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Space-time statistical models for detecting emerging outbreaks of rare events.

Research Project

Project/Area Number 20300101
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Statistical science
Research InstitutionNational Institute of Public Health

Principal Investigator

TANGO Toshiro  National Institute of Public Health, 生活機構研究科, 客員教授 (70124477)

Co-Investigator(Renkei-kenkyūsha) TAKAHASHI Kunihiko  国立保健医療科学院, 技術評価部, 主任研究官 (50323259)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
Fiscal Year 2010: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2008: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Keywords空間・環境統計 / 症侯サーベイランス / 空間疫学 / 疾病集積性 / 尤度比検定 / ボアッソン分布 / ポアッソン分布
Research Abstract

We have developed new statistical models as important tools for detecting emerging outbreaks of rare events threatening human health. The existing methods cannot detect irregularly shaped outbreak areas timely and appropriately. First, we developed a new restricted likelihood ratio to avoid the property of existing scan statistics that tend to detect the cluster much larger than the true cluster by swallowing neighboring regions with non-elevated risk. Second, we developed a new space-time scan statistic which compares the observed number of cases with the unconditional expected number of cases, takes a time-to-time variation of Poisson mean into account and implements an outbreak model to capture localized emerging disease outbreaks more timely and correctly. The proposed models are illustrated with data from weekly surveillance of the number of absentees in primary schools in Kita-Kyushu, Japan, 2006.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (19 results)

All 2011 2010 2009 2008 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (6 results) Book (3 results) Remarks (1 results)

  • [Journal Article] A space-time scan statistic for detecting emerging outbreaks.2011

    • Author(s)
      Tango T, Takahashi K, Kohriyama K.
    • Journal Title

      Statistics in Medicine 67

      Pages: 106-115

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A space-time scan statistic for detecting emerging outbreaks.2011

    • Author(s)
      Tango T, Takahashi K, Kohriyama K.
    • Journal Title

      Biometrics

      Volume: 67 Pages: 106-115

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Assignment of grouped exposure levels for trend estimation in a regression analysis of summarized data2010

    • Author(s)
      Takahashi K., Tango T.
    • Journal Title

      Statistics in Medicine 29

      Pages: 2605-2616

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Temporal trends and geographic clusters of mortality from amyotrophic lateral sclerosis in Japan, 1995-2004.2010

    • Author(s)
      Doi Y, Yokoyama T, Tango T, Takahashi K, Fujimoto K, Nakano I
    • Journal Title

      Journal of the Neurological Sciences 298

      Pages: 78-84

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Assignment of grouped exposure levels for trend estimation in a regression analysis of summarized data2010

    • Author(s)
      Takahashi K., Tango T
    • Journal Title

      Statistics in Medicine

      Volume: 29 Pages: 2605-2616

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Temporal trends and geographic clusters of mortality from amyotrophic lateral sclerosis in Japan, 1995-20042010

    • Author(s)
      Doi Y, Yokoyama T, Tango T, Takahashi K, Fujimoto K, Nakano I.
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 298 Pages: 78-84

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A spatial scan statistic with a restricted likelihood ratio.2008

    • Author(s)
      Tango T.
    • Journal Title

      Japanese Journal of Biometrics 29

      Pages: 75-95

    • NAID

      10025157933

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A spatial scan statistic with a restricted likelihood ratio2008

    • Author(s)
      Tango T
    • Journal Title

      Japanese Journal of Biometrics 29

      Pages: 75-95

    • NAID

      10025157933

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A flexibly shaped space-time scan statistic for disease outbreak detection and monitoring2008

    • Author(s)
      Takahashi K, Kulldorff M, Tango T, Yih K
    • Journal Title

      International Journal of Health Geographics 7

      Pages: 14-14

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Geographical clustering of caries prevalence on 3-year-old children in Hokkaido2010

    • Author(s)
      Aida J, Takahashi K, Yamaoka K, Tango T
    • Organizer
      国際疫学会西太平洋地域学術会議、第20回日本疫学会学術総会
    • Place of Presentation
      埼玉県立大学
    • Year and Date
      2010-01-10
    • Related Report
      2010 Final Research Report
  • [Presentation] Geographical clustering of caries prevalence on 3-year-old children in Hokkaido2010

    • Author(s)
      Aida J, Takahashi K, Yamaoka K, Tango T
    • Organizer
      第20回日本疫学会学術総会
    • Place of Presentation
      埼玉県立大学
    • Year and Date
      2010-01-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Space-Time Scan Statistics for Outbreak Detection.2009

    • Author(s)
      Tango T.
    • Organizer
      Invited Paper of The 57th Session of the International Statistics Institute, at International Convention Center
    • Place of Presentation
      Durban, South Africa.
    • Year and Date
      2009-08-18
    • Related Report
      2010 Final Research Report
  • [Presentation] Space-Time Scan Statistics for Outbreak Detection2009

    • Author(s)
      Tango T.
    • Organizer
      The 57th Session of the International Statistics Institute
    • Place of Presentation
      Durban, South Africa
    • Year and Date
      2009-08-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] A spatial scan statistic with a modified likelihood ratio.2008

    • Author(s)
      Tango T.
    • Organizer
      The 25th International Biometric Conference, at University College Dublin
    • Place of Presentation
      Dublin, Ireland.
    • Related Report
      2010 Final Research Report
  • [Presentation] A spatial scan statistic with a modified likelihood ratio2008

    • Author(s)
      Tango T.
    • Organizer
      XXIVth International Biometric Conference
    • Place of Presentation
      Dublin, Ireland
    • Related Report
      2008 Annual Research Report
  • [Book] Statistical Methods for Disease Clustering2010

    • Author(s)
      丹後俊郎
    • Total Pages
      240
    • Publisher
      Springer
    • Related Report
      2010 Final Research Report
  • [Book] 医学統計学の事典(小西貞則 編)2010

    • Author(s)
      丹後俊郎
    • Total Pages
      472
    • Publisher
      朝倉書店
    • Related Report
      2010 Final Research Report
  • [Book] Statistical Methods for Disease Clustering2010

    • Author(s)
      Toshiro Tango
    • Total Pages
      240
    • Publisher
      Springer
    • Related Report
      2009 Annual Research Report
  • [Remarks] Takahashi K, Yokoyama T, Tango T. FleXScan ver.3.1: Software for the Flexible Spatial Scan Statistic, National Institute of Public Health, Japan, 2010.

    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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