Novel PET ligands for brain-function imaging with the brain-targeting peptide molecules

• Project/Area Number: 20300127
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Nagoya University
• Principal Investigator: SAWADA Makoto Nagoya University, 環境医学研究所, 教授 (10187297)
• Co-Investigator(Kenkyū-buntansha): TOYAMA Hiroshi 藤田保健衛生大学, 医学部, 准教授 (90247643) ; HATANO Kentaro 国立長寿医療センター, 室長 (50228475)
• Co-Investigator(Renkei-kenkyūsha): ONO Kenji 名古屋大学, 環境医学研究所, 助教 (80329698) ; SUZUKI Hiromi 名古屋大学, 環境医学研究所, 助教 (30340269)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000); Fiscal Year 2010: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000); Fiscal Year 2009: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2008: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
• Keywords: 脳・神経 / 放射線 / PET / 脳移行性 / イメージング

Research Abstract

We investigated the feasibility of our originally established brain-targeting (BT) peptide for novel ligand development of brain PET imaging. We successfully demonstrated the potential of [11C]MQNB-BT peptide conjugate in brain-penetrating activity, whereas [11C]MQNB itself has no such activity. Quantitative analysis indicated that [11C]MQNB-BT peptide conjugate had about 10% brain-penetrating activity of [11C]NMPB, which is permeable to blood-brain barrier. These results suggested that BT peptide has a potential of a DDS carrier for brain function imaging tools.

Research Products

• [Journal Article] Time-dependent changes in proinfl-ammatory and neurotrophic responses of microglia and astrocytes in a rat model of osmotic demyelination syndrome. (2011)
  • Author(s): IWAMA S, SUGIMURA Y, SUZUKI H, SUZUKI H, MURASE T, OZAKI N, NAGASAKI H, ARIMA H, MURATA Y, SAWADA M, OISO Y
  • Journal Title: Glia 59(3) Pages: 452-462
  • Peer Reviewed
• [Journal Article] Time-dependent changes in proinflammatory and neurotrophic responses of microglia and astrocytes in a rat model of osmotic demyelination syndrome. (2011)
  • Author(s): IWAMA S, SUGIMURA Y, SUZUKI H, SUZUKI H, MURASE T, OZAKI N, NAGASAKI H, ARIMA H, MURATA Y, SAWADA M, OISO Y
  • Journal Title: Glia Volume: 59(3) Pages: 452-462
  • Peer Reviewed
• [Journal Article] Neuroprotective and neurotoxic phenotypes of activated microglia in neonatal mice with respective MPTP-and ethanol-induced brain injury. (2010)
  • Author(s): SAWADA H, SUZUKI H, NAGATSU T, SAWADA M
  • Journal Title: Neuro-degener Dis 7(1-3) Pages: 64-67
  • Peer Reviewed
• [Journal Article] Two activated stages of microglia and PET imaging of peripheral benzodiazepine receptors with [(11)C] PK 11195 in rats. (2010)
  • Author(s): ITO F, TOYAMA H, KURD G, SUZUKI H, HATANO K, ICHISE M, KATADA K, ITO K, SAWADA M
  • Journal Title: An Nucl Med 24(3) Pages: 163-169
  • NAID: 10026390913
  • Peer Reviewed
• [Journal Article] Delayed neural damage is induced by iNOS-expressing microglia in a brain injury model. (2010)
  • Author(s): ONO K, SUZUKI H, SAWADA M
  • Journal Title: Neurosci Lett 473(2) Pages: 146-150
  • Peer Reviewed
• [Journal Article] Quantum dots labeling using octa-arginine peptides for imaging of adipose tissue-derived stem cells. (2010)
  • Author(s): YUKAWA H, KAGAMI Y, WATANABE M, OISHI K, MIYAMOTO Y, OKAMOTO Y, TOKESHI M, KAJI N, NOGUCHI H, ONO K, SAWADA M, et al.
  • Journal Title: Biomaterials 31(14) Pages: 4094-4103
  • Peer Reviewed
• [Journal Article] One-pot biofunctionalization of magnetic nanoparticles via thiol-ene click reation for magnetic hyperthermia and magnetic resonance imaging. (2010)
  • Author(s): HAYASHI K, ONO K, SUZUKI H, SAWADA M, et al.
