• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Function of Fields in the Auditory Cortex

Research Project

Project/Area Number 20300112
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionKumamoto University

Principal Investigator

SONG Wen-Jie  Kumamoto University, 大学院・生命科学研究部, 教授 (90216573)

Co-Investigator(Kenkyū-buntansha) KAZUYA Saitoh  熊本大学, 教育学部, 准教授 (20301997)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Keywords神経科学 / 生理学 / 脳・神経
Research Abstract

We have carried out optical imaging studies, behavioral studies, as well as electrophysiological studies to probe the function of auditory fields in guinea pigs. We found 1) focal activation of the primary auditory field at a single site can evoke an eyelid response conditioned with a pure tone, 2) there are spontaneous activity events in the primary field and some events exhibited a spatiotemporal pattern highly similar to the tone-evoked activity, and 3) frequency discrimination by the population activity of the primary fields outperforms behavioral frequency discrimination results. These results not only suggest a role of the primary auditory cortex in tone perception and frequency discrimination, but also have an impact on auditory prosthesis by cortical stimulation.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (36 results)

All 2011 2010 2009 2008 Other

All Journal Article (10 results) (of which Peer Reviewed: 9 results) Presentation (22 results) Book (2 results) Remarks (2 results)

  • [Journal Article] Voltage-gated K+ channel KCNQ1 regulates insulin secretion in MIN6 beta-cell line.2011

    • Author(s)
      Kazuya Yamagata, Takafumi Senoguchi, Meihong Lu, Makoto Takemoto, Fazlul Karim, Chisa Go, Yoshifumi Sato, Mitsutoki Hatta, Tatsuya Yoshizawa, Eiichi Araki, Junichi Miyazaki, Wen-Jie Song
    • Journal Title

      Biochem Biophys Res Comm. 407

      Pages: 620-625

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial dysfunction and increased reactive oxygen species impair insulin secretion in sphingomyelin synthase 1 null mice.2011

    • Author(s)
      Yano M, Watanabe K, Yamamoto T, Ikeda K, Senokuchi T, Lu M, Kadomatsu T, Tsukano H, Ikawa M, Okabe M, Yamaoka S, Okazaki T, Umehara H, Gotoh T, Song WJ, Node K, Taguchi R, Yamagata K, Oike Y.
    • Journal Title

      J Biol Chem 286(5)

      Pages: 3992-4002

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial dysfunction and increased reactive oxygen species impair insulin secretion in sphingomyelin synthase 1 null mice.2011

    • Author(s)
      Yano M, et al.
    • Journal Title

      J Biol Chem

      Volume: 286 Pages: 3992-4002

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spontaneous activity resembling tone-evoked activity in the primary auditory cortex of guinea pigs.2010

    • Author(s)
      Kazuya Saitoh, Shinji Inagaki, Masataka Nishimura, Hideo Kawaguchi, Wen-Jie Song.
    • Journal Title

      Neurosci Res. 68

      Pages: 107-113

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nucleocytoplasmic translocation of HDAC9 regulates gene expression and dendritic growth in developing cortical neurons.2010

    • Author(s)
      Noriyuki Sugo, Hiroaki Oshiro, Mitsuhiro Takemura, Toshiaki Kobayashi, Yusuke Kohno, Naofumi Uesaka, Wen-Jie Song, Nobuhiko Yamamoto.
    • Journal Title

      Eur J Neurosci 31

      Pages: 1521-1532

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nucleocytoplasmic translocation of HDAC9 regulates gene expression and dendritic growth in developing cortical neurons.2010

    • Author(s)
      Sugo N, et al.
    • Journal Title

      Eur.J.Neurosci.

      Volume: 31 Pages: 1521-1532

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spontaneous activity resembling tone-evoked activity in the primary auditory cortex of guinea pigs2010

    • Author(s)
      Saitoh K, Inagaki S, Nishimura M, Kawaguchi H, Song W-J
    • Journal Title

      Neurosci Res.

