The effect of social isolation on the circuit formation in the brain

• Project/Area Number: 20300131
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Yokohama City University
• Principal Investigator: TAKAHASHI Takuya Yokohama City University, 医学研究科, 教授 (20423824)
• Co-Investigator(Renkei-kenkyūsha): HUNABASHI Toshiya 聖マリアンナ医科大学, 医学部, 教授 (70229102) ; MITSUSHIMA Dai 横浜市立大学, 医学研究科, 准教授 (70264603) ; TAKASE Kenkichi 東邦大学, 医学部, 助教 (80381474)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000); Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2009: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2008: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
• Keywords: AMPA受容体 / 社会的隔離 / シナプス / 可塑性 / バレル皮質 / 経験依存的 / 神経生物学 / ストレスホルモン / アンタゴニスト

Research Abstract

Stressful events during early childhood can have a profound lifelong influence on emotional and cognitive behaviors. However, the mechanisms by which stress affects neonatal brain circuit formation are poorly understood. In this program, we analyzed the effect of neonatal social isolation on the brain circuit formation at the molecular level. We found that neonatal social isolation disrupts experience-dependent synaptic AMPA receptors delivery in the barrel cortex of male rats but not female rats.

Research Products

• [Journal Article] Serotonin mediates cross-modal reorganization of cortical circuits. (2011)
  • Author(s): Jitsuki S, Takemoto K, Kawasaki T, Tada H, Takahashi A, Becamel C, Sano A, Yuzaki M, Zukin RS, Ziff EB, Kessels HW, Takahashi T.
  • Journal Title: Neuron 69 Pages: 780-792
  • Peer Reviewed
• [Journal Article] Serotonin mediates cross-modal reorganization of cortical circuits. (2011)
  • Author(s): Jitsuki S, Takemoto K, Kawasaki T, Tada T, Takahashi A, Becamel C, Sano A, Yuzaki M, Zukin RS, Ziff EB, Kessels HW, Takahashi T
  • Journal Title: Neuron Volume: 69 Pages: 780-792
  • Peer Reviewed
• [Journal Article] Fbxo45, a novel ubiquitin ligase, regulates synaptic activity. (2010)
  • Author(s): Tada H, Okano HJ, Takagi H, Shibata S, Yao I, Matsumoto M, Saiga T, Nakayama KI, Kashima H, Takahashi T, Setou M, Okano H
  • Journal Title: J Biol Chem 285(6) Pages: 3840-3849
  • Peer Reviewed
• [Journal Article] The ARMS/Kidins220 scafford protein modulates synaptic transmission. (2010)
  • Author(s): Arevalo JC, Wu SH, Takahashi T, Zhang H, Yu T, Yano H, Milner TA, Tessarollo L, Ninan I, Arancio O, Chao MV
  • Journal Title: Mol Cell Neurosci 45(2) Pages: 92-100
  • Peer Reviewed
• [Journal Article] Fbxo45, a novel ubiquitin ligase, regulates synaptic activity. (2010)
  • Author(s): Tada H, Okano HJ, Takagi H, Shibata S, Yao I, Matsumoto M, Saiga T, Nakayama KI, Kashima H, Takahashi T, Setou M, Okano H
  • Journal Title: J Biol Chem Volume: 285(6) Pages: 3840-3849
  • Peer Reviewed
• [Journal Article] The ARMS/Kidins220 scafford protein modulates synaptic transmission (2010)
  • Author(s): Arevalo JC, Wu SH, Takahashi T, Zhang H, Yu T, Yano H, Milner TA, Tessarollo L, Ninan I, Arancio O, Chao MV
  • Journal Title: Mol Cell Neurosci Volume: 45(2) Pages: 92-100
  • Peer Reviewed
• [Journal Article] Activational and organizational effects of gonadal steroids on sex-specific acetylcholine release in the dorsal hippocampus. (2009)
  • Author(s): Mitsushima D, Takase K, Takahashi T, Kimura F
  • Journal Title: Journal of Neuroendocrinology 21(4) Pages: 400-405
  • Peer Reviewed
• [Journal Article] Sex-specific 24-h profile of extracellular serotonin levels in the medial prefrontal cortex. (2009)
  • Author(s): Jitsuki S, Kimura F, Funabashi T, Takahashi T, Mitsushima D
  • Journal Title: Brain Research 1260 Pages: 30-37
  • Peer Reviewed
• [Journal Article] The cAMP response element-binding protein in the bed nucleus of the stria terminalis modulates the formalin-induced pain behavior in the female rat. (2009)
  • Author(s): Hagiwara H, Ishida M, Arita J, Mitsushima D, Takahashi T, Kimura F, Funabashi T
  • Journal Title: European Journal of Neuroscience 30 Pages: 2379-2386
  • Peer Reviewed
• [Presentation] Experience driven synaptic delivery of AMPA receptors in vivo. (2010)
  • Author(s): 高橋琢哉
  • Organizer: 第33回日本分子生物学会年会(BMB2010)
  • Place of Presentation: 東京(招待シンポジウム)
  • Year and Date: 2010-12-07
• [Presentation] Experience driven synaptic delivery of AMPA receptors in vivo. (2010)
  • Author(s): 高橋琢哉
  • Organizer: 第33回日本分子生物学会年会(BMB2010)
  • Place of Presentation: 神戸,神戸国際会議場国際会議室(招待シンポジウム)
  • Year and Date: 2010-12-07
• [Presentation] 経験依存的AMPA受容体シナプス移行 (2010)
  • Author(s): 高橋琢哉
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸,神戸国際展示場2号館
  • Year and Date: 2010-09-04
• [Presentation] 経験依存的AMPA受容体シナプス移行 (2010)
  • Author(s): 高橋琢哉
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-03
• [Presentation] 経験依存的AMPA受容体シナプス移行 (2009)
  • Author(s): 高橋琢哉
  • Organizer: 第32回日本神経科学大会,シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-18
• [Presentation] 経験依存的AMPA受容体シナプス移行 (2009)
  • Author(s): 高橋琢哉
  • Organizer: 第52回日本神経化学会大会
  • Place of Presentation: 伊香保温泉 ホテル天保
• [Presentation] 経験依存的AMPA受容体シナプス移行 (2008)
  • Author(s): 高橋琢哉
  • Organizer: 第31回日本神経科学大会,シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2008-07-11
• [Presentation] 経験依存的AMPA受容体シナプス移行 (2008)
  • Author(s): 高橋琢哉
  • Organizer: 第85回日本生理学会大会,シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2008-03-27
• [Remarks] ホームページ等
  • URL: http://neurosci.med.yokohama-cu.ac.jp/2.html
• [Remarks]
  • URL: http://neurosei.med.yokohama-cu.ac.jp/publications.html