  • Journal Title: Chem Mater 22(12) Pages: 3768-3772
  • Peer Reviewed
• [Journal Article] High-frequency, magnetic-field-responsive drug release from magnetic nano-particle/organic hybrid based on hyperthermic effect. (2010)
  • Author(s): HAYASHI K, ONO K, SUZUKI H, SAWADA M, et al.
  • Journal Title: ACS Appl Mater Interfaces 2(7) Pages: 1903-1911
  • Peer Reviewed
• [Journal Article] Electrosprayed synthesis of Red-Blood-Cell-Like particles with dual modality for magnetic resonance and fluorescence imaging. (2010)
  • Author(s): HAYASHI K, ONO K, SUZUKI H, SAWADA M, et al.
  • Journal Title: Small 6(21) Pages: 2384-2391
  • Peer Reviewed
• [Journal Article] Minocycline prevents osmotic demyelination syndrome by inhibiting the activation of microglia. (2010)
  • Author(s): SUZUKI H, SUGIMURA Y, IWAMA S, SUZUKI H, OZAKI N, NAGASAKI H, ARIMA H, SAWADA M, OISO Y
  • Journal Title: J Am Soc Nephrol 21(12) Pages: 2090-2098
  • Peer Reviewed
• [Journal Article] One-pot biofunctionalization of magnetic nanoparticles via thiol-ene click reaction for magnetic hyperthermia and magnetic resonance imaging (2010)
  • Author(s): HAYASHI K, ONO K, SUZUKI H, SAWADA M, MORIYA M, SAKAMOTO W, YOGO T
  • Journal Title: Chemistry of Materials Volume: 22(12) Pages: 3768-3772
  • Peer Reviewed
• [Journal Article] High-frequency, magnetic-field-responsive drug release from magnetic nanoparticle/organic hybrid based on hyperthermic effect. (2010)
  • Author(s): HAYASHI K, ONO K, SUZUKI H, SAWADA M, MORIYA M, SAKAMOTO W, YOGO T
  • Journal Title: ACS Applied Materials & Interfaces Volume: 2(7) Pages: 1903-1911
  • Peer Reviewed
• [Journal Article] Electrosprayed Synthesis of Red-Blood-Cell-Like Particles with Dual Modality for Magnetic Resonance and Fluorescence Imaging. (2010)
  • Author(s): HAYASHI K, ONO K, SUZUKI H, SAWADA M, MORIYA M, SAKAMOTO W, YOGO T
  • Journal Title: Small Volume: 6(21) Pages: 2384-2391
  • Peer Reviewed
• [Journal Article] Minocycline prevents osmotic demyelination syndrome by inhibiting the activation of microglia. (2010)
  • Author(s): SUZUKI H, SUGIMURA Y, IWAMA S, SUZUKI H, OZAKI N, NAGASAKI H, ARIMA H, SAWADA M, OISO Y.
  • Journal Title: Journal of the American Society of Nephrology Volume: 21(12) Pages: 2090-2098
  • Peer Reviewed
• [Journal Article] Two activated stages of microglia and PET imaging of peripheral benzodiazepine receptors with [(11)C]PK11195 in rats (2010)
  • Author(s): ITO F, TOYAMA H, KUDO G, SUZUKI H, HATANO K, ICHISE M, KATADA K, ITO K, SAWADA M
  • Journal Title: Annals of Nuclear Medicine Volume: 24(3) Pages: 163-169
  • NAID: 10026390913
  • Peer Reviewed
• [Journal Article] Neuroprotective and Neurotoxic Phenotypes of Activated Microglia in Neonatal Mice with Respective MPTP- and Ethanol-Induced Brain Injury (2010)
  • Author(s): SAWADA H, SUZUKI H, NAGATSU T, SAWADA M
  • Journal Title: Neuro-degenerative Diseases Volume: 7(1-3) Pages: 64-67
  • Peer Reviewed
• [Journal Article] Quantum dots labeling using octa-arginine peptides for imaging of adipose tissue-derived stem cells (2010)
  • Author(s): YUKAWA H, KAGAMI Y, WATANABE M, OISI K, MIYAMOTO Y, OKAMOTO Y, TOKESHI M, KAJI N, NOGUCHI H, ONO K, SAWADA M, BABA Y, HAMAJIMA N, HAYASHI S
  • Journal Title: Biomaterials Volume: 31(14) Pages: 4094-4103
  • Peer Reviewed
• [Journal Article] Delayed neural damage is induced by iNOS-expressing microglia in a brain injury model (2010)
  • Author(s): ONO K, SUZUKI H, SAWADA M
  • Journal Title: Neuroscience Letters Volume: 473(2) Pages: 146-150
  • Peer Reviewed
• [Journal Article] L-dopa therapy for Parkinson's disease : Past, present, and future. (2009)
  • Author(s): NAGATSC T, SAWADA M
  • Journal Title: Parkinsonism & Related Disorders 15
• [Journal Article] Neuroprotective and toxic changes in microglia in neurodegener-ative disease. (2009)
  • Author(s): SAWADA M
  • Journal Title: Parkinsonism & Related Disorders 15
• [Journal Article] Marked induction of inducible nitric oxide synthase and tumor necrosis factor-alpha in rat CD40(+) microglia by comparison to CD40(-) microglia. (2009)
