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Positive and negative reward coding by serotonin, acetylcholine, and dopamine network.

Research Project

Project/Area Number 20300139
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurophysiology and muscle physiology
Research InstitutionKansai Medical University

Principal Investigator

NAKAMURA Kae  関西医科大学, 医学部, 教授 (40454607)

Co-Investigator(Kenkyū-buntansha) KOBAYASHI Yasushi  大阪大学, 生命機能研究科, 准教授 (60311198)
Project Period (FY) 2008 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2008: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Keywordsドパミン / セロトニン / アセチルコリン / 強化学習 / 報酬 / 脚橋被蓋核 / 縫線核 / 霊長類 / モノアミン神経伝達物質 / 嫌悪 / 眼球運動 / サル / reinforcement learning
Research Abstract

The strength of firing of midbrain dopaminergic neurons has been revealed that it carries reward prediction error signal in the framework of reinforcement learning where an agent chooses actions to maximize rewards. The dopamine neurons receive inputs from the pedunculopontine tegmental nucleus(PPTN), where many cholinergic neurons exist, and the dorsal raphe nucleus(DRN), where many serotonergic neurons exist. Thus we measured single neuronal activity of PPTN and DRN while monkeys performed eye movement tasks to obtain reward of different values and the Pavlovian conditioning task in which appetitive and aversive events were imposed. We found that while different PPTN neurons encoded predicted reward and actual rewards separately, DRN neurons often carried predicted and actual rewards by single neurons. Such different reward signals may be fed and integrated in the dopamine neurons to compute reward prediction error signal, which is used for the control of action and decision making.

Report

(6 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (106 results)

All 2012 2011 2010 2009 2008 Other

All Journal Article (22 results) (of which Peer Reviewed: 18 results) Presentation (69 results) Book (3 results) Remarks (12 results)

  • [Journal Article] 強化学習の神経機構2012

    • Author(s)
      小林康
    • Journal Title

      ブレインサイエンスレビュー

      Pages: 127-150

    • Related Report
      2011 Final Research Report
  • [Journal Article] 強化学習の神経機構2012

    • Author(s)
      小林康
    • Journal Title

      ブレインサイエンスレビュー2012

      Pages: 127-150

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serotonin and dopamine : Unifying affective, activational, and decision functions2011

    • Author(s)
      Cools, R., Nakamura, K., Daw N. D.
    • Journal Title

      Neuropsychopharmacology

      Volume: 36 Pages: 98-113

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A neural correlate of predicted and actual reward-value information in monkey pedunculopontine tegmental and dorsal raphe nucleus during saccade tasks2011

    • Author(s)
      Okada K, Nakamura K, Kobayashi Y
    • Journal Title

      Neural Plasticity

      Pages: 1-21

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serotonin and dopamine : Unifying affective, activational, and decision functions.2011

    • Author(s)
      Cools, R., Nakamura, K., Daw, N.D.
    • Journal Title

      Neuropsychopharmacology 36

      Pages: 98-113

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Cerebromalacia with epilepsy and cortical blindness in a laboratory Japanese macaque2010

    • Author(s)
      Yoshizawa, K., Nakao, K., Habiro, M., Hayashi, K., Kuwata, M., Uehara, N., Takashi, Y., Nakamura, K., Tsubura, A.
    • Journal Title

      Toxicologic Pathology

      Volume: 38(7) Pages: 1058-1063

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Coding of task reward value in the dorsal raphe nucleus2010

    • Author(s)
      Bromberg-Martin, E. S., Hikosaka, O., Nakamura, K.
    • Journal Title

      The Journal of Neuroscience

      Volume: 30(18) Pages: 6262-6272

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cerebromalacia with epilepsy and cortical blindness in a laboratory Japanese macaque (Macaca fuscata).2010

    • Author(s)
      Yoshizawa, K., Nakao, K., Habiro, M., Hayashi, K., Kuwata, M., Uehara, N., Takashi, Y., Nakamura, K., Tsubura, A.
    • Journal Title

