Regulatory mechanism and cellular dynamics of exocytosis of BDNF-containing secretory vesicles by CAPS2

• Project/Area Number: 20300134
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: FURUICHI Tei-Ichi The Institute of Physical and Chemical Research, 分子神経形成研究チーム, チームリーダー (50219094)
• Co-Investigator(Renkei-kenkyūsha): SADAKATA Tetsushi 独立行政法人理化学研究所, 分子神経形成研究チーム, 基礎科学特別研究員 (90391961) ; SHINODA Yo 独立行政法人理化学研究所, 分子神経形成研究チーム, 研究員 (80403096)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000); Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2009: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2008: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
• Keywords: CAPS2 / 脳由来神経栄養因子 / 有芯小胞 / トランスゴルジ輸送 / 不安行動 / GABA / 抑制性シナプス / 脳由来神経脳栄養因子 / GABA作動性 / small GTPase Arf4/5 / トランスゴルジ網trans-Golgi / BDNF / 分泌 / 長期増強 / 海馬シナプス / 自閉症 / 発達障害 / 有芯性分泌小胞

Research Abstract

We analyzed cellular function and biological significance of secretion-associated protein CAPS and reported the following findings.
1) CAPS2 promotes kinetics of activity-dependent secretion of brain-derived neuotrophic factor BDNF. CAPS2 KO mice have impairments in development and function of GABAergic inhibitory circuits and exhibit increased anxiety-like phenotype.
2) In addition to involvement in exocytosis of dense core vesicles, CAPS associates with small GTPase Arf4/5 and is associated with biogenesis and trafficking of dense-core vesicles in the trans-Golgi network.

Research Products

• [Journal Article] Calcium-dependent activator protein for secretion 2 (CAPS2) promotes BDNF secretion and is critical for the development of GABAergic interneuron network. (2011)
  • Author(s): Shinoda Y., Sadakata T., Nakao K., Katoh-Semba R., Kinameri E., Furuya A., Yanagawa Y., Hirase H., Furuichi T.
  • Journal Title: Proc.Natl.Acad.Sci.U.S.A. 108 Pages: 373-378
  • NAID: 120002771000
  • Peer Reviewed
• [Journal Article] Interaction between very-KIND RasGEF and MAP2, and its role in dendrite growth : structure and function of the second kinase non-catalytic C-lobe domain. (2011)
  • Author(s): Huang J., Furuya A., Hayashi K., Furuichi T.
  • Journal Title: FEBS J 278 Pages: 1651-1661
  • Peer Reviewed
• [Journal Article] Systematizing and cloning of genes involved in the cerebellar cortex circuit development. (2011)
  • Author(s): Furuichi T., Shiraishi-Yamaguchi Y., Sato A., Sadakata T., Huang J., Shinoda Y., Hayashi K., Mishima Y., Tomomura M., Nishibe H., Yoshikawa F.
  • Journal Title: Neurochem Res (In press)
  • Peer Reviewed
• [Journal Article] Interaction of CAPS1 with the class II Arf small GTPases is required for dense-core vesicle trafficking in the trans-Golgi network. (2010)
  • Author(s): Sadakata T., Shinoda Y., Sekine Y., Saruta C., Itakura M., Takahashi M., Furuichi T.
  • Journal Title: J.Biol.Chem 285 Pages: 38710-38719
  • Peer Reviewed
• [Journal Article] Phospholipase D family member 4, a transmembrane glycoprotein with no phospholipase D activity, expression in spleen and early postnatal microglia. (2010)
  • Author(s): Yoshikawa F., Banno Y., Otani Y., Yamaguchi Y., Nagakura-Takagi Y., Morita N., Sato Y., Saruta C., Nishibe H., Sadakata T., Shinoda Y., Hayashi K., Mishima Y., Baba H., Furuichi T.
  • Journal Title: PLoS ONE 5(11)
  • NAID: 120002753724
  • Peer Reviewed
• [Journal Article] Expression of the IP3R1 promoter-driven nls-lacZ transgene in Purkinje cell parasagittal arrays of developing mouse cerebellum. (2010)
  • Author(s): Furutama D., Morita N., Takano R., Sekine Y., Sadakata T., Shinoda Y., Hayashi K., Mishima Y., Mikoshiba K., Hawkes R., Furuichi T.