  • Author(s): KAWAHARA K, YOSHIDA A, KOGA K, YOKOO S, KUNIYASU A, GOTOH T, SAWADA M, et al
  • Journal Title: J Neuroimmunol 208(1-2) Pages: 70-79
  • Peer Reviewed
• [Journal Article] Transforming growth factor-betal up-regulates keratan sulfate and chondroitin sulfate biosynthesis in microglia after brain injury. (2009)
  • Author(s): YIN J, SAKAMOTO K, ZHANG H, ITO Z, IMAGAMA S, KISHIDA S, NATORI T, SAWADA M, et al
  • Journal Title: Brain Res 1263 Pages: 10-22
  • Peer Reviewed
• [Journal Article] Temperature dependence of proton permeation through a voltage-gated proton channel. (2009)
  • Author(s): KUNO M, ANDO H, MORIHATA H, SAKAI H, MORI H, SAWADA M, OIKI S
  • Journal Title: J Gen Physiol 134(3) Pages: 191-205
  • Peer Reviewed
• [Journal Article] Interleukin-6 induces prostaglandin E_2 synthesis in mouse astrocytes. (2009)
  • Author(s): CHIKUMA T, YOSHIMOTO T, OHBA M, SAWADA M, et al.
  • Journal Title: J Mol Neurosci 39(1-2) Pages: 175-184
  • Peer Reviewed
• [Journal Article] Ferritin reporter used for gene expression imaging by magnetic resonance. (2009)
  • Author(s): ONO K, FUMA K, TABATA K, SAWADA M
  • Journal Title: Biochem Biophys Res Commun 388(3) Pages: 589-594
  • Peer Reviewed
• [Journal Article] Temperature dependence of proton permeation through a voltage-gated proton channel. (2009)
  • Author(s): KUNO M, ANDO H, MORIHATA H, SAKAI H, MORI H, SAWADA M, OIKI S
  • Journal Title: The Journal of General Physiology Volume: 134(3) Pages: 191-205
  • Peer Reviewed
• [Journal Article] Interleukin-6 induces prostaglandin E_2 synthesis in mouse astrocytes. (2009)
  • Author(s): CHIKUMA T, YOSHIMOTO T, OHBA M, SAWADA M, KATO T, SAKAMOTO T, HIYAMA Y, HOJO H
  • Journal Title: Journal of Molecular Neuroscience Volume: 39(1-2) Pages: 175-184
  • Peer Reviewed
• [Journal Article] Ferritin reporter used for gene expression imaging by magnetic resonance (2009)
  • Author(s): ONO K, FUMA K, TABATA K, SAWADA M
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 388(3) Pages: 589-594
  • Peer Reviewed
• [Journal Article] L-dopa therapy for Parkinson's disease : Past, present, and future (2009)
  • Author(s): NAGATSU T, SAWADA M
  • Journal Title: Parkinsonism & Related Disorders 15
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): SAWADA. M
  • Journal Title: Parkinsonism & Related Disorders 15
  • Peer Reviewed
• [Journal Article] Marked induction of inducible nitric oxide synthase and tumor necrosis factor-alpha in rat CD40(+) microglia by comparison to CD40(-)microglia (2009)
  • Author(s): KAWAHARA K, YOSHIDA A, KOGA K, YOKOO S, KUMYASU A, GOTOH T, SAWADA M, NAKAYAMA H
  • Journal Title: Journal of Neuroimmunology 208(1-2) Pages: 70-79
  • Peer Reviewed
• [Journal Article] A link between stress and depression : Shifts in the balance between the kynurenine and serotonin pathways of tryptophan metabolism and the etiology and pathophysiology of depression. (2008)
  • Author(s): MIURA H, OZAKI N, SAWADA M, et al
  • Journal Title: Stress 11(3) Pages: 198-209
  • Peer Reviewed
• [Journal Article] In vivo imaging of microglial activation using a peripheral benzodiazepine receptor ligand : [11C] PK-11195 and animal PET following ethanol injury in rat striatum. (2008)
  • Author(s): TOYAMA H, HATANO K, SUZUKI H, ICHISIE M, MOMOSAKI S, KUDO G, ITO F, KATO T, YAMAGCCHI H, KATADA K, SAWADA M, ITO K
  • Journal Title: Ann Nucl Med 22(5) Pages: 417-424
  • NAID: 10021281455
  • Peer Reviewed
• [Journal Article] Imaging of Peripheral Benzodiazepine Receptor Expression as Biomarkers of Detrimental versus Beneficial Glial Responses in Mouse Models of Alzheimer's and Other CNS Pathologies. (2008)
  • Author(s): JI Bin, MAEDA J, SAWADA M, et al
  • Journal Title: J Neurosci 28(47) Pages: 12255-12267
  • Peer Reviewed
• [Journal Article] Increase in hemokinin-1 mRNA in the spinal cord during the early phase of a neuropathic pain state. (2008)
  • Author(s): MATSUMURA T, SAKAI A, NAGANO M, SAWADA M, et al.