      Toxicologic Pathology 38(7)

      Pages: 1058-1063

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Coding of task reward value in the dorsal raphe nucleus.2010

    • Author(s)
      Bromberg-Martin,E.S., Hikosaka.O., Nakamura, K.
    • Journal Title

      The Journal of Neuroscience 30(18)

      Pages: 6262-6272

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Cerebromalacia with epilepsy and cortical blindness in a laboratory Japanese macaque(Macaca fuscata)2010

    • Author(s)
      Yoshizawa, K., Nakao, K., Habiro, M., Hayashi, K., Kuwata, M., Uehara, N., Takashi, Y., Nakamura K., Tsubura, A.
    • Journal Title

      Toxicologic Pathology

      Volume: 38(7) Pages: 1058-1063

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coding of task reward value in the dorsal raphe nucleus2010

    • Author(s)
      Bromberg-Martin, E.S., Hikosaka, O., Nakamura, K.
    • Journal Title

      The Journal of Neuroscience (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of oculomotor and visual activities in the primate pedunculopontine tegmental nucleus during visually guided saccade tasks2009

    • Author(s)
      Ken-ichi Okada, Yasushi Kobayashi
    • Journal Title

      European Journal of Neuroscience

      Volume: 30 Pages: 2211-2233

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Different Pedunculopontine Tegmental Neurons Signal Predicted and Actual Task Rewards2009

    • Author(s)
      Ken-ichi Okada, Keisuke Toyama, Yuka Inoue, Tadashi Isa and Yasushi Kobayashi
    • Journal Title

      The Journal of Neuroscience

      Volume: 29 Pages: 4858-4870

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reward processing of the basal ganglia : Reward function of Pedunculopontine tegmental nucleus2009

    • Author(s)
      Yasushi Kobayashi, Ken-ichi Okada
    • Journal Title

      Brain and Nerve神経研究の進歩

      Volume: 61 Pages: 397-404

    • NAID

      40016613391

    • Related Report
      2011 Final Research Report
  • [Journal Article] Characterization of oculomotor and visual activities in the primate pedunculopontine tegmental nucleus during visually guided saccade tasks.2009

    • Author(s)
      Ken-ichi Okada, Yasushi Kobayashi
    • Journal Title

      European Journal of Neuroscience 30

      Pages: 2211-2223

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Reward processing of the basal ganglia : Reward function of Pedunculopontine tegmental nucleus.2009

    • Author(s)
      Yasushi Kobayashi, Ken-ichi Okada
    • Journal Title

      Brain and Nerve神経研究の進歩 61(4)

      Pages: 397-404

    • NAID

      40016613391

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Different Pedunculopontine Tegmental Neurons Signal Predicted and Actual Task Rewards.2009

    • Author(s)
      Ken-ichi Okada, Keisuke Toyama, Yuka Inoue, Tadashi Isa, Yasushi Kobayashi
    • Journal Title

      The Journal of Neuroscience 29

      Pages: 4858-4870

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Reward processing of the basal ganglia : Reward function of Pedunculopontine tegmental nucleus2009

    • Author(s)
      Kobayashi Y, Okada K
    • Journal Title

      Brain and Nerve 61-4

      Pages: 397-404

    • NAID

      40016613391

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Different Pedunculopontine Tegmental Neurons Signal Predicted and Actual Task Rewards2009

    • Author(s)
      Okada K, Toyama K, Inoue Y, Isa T, Kobayashi Y
    • Journal Title

      Journal of Neuroscience 29

      Pages: 4858-4870

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of oculomotor and visual activities in the primate pedunculopontine tegmantal nucleus during visually guided saccade tasks2009

    • Author(s)
      Okada K, Kobayashi Y
    • Journal Title

      European Journal of Neuroscience 30

      Pages: 2211-2223

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reward processing of the basal ganglia : Reward function of Pedunculopontine tegmental nucleus2009

    • Author(s)
      Yasushi Kobayashi, Ken-ichi Okada
    • Journal Title

      Brain and Nerve 61-4(In press)

