Roles of the cortico-basal ganglia loop in rule-based behavioral choice
Project/Area Number |
20300136
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neurophysiology and muscle physiology
|
Research Institution | Hokkaido University |
Principal Investigator |
TANAKA Masaki Hokkaido University, 大学院・医学研究科, 教授 (90301887)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2008: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
|
Keywords | 神経科学 / 脳科学 / 神経生理学 / 霊長類 / 大脳基底核 / 大脳皮質 / 眼球運動 / 神経活動 / 行動選択 / 運動性視床 |
Research Abstract |
We select from multiple actions depending on a given situation. Analysis of the underlying neural mechanisms may shed light on the understanding of the pathophysiology in a variety of neurological and psychiatric disorders which accompany behavioral deficits. We examined neuronal activity in the basal ganglia and the thalamus in monkeys performing eye movement tasks, and found that neuronal activity was enhanced as the animals were required to suppress impulsive behavior. Inactivation of the recording sites resulted in the increment of impulsive behavior, suggesting that the basal ganglia?thalamocortical pathways may play a causal role in the organization of purposeful behavior.
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Report
(4 results)
Research Products
(81 results)
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[Presentation] 脳による時間情報処理2010
Author(s)
田中真樹
Organizer
第15回情報バイオトロニクス研究会
Place of Presentation
北海道大学(札幌市) 招待講演
Year and Date
2010-06-11
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[Presentation] 眼球運動の随意性制御2008
Author(s)
田中真樹
Organizer
日本生理学会主催第8回生理学若手サマースクール
Place of Presentation
国立オリンピック記念青少年総合センター、東京
Year and Date
2008-08-03
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