  • Journal Title: Br J Pharmacol 155(5) Pages: 767-774
  • Peer Reviewed
• [Journal Article] Interleukin-4-induced Selective Clearance of Oligomeric β-Amyloid Peptide(1-42) by Rat Primary Type-2 Microglia. (2008)
  • Author(s): SHIMIZU E, KAWAHARA K, KAJIZONO M, SAWADA M, NAKAYAMA H
  • Journal Title: J Immunol 181(9) Pages: 6503-6513
  • Peer Reviewed
• [Journal Article] Blockade of microglial glutamate release protects against ischemic brain injury. (2008)
  • Author(s): TAKEUCHI H, SHIJIE J, SUZUKI H, DOI Y, JIANFENG L, KAWANOKUCHI J, MIZUNO T, SAWADA M, SUZUMURA A
  • Journal Title: Exp Neurol 214(1) Pages: 149-146
  • Peer Reviewed
• [Journal Article] A link between stress and depression : shifts in the balance between the kynurenine and serotonin pathways of tryptophan metabolism and the etiology and pathophysiology of depression (2008)
  • Author(s): MIURA H, OZAKI N, SAWADAM, ISOBE K, OHTA T, NAGATSU T
  • Journal Title: stress 11(3) Pages: 198-209
  • Peer Reviewed
• [Journal Article] In vivo imaging of microglial activation using a peripheral benzodiazepine recent or ligand : [(11)C]PK-11195 and animal PET following ethanol injury in rat striatum (2008)
  • Author(s): TOYAMA H, HATANO K, SUZUKI H, ICHISE M, MOMOSAKI S, KUDO G, ITO F, KATO T, YAMAGUCHI H, KATADA K, SAWADA M, ITO K
  • Journal Title: Annals of Nuclear Medicine 22(5) Pages: 417-424
  • Peer Reviewed
• [Journal Article] Imaging of Peripheral Benzodiazepine Receptor Expression as Biomarkers of Detrimental versus Beneficial Glial Responses in Mouse Models of Alzheimer's and Other CNS Pathologies (2008)
  • Author(s): JI Bin, MAEDA J, SAWADA M, ONO M, OKAUCHI T, INAJI M, ZHANG Ming-Rong, SUZUKI K, ANDO K, STAUFENBIEL Matthias, TROLANOWSKI John Q, LEE Virginia M. Y., HIGUCHI M, SUHARA T
  • Journal Title: Journal of Neuroscience 28(47) Pages: 12255-12267
  • Peer Reviewed
• [Journal Article] Increase in hemokinin-1 mRNA in the spinal cord during the early phase of a neuropathic pain state (2008)
  • Author(s): MATSUMURA T, SAKAI A, NAGANO M, SAWADA M, SUZUKI H, UMINO M, SUZUKIH
  • Journal Title: British Journal of Pharmacology 155(5) Pages: 767-774
  • Peer Reviewed
• [Journal Article] Interleukin-4-induced Selective Clearance of Oligomeric b-Amyloid Peptide by Rat Primary Type-2 Microglial (2008)
  • Author(s): SHIMIZU E, KAWAHARA K, KAJIZONO M, SAWADA M, NAKAYAMA H
  • Journal Title: Journal of Immunology 181(9) Pages: 6503-6513
  • Peer Reviewed
• [Journal Article] Blockade of microglial glutamate release protects against ischemic brain injury (2008)
  • Author(s): TAKEUCHI H, SHIJIE J, SUZUKI H, DOI Y, JIANFENG Liang, KAWANOKUCHI J, MIZUNO T, SAWADA. SUZUMUEA A
  • Journal Title: Experimental Neurology 214(1) Pages: 144-146
  • Peer Reviewed
• [Presentation] 毒性転換したミクログリアのin vivoイメージングと脳の標的化DDS技術 (2010)
  • Author(s): 澤田誠
  • Organizer: 第16回創剤フォーラム若手研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-12-11