    • NAID

      40016613391

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Different Peduneulopontine Tegmental Neurons Signal Predicted and Actual Task Rewards2009

    • Author(s)
      Ken-ichi Okada, Keisuke Toyama, Yuka Inoue, Tadashl Isa, Yasushi Kobayashi
    • Journal Title

      Journal of Neuroscience (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] APPETITIVE AND AVERSIVE CODING BY THE PRIMATE DORSAL RAPHE NUCLEUS2012

    • Author(s)
      Kae Nakamura
    • Organizer
      11th International Conference on Cognitive Neuroscience (ICON XI)
    • Place of Presentation
      Mallorea・Spain
    • Year and Date
      2012-09-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Saccade-related modulation of rhythmic firing pattern on pedunculopontine tegmental nucleus neurons in behaving monkeys2011

    • Author(s)
      Ken-ichi Okada, Yasushi Kobayashi
    • Organizer
      Society for Neuroscience Meeting
    • Place of Presentation
      The Walter E. Washington Convention Center(Washington, DC., USA)
    • Year and Date
      2011-11-15
    • Related Report
      2011 Final Research Report
  • [Presentation] Saccade-related modulation of rhythmic firing pattern on pedunculopontine tegmental nucleus neurons in behaving monkeys2011

    • Author(s)
      K.-I.OKADAI, Y.KOBAYASHI
    • Organizer
      Neuroscience2011
    • Place of Presentation
      The Walter E.Washington Convention Center (Washington, DC., USA)
    • Year and Date
      2011-11-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Comparison of neuronal signals for reward value in appetitive and aversive contexts in the primate lateral hypothalamus area2011

    • Author(s)
      Atsushi Noritake, Kae Nakamura
    • Organizer
      Society for Neuroscience Meeting
    • Place of Presentation
      The Walter E. Washington Convention Center(Washington, DC., USA)
    • Year and Date
      2011-11-13
    • Related Report
      2011 Final Research Report
  • [Presentation] Neuronal activity in the primate dorsal raphe nucleus encodes positive and negative value2011

    • Author(s)
      Kazuko Hayashi, Kazuko Nakao, Ryuichi Matsuzaki, Ken-ichi Okada, Yasushi Kobayashi, Kae Nakamura
    • Organizer
      Society for Neuroscience Meeting
    • Place of Presentation
      The Walter E. Washington Convention Center(Washington, DC., USA)
    • Year and Date
      2011-11-13
    • Related Report
      2011 Final Research Report
  • [Presentation] Comparison of neuronal signals for reward value in appetitive and aversive contexts in the primate lateral hypothalamus area2011

    • Author(s)
      Atsushi Noritake, Kae Nakamura
    • Organizer
      Society for Neuroscience Meeting
    • Place of Presentation
      The Walter E.Washington Convention Center (Washington, DC., USA)
    • Year and Date
      2011-11-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Neuronal activity in the primate dorsal raphe nucleus encodes positive and negative value2011

    • Author(s)
      Kazuko Hayashi, Kazuko Nakao, Ryuichi Matsuzaki, Ken-ichi Okada, Yasushi Kobayashi, Kae Nakamura
    • Organizer
      Society for Neuroscience Meeting
    • Place of Presentation
      The Walter E.Washington Convention Center (Washington, DC., USA)
    • Year and Date
      2011-11-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] APPETITIVE AND AVERSIVE CODING BY THE PRIMATE DORSAL RAPHe NUCLEUS2011

    • Author(s)
      Kae Nakamura
    • Organizer
      11th International Conference on Cognitive Neuroscience(ICON XI)
    • Place of Presentation
      Mallorca(Spain)
    • Year and Date
      2011-09-28
    • Related Report
      2011 Final Research Report
  • [Presentation] Neuronal modulation in appetitive and aversive contexts in the primate lateral hypothalamus2011

    • Author(s)
      Atsushi Noritake, Kae Nakamura
    • Organizer
      日本神経科学会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Cognitive control of response inhibition in the primate2011