  • Journal Title: J.Neurosci.Res 88 Pages: 2810-2825
  • Peer Reviewed
• [Journal Article] Ca^<2+>-dependent activator protein for secretion 2 and autistic-like phenotypes. (2010)
  • Author(s): Sadakata T., Furuichi T.
  • Journal Title: Neurosci Res 67 Pages: 197-202
  • Peer Reviewed
• [Journal Article] The RIKEN integrated database of mammals (2010)
  • Author(s): Masuya Hiroshi
  • Journal Title: Nucleic Acids Research Volume: 39
  • Peer Reviewed
• [Journal Article] Phospholipase D Family Member 4, a Transmembrane Glycoprotein with No Phospholipase D Activity Expression in Spleen and Early Postnatal Microglia (2010)
  • Author(s): Yoshikawa Fumio
  • Journal Title: PLoS One Volume: 5
  • Peer Reviewed
• [Journal Article] Caicium-dependent activator protein for secretion 2 (CAPS2) promotes BDNF secretion and is critical for the development of GAB Aergic interneuron network (2010)
  • Author(s): Shinoda Yo
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 108 Pages: 373-378
  • Peer Reviewed
• [Journal Article] Interaction of Calcium-dependent Activator Protein for Secretionl (CAPS1) with the Class II ADP-ribosylation Factor Small GTPases Is Required for Dense-core Vesicle Trafficking in the trans}-Golgi Network (2010)
  • Author(s): Sadakata Tetsushi
  • Journal Title: The Journal of Biological Chemistry Volume: 285 Pages: 38710-38719
  • Peer Reviewed
• [Journal Article] Expression of the IP3R1 Promoter Driven nls-LacZ} Transgene in Purkinje Cell Parasagittal Arrays of Developing Mouse Cerebellum (2010)
  • Author(s): Furutama Daisuke
  • Journal Title: Journal of Neuroscience Research Volume: 88 Pages: 2810-2825
  • Peer Reviewed
• [Journal Article] 有芯小胞の分泌制御因子CAPS2と自閉症感受性 (2010)
  • Author(s): 定方哲史
  • Journal Title: 実験医学 (印刷中)
• [Journal Article] 自閉症の感受性候補遺伝子と動物モデル (2010)
  • Author(s): 篠田陽
  • Journal Title: 脳と精神の医学 (印刷中)
  • NAID: 10028262699
• [Journal Article] Interaction of Cupidin/Homer2 with two actin cytoskeletal regulators, Cdc42 small GTPase and Drebrin, in dendritic spines. (2009)
  • Author(s): Shiraishi-Yamaguchi Y., Sato Y., Sakai R., Mizutani A., Knopfel T., Mori N., Mikoshiba K., Furuichi T.
  • Journal Title: BMC Neuroscience 10 Pages: 25-25
  • NAID: 120006984146
  • Peer Reviewed
• [Journal Article] Developmentally regulated Ca2+-dependent activator protein for secretion 2 (CAPS2) is involved in BDNF secretion and is associated with autism susceptibility. (2009)
  • Author(s): Sadakata T., Furuichi T.
  • Journal Title: Cerebellum 8 Pages: 312-322
  • Peer Reviewed
• [Journal Article] Developmentally regulated Ca^<2+>-dependent activator protein for secretion 2(CAPS2)is involved in BDNF secretion and is associated with autism susceptibility (2009)
  • Author(s): 定方哲史
  • Journal Title: Cerebellum 8巻 Pages: 312-322
  • Peer Reviewed
• [Journal Article] Interaction of Cupidin/Homer2 with two actin cytoskeletal regulators, Cdc42 small GTPase and Drebrin, in dendritic spines (2009)
  • Author(s): Shiraishi-Yamaguchi, Y.