• [Presentation] 毒性転換したミクログリアのin vivoイメージングと脳の標的化DDS技術 (2010)
  • Author(s): 澤田誠
  • Organizer: 第16回創剤フォーラム若手研究会
  • Place of Presentation: 愛知学院大学楠元キャンパス(名古屋)
  • Year and Date: 2010-12-11
• [Presentation] Control of activation in ChR2-expressing astrocytes by blue light exposure. (2010)
  • Author(s): ONO K, HIGH M, TABATA K, SUZUKI H, SAWADA M
  • Organizer: 第83回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-07
• [Presentation] Control of activation in ChR2-expressing astrocytes by blue light exposure (2010)
  • Author(s): ONO K, HIGA M, TABATA K, SUZUKI H, SAWADA M
  • Organizer: 第83回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(神戸)
  • Year and Date: 2010-12-07
• [Presentation] Comparative analysis of gene expression profiles of microglia from demyelinative lesions in osmotic demyelination syndrome rat model. (2010)
  • Author(s): SUZUKI H, SUGIMURA Y, IWAMA S, SUZUKI H, KIYOTA A, SAWADA M, OISO Y
  • Organizer: 10^<th> International Congress of Neuroimmunology
  • Place of Presentation: Barcelona
  • Year and Date: 2010-10-27
• [Presentation] Comparative analysis of gene expression profiles of microglia from demyelinative lesions in osmotic demyelination syndrome rat model (2010)
  • Author(s): SUZUKI H, SUGIMURA Y, IWAMA S, SUZUKI H, KIYOTA A, SAWADA M, OISO Y
  • Organizer: 10^<th> International Congress of Neuroimmunology
  • Place of Presentation: Barcelona
  • Year and Date: 2010-09-27
• [Presentation] Control of activation in ChR2-expressing astrocytes by blue light exposure. (2010)
  • Author(s): ONO K, HIGA M, TABATA K, SUZUKI H, SAWADA M
  • Organizer: 第53回日本神経化学会(神戸)大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-02
• [Presentation] Control of activation in ChR2-expressing astrocytes by blue light exposure (2010)
  • Author(s): ONO K, HIGA M, TABATA K, SUZUKI H, SAWADA M
  • Organizer: 第53回日本神経化学会(神戸)大会
  • Place of Presentation: 神戸ポートアイランド(神戸)
  • Year and Date: 2010-09-02
• [Presentation] ミクログリアの毒性転換のin vivoイメージングと脳の標的化DDS技術 (2009)
  • Author(s): 澤田誠
  • Organizer: 第3回アルツハイマー病の早期診断・治療・予防法の開発研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-12-22
• [Presentation] ミクログリアの毒性転換のIn vivoイメージングと脳の標的化DDS技術 (2009)
  • Author(s): 澤田誠
  • Organizer: 第3回アルツハイマー病の早期診断・治療・予防法の開発研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-12-22
• [Presentation] 遺伝子発現変化を核磁気共鳴イメージングで可視化する方法の開発 (2009)
  • Author(s): 小野健治、夫馬和也、田畑香織、澤田誠
  • Organizer: 日本生化学会第82回大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-24
• [Presentation] インターロイキン4で活性化したラット初代培養2型ミクログリアによるオリゴマー状アミロイドβペプチド_<1-42>の選択的クリアランス (2009)
  • Author(s): 川原浩一、清水英介, 鍛治園誠、澤田誠、中山仁
  • Organizer: 日本生化学会第82回大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-24
• [Presentation] インターロイキン4で活性化したラット初代培養2型ミクログリアによるオリゴマー状アミロイドβペプチド_<1-42>選択的クリアランス (2009)
  • Author(s): 川原浩一、清水英介、鍛治園誠、澤田誠、中山仁
  • Organizer: 日本生化学会第82回大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-24