    • Author(s)
      Kazuko Hayashi, Atsushi Noritake, Kae Nakamura
    • Organizer
      日本神経科学会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] The pedunculopontine tegmental nucleus neurons encode predicted reward signal by tonic regular firing and given reward signal phasically2011

    • Author(s)
      Yasushi Kobayashi and Ken-ichi Okada
    • Organizer
      日本神経科学会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2011-09-16
    • Related Report
      2011 Final Research Report
  • [Presentation] The pedunculopontine tegmental nucleus neurons encode predicted reward signal by tonic regular firing and given reward signal phasically2011

    • Author(s)
      Yasushi Kobayashi, Ken-ichi Okada
    • Organizer
      Neuro 2011 Yokohama
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Neural mechanism of reinforcement learning and motivation2011

    • Author(s)
      小林康
    • Organizer
      上海交通大学BioX-project
    • Place of Presentation
      上海交通大学(上海)
    • Year and Date
      2011-07-23
    • Related Report
      2011 Final Research Report
  • [Presentation] Neural mechanism of reinforcement learning and motivation2011

    • Author(s)
      小林康
    • Organizer
      上海交通大学BioX-projec
    • Place of Presentation
      上海交通大学(上海)
    • Year and Date
      2011-07-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 運動誤差学習と強化学習、小脳と脳幹の神経振動2011

    • Author(s)
      小林康
    • Organizer
      北海道大学電子科学研究所陰的制御研究会
    • Place of Presentation
      北海道大学(札幌)
    • Related Report
      2011 Annual Research Report
  • [Presentation] サル脚橋被蓋核ニューロンの周期発火とサッカード抑制応答2011

    • Author(s)
      岡田研一、小林康
    • Organizer
      第5回Motor Control研究会
    • Place of Presentation
      岡崎(愛知)
    • Related Report
      2011 Annual Research Report
  • [Presentation] サル脚橋被蓋核におけるサッカードに伴う周期的活動の変調2011

    • Author(s)
      岡田研一、小林康
    • Organizer
      第15回視覚科学フォーラム研究会
    • Place of Presentation
      大阪大学(大阪)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Context dependent firing regularity of pedunculopontine tegmental nucleus of behaving monkeys2010

    • Author(s)
      Ken-ichi Okada, Yasushi Kobayashi
    • Organizer
      Society for Neuroscience Meeting
    • Place of Presentation
      San Diego Convention Center,(San Diego, USA)
    • Year and Date
      2010-11-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Context dependent firing regularity of pedunculopontine tegmental nucleus of behaving monkeys.2010

    • Author(s)
      Ken-ichi Okada, Yasushi Kobayashi
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego Convention Center (San Diego, USA)
    • Year and Date
      2010-11-16
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Context dependent firing regularity of pedunculopontine tegmental nucleus of behaving monkeys.2010

    • Author(s)
      Ken-ichi Okada, Yasushi Kobayashi
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego Convention Center(San Diego, USA)
    • Year and Date
      2010-11-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Neural processing of appetitive and aversive stimuli in the primate dorsal raphe nucleus2010

    • Author(s)
      Hayashi, K., Nakao, K., Okada, K., Kobayashi, Y., Nakamura, K.
    • Organizer
      Society for Neuroscience Meeting
    • Place of Presentation
      San Diego Convention Center(San Diego, USA)
    • Year and Date
      2010-11-15
    • Related Report
      2011 Final Research Report
  • [Presentation] Positive and negative reward value coding in the primate lateral hypothalamus2010

    • Author(s)
      Noritake, A., Nakamura, K.
    • Organizer
      Society for Neuroscience Meeting
    • Place of Presentation
      San Diego Convention Center(San Diego, USA)
    • Year and Date
      2010-11-15
    • Related Report
      2011 Final Research Report
  • [Presentation] Positive and negative reward value coding in the primate lateral hypothalamus.2010

