Molecular Mechanisms for neuronal interactions during synapse formation
| Project/Area Number |
20300115
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
HAMA Chihiro The Institute of Physical and Chemical Research, 総合生命科学部, 教授 (50238052)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2008: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Keywords | 軸索 / 嗅覚 / ショウジョウバエ / 突然変異 / Wnt5 / Drl / ヒストン / ショウジョウバェ / シナプス / 糸球体 / メチル化 / 発生 / 神経回路 / 嗅覚系 / Drl-2 / 神経 |
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| Research Abstract |
We have studied several mutants showing that the olfactory receptor neurons exhibit abnormal axonal projection or synaptic targeting in the first olfactory processing center in the brain. Among these, we have concentrated our attention on the mutants of Wnt5, Drl and Drl-2. All these molecules constitute Wnt5 signaling, each expressed in a distinct pattern, and regulate the distribution of glomeruli in the olfactory center. Notably, both Drl and Drl-2 can play opposing roles in Wnt5 signaling, depending on the cells where they are expressed. These findings suggest a new mechanism for Wnt5 signaling in the development of neural circuits.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Differentially expressed Drl and Drl-2 play opposing roles in Wnt5 signaling during Drosophila olfactory system development.2009
Author(s)
Sakurai, M., Aoki, T., Yoshikawa, S., Santschi, L.A., Saito, H., Endo, K., Ishikawa, K., Kimura, K-i., Ito, K., Thomas, J.B., Hama, C.
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Journal Title
The Journal of Neuroscience 29
Pages: 4972-4980
Related Report
Peer Reviewed
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