• [Presentation] Protective effects of minocycline on osmotic demyelination syndrome in rats. (2009)
  • Author(s): 鈴木陽之, 椙村益久, 岩間信太郎, 鈴木弘美, 有馬寛, 澤田誠, 大磯ユタカ
  • Organizer: Neuroscience 2009
  • Place of Presentation: Chicago
  • Year and Date: 2009-10-18
• [Presentation] Protective effects of minocycline on osmotic demyelination syndrome in rats (2009)
  • Author(s): SUZUKI H, SUGIMURA Y, IWAMA S, SUZUKI H, ARIMA H, SAWADA M, OISO Y
  • Organizer: Neuroscience 2009
  • Place of Presentation: Chicago
  • Year and Date: 2009-10-18
• [Presentation] ミクログリアの毒性転換のin vivoイメージング (2009)
  • Author(s): 澤田誠
  • Organizer: 第7回神経科学研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-09-19
• [Presentation] ミクログリアの毒性転換のIn vivoイメージング (2009)
  • Author(s): 澤田誠
  • Organizer: 第7回神経科学研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-09-19
• [Presentation] The differing pathological effects of nitric oxide synthase isoforms in osmotic demyelination syndrome in rats. (2009)
  • Author(s): 椙村益久、村瀬孝司、竹藤聖子、高木博史、岩間信太郎、鈴木陽之、高岸芳子、有馬寛、澤田誠、大磯ユタカ、村田善晴
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-17
• [Presentation] The differing pathological effects of nitric oxide synthase isoforms in osmotic demyelination syndrome in rats (2009)
  • Author(s): 椙村益久、村瀬孝司、竹藤聖子、高木博史、岩間信太郎、鈴木陽之、高岸芳子、有馬寛、澤田誠、大磯ユタカ、村田善晴
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-17
• [Presentation] Protective roles of brain-migrated immature bone marrow cells against NO-dependent neurotoxicity in a brain injury model. (2009)
  • Author(s): 小野健治、山本奈穂、鈴木弘美、澤田誠
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-16
• [Presentation] Neuroprotective or neurotoxic phenotypes of activated microglia in neonatal mice in neuronal injuries. (2009)
  • Author(s): 澤田浩秀、鈴木弘美、永津俊治, 澤田誠
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-16
• [Presentation] Protective roles of brain-migrated immature bone marrow cells against NO-dependent neurotoxicity in a brain injury model (2009)
  • Author(s): 小野健治、山本奈穂、鈴木弘美、澤田誠
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-16
• [Presentation] Neuroprotective or neurotoxic phenotypes of activated microglia in neonatal mice in neuronal injuries (2009)
  • Author(s): 澤田浩秀、鈴木弘美、永津俊治, 澤田誠
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-16
• [Presentation] Minocycline prevents osmotic demyelination by inhibiting the activation of microglia in rats. (2009)
  • Author(s): 籏野健太郎, 椙村益久, 岩間信太郎, 鈴木弘美, 有馬寛, 澤田誠, 大磯ユタカ
  • Organizer: 第8回国際下垂体後葉ホルモン学会
  • Place of Presentation: 北九州
  • Year and Date: 2009-09-07
• [Presentation] Minocycline prevents osmotic demyelination by inhibiting the activation of microglia in rats (2009)
  • Author(s): SUZUKI H, SUGIMURA Y, IWAMA S, SUZUKI H, ARIMA H, SAWADA M, OISO Y
  • Organizer: 第8回国際下垂体後葉ホルモン学会
  • Place of Presentation: 北九州
  • Year and Date: 2009-09-07
• [Presentation] SIADHモデルラットにおいてミノサイクリンは浸透圧性脱随の発症・進展を防止する (2009)
