| Project/Area Number |
20300120
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Kyushu University |
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Principal Investigator |
KOSAKA Toshio Kyushu University, 医学研究院, 教授 (00126054)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2008: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Keywords | 解剖学 / 神経科学 / 脳・神経 / 嗅覚中枢 / 投射ニューロン / 介在ニューロン / トレーサー実験 / 免疫細胞化学 / 共焦点レーザー顕微鏡 / カルシウム結合蛋白 |
|---|
| Research Abstract |
In the olfactory bulb, the first center of the olfaction, there are various types of GABergic so-called "short-axon cells", which are rather small in number but regarded to be functionally important in the information processing. In our previous studies we revealed that some of NOS positive neurons, apparently different from mitral/tufted cells and thus considered as "short-axon cells", are projection neurons. In the present study we further revealed that some of calbindin positive neurons, also regarded as "short-axon cells", are projection neurons. These observations led us to propose "nonprincipal projection neurons, NPP neurons, in the olfactory bulb." However, importantly, only a small population of those NPP neurons have been characterized chemically so far, indicating that NPP neurons might be heterogeneous in chemical properties. On the other hand we also revealed two types of intrabulbar association systems located near the glomerular layer ; one is inhibitory juxtaglomerular association system IJGA in which the large type of dopaminergic-GABAergic neurons play the major role, and the other is excitatory juxtaglomerular association system EJGA, in which the external tufted cells play the major role.
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