      Volume: 68 Pages: 107-113

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nucleocytoplasmic translocation of HDAC9 regulates gene expression and dendritic growth in developing cortical neurons2010

    • Author(s)
      Noriyuki Sugo
    • Journal Title

      Eur J Neurosci (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 聴覚野の区分とトノトピー

    • Author(s)
      宋文杰
    • Journal Title

      Clinical Neuroscience in press

    • Related Report
      2010 Final Research Report
  • [Journal Article] A train of electrical pulses applied to the primary auditory cortex evokes a conditioned response in guinea pigs.

    • Author(s)
      Okuda Y, Shikata S, Song WJ
    • Journal Title

      Neurosci Res. (in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] Area map of auditory and somatosensory cortex in mice.2010

    • Author(s)
      澤渡浩之、田中良秀、西村方孝、宋文杰
    • Organizer
      第15回聴覚研究フォーラム、P22
    • Place of Presentation
      同志社大学琵琶湖リトリートセンター
    • Year and Date
      2010-12-04
    • Related Report
      2010 Final Research Report
  • [Presentation] マウス大脳皮質聴覚野と体性感覚野のマッピング-in vivoイメージングによる 研究一2010

    • Author(s)
      澤渡浩之、田中良秀、西村方孝、宋文杰
    • Organizer
      日本音響学会聴覚研究会、40(9):773-776
    • Place of Presentation
      豊橋技術科学大学
    • Year and Date
      2010-11-26
    • Related Report
      2010 Final Research Report
  • [Presentation] 光学計測における除算信号推定での雑音低減のための定式化2010

    • Author(s)
      西村方孝、宋文杰
    • Organizer
      第33回日本神経科学大会、P3-r17
    • Place of Presentation
      神戸コンベンションセンター
    • Year and Date
      2010-09-04
    • Related Report
      2010 Final Research Report
  • [Presentation] マウス大脳皮質聴覚野の領野構成2010

    • Author(s)
      澤渡浩之、田中良秀、西村方孝、宋文杰
    • Organizer
      第33回日本神経科学学会、P2-i05
    • Place of Presentation
      神戸コンベンションセンター
    • Year and Date
      2010-09-03
    • Related Report
      2010 Final Research Report
  • [Presentation] Optical imaging-based parcellation of mouse auditory cortex2010

    • Author(s)
      Hiroyuki Sawatari
    • Organizer
      第33回日本神経科学学会
    • Place of Presentation
      神戸コンベンションセンター
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Frequency discrimination by neural activity in the primary auditory cortex.2010

    • Author(s)
      宋文杰、西村方孝、齋藤和也、竹本誠
    • Organizer
      平成22年電気学会電子・情報・システム部門大会講演論文集、P33
    • Place of Presentation
      熊本大学
    • Year and Date
      2010-09-02
    • Related Report
      2010 Final Research Report
  • [Presentation] Subfield organization and functional domains of rodent auditory cortex as revealed by optical imaging.2009

    • Author(s)
      宋文杰, 西村方孝, 西村方孝, 田中良秀
    • Organizer
      The 14th auditory research forum
    • Place of Presentation
      Biwako Retreat Center, Doshisha University
    • Year and Date
      2009-12-06
    • Related Report
      2010 Final Research Report
  • [Presentation] Optical imaging of cortical activity in vivo using fluorescent voltage-sensitive dyes.2009

    • Author(s)
      宋文杰
    • Organizer
      Forum in DOJIN 20th anniversary international symposium. p41-46.
    • Place of Presentation
      Tetoria, Kumamoto
    • Year and Date
      2009-11-27
    • Related Report
      2010 Final Research Report
  • [Presentation] モルモット一次聴覚野における周波数弁別能2009

    • Author(s)
      齋藤和也、西村方孝、宋文杰
    • Organizer
      日本音響学会聴覚研究会、39(7):489-494.
    • Place of Presentation
      豊橋技術科学大学
    • Year and Date
      2009-11-13
    • Related Report
      2010 Final Research Report
  • [Presentation] Mutual information between acoustic stimuli and optical signals in the primary auditory cortex.2009

    • Author(s)
      西村方孝, 西村方孝, 宋文杰
    • Organizer
      32nd Japan Annual Neuroscience Meeting
    • Place of Presentation
      Nagoya Congress Center
    • Year and Date
      2009-09-18
    • Related Report
      2010 Final Research Report
  • [Presentation] Mutual information between acoustic stimuli and optical signals in the primary auditory cortex2009