  • Author(s): 鈴木陽之、椙村益久、岩間信太郎、鈴木弘美、有馬寛、澤田誠、大磯ユタカ
  • Organizer: 第36回日本神経内分泌学会学術集会
  • Place of Presentation: 北九州
  • Year and Date: 2009-09-04
• [Presentation] SIADHモデルラットにおいてミノサイクリシは浸透圧性脱随の発症・進展を防止する (2009)
  • Author(s): 鈴木陽之、椙村益久、岩間信太郎、鈴木弘美、有馬寛、澤田誠、大磯ユタカ
  • Organizer: 第36回日本神経内分泌学会学術集会
  • Place of Presentation: 北九州
  • Year and Date: 2009-09-04
• [Presentation] シンクロトロン光を用いた細胞制御脳研究への道 (2009)
  • Author(s): 澤田誠
  • Organizer: 第16回「先端技術と原子力」シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2009-08-20
• [Presentation] A practical preparation of [18F] FEPPA using a protic solvent system. (2009)
  • Author(s): HATANO K, TOYAMA H, YAMADA T, KUDO G, SUZUKI H, ICHISE M, WILSON A.A., SAWADA M, ITO K
  • Organizer: 18^<th> International Symposium on Radiopharmaceutical Sciences
  • Place of Presentation: Edmonton
  • Year and Date: 2009-07-12
• [Presentation] A practical preparation of [18F]FEPPA using a protic solvent system (2009)
  • Author(s): HATANO K, TOYAMA H, YAMADA T, KUDO G, SUZUKI H, ICHISE M, WILSON A.A., SAWADA M, ITO K
  • Organizer: 18^<th> International Symposium on Radiopharmaceutical Sciences
  • Place of Presentation: Edmonton, CANADA
• [Presentation] Enhancement of glioma formation and growth by brain-migrated immature bone marrow cells. (2008)
  • Author(s): 小野健治, 古川大記, 鈴木弘美, 佐藤愛美, 澤田誠
  • Organizer: 第81回日本生化学会大会第31回日本分子生物学会年会合同大会(BMB2008)
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-12
• [Presentation] Enhancement of glioma formation and growth by brain-migrated immature bone marrow cells (2008)
  • Author(s): ONO K, FURUKAWA T, SUZUKIH, SATO E, SAWADA M
  • Organizer: 第81回日本生化学会大会第31回日本分子生物学会年会合同大会(BMB2008)
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-12
• [Presentation] ミクログリアの毒性転換のin vivoイメージングと脳の標的化DDS技術 (2008)
  • Author(s): 澤田誠
  • Organizer: 第39回中部化学関係学協会支部連合秋季大会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-11-09
• [Presentation] The expression of proinflammatory cytokines and neurotrophins in glia in osmotic demyelination syndrom. (2008)
  • Author(s): 椙村益久, 岩間信太郎, 鈴木弘美, 有馬寛, 高岸芳子, 村田善晴, 澤田誠, 大磯ユタカ
  • Organizer: Society for Neuroscience
  • Place of Presentation: Washington.DC
  • Year and Date: 2008-11-01
• [Presentation] ミクログリアイメージングの意義-基礎から臨床へ- (2008)
  • Author(s): 澤田誠
  • Organizer: 第24回ブレイン・ファンクション・イメージング・カンファレンス
  • Place of Presentation: 神戸
  • Year and Date: 2008-09-13
• [Presentation] ミクログリアイメージングの意義・基礎から臨床へ (2008)
  • Author(s): 澤田 誠
  • Organizer: 第24回ブレイン・ファンクション・イメージング・カンファレンス
  • Place of Presentation: 神戸
  • Year and Date: 2008-09-13
• [Presentation] 脳損傷モデルマウスにおける脳移行性骨髄細胞の神経保護効果 (2008)
  • Author(s): 小野健治、山本奈穂、鈴木弘美、佐藤愛美、澤田誠
  • Organizer: 第51回神経化学会大会
  • Place of Presentation: 富山
  • Year and Date: 2008-09-12
• [Presentation] 脳移行性骨髄細胞の脳腫瘍形成・増殖に対する促進的関与 (2008)
  • Author(s): 小野健治、古川大記、鈴木弘美、佐藤愛美、澤田誠
  • Organizer: 第31回神経科学学会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-11