    • Author(s)
      Noritake, A., Nakamura, K.
    • Organizer
      Society for Neuroscience Meeting
    • Place of Presentation
      San Diego Convention Center, San Diego, USA
    • Year and Date
      2010-11-15
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Neural processing of appetitive and aversive stimuli in the primate dorsal raphe nucleus.2010

    • Author(s)
      Hayashi, K., Nakao, K., Okada, K., Kobayashi, Y., Nakamura, K.
    • Organizer
      Society for Neuroscience Meeting
    • Place of Presentation
      San Diego Convention Center, San Diego, USA
    • Year and Date
      2010-11-15
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Neural processing of appetitive and aversive stimuli in the primate dorsal raphe nucleus.2010

    • Author(s)
      Hayashi, K., Nakao, K., Okada, K., Kobayashi, Y., Nakamura, K.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego Convention Center(San Diego, USA)
    • Year and Date
      2010-11-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Positive and negative reward value coding in the primate lateral hypothalamus.2010

    • Author(s)
      Noritake, A., Nakamura, K.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego Convention Center (San Diego, USA)
    • Year and Date
      2010-11-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Saccadic eye movements as a neural correlate measure of preparatory set in children with ADHD.2010

    • Author(s)
      Yuri Kitamura, Yuka Matsuo, Masako Taniike, Ikuko Mohri, Yasushi Kobayashi, Kanehisa Morimoto
    • Organizer
      日本神経科学会
    • Place of Presentation
      神戸コンベンションセンター(神戸)
    • Year and Date
      2010-09-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 価値に基づく意思決定の神経機構-新たな展開New perspectives on value-based decision making2010

    • Author(s)
      Nakamura, K.
    • Organizer
      日本神経科学会
    • Place of Presentation
      神戸コンベンションセンター(神戸)
    • Year and Date
      2010-09-04
    • Related Report
      2011 Final Research Report
  • [Presentation] サル背側縫線核における報酬および嫌悪刺激の情報表現Neuronal coding of rewarding and aversive stimuli in the primate dorsal raphe mucieus2010

    • Author(s)
      Hayashi, K, . Nakao, K., Okada, K., Kobayashi, Y., Nakamura, K.
    • Organizer
      日本神経科学会
    • Place of Presentation
      神戸コンベンションセンター(神戸)
    • Year and Date
      2010-09-04
    • Related Report
      2011 Final Research Report
  • [Presentation] サル視床下部外側野における報酬情報表現は部位により異なるRward-coding by the primate lateral hypothalamus is spatially distinct2010

    • Author(s)
      Noritake, A., Nakamura, K.
    • Organizer
      日本神経科学会
    • Place of Presentation
      神戸コンベンションセンター(神戸)
    • Year and Date
      2010-09-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 価値に基づく意思決定の神経機構-新たな展開New perspectives on value-based decision making.2010

    • Author(s)
      Nakamura, K.
    • Organizer
      日本神経科学会
    • Place of Presentation
      神戸コンベンションセンター(神戸)
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] サル背側縫線核における報酬および嫌悪刺激の情報表現Neuronal coding of rewarding and aversive stimuli in the primate dorsal raphe mucieus.2010

    • Author(s)
      Hayashi, K., Nakao, K., Okada, K., Kobayashi, Y., Nakamura, K.
    • Organizer
      日本神経科学会
    • Place of Presentation
      神戸コンベンションセンター(神戸)
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] サル視床下部外側野における報酬情報表現は部位により異なるRward-coding by the primate lateral hypothalamus is spatially distinct.2010

    • Author(s)
      Noritake, A., Nakamura, K.
    • Organizer
      日本神経科学会
    • Place of Presentation
      神戸コンベンションセンター(神戸)
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Saccadic eye movements as a neural correlate measure of preparatory set in children with ADHD2010