  • Journal Title: BMC Neurosci. 10巻 Pages: 25-25
  • Peer Reviewed
• [Journal Article] DSCAM deficiency causes loss of pre-inspiratory neuron synchroneity and perinatal death (2009)
  • Author(s): Amano, K.
  • Journal Title: J.Neurosci. 29巻 Pages: 2984-2996
  • Peer Reviewed
• [Journal Article] CADPS2と自閉症感受性 (2009)
  • Author(s): 定方哲史
  • Journal Title: 分子精神医学 9巻, 3号 Pages: 16-22
• [Journal Article] Opalin, a transmembrane sialylglycoprotein located in the CNS myelin paranodal loop membrane. (2008)
  • Author(s): Yoshikawa F., Sato Y., Tohyama K., Akagi T., Hashikawa T., Nagakura-Takagi Y., Sekine Y., Morita N., Baba H., Suzuki Y., Sugano S., Sato A., Furuichi T.
  • Journal Title: J.Biol.Chem 283 Pages: 20830-20840
  • Peer Reviewed
• [Journal Article] Cerebellar Development Transcriptome Database (CDT-DB) : profiling of spatio-temporal gene expression during the postnatal development of mouse cerebellum. (2008)
  • Author(s): Sato A., Sekine Y., Saruta C., Nishibe H., Morita N., Sato Y., Sadakata T., Shinoda Y., Kojima T., Furuichi T.
  • Journal Title: Neural Networks 21 Pages: 1056-1069
  • Peer Reviewed
• [Journal Article] Palmitoylation-dependent endosomal localization of AATYK1A and its interaction with Src (2008)
  • Author(s): Tsutsumi K.
  • Journal Title: Genes Cells 13巻 Pages: 949-964
  • Peer Reviewed
• [Journal Article] Opalin, a Transmembrane Sialylglycoprotein Located in the Central Nervous System Myelin Paranodal Loop Membrane (2008)
  • Author(s): Yoshikawa F.
  • Journal Title: J. Biol. Chem. 283巻 Pages: 20830-20840
  • Peer Reviewed
• [Journal Article] Cerebellar development transcriptome database (CDT-DB) : Profiling of spatio-temporal gene expression during the postnatal development of mouse cerebellum (2008)
  • Author(s): Sato A.
  • Journal Title: Neural Networks 21巻 Pages: 1056-1069
  • Peer Reviewed
• [Journal Article] Japanese neuroinformatics node and platforms (2008)
  • Author(s): Usui S.
  • Journal Title: Lect. Notes Comput. Sci. 4985巻 Pages: 884-894
• [Journal Article] Phosphorylation of Homer3 by Calcium/Calmodulin-Dependent Kinase II Regulates a Coupling State of Its Target Molecules in Purkinje Cells (2008)
  • Author(s): Mizutani A.
  • Journal Title: J. Neurosci. 28巻 Pages: 5369-5382
  • Peer Reviewed
• [Journal Article] CADPS2 (2008)
  • Author(s): 定方哲史
  • Journal Title: 分子精神医学 8巻 Pages: 150-151
• [Journal Article] 自閉症の遺伝要因とCAPS2遺伝子 (2008)
  • Author(s): 定方哲史
  • Journal Title: 実験医学 26巻 Pages: 2015-2023
• [Journal Article] 自閉症と感受性候補遺伝子CADPS2 (2008)
  • Author(s): 古市貞一
  • Journal Title: 生体の科学 59巻 Pages: 476-477
• [Journal Article] Phase advance of the light-dark cycle perturbs diurnal rhythms of brain-derived neurotrophic factor and neurotrophin-3 levels, which reduces synaptophysin-positive presynaptic terminals in the cortex of juvenile rats.
  • Author(s): Hamatake M., Miyazaki N., Sudo K., Matsuda M., Sadakata T., Furuya A., Ichisaka S., Hata Y., Nakagawa C., Nagata K., Furuichi T., Katoh-Semba R.