• [Presentation] 脳移行性骨髄細胞の脳藤瘍形成・増殖に対する促進的関与 (2008)
  • Author(s): 小野健治, 古川大記, 鈴木弘美, 佐澤愛美, 澤田誠
  • Organizer: 第31回神経科学学会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-11
• [Presentation] 血液脳関門を壊さない脳の標的化DDS技術 (2008)
  • Author(s): 澤田誠
  • Organizer: 第16回群馬遺伝子診療研究会
  • Place of Presentation: 前橋
  • Year and Date: 2008-06-24
• [Presentation] 新規抹消性ベンゾジアゼピン受容体製剤:{18F}FEPPA PETとパーキンソン病モデルラットを川いた活性化ミクログリアのイメージング (2008)
  • Author(s): 鈴木弘美、外山宏、籏野健太郎、工藤元、伊藤文隆、小野健治、加藤隆司、Alan Wilson, 伊藤健吾、市瀬正則、澤田誠
  • Organizer: 第3回日本分子イメージング学会
  • Place of Presentation: さいたま
  • Year and Date: 2008-05-22
• [Presentation] 新規抹消性ベンゾジアゼピン受容体製剤 : ; {18F}FEPPA PETとパーキンソン病モデルラツトを用いた活性化ミクロクリアのイメージング (2008)
  • Author(s): 鈴木弘美, 外山宏, 旗野健太郎, 工藤元, 伊藤文隆, 小野健治, 加藤隆司, Alan Wilson, 伊藤健吾, 市澤瀬正則, 澤田誠
  • Organizer: 第3回日本分子イメージング学会
  • Place of Presentation: 埼玉
  • Year and Date: 2008-05-22
• [Presentation] 血液脳関門を壊さない脳標的化技術:脳疾患の新規治療 (2008)
  • Author(s): 澤田誠
  • Organizer: 医薬ライセンシング協会講演第200回記念講演会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-21
• [Presentation] 血液脳関門を壊さない脳標的化技術 : 脳疾患の新規治療 (2008)
  • Author(s): 澤田誠
  • Organizer: 医藤ライセンシング協会護演第200回記念護演会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-21
• [Presentation] 浸透圧性脱髄症候群ラットモデルにおけるグリア細胞の各種サイトカイン及び神経栄養因子の発現解析の検討 (2008)
  • Author(s): 椙村益久、岩間信太郎、鈴木弘美、有馬寛、高岸芳子、村田善晴、澤田誠、大磯ユタカ
  • Organizer: 第81回日本内分泌学会学術総会
  • Place of Presentation: 青森
  • Year and Date: 2008-05-17
• [Book] 小動物における定量的画像解析.脳循環代謝21(2) (2010)
  • Author(s): 外山宏、籏野健太郎、鈴木弘美、工藤元、野村昌彦、山田貴史、木村裕一、市瀬正則、澤田誠
• [Book] 脳循環代謝:小動物における定量的画像解析 (2010)
  • Author(s): 外山宏、籏野健太郎、鈴木弘美、工藤元、野村昌彦、山田貴史、木村裕一、市瀬正則、澤田誠
  • Publisher: 日本脳循環代謝学会
• [Book] 家族性パーキンソン病は孤発性パーキンソン病のモデルになるか?「NO」の立場からFrontiers inParkinson Disease (2009)
  • Author(s): 澤田誠
• [Book] 炎症:パーキンソン病-基礎・臨床研究のアップデート- (2009)
  • Author(s): 澤田誠意
  • Publisher: 日本臨林
• [Book] Isolation of microglia subpopulations. Protocols for Neural Cell Culture 4 (2009)
  • Author(s): 澤田誠意, 鈴木弘美
• [Book] 炎症:パーキンソン病-基礎・臨床研究のアップデート- (2009)
  • Author(s): 澤田誠
  • Publisher: 日本臨牀
• [Book] 家族性パーキンソン病は孤発性パーキンソン病のモデルになるか?「No」の立場からFrontiers in Parkinson Disease (2009)
  • Author(s): 澤田誠
  • Publisher: メディカルレビュー社
• [Book] Isolation of microglia subpopulations : Protocols for Neural Cell Culture (2009)
  • Author(s): SAWADA M, SUZUKI H
  • Publisher: Springer
• [Remarks] ホームページ等
• [Patent(Industrial Property Rights)] 脳移行型融合ポリペプチド (2009)
  • Inventor(s): 澤田誠
  • Industrial Property Rights Holder: プロテウスサイエンス
  • Industrial Property Number: 2009-276496
  • Filing Date: 2009-12-04
• [Patent(Industrial Property Rights)] 株化ミクログリア (2009)
  • Inventor(s): 澤田誠
  • Industrial Property Rights Holder: (独)科学技術振興機構
  • Acquisition Date: 2009-10-09
• [Patent(Industrial Property Rights)] 脳移行型融合ポリペプチド (2009)
  • Inventor(s): 澤田誠, 他
  • Industrial Property Rights Holder: (株)プロテウスサイエンス
  • Industrial Property Number: 2009-276496
  • Filing Date: 2009-12-04