    • Author(s)
      Yuri Kitamura, Yuka Matsuo, Masako Taniike, Ikuko Mohri, Yasushi Kobayashi, Kanehisa Morimoto
    • Organizer
      日本神経科学会
    • Place of Presentation
      神戸コンベンションセンター(神戸)
    • Year and Date
      2010-09-03
    • Related Report
      2011 Final Research Report
  • [Presentation] Rhythmic firing of pedunculopontine tegmental nucleus neurons in behaving monkeys2010

    • Author(s)
      Ken-ichi Okada, Yasushi Kobayashi
    • Organizer
      日本神経科学会
    • Place of Presentation
      神戸コンベンションセンター(神戸)
    • Year and Date
      2010-09-03
    • Related Report
      2011 Final Research Report
  • [Presentation] Rhythmic firing of pedunculopontine tegmental nucleus neurons in behaving monkeys.2010

    • Author(s)
      Ken-ichi Okada, Yasushi Kobayashi
    • Organizer
      日本神経科学会
    • Place of Presentation
      神戸コンベンションセンター(神戸)
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] The pedunculopontine tegmental nucleus neurons relay predicted and actual reward and context dependent visuomotor information2010

    • Author(s)
      Yasushi Kobayashi, Ken-ichi Okada
    • Organizer
      日本神経科学会
    • Place of Presentation
      神戸コンベンションセンター(神戸)
    • Year and Date
      2010-09-02
    • Related Report
      2011 Final Research Report
  • [Presentation] The pedunculopontine tegmental nucleus neurons relay predicted and actual reward and context dependent visuomotor information.2010

    • Author(s)
      Yasushi Kobayashi, Ken-ichi Okada
    • Organizer
      日本神経科学会
    • Place of Presentation
      神戸コンベンションセンター(神戸)
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 報酬獲得行動におけるドパミンとセロトニンの役割2009

    • Author(s)
      中村加枝
    • Organizer
      神経科学セミナー
    • Place of Presentation
      東京都神経科学研究所, 東京
    • Year and Date
      2009-12-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] Coding of appetitive and aversive value in the primate dorsal raphe nucleus2009

    • Author(s)
      中村加枝
    • Organizer
      玉川大学国際シンポジウム
    • Place of Presentation
      玉川大学, 東京
    • Year and Date
      2009-11-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] Positive and negative value coding in the primate dorsal raphe nucleus2009

    • Author(s)
      Nakamura, K., Kobayashi, Y., Okada, O., Noritake, A., Matsuzaki, R., Nakao, K.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      McCormick Place(Chicago, USA)
    • Year and Date
      2009-10-20
    • Related Report
      2011 Final Research Report
  • [Presentation] Analyses of the time course of neuronal activity of the pedunculopontine tegmental nucleus in monkeys for reward conditioned saccade task2009

    • Author(s)
      Okada K and Kobayashi Y
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      McCormick Place(Chicago, USA)
    • Year and Date
      2009-10-20
    • Related Report
      2011 Final Research Report
  • [Presentation] Positive and negative value coding in the primate dorsal raphe nucleus.2009

    • Author(s)
      Nakamura, K., Kobayashi, Y., Okada, O., Noritake, A., Matsuzaki, R., Nakao, K.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      McCormick Place, Chicago, USA
    • Year and Date
      2009-10-20
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Analyses of the time course of neuronal activity of the pedunculopontine tegmental nucleus in monkeys for reward conditioned saccade task.2009

    • Author(s)
      Okada K, Kobayashi Y
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      McCormick Place, Chicago, USA
    • Year and Date
      2009-10-20
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Positive and negative value coding in the primate dorsal raphe nucleus2009

    • Author(s)
      Nakamura, K., Kobayashi, Y., Okada, O., Noritake, A., Matsuzaki, R., Nakao, K.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      McCormick Place, Chicago, USA
    • Year and Date
      2009-10-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] Analyses of the time course of neuronal activity of the pedunculopontine tegmental nucleus in monkeys for reward conditioned saccade task2009

    • Author(s)
      Okada K, Kobayashi Y
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      McCormick Place, Chicago, USA
    • Year and Date
      2009-10-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] Reward-dependent modulation of neuronal activity in the primate ventral striatum2009

