Novel PET ligands for brain-function imaging with the brain-targeting peptide molecules
Project/Area Number |
20300127
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neurochemistry/Neuropharmacology
|
Research Institution | Nagoya University |
Principal Investigator |
SAWADA Makoto Nagoya University, 環境医学研究所, 教授 (10187297)
|
Co-Investigator(Kenkyū-buntansha) |
TOYAMA Hiroshi 藤田保健衛生大学, 医学部, 准教授 (90247643)
HATANO Kentaro 国立長寿医療センター, 室長 (50228475)
|
Co-Investigator(Renkei-kenkyūsha) |
ONO Kenji 名古屋大学, 環境医学研究所, 助教 (80329698)
SUZUKI Hiromi 名古屋大学, 環境医学研究所, 助教 (30340269)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2010: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2009: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2008: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
|
Keywords | 脳・神経 / 放射線 / PET / 脳移行性 / イメージング |
Research Abstract |
We investigated the feasibility of our originally established brain-targeting (BT) peptide for novel ligand development of brain PET imaging. We successfully demonstrated the potential of [11C]MQNB-BT peptide conjugate in brain-penetrating activity, whereas [11C]MQNB itself has no such activity. Quantitative analysis indicated that [11C]MQNB-BT peptide conjugate had about 10% brain-penetrating activity of [11C]NMPB, which is permeable to blood-brain barrier. These results suggested that BT peptide has a potential of a DDS carrier for brain function imaging tools.
|
Report
(4 results)
Research Products
(100 results)
-
[Journal Article] Time-dependent changes in proinfl-ammatory and neurotrophic responses of microglia and astrocytes in a rat model of osmotic demyelination syndrome.2011
Author(s)
IWAMA S, SUGIMURA Y, SUZUKI H, SUZUKI H, MURASE T, OZAKI N, NAGASAKI H, ARIMA H, MURATA Y, SAWADA M, OISO Y
-
Journal Title
Glia 59(3)
Pages: 452-462
Related Report
Peer Reviewed
-
[Journal Article] Time-dependent changes in proinflammatory and neurotrophic responses of microglia and astrocytes in a rat model of osmotic demyelination syndrome.2011
Author(s)
IWAMA S, SUGIMURA Y, SUZUKI H, SUZUKI H, MURASE T, OZAKI N, NAGASAKI H, ARIMA H, MURATA Y, SAWADA M, OISO Y
-
Journal Title
Glia
Volume: 59(3)
Pages: 452-462
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Quantum dots labeling using octa-arginine peptides for imaging of adipose tissue-derived stem cells.2010
Author(s)
YUKAWA H, KAGAMI Y, WATANABE M, OISHI K, MIYAMOTO Y, OKAMOTO Y, TOKESHI M, KAJI N, NOGUCHI H, ONO K, SAWADA M, et al.
-
Journal Title
Biomaterials 31(14)
Pages: 4094-4103
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Quantum dots labeling using octa-arginine peptides for imaging of adipose tissue-derived stem cells2010
Author(s)
YUKAWA H, KAGAMI Y, WATANABE M, OISI K, MIYAMOTO Y, OKAMOTO Y, TOKESHI M, KAJI N, NOGUCHI H, ONO K, SAWADA M, BABA Y, HAMAJIMA N, HAYASHI S
-
Journal Title
Biomaterials
Volume: 31(14)
Pages: 4094-4103
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article]2009
Author(s)
SAWADA. M
-
Journal Title
Parkinsonism & Related Disorders 15
Related Report
Peer Reviewed
-
-
-
[Journal Article] In vivo imaging of microglial activation using a peripheral benzodiazepine receptor ligand : [11C] PK-11195 and animal PET following ethanol injury in rat striatum.2008
Author(s)
TOYAMA H, HATANO K, SUZUKI H, ICHISIE M, MOMOSAKI S, KUDO G, ITO F, KATO T, YAMAGCCHI H, KATADA K, SAWADA M, ITO K
-
Journal Title
Ann Nucl Med 22(5)
Pages: 417-424
NAID
Related Report
Peer Reviewed
-
-
-
-
-
-
[Journal Article] In vivo imaging of microglial activation using a peripheral benzodiazepine recent or ligand : [(11)C]PK-11195 and animal PET following ethanol injury in rat striatum2008
Author(s)
TOYAMA H, HATANO K, SUZUKI H, ICHISE M, MOMOSAKI S, KUDO G, ITO F, KATO T, YAMAGUCHI H, KATADA K, SAWADA M, ITO K
-
Journal Title
Annals of Nuclear Medicine 22(5)
Pages: 417-424
Related Report
Peer Reviewed
-
[Journal Article] Imaging of Peripheral Benzodiazepine Receptor Expression as Biomarkers of Detrimental versus Beneficial Glial Responses in Mouse Models of Alzheimer's and Other CNS Pathologies2008
Author(s)
JI Bin, MAEDA J, SAWADA M, ONO M, OKAUCHI T, INAJI M, ZHANG Ming-Rong, SUZUKI K, ANDO K, STAUFENBIEL Matthias, TROLANOWSKI John Q, LEE Virginia M. Y., HIGUCHI M, SUHARA T
-
Journal Title
Journal of Neuroscience 28(47)
Pages: 12255-12267
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 新規抹消性ベンゾジアゼピン受容体製剤 : ; {18F}FEPPA PETとパーキンソン病モデルラツトを用いた活性化ミクロクリアのイメージング2008
Author(s)
鈴木弘美, 外山宏, 旗野健太郎, 工藤元, 伊藤文隆, 小野健治, 加藤隆司, Alan Wilson, 伊藤健吾, 市澤瀬正則, 澤田誠
Organizer
第3回日本分子イメージング学会
Place of Presentation
埼玉
Year and Date
2008-05-22
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-