    • Author(s)
      Kazuya Saitoh
    • Organizer
      第32回日本神経科学学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Frequency- and level-dependent detectable change of auditory response pattern in the cortex.2009

    • Author(s)
      西村方孝, 西村方孝, 宋文杰
    • Organizer
      IUPS2009, P4AM-16-10
    • Place of Presentation
      Kyoto Convention Center
    • Year and Date
      2009-07-31
    • Related Report
      2010 Final Research Report
  • [Presentation] Auditory brainstem response in mice.2009

    • Author(s)
      M Lu, M Nishimura, K Saitoh, WJ Song
    • Organizer
      IUPS2009, P1PM-13-13
    • Place of Presentation
      Kyoto Convention Center
    • Year and Date
      2009-07-28
    • Related Report
      2010 Final Research Report
  • [Presentation] Auditory brainstem response in mice2009

    • Author(s)
      Meihong Lu
    • Organizer
      第36回国際生理学会
    • Place of Presentation
      京都国立京都国際会館
    • Year and Date
      2009-07-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Frequency- and level-dependent detectable change of auditory response pattern in the cortex2009

    • Author(s)
      Kazuya Saitoh
    • Organizer
      第36回国際生理学会
    • Place of Presentation
      京都国立京都国際会館
    • Year and Date
      2009-07-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] モルモット聴覚領野における応答潜時の周波数依存性2009

    • Author(s)
      西村方孝
    • Organizer
      日本神経科学大会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] モルモット一次聴覚皮質における純音刺激で誘発される応答振幅のばらつきと応答パタンの安定性2009

    • Author(s)
      齋藤和也
    • Organizer
      日本神経科学大会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] マウス大脳皮質におけるカルレチニン陽性細胞の機能解析のためのCalretinin-Creマウス及びHR-Chop2-GYFP Cre-reporterマウスの作製2009

    • Author(s)
      棚平ゆかり
    • Organizer
      日本神経科学大会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] 光信号から見た一次聴覚野の周波数弁別能2008

    • Author(s)
      齋藤和也、西村方孝、宋文杰
    • Organizer
      日本音響学会聴覚研究会、38(7):727-732
    • Place of Presentation
      豊橋技術科学大学
    • Year and Date
      2008-11-29
    • Related Report
      2010 Final Research Report
  • [Presentation] マウス大脳皮質におけるカルレチニン陽性細胞の機能解析のためのCalretinin-Creマウス及びHR-Chop2-GYFP Cre-reporterマウスの作製2008

    • Author(s)
      平上ゆかり、棚平千代子、宋文杰、玉巻伸章
    • Organizer
      第31回日本神経科学大会、、P3-g06
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-07-11
    • Related Report
      2010 Final Research Report
  • [Presentation] モルモットー次聴覚皮質における純音刺激で誘発される応答振幅のばらつきと応答パターンの安定性2008

    • Author(s)
      齋藤和也、西村方孝、宋文杰
    • Organizer
      第31回日本神経科学大会、P3-k16
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-07-11
    • Related Report
      2010 Final Research Report
  • [Presentation] モルモット皮質領野における応答潜時の周波数依存性2008

    • Author(s)
      西村方孝、齋藤和也、宋文杰
    • Organizer
      第31回日本神経科学大会、P3-k15
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-07-11
    • Related Report
      2010 Final Research Report
  • [Book] Auditory Cortex in guinea pigs : subfield organization and functional domains.2011

    • Author(s)
      Song W-J, Nishimura M, Saitoh K.
    • Publisher
      Nova Science Publishers(in press)
    • Related Report
      2010 Annual Research Report
  • [Book] Auditory Cortex in Guinea Pigs : subfield organization and functional domains.(In "Auditory Cortex : Anatomy, Functions and Disorders")

    • Author(s)
      Wen-Jie Song, Masataka Nishimura, Kazuya Saitoh.
    • Publisher
      Nova Science Publishers, Inc.(in press)
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • URL

      http://srv02.medic.kumamoto-u.ac.jp/dept/physiol2/physiol2.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://srv02.medic.kumamoto-u.ac.jp/dept/physio12/physio12.html

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi