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Regulatory mechanism and cellular dynamics of exocytosis of BDNF-containing secretory vesicles by CAPS2

Research Project

Project/Area Number 20300134
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

FURUICHI Tei-Ichi  The Institute of Physical and Chemical Research, 分子神経形成研究チーム, チームリーダー (50219094)

Co-Investigator(Renkei-kenkyūsha) SADAKATA Tetsushi  独立行政法人理化学研究所, 分子神経形成研究チーム, 基礎科学特別研究員 (90391961)
SHINODA Yo  独立行政法人理化学研究所, 分子神経形成研究チーム, 研究員 (80403096)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2009: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2008: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
KeywordsCAPS2 / 脳由来神経栄養因子 / 有芯小胞 / トランスゴルジ輸送 / 不安行動 / GABA / 抑制性シナプス / 脳由来神経脳栄養因子 / GABA作動性 / small GTPase Arf4/5 / トランスゴルジ網trans-Golgi / BDNF / 分泌 / 長期増強 / 海馬シナプス / 自閉症 / 発達障害 / 有芯性分泌小胞
Research Abstract

We analyzed cellular function and biological significance of secretion-associated protein CAPS and reported the following findings.
1) CAPS2 promotes kinetics of activity-dependent secretion of brain-derived neuotrophic factor BDNF. CAPS2 KO mice have impairments in development and function of GABAergic inhibitory circuits and exhibit increased anxiety-like phenotype.
2) In addition to involvement in exocytosis of dense core vesicles, CAPS associates with small GTPase Arf4/5 and is associated with biogenesis and trafficking of dense-core vesicles in the trans-Golgi network.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (93 results)

All 2011 2010 2009 2008 Other

All Journal Article (31 results) (of which Peer Reviewed: 24 results) Presentation (53 results) Book (6 results) Remarks (3 results)

  • [Journal Article] Calcium-dependent activator protein for secretion 2 (CAPS2) promotes BDNF secretion and is critical for the development of GABAergic interneuron network.2011

    • Author(s)
      Shinoda Y., Sadakata T., Nakao K., Katoh-Semba R., Kinameri E., Furuya A., Yanagawa Y., Hirase H., Furuichi T.
    • Journal Title

      Proc.Natl.Acad.Sci.U.S.A. 108

      Pages: 373-378

    • NAID

      120002771000

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interaction between very-KIND RasGEF and MAP2, and its role in dendrite growth : structure and function of the second kinase non-catalytic C-lobe domain.2011

    • Author(s)
      Huang J., Furuya A., Hayashi K., Furuichi T.
    • Journal Title

      FEBS J 278

      Pages: 1651-1661

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Systematizing and cloning of genes involved in the cerebellar cortex circuit development.2011

    • Author(s)
      Furuichi T., Shiraishi-Yamaguchi Y., Sato A., Sadakata T., Huang J., Shinoda Y., Hayashi K., Mishima Y., Tomomura M., Nishibe H., Yoshikawa F.
    • Journal Title

      Neurochem Res (In press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interaction of CAPS1 with the class II Arf small GTPases is required for dense-core vesicle trafficking in the trans-Golgi network.2010

    • Author(s)
      Sadakata T., Shinoda Y., Sekine Y., Saruta C., Itakura M., Takahashi M., Furuichi T.
    • Journal Title

      J.Biol.Chem 285

      Pages: 38710-38719

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phospholipase D family member 4, a transmembrane glycoprotein with no phospholipase D activity, expression in spleen and early postnatal microglia.2010

    • Author(s)
      Yoshikawa F., Banno Y., Otani Y., Yamaguchi Y., Nagakura-Takagi Y., Morita N., Sato Y., Saruta C., Nishibe H., Sadakata T., Shinoda Y., Hayashi K., Mishima Y., Baba H., Furuichi T.
    • Journal Title

      PLoS ONE 5(11)

    • NAID

      120002753724

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of the IP3R1 promoter-driven nls-lacZ transgene in Purkinje cell parasagittal arrays of developing mouse cerebellum.2010

    • Author(s)
      Furutama D., Morita N., Takano R., Sekine Y., Sadakata T., Shinoda Y., Hayashi K., Mishima Y., Mikoshiba K., Hawkes R., Furuichi T.
    • Journal Title

      J.Neurosci.Res 88

      Pages: 2810-2825

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ca^<2+>-dependent activator protein for secretion 2 and autistic-like phenotypes.2010

    • Author(s)
      Sadakata T., Furuichi T.
    • Journal Title

      Neurosci Res 67

      Pages: 197-202

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The RIKEN integrated database of mammals2010

    • Author(s)
      Masuya Hiroshi
    • Journal Title

      Nucleic Acids Research

      Volume: 39

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phospholipase D Family Member 4, a Transmembrane Glycoprotein with No Phospholipase D Activity Expression in Spleen and Early Postnatal Microglia2010

    • Author(s)
      Yoshikawa Fumio
    • Journal Title

      PLoS One

      Volume: 5

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Caicium-dependent activator protein for secretion 2 (CAPS2) promotes BDNF secretion and is critical for the development of GAB Aergic interneuron network2010

    • Author(s)
      Shinoda Yo
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America

      Volume: 108 Pages: 373-378

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interaction of Calcium-dependent Activator Protein for Secretionl (CAPS1) with the Class II ADP-ribosylation Factor Small GTPases Is Required for Dense-core Vesicle Trafficking in the trans}-Golgi Network2010

    • Author(s)
      Sadakata Tetsushi
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 285 Pages: 38710-38719

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of the IP3R1 Promoter Driven nls-LacZ} Transgene in Purkinje Cell Parasagittal Arrays of Developing Mouse Cerebellum2010

    • Author(s)
      Furutama Daisuke
    • Journal Title

      Journal of Neuroscience Research

      Volume: 88 Pages: 2810-2825

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 有芯小胞の分泌制御因子CAPS2と自閉症感受性2010

    • Author(s)
      定方哲史
    • Journal Title

      実験医学 (印刷中)

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 自閉症の感受性候補遺伝子と動物モデル2010

    • Author(s)
      篠田陽
    • Journal Title

      脳と精神の医学 (印刷中)

    • NAID

      10028262699

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Interaction of Cupidin/Homer2 with two actin cytoskeletal regulators, Cdc42 small GTPase and Drebrin, in dendritic spines.2009

    • Author(s)
      Shiraishi-Yamaguchi Y., Sato Y., Sakai R., Mizutani A., Knopfel T., Mori N., Mikoshiba K., Furuichi T.
    • Journal Title

      BMC Neuroscience 10

      Pages: 25-25

    • NAID

      120006984146

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Developmentally regulated Ca2+-dependent activator protein for secretion 2 (CAPS2) is involved in BDNF secretion and is associated with autism susceptibility.2009

    • Author(s)
      Sadakata T., Furuichi T.
    • Journal Title

      Cerebellum 8

      Pages: 312-322

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Developmentally regulated Ca^<2+>-dependent activator protein for secretion 2(CAPS2)is involved in BDNF secretion and is associated with autism susceptibility2009

    • Author(s)
      定方哲史
    • Journal Title

      Cerebellum 8巻

      Pages: 312-322

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interaction of Cupidin/Homer2 with two actin cytoskeletal regulators, Cdc42 small GTPase and Drebrin, in dendritic spines2009

    • Author(s)
      Shiraishi-Yamaguchi, Y.
    • Journal Title

      BMC Neurosci. 10巻

      Pages: 25-25

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DSCAM deficiency causes loss of pre-inspiratory neuron synchroneity and perinatal death2009

    • Author(s)
      Amano, K.
    • Journal Title

      J.Neurosci. 29巻

      Pages: 2984-2996

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CADPS2と自閉症感受性2009

    • Author(s)
      定方哲史
    • Journal Title

      分子精神医学 9巻, 3号

      Pages: 16-22

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Opalin, a transmembrane sialylglycoprotein located in the CNS myelin paranodal loop membrane.2008

    • Author(s)
      Yoshikawa F., Sato Y., Tohyama K., Akagi T., Hashikawa T., Nagakura-Takagi Y., Sekine Y., Morita N., Baba H., Suzuki Y., Sugano S., Sato A., Furuichi T.
    • Journal Title

      J.Biol.Chem 283

      Pages: 20830-20840

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cerebellar Development Transcriptome Database (CDT-DB) : profiling of spatio-temporal gene expression during the postnatal development of mouse cerebellum.2008

    • Author(s)
      Sato A., Sekine Y., Saruta C., Nishibe H., Morita N., Sato Y., Sadakata T., Shinoda Y., Kojima T., Furuichi T.
    • Journal Title

      Neural Networks 21

      Pages: 1056-1069

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Palmitoylation-dependent endosomal localization of AATYK1A and its interaction with Src2008

    • Author(s)
      Tsutsumi K.
    • Journal Title

      Genes Cells 13巻

      Pages: 949-964

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Opalin, a Transmembrane Sialylglycoprotein Located in the Central Nervous System Myelin Paranodal Loop Membrane2008

    • Author(s)
      Yoshikawa F.
    • Journal Title

      J. Biol. Chem. 283巻

      Pages: 20830-20840

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cerebellar development transcriptome database (CDT-DB) : Profiling of spatio-temporal gene expression during the postnatal development of mouse cerebellum2008

    • Author(s)
      Sato A.
    • Journal Title

      Neural Networks 21巻

      Pages: 1056-1069

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Japanese neuroinformatics node and platforms2008

    • Author(s)
      Usui S.
    • Journal Title

      Lect. Notes Comput. Sci. 4985巻

      Pages: 884-894

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Phosphorylation of Homer3 by Calcium/Calmodulin-Dependent Kinase II Regulates a Coupling State of Its Target Molecules in Purkinje Cells2008

    • Author(s)
      Mizutani A.
    • Journal Title

      J. Neurosci. 28巻

      Pages: 5369-5382

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CADPS22008

    • Author(s)
      定方哲史
    • Journal Title

      分子精神医学 8巻

      Pages: 150-151

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 自閉症の遺伝要因とCAPS2遺伝子2008

    • Author(s)
      定方哲史
    • Journal Title

      実験医学 26巻

      Pages: 2015-2023

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 自閉症と感受性候補遺伝子CADPS22008

    • Author(s)
      古市貞一
    • Journal Title

      生体の科学 59巻

      Pages: 476-477

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Phase advance of the light-dark cycle perturbs diurnal rhythms of brain-derived neurotrophic factor and neurotrophin-3 levels, which reduces synaptophysin-positive presynaptic terminals in the cortex of juvenile rats.

    • Author(s)
      Hamatake M., Miyazaki N., Sudo K., Matsuda M., Sadakata T., Furuya A., Ichisaka S., Hata Y., Nakagawa C., Nagata K., Furuichi T., Katoh-Semba R.
    • Journal Title

      J.Biol.Chem (in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] Enhanced secretion of BDNF by CAPS2 is critical for proper brain development and function.2011

    • Author(s)
      古市貞一
    • Organizer
      International Workshop in UOEH 2011 "Calcium dynamics in cells"
    • Place of Presentation
      Kitakyushu, Japan
    • Year and Date
      2011-01-21
    • Related Report
      2010 Final Research Report
  • [Presentation] Enhanced secretion of BDNF by CAPS2 is critical for proper brain development and function2011

    • Author(s)
      Furuichi Teiichi
    • Organizer
      Calcium Dynamics in Cells
    • Place of Presentation
      Kitakyuusyu Japan
    • Year and Date
      2011-01-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 理研哺乳類統合データベース2010

    • Author(s)
      桝屋啓志
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会(BMB2010)
    • Place of Presentation
      神戸 日本
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] The development of the integrated database of mammals in RIKEN2010

    • Author(s)
      Masuya Hiroshi
    • Organizer
      24th International Mammalian Genome Conference (IMGC2010)
    • Place of Presentation
      Crete Greece
    • Year and Date
      2010-10-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] Increased expression of a rare alternative splicing CAPS2/CADPS2 variant in autism.2010

    • Author(s)
      古市貞一
    • Organizer
      XVIIIth World Congress on Psychiatric Genetics
    • Place of Presentation
      Athens, Greece
    • Related Report
      2010 Final Research Report
  • [Presentation] 泌小胞関連タンパク質CAPS2による神経栄養因子BDNF分泌の速度論的増強:KOマウスにおけるBDNFの減少、海馬GABAニューロンの発達異常、および不安様行動の増加2010

    • Author(s)
      篠田陽
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡 日本
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脳特異的に発現するRasGEF, very-KINDの樹状突起形成における機能解析2010

    • Author(s)
      林周宏
    • Organizer
      第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会合同大会(Neuro2010)
    • Place of Presentation
      神戸 日本
    • Related Report
      2010 Annual Research Report
  • [Presentation] LacZ複合遺伝子を導入したマウスでの小脳縦縞コンパートメント構造の発達2010

    • Author(s)
      藤田啓史
    • Organizer
      第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会合同大会(Neuro2010)
    • Place of Presentation
      神戸 日本
    • Related Report
      2010 Annual Research Report
  • [Presentation] 分泌小胞関連タンパク質CAPS2による神経栄養因子BDNF分泌制御のイメージング解析2010

    • Author(s)
      篠田陽
    • Organizer
      第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会合同大会(Neuro2010)
    • Place of Presentation
      神戸 日本
    • Related Report
      2010 Annual Research Report
  • [Presentation] CAPS2のエクソン3スキップマウスは自閉症様形質を示す2010

    • Author(s)
      定方哲史
    • Organizer
      第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会合同大会(Neuro2010)
    • Place of Presentation
      神戸 日本
    • Related Report
      2010 Annual Research Report
  • [Presentation] 貪食細胞の貪食にはPLD4が関与する2010

    • Author(s)
      大谷嘉典
    • Organizer
      第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会合同大会(Neuro2010)
    • Place of Presentation
      神戸 日本
    • Related Report
      2010 Annual Research Report
  • [Presentation] Amphotericin Bによる培養アストロサイトの活性化について:NOおよびサイトカイン産生の誘導と神経栄養因子産生の変化2010

    • Author(s)
      本吉晃子
    • Organizer
      第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会合同大会(Neuro2010)
    • Place of Presentation
      神戸 日本
    • Related Report
      2010 Annual Research Report
  • [Presentation] Genes and trascriptome underlying postnatal development of the mouse cerebellum2010

    • Author(s)
      Furuichi Tei-ichi
    • Organizer
      40th Annual Meeting of the Society for Neuroscience (Neuroscience 2010)
    • Place of Presentation
      San Diego USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] (Demo for SfN2010) INCF Japan-node and platforms : neuroimaging platform, cerebellar development transcriptome database, and simulation platform2010

    • Author(s)
      Nota Y
    • Organizer
      40th Annual Meeting of the Society for Neuroscience (Neuroscience 2010)
    • Place of Presentation
      San Diego USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Increased expression of a rare alternative splicing CAPS2/CADPS2 variant in autism2010

    • Author(s)
      Furuichi Tei-ichi
    • Organizer
      18th World Congress on Psychiatric Genetics
    • Place of Presentation
      Athens Greece
    • Related Report
      2010 Annual Research Report
  • [Presentation] Autistic-like phenotypes in CAPS2 exon 3-skipped mice2010

    • Author(s)
      Sadakata Tetsushi
    • Organizer
      18th World Congress on Psychiatric Genetics
    • Place of Presentation
      Athens Greece
    • Related Report
      2010 Annual Research Report
  • [Presentation] Alternative Splicing as a Mechanism for Psychiatric Disorders2010

    • Author(s)
      Furuichi Tei-ichi
    • Organizer
      18th World Congress on Psychiatric Genetics
    • Place of Presentation
      Athens Greece
    • Related Report
      2010 Annual Research Report
  • [Presentation] Application of target enrichment and massively parallel sequencing to mutation screening of autism2009

    • Author(s)
      足立直樹
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜(神奈川県)
    • Year and Date
      2009-12-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 神経回路の発達と機能に必要なCAPS2の遺伝子欠損マウスは社会性相互作用の障害と不安行動の増加を示す2009

    • Author(s)
      古市貞一
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜(神奈川県)
    • Year and Date
      2009-12-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] CAPS and ARFs are associated with dense-core vesicle biogenesis from the Golgi complex2009

    • Author(s)
      定方哲史
    • Organizer
      6th Japan-Korea Conference on Cellular Signaling for Young Scientists
    • Place of Presentation
      Sasebo Nagasaki
    • Year and Date
      2009-11-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] CAPS1とクラス2ARFはゴルジ体における有芯小胞の生成に関わる2009

    • Author(s)
      定方哲史
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸市(兵庫県)
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] CAPS2タンパク質による有芯小胞分泌経路の制御と発達障害の感受性2009

    • Author(s)
      古市貞一
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸市(兵庫県)
    • Year and Date
      2009-10-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] Secretory vesicle-related gene CAPS2 knock-out mice exhibit the reduced number of hippocampal GABAergic interneuron and the impairments in synaptic plasticity and behavior2009

    • Author(s)
      Shinoda Yo
    • Organizer
      39th Annual Meeting of the Society for Neuroscience(Neuroscience 2009)
    • Place of Presentation
      Chicago USA
    • Year and Date
      2009-10-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] Brain specific RasGEF, v-KIND regulates dendrite arborization2009

    • Author(s)
      Hayashi Kanehiro
    • Organizer
      39th Annual Meeting of the Society for Neuroscience(Neuroscience 2009)
    • Place of Presentation
      Chicago USA
    • Year and Date
      2009-10-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 分泌関連Ca^<2+>依存性活性化タンパク質2(CAPS2)と自閉症感受性2009

