The effect of social isolation on the circuit formation in the brain
Project/Area Number |
20300131
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neurochemistry/Neuropharmacology
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Research Institution | Yokohama City University |
Principal Investigator |
TAKAHASHI Takuya Yokohama City University, 医学研究科, 教授 (20423824)
|
Co-Investigator(Renkei-kenkyūsha) |
HUNABASHI Toshiya 聖マリアンナ医科大学, 医学部, 教授 (70229102)
MITSUSHIMA Dai 横浜市立大学, 医学研究科, 准教授 (70264603)
TAKASE Kenkichi 東邦大学, 医学部, 助教 (80381474)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2008: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
|
Keywords | AMPA受容体 / 社会的隔離 / シナプス / 可塑性 / バレル皮質 / 経験依存的 / 神経生物学 / ストレスホルモン / アンタゴニスト |
Research Abstract |
Stressful events during early childhood can have a profound lifelong influence on emotional and cognitive behaviors. However, the mechanisms by which stress affects neonatal brain circuit formation are poorly understood. In this program, we analyzed the effect of neonatal social isolation on the brain circuit formation at the molecular level. We found that neonatal social isolation disrupts experience-dependent synaptic AMPA receptors delivery in the barrel cortex of male rats but not female rats.
|
Report
(4 results)
Research Products
(19 results)
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[Journal Article] Serotonin mediates cross-modal reorganization of cortical circuits.2011
Author(s)
Jitsuki S, Takemoto K, Kawasaki T, Tada H, Takahashi A, Becamel C, Sano A, Yuzaki M, Zukin RS, Ziff EB, Kessels HW, Takahashi T.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Serotonin mediates cross-modal reorganization of cortical circuits.2011
Author(s)
Jitsuki S, Takemoto K, Kawasaki T, Tada T, Takahashi A, Becamel C, Sano A, Yuzaki M, Zukin RS, Ziff EB, Kessels HW, Takahashi T
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Journal Title
Neuron
Volume: 69
Pages: 780-792
Related Report
Peer Reviewed
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[Journal Article] Fbxo45, a novel ubiquitin ligase, regulates synaptic activity.2010
Author(s)
Tada H, Okano HJ, Takagi H, Shibata S, Yao I, Matsumoto M, Saiga T, Nakayama KI, Kashima H, Takahashi T, Setou M, Okano H
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Journal Title
J Biol Chem 285(6)
Pages: 3840-3849
Related Report
Peer Reviewed
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[Journal Article] The ARMS/Kidins220 scafford protein modulates synaptic transmission.2010
Author(s)
Arevalo JC, Wu SH, Takahashi T, Zhang H, Yu T, Yano H, Milner TA, Tessarollo L, Ninan I, Arancio O, Chao MV
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Journal Title
Mol Cell Neurosci 45(2)
Pages: 92-100
Related Report
Peer Reviewed
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[Journal Article] Fbxo45, a novel ubiquitin ligase, regulates synaptic activity.2010
Author(s)
Tada H, Okano HJ, Takagi H, Shibata S, Yao I, Matsumoto M, Saiga T, Nakayama KI, Kashima H, Takahashi T, Setou M, Okano H
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Journal Title
J Biol Chem
Volume: 285(6)
Pages: 3840-3849
Related Report
Peer Reviewed
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[Journal Article] The ARMS/Kidins220 scafford protein modulates synaptic transmission2010
Author(s)
Arevalo JC, Wu SH, Takahashi T, Zhang H, Yu T, Yano H, Milner TA, Tessarollo L, Ninan I, Arancio O, Chao MV
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Journal Title
Mol Cell Neurosci
Volume: 45(2)
Pages: 92-100
Related Report
Peer Reviewed
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