Comprehensive analysis of protein tyrosine phosphatase receptor type O

• Project/Area Number: 20300113
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: National Institute for Basic Biology
• Principal Investigator: SHINTANI Takafumi National Institute for Basic Biology, 統合神経生物学研究部門, 准教授 (10312208)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000); Fiscal Year 2010: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2009: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2008: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
• Keywords: チロシンホスファターゼ / チロシンキナーゼ / 視神経 / 投射 / 行動解析 / 行動学的解析 / 神経回路形成

Research Abstract

In this study, we analyzed Ptpro-deficient mice. In the axonal projections from the retina to the brain, we could not find any differences between wild-type and Ptpro-deficient mice. On the other hand, in some behavioral tests, we detected a significant difference between wild-type and Ptpro-deficient mice. We also found that Ptpro regulates multiple RPTKs in collaboration with other members of the R3 PTP subfamily.

Research Products

• [Journal Article] Ephによるシナプスの形成と可塑性の制御機構 (2010)
  • Author(s): 新谷隆史、野田昌晴
  • Journal Title: 生体の科学 61 Pages: 468-469
• [Journal Article] APC2 plays an essential role in axonal projections through the regulation of microtubule stability. (2009)
  • Author(s): Shintani T., Ihara M., Tani S., Sakuraba J., Sakuta H., Noda M.
  • Journal Title: J.Neurosci. 29 Pages: 11628-11640
  • Peer Reviewed
• [Journal Article] Functional mode of FoxD1/CBF2 for the establishment of temporal retinal specificity in the developing chick retina. (2009)
  • Author(s): Takahashi H., Sakuta H., Shintani T., Noda M.
  • Journal Title: Dev.Biol. 331 Pages: 300-310
  • Peer Reviewed
• [Journal Article] Identification of retinal ganglion cells and their projections involved in central transmission of information about upward and downward image motion. (2009)
  • Author(s): Yonehara K., Ishikane H., Sakuta H., Shintani T., Nakamura-Yonehara K., Kamiji N.L., Usui S., Noda M.
  • Journal Title: PLoS ONE 4
  • Peer Reviewed
• [Journal Article] Protein tyrosine phosphatase receptor type Z dephosphorylates TrkA receptors and attenuates NGF-dependent neurite outgrowth of PC12 cells. (2008)
  • Author(s): Shintani T., Noda M.
  • Journal Title: J.Biochem. 144 Pages: 259-266
  • NAID: 10024911885
  • Peer Reviewed
• [Journal Article] Expression of SPIG1 reveals development of a retinal ganglion cell subtype projecting to the medial terminal nucleus in the mouse. (2008)
  • Author(s): Yonehara K., Shintani T., Suzuki R., Sakuta H., Takeuchi Y., Nakamura-Yonehara K., Noda M.
  • Journal Title: PLoS ONE 3
  • Peer Reviewed
• [Journal Article] 視神経投射における受容体型プロテインチロシンホスファターゼの役割 (2008)
  • Author(s): 新谷隆史、野田昌晴
  • Journal Title: 生化学 80 Pages: 733-742
• [Journal Article] Protein Tyrosine Phosphatase Receptor Type Z Dephosphorylates TrkA Receptors and AttenuatesNGF-dependent Neurite Outgrowth of PC12 Cells (2008)
  • Author(s): Shintani, T., Noda, M.
  • Journal Title: Journal of Biochemistry 144 Pages: 259-266
  • Peer Reviewed
• [Journal Article] 視神経投射形成における受容体型プロテインチロシンホスファターゼの役割 (2008)
  • Author(s): 新谷隆史, 野田昌晴
  • Journal Title: 生化学 80 Pages: 733-742
  • NAID: 10021924976
• [Presentation] Protein tyrosine phosphatase receptor type Z dephosphorylates TrkA receptors and attenuates NGF-dependent neurite outgrowth of PC12 cells. (2009)
  • Author(s): 新谷隆史
  • Organizer: 日本生化学会大会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2009-10-23
• [Remarks] ホームページ等
  • URL: http://niwww3.nibb.ac.jp/