  • Journal Title: J.Biol.Chem (in press)
  • Peer Reviewed
• [Presentation] Enhanced secretion of BDNF by CAPS2 is critical for proper brain development and function. (2011)
  • Author(s): 古市貞一
  • Organizer: International Workshop in UOEH 2011 "Calcium dynamics in cells"
  • Place of Presentation: Kitakyushu, Japan
  • Year and Date: 2011-01-21
• [Presentation] Enhanced secretion of BDNF by CAPS2 is critical for proper brain development and function (2011)
  • Author(s): Furuichi Teiichi
  • Organizer: Calcium Dynamics in Cells
  • Place of Presentation: Kitakyuusyu Japan
  • Year and Date: 2011-01-21
• [Presentation] 理研哺乳類統合データベース (2010)
  • Author(s): 桝屋啓志
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会(BMB2010)
  • Place of Presentation: 神戸 日本
  • Year and Date: 2010-12-10
• [Presentation] The development of the integrated database of mammals in RIKEN (2010)
  • Author(s): Masuya Hiroshi
  • Organizer: 24th International Mammalian Genome Conference (IMGC2010)
  • Place of Presentation: Crete Greece
  • Year and Date: 2010-10-05
• [Presentation] Increased expression of a rare alternative splicing CAPS2/CADPS2 variant in autism. (2010)
  • Author(s): 古市貞一
  • Organizer: XVIIIth World Congress on Psychiatric Genetics
  • Place of Presentation: Athens, Greece
• [Presentation] 泌小胞関連タンパク質CAPS2による神経栄養因子BDNF分泌の速度論的増強:KOマウスにおけるBDNFの減少、海馬GABAニューロンの発達異常、および不安様行動の増加 (2010)
  • Author(s): 篠田陽
  • Organizer: 第87回日本生理学会大会
  • Place of Presentation: 盛岡 日本
• [Presentation] 脳特異的に発現するRasGEF, very-KINDの樹状突起形成における機能解析 (2010)
  • Author(s): 林周宏
  • Organizer: 第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会合同大会(Neuro2010)
  • Place of Presentation: 神戸 日本
• [Presentation] LacZ複合遺伝子を導入したマウスでの小脳縦縞コンパートメント構造の発達 (2010)
  • Author(s): 藤田啓史
  • Organizer: 第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会合同大会(Neuro2010)
  • Place of Presentation: 神戸 日本
• [Presentation] 分泌小胞関連タンパク質CAPS2による神経栄養因子BDNF分泌制御のイメージング解析 (2010)
  • Author(s): 篠田陽
  • Organizer: 第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会合同大会(Neuro2010)
  • Place of Presentation: 神戸 日本
• [Presentation] CAPS2のエクソン3スキップマウスは自閉症様形質を示す (2010)
  • Author(s): 定方哲史
  • Organizer: 第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会合同大会(Neuro2010)
  • Place of Presentation: 神戸 日本
• [Presentation] 貪食細胞の貪食にはPLD4が関与する (2010)
  • Author(s): 大谷嘉典
  • Organizer: 第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会合同大会(Neuro2010)
  • Place of Presentation: 神戸 日本
• [Presentation] Amphotericin Bによる培養アストロサイトの活性化について:NOおよびサイトカイン産生の誘導と神経栄養因子産生の変化 (2010)
  • Author(s): 本吉晃子
  • Organizer: 第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会合同大会(Neuro2010)
  • Place of Presentation: 神戸 日本
• [Presentation] Genes and trascriptome underlying postnatal development of the mouse cerebellum (2010)
  • Author(s): Furuichi Tei-ichi
  • Organizer: 40th Annual Meeting of the Society for Neuroscience (Neuroscience 2010)
  • Place of Presentation: San Diego USA
• [Presentation] (Demo for SfN2010) INCF Japan-node and platforms : neuroimaging platform, cerebellar development transcriptome database, and simulation platform (2010)
  • Author(s): Nota Y
  • Organizer: 40th Annual Meeting of the Society for Neuroscience (Neuroscience 2010)
  • Place of Presentation: San Diego USA
• [Presentation] Increased expression of a rare alternative splicing CAPS2/CADPS2 variant in autism (2010)
