOTO Teruko 東北大, 院・歯学, 教授 (00127250)
SONOYAMA Wataru 岡山大, 医・歯学部附属病院, 助教 (40325121)
SAITO Masahiro 東京理科大, 基礎工学部, 准教授 (40215562)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥48,620,000 (Direct Cost: ¥37,400,000、Indirect Cost: ¥11,220,000)
Fiscal Year 2010: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2009: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2008: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
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| Keywords | 再生 / 歯 / 再生医療 / 幹細胞 / 歯胚 |
|---|
| Research Abstract |
In current research on whole-tooth regenerative therapy, a basic strategy is being pursued in which a bioengineered tooth germ is induced to develop into a fully functional tooth. We developed a three-dimensional organ-germ culture method for the reconstitution a bioengineered organ germ. We successfully demonstrated that our bioengineered tooth germ could develop a fully functioning tooth, which has hardness for masticatory potential, the functional responsibility against a mechanical stress, and perceptive potentials of neural fibers. Furthermore, we demonstrated a further development in this regard in which a bioengineered tooth unit comprising mature tooth, periodontal ligament and alveolar bone, was successfully transplanted into a properly-sized bony hole in the alveolar bone through bone integration by recipient bone remodeling in a murine transplantation model system. These results showed that the bioengineered tooth germ and mature tooth unit could regenerate a fully functioning tooth and an organ replacement regenerative therapy might be feasible.
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