    • Author(s)
      古市貞一
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋(愛知県)
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] ペプチドを含む有芯小胞は Golgi 体よりいかにして生まれるか2009

    • Author(s)
      定方哲史
    • Organizer
      第36回日本神経内分泌学会
    • Place of Presentation
      北九州市(福岡県)
    • Year and Date
      2009-09-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] 神経発達障害のモデルマウスと環境-遺伝子相互作用2009

    • Author(s)
      古市貞一
    • Organizer
      脳を巡る環境-遺伝子相互作用の分子基盤シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2009-08-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 神経発達障害のモデルマウスと環境-遺伝子相互作用2009

    • Author(s)
      古市貞一
    • Organizer
      「脳を巡る環境-遺伝子相互作用の分子基盤」シンポジウム
    • Place of Presentation
      東京都
    • Year and Date
      2009-08-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] Vesicle associated protein CAPS2 KO mice show impaired synapse function of hippocampus and exhibit depression-like behavior2009

    • Author(s)
      Shinoda Yo
    • Organizer
      36th Congress of the International Union of Physiological Sciences(IUPS2009)
    • Place of Presentation
      Kyoto-city Kyoto
    • Year and Date
      2009-08-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウス小脳発達トランスクリプトーム解析:小脳神経回路発達の遺伝基盤の解明に向けて2009

    • Author(s)
      林周宏
    • Organizer
      第52回日本神経化学会大会
    • Place of Presentation
      伊香保(群馬県)
    • Year and Date
      2009-06-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Neurotrophin secretion2009

    • Author(s)
      古市貞一
    • Organizer
      Gordon Research Conferences on Neurotrophic Factors
    • Place of Presentation
      Newport, RI, USA
    • Year and Date
      2009-06-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウス小脳発達トランスクリプトームデータベースCDT-DB2009

    • Author(s)
      古市貞一
    • Organizer
      文部科学省 統合データベースプロジェクトシンポジウム「データベースが拓くこれからのライフサイエンス」
    • Place of Presentation
      東京都
    • Year and Date
      2009-06-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] Ca^<2+>依存性活性化分泌関連タンパク質CAPS2は正常な脳の発達と行動に必須な役割を果たす2009

    • Author(s)
      古市貞一
    • Organizer
      第61回日本細胞生物学会大会
    • Place of Presentation
      名古屋市(愛知県)
    • Year and Date
      2009-06-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 分泌関連Ca^<2+>依存性活性化タンパク質2(CAPS2/CADPS2)と社会性行動形質2009

    • Author(s)
      古市貞一
    • Organizer
      行動遺伝学研究会(国立遺伝学研究所)
    • Place of Presentation
      三島
    • Year and Date
      2009-03-12
    • Related Report
      2010 Final Research Report
  • [Presentation] 神経回路の発達と機能に必要なCAPS2の遺伝子欠損マウスは社会性相互作用の障害と不安行動の増加を示す2009

    • Author(s)
      古市貞一、定方哲史、篠田陽、仙波りつ子
    • Organizer
      第32回日本分子生物学会年会・シンポジウム
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] CAPS2タンパク質による有芯小胞分泌経路の制御と発達障害の感受性2009

    • Author(s)
      古市貞一、定方哲史、篠田陽、仙波りつ子
    • Organizer
      第82回日本生化学会大会・シンポジウム
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] 分泌関連Ca2+依存性活性化タンパク質2(CAPS2)と自閉症感受性2009

    • Author(s)
      古市貞一
    • Organizer
      第32回日本神経科学大会・シンポジウム
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report
  • [Presentation] Neurotrophin secretion.2009

    • Author(s)
      古市貞一
    • Organizer
      Gordon Research Conferences on Neurotrophic Factors
    • Place of Presentation
      Newport, RI, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Ca^<2+>依存性活性化分泌関連タンパク質CAPS2は正常な脳の発達と行動に必須な役割を果たす2009

    • Author(s)
      古市貞一、定方哲史、篠田陽
    • Organizer
      第61回日本細胞生物学会大会・シンポジウム
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report
  • [Presentation] 脳の発達とその障害の遺伝基盤:CAPS2によるBDNF分泌調節と自閉症感受性2008

    • Author(s)
      古市貞一
    • Organizer
      第18回脳・ライフ研シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2008-10-17
    • Related Report
      2010 Final Research Report
  • [Presentation] CAPS2に依存したBDNF分泌の欠損は自閉症感受性と関連する2008