  • Author(s): Furuichi Tei-ichi
  • Organizer: 18th World Congress on Psychiatric Genetics
  • Place of Presentation: Athens Greece
• [Presentation] Autistic-like phenotypes in CAPS2 exon 3-skipped mice (2010)
  • Author(s): Sadakata Tetsushi
  • Organizer: 18th World Congress on Psychiatric Genetics
  • Place of Presentation: Athens Greece
• [Presentation] Alternative Splicing as a Mechanism for Psychiatric Disorders (2010)
  • Author(s): Furuichi Tei-ichi
  • Organizer: 18th World Congress on Psychiatric Genetics
  • Place of Presentation: Athens Greece
• [Presentation] Application of target enrichment and massively parallel sequencing to mutation screening of autism (2009)
  • Author(s): 足立直樹
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜(神奈川県)
  • Year and Date: 2009-12-10
• [Presentation] 神経回路の発達と機能に必要なCAPS2の遺伝子欠損マウスは社会性相互作用の障害と不安行動の増加を示す (2009)
  • Author(s): 古市貞一
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜(神奈川県)
  • Year and Date: 2009-12-10
• [Presentation] CAPS and ARFs are associated with dense-core vesicle biogenesis from the Golgi complex (2009)
  • Author(s): 定方哲史
  • Organizer: 6th Japan-Korea Conference on Cellular Signaling for Young Scientists
  • Place of Presentation: Sasebo Nagasaki
  • Year and Date: 2009-11-24
• [Presentation] CAPS1とクラス2ARFはゴルジ体における有芯小胞の生成に関わる (2009)
  • Author(s): 定方哲史
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸市(兵庫県)
  • Year and Date: 2009-10-23
• [Presentation] CAPS2タンパク質による有芯小胞分泌経路の制御と発達障害の感受性 (2009)
  • Author(s): 古市貞一
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸市(兵庫県)
  • Year and Date: 2009-10-21
• [Presentation] Secretory vesicle-related gene CAPS2 knock-out mice exhibit the reduced number of hippocampal GABAergic interneuron and the impairments in synaptic plasticity and behavior (2009)
  • Author(s): Shinoda Yo
  • Organizer: 39th Annual Meeting of the Society for Neuroscience(Neuroscience 2009)
  • Place of Presentation: Chicago USA
  • Year and Date: 2009-10-20
• [Presentation] Brain specific RasGEF, v-KIND regulates dendrite arborization (2009)
  • Author(s): Hayashi Kanehiro
  • Organizer: 39th Annual Meeting of the Society for Neuroscience(Neuroscience 2009)
  • Place of Presentation: Chicago USA
  • Year and Date: 2009-10-19
• [Presentation] 分泌関連Ca^<2+>依存性活性化タンパク質2(CAPS2)と自閉症感受性 (2009)
  • Author(s): 古市貞一
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋(愛知県)
  • Year and Date: 2009-09-18
• [Presentation] ペプチドを含む有芯小胞は Golgi 体よりいかにして生まれるか (2009)
  • Author(s): 定方哲史
  • Organizer: 第36回日本神経内分泌学会
  • Place of Presentation: 北九州市(福岡県)
  • Year and Date: 2009-09-04
• [Presentation] 神経発達障害のモデルマウスと環境-遺伝子相互作用 (2009)
  • Author(s): 古市貞一
  • Organizer: 脳を巡る環境-遺伝子相互作用の分子基盤シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2009-08-29
• [Presentation] 神経発達障害のモデルマウスと環境-遺伝子相互作用 (2009)
  • Author(s): 古市貞一
  • Organizer: 「脳を巡る環境-遺伝子相互作用の分子基盤」シンポジウム
  • Place of Presentation: 東京都
  • Year and Date: 2009-08-29
• [Presentation] Vesicle associated protein CAPS2 KO mice show impaired synapse function of hippocampus and exhibit depression-like behavior (2009)
  • Author(s): Shinoda Yo
  • Organizer: 36th Congress of the International Union of Physiological Sciences(IUPS2009)
  • Place of Presentation: Kyoto-city Kyoto
  • Year and Date: 2009-08-01
