The Mechanism Underlying the Formation of Activity-Dependent Thalamocortical Projection
Project/Area Number |
20300110
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neuroscience in general
|
Research Institution | Osaka University |
Principal Investigator |
YAMAMOTO Nobuhiko Osaka University, 大学院・生命機能研究科, 教授 (00191429)
|
Co-Investigator(Kenkyū-buntansha) |
SUGO Noriyuki 大阪大学, 大学院・生命機能研究科, 助教 (20372625)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2009: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2008: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
|
Keywords | 軸索分岐 / 軸索誘導 / 神経活動 / 層特異性 / 視床 / 大脳 / HDAC9 / 遺伝子発現調節 / c-fos / 樹状突起 / 核細胞質移動 / 軸索 / 同期性 / Kir2.1 / 軸索分枝 / RhoA / 神経回路 |
Research Abstract |
Neural activity is well known to play an important role in neural circuit formation. However, the mechanism is largely unknown. We studied the role of neural activity in axonal branch formation, focusing on the thalamocortical projection in the mammalian brain. The result shows that both activities of growing thalamic axons (presynaptic) and their target cortical neurons (postsynaptic) promote axon branching. Evidence also suggests the underlying molecular mechanisms.
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Report
(4 results)
Research Products
(30 results)