    • Author(s)
      古市貞一、定方哲史、篠田陽
    • Organizer
      第31回日本神経科学大会・シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2008-07-09
    • Related Report
      2010 Final Research Report
  • [Presentation] Regulated secretion in relation to autism.2008

    • Author(s)
      古市貞一
    • Organizer
      Gordon Research Conferences on Proprotein Processing, Trafficking and Secretion
    • Place of Presentation
      New London, NH, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Purkinje 細胞における Homer 3のリン酸化2008

    • Author(s)
      水谷顕洋
    • Organizer
      第31回日本神経科学大会(Neuroscience 2008)
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] Regulated secretion in relation to autism2008

    • Author(s)
      古市貞一
    • Organizer
      2008 Gordon Research Conferences on Proprotein Processing, Trafficking and Secretion
    • Place of Presentation
      New London USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] CAPS2に依存したBDNF分泌の欠損は自閉症感受性と関連する2008

    • Author(s)
      古市貞一
    • Organizer
      第31回日本神経科学大会(Neuroscience 2008
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 分泌小胞会合タンパク質CAPS2の海馬LTPへの寄与2008

    • Author(s)
      篠田陽
    • Organizer
      第31回日本神経科学大会(Neuroscience 2008)
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] The functional analyses of CAPS family proteins2008

    • Author(s)
      定方哲史
    • Organizer
      第31回日本神経科学大会(Neuroscience 2008)
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] Regulation of endosomal localization of AATYK1A and its interaction with Src by palmitoylation2008

    • Author(s)
      Tsutsumi K.
    • Organizer
      第51回日本神経化学会大会
    • Place of Presentation
      富山
    • Related Report
      2008 Annual Research Report
  • [Presentation] Analysis of the Expression of PLD4 in the early postnatal mouse cerebellum2008

    • Author(s)
      Otani Y.
    • Organizer
      第51回日本神経化学会大会
    • Place of Presentation
      富山
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脳研究分野におけるデータベースの整備とその活用2008

    • Author(s)
      古市貞一
    • Organizer
      理研ライフサイエンス系総合データベースの整備と戦略的研究-大規模情報の活用とチャンス発見の情報テクノロジ-
    • Place of Presentation
      北杜
    • Related Report
      2008 Annual Research Report
  • [Presentation] Electropyhsiological and behavioral analysis of CAPS2 in mouse hippocampus2008

    • Author(s)
      Shinoda Y.
    • Organizer
      38th Annual Meeting of Society for Neuroscience (Neuroscience 2008)
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Interaction of very-KIND RasGEF with MAP2 regulates dendrite growth2008

    • Author(s)
      Furuichi T.
    • Organizer
      38th Annual Meeting of Society for Neuroscience (Neuroscience 2008)
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] CAPS2 function in dense-core vesicle trafficking2008

    • Author(s)
      定方哲史
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会(BMB2008)
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Book] 有芯小胞の分泌制御因子CAPS2と自閉症感受性(Vol.28No.5)2010

    • Author(s)
      定方哲史、篠田陽、林周宏、古市貞一
    • Publisher
      実験医学増刊号(羊土社)
    • Related Report
      2010 Final Research Report
  • [Book] 自閉症の感受性候補遺伝子と動物モデル(Vol.20No.4)2010

    • Author(s)
      篠田陽、定方哲史、林周宏、古市貞一
    • Publisher
      脳と精神の医学(新興医学出版社)
    • Related Report
      2010 Final Research Report
  • [Book] 自閉症と感受性候補遺伝子CADPS2生体の科学(Vol.50No9)2008

    • Author(s)
      古市貞一
    • Publisher
      医学書院
    • Related Report
      2010 Final Research Report
  • [Book] 自閉症の遺伝要因とCAPS2遺伝子実験医学増刊号(Vol.26No.12)2008

    • Author(s)
      定方哲史、篠田陽、古市貞一
    • Publisher
      羊土社
    • Related Report
      2010 Final Research Report
  • [Book] CADPS2分子精神医学(Vol8No.2)2008

    • Author(s)
      定方哲史、古市貞一
    • Publisher
      先端医学社
    • Related Report
      2010 Final Research Report
  • [Book] シリーズ脳科学(甘利俊一監修)(分子・細胞・シナプスからみる脳)2008

    • Author(s)
      古市貞一(編集)
    • Publisher
      東京大学出版会
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.brain.riken.go.jp/labs/lmn/indexj.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.brain.riken.go.jp/jp/t_furuichi.html

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2024-08-08  

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