• [Presentation] マウス小脳発達トランスクリプトーム解析:小脳神経回路発達の遺伝基盤の解明に向けて (2009)
  • Author(s): 林周宏
  • Organizer: 第52回日本神経化学会大会
  • Place of Presentation: 伊香保(群馬県)
  • Year and Date: 2009-06-23
• [Presentation] Neurotrophin secretion (2009)
  • Author(s): 古市貞一
  • Organizer: Gordon Research Conferences on Neurotrophic Factors
  • Place of Presentation: Newport, RI, USA
  • Year and Date: 2009-06-21
• [Presentation] マウス小脳発達トランスクリプトームデータベースCDT-DB (2009)
  • Author(s): 古市貞一
  • Organizer: 文部科学省 統合データベースプロジェクトシンポジウム「データベースが拓くこれからのライフサイエンス」
  • Place of Presentation: 東京都
  • Year and Date: 2009-06-12
• [Presentation] Ca^<2+>依存性活性化分泌関連タンパク質CAPS2は正常な脳の発達と行動に必須な役割を果たす (2009)
  • Author(s): 古市貞一
  • Organizer: 第61回日本細胞生物学会大会
  • Place of Presentation: 名古屋市(愛知県)
  • Year and Date: 2009-06-02
• [Presentation] 分泌関連Ca^<2+>依存性活性化タンパク質2(CAPS2/CADPS2)と社会性行動形質 (2009)
  • Author(s): 古市貞一
  • Organizer: 行動遺伝学研究会(国立遺伝学研究所)
  • Place of Presentation: 三島
  • Year and Date: 2009-03-12
• [Presentation] 神経回路の発達と機能に必要なCAPS2の遺伝子欠損マウスは社会性相互作用の障害と不安行動の増加を示す (2009)
  • Author(s): 古市貞一、定方哲史、篠田陽、仙波りつ子
  • Organizer: 第32回日本分子生物学会年会・シンポジウム
  • Place of Presentation: 横浜
• [Presentation] CAPS2タンパク質による有芯小胞分泌経路の制御と発達障害の感受性 (2009)
  • Author(s): 古市貞一、定方哲史、篠田陽、仙波りつ子
  • Organizer: 第82回日本生化学会大会・シンポジウム
  • Place of Presentation: 神戸
• [Presentation] 分泌関連Ca2+依存性活性化タンパク質2(CAPS2)と自閉症感受性 (2009)
  • Author(s): 古市貞一
  • Organizer: 第32回日本神経科学大会・シンポジウム
  • Place of Presentation: 名古屋
• [Presentation] Neurotrophin secretion. (2009)
  • Author(s): 古市貞一
  • Organizer: Gordon Research Conferences on Neurotrophic Factors
  • Place of Presentation: Newport, RI, USA
• [Presentation] Ca^<2+>依存性活性化分泌関連タンパク質CAPS2は正常な脳の発達と行動に必須な役割を果たす (2009)
  • Author(s): 古市貞一、定方哲史、篠田陽
  • Organizer: 第61回日本細胞生物学会大会・シンポジウム
  • Place of Presentation: 名古屋
• [Presentation] 脳の発達とその障害の遺伝基盤:CAPS2によるBDNF分泌調節と自閉症感受性 (2008)
  • Author(s): 古市貞一
  • Organizer: 第18回脳・ライフ研シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2008-10-17
• [Presentation] CAPS2に依存したBDNF分泌の欠損は自閉症感受性と関連する (2008)
  • Author(s): 古市貞一、定方哲史、篠田陽
  • Organizer: 第31回日本神経科学大会・シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2008-07-09
• [Presentation] Regulated secretion in relation to autism. (2008)
  • Author(s): 古市貞一
  • Organizer: Gordon Research Conferences on Proprotein Processing, Trafficking and Secretion
  • Place of Presentation: New London, NH, USA
• [Presentation] Purkinje 細胞における Homer 3のリン酸化 (2008)
  • Author(s): 水谷顕洋
  • Organizer: 第31回日本神経科学大会(Neuroscience 2008)
  • Place of Presentation: 東京
• [Presentation] Regulated secretion in relation to autism (2008)
  • Author(s): 古市貞一
  • Organizer: 2008 Gordon Research Conferences on Proprotein Processing, Trafficking and Secretion
  • Place of Presentation: New London USA
• [Presentation] CAPS2に依存したBDNF分泌の欠損は自閉症感受性と関連する (2008)
  • Author(s): 古市貞一
  • Organizer: 第31回日本神経科学大会(Neuroscience 2008
  • Place of Presentation: 東京
• [Presentation] 分泌小胞会合タンパク質CAPS2の海馬LTPへの寄与 (2008)
  • Author(s): 篠田陽
  • Organizer: 第31回日本神経科学大会(Neuroscience 2008)
  • Place of Presentation: 東京
• [Presentation] The functional analyses of CAPS family proteins (2008)
  • Author(s): 定方哲史
  • Organizer: 第31回日本神経科学大会(Neuroscience 2008)
  • Place of Presentation: 東京
• [Presentation] Regulation of endosomal localization of AATYK1A and its interaction with Src by palmitoylation (2008)
  • Author(s): Tsutsumi K.