    • Author(s)
      Nakamura, K., Nakao, K., Matsuzaki, R.
    • Organizer
      日本神経科学会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2009-09-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Reward coding by the primate dorsal raphe neurons is context dependent2009

    • Author(s)
      Nakamura, K., Kobayashi, Y., Okada, O. Matsuzaki, R., Nakao, K.
    • Organizer
      日本神経科学会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2009-09-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Computational mechanism of reward prediction error by the Pedunculopontine tegmental nucleus neurons2009

    • Author(s)
      Kobayashi Y, Okada K
    • Organizer
      日本神経科学会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2009-09-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Relation of pedunculopontine tegmental nucleus neurons in monkeys to reward prediction and behavior2009

    • Author(s)
      Okada K and Kobayashi Y
    • Organizer
      日本神経科学会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2009-09-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Reward-dependent modulation of neuronal activity in the primate ventral striatum2009

    • Author(s)
      Nakamura, K., Nakao, K., Matsuzaki, R.
    • Organizer
      日本神経科学会
    • Place of Presentation
      名古屋国際会議場, 名古屋
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Reward coding by the primate dorsal raphe neurons is context dependent2009

    • Author(s)
      Nakamura, K., Kobayashi, Y., Okada, O.Matsuzaki, R., Nakao, K.
    • Organizer
      日本神経科学会
    • Place of Presentation
      名古屋国際会議場, 名古屋
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Computational mechanism of reward prediction error by the Pedunculopontine tegmental nucleus neurons2009

    • Author(s)
      Kobayashi Y, Okada K
    • Organizer
      日本神経科学会
    • Place of Presentation
      名古屋国際会議場, 名古屋
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Relation of pedunculopontine tegmental nucleus neurons in monkeys to reward prediction and behavior2009

    • Author(s)
      Okada K, Kobayashi Y
    • Organizer
      日本神経科学会
    • Place of Presentation
      名古屋国際会議場, 名古屋
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] ドパミンとセロトニンによる報酬獲得行動の制御のメカニズム2009

    • Author(s)
      中村加枝
    • Organizer
      第27回頭頸部自律神経研究会
    • Place of Presentation
      ホテルグランヴィア大阪, 大阪
    • Year and Date
      2009-08-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] Reward prediction error computation in the pedunculopontine tegmental nucleus Neurons2009

    • Author(s)
      Kobayashi Y
    • Organizer
      International Symposium on Mobiligence
    • Place of Presentation
      Awaji Yumebutai International Conference Center(淡路)
    • Related Report
      2011 Final Research Report
  • [Presentation] The pedunculopontine tegmental nucleus Neurons relay predicted and actual rewarded information2009

    • Author(s)
      Kobayashi Y, Okada K
    • Organizer
      International Symposium on Construction and Reconstruction of the brain
    • Place of Presentation
      Awaji Yumebutai International Conference Center(淡路)
    • Related Report
      2011 Final Research Report
  • [Presentation] Reward prediction error computation in the pedunculopontine tegmental nucleus neurons2009

    • Author(s)
      Kobayashi Y
    • Organizer
      International Symposium on Mobiligence
    • Place of Presentation
      Awaji Yumebutai International Conference Center, 淡路
    • Related Report
      2009 Annual Research Report
  • [Presentation] The pedunculopontine tegmental nucleus neurons relay predicted and actual rewarded information2009

    • Author(s)
      Kobayashi Y, Okada K
    • Organizer
      International Symposium on Construction and Reconstruction of the brain
    • Place of Presentation
      Awaji Yumebutai International Conference Center, 淡路
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effects of relative and absolute magnitudes of reward on dorsal raphe neuronal activity in monkeys2008

    • Author(s)
      Nakamura, K., Matsumoto, M., Hikosaka, O.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Walter E. Washington Convention Center(Washington, DC., USA)
    • Year and Date
      2008-11-15
    • Related Report
      2011 Final Research Report
  • [Presentation