  • Organizer: 第51回日本神経化学会大会
  • Place of Presentation: 富山
• [Presentation] Analysis of the Expression of PLD4 in the early postnatal mouse cerebellum (2008)
  • Author(s): Otani Y.
  • Organizer: 第51回日本神経化学会大会
  • Place of Presentation: 富山
• [Presentation] 脳研究分野におけるデータベースの整備とその活用 (2008)
  • Author(s): 古市貞一
  • Organizer: 理研ライフサイエンス系総合データベースの整備と戦略的研究-大規模情報の活用とチャンス発見の情報テクノロジ-
  • Place of Presentation: 北杜
• [Presentation] Electropyhsiological and behavioral analysis of CAPS2 in mouse hippocampus (2008)
  • Author(s): Shinoda Y.
  • Organizer: 38th Annual Meeting of Society for Neuroscience (Neuroscience 2008)
  • Place of Presentation: Washington DC, USA
• [Presentation] Interaction of very-KIND RasGEF with MAP2 regulates dendrite growth (2008)
  • Author(s): Furuichi T.
  • Organizer: 38th Annual Meeting of Society for Neuroscience (Neuroscience 2008)
  • Place of Presentation: Washington DC, USA
• [Presentation] CAPS2 function in dense-core vesicle trafficking (2008)
  • Author(s): 定方哲史
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会(BMB2008)
  • Place of Presentation: 神戸
• [Book] 有芯小胞の分泌制御因子CAPS2と自閉症感受性(Vol.28No.5) (2010)
  • Author(s): 定方哲史、篠田陽、林周宏、古市貞一
  • Publisher: 実験医学増刊号(羊土社)
• [Book] 自閉症の感受性候補遺伝子と動物モデル(Vol.20No.4) (2010)
  • Author(s): 篠田陽、定方哲史、林周宏、古市貞一
  • Publisher: 脳と精神の医学(新興医学出版社)
• [Book] 自閉症と感受性候補遺伝子CADPS2生体の科学(Vol.50No9) (2008)
  • Author(s): 古市貞一
  • Publisher: 医学書院
• [Book] 自閉症の遺伝要因とCAPS2遺伝子実験医学増刊号(Vol.26No.12) (2008)
  • Author(s): 定方哲史、篠田陽、古市貞一
  • Publisher: 羊土社
• [Book] CADPS2分子精神医学(Vol8No.2) (2008)
  • Author(s): 定方哲史、古市貞一
  • Publisher: 先端医学社
• [Book] シリーズ脳科学(甘利俊一監修)(分子・細胞・シナプスからみる脳) (2008)
  • Author(s): 古市貞一(編集)
  • Publisher: 東京大学出版会
• [Remarks] ホームページ等
• [Remarks]
  • URL: http://www.brain.riken.go.jp/labs/lmn/indexj.html
• [Remarks]
  • URL: http://www.brain.riken.go.jp/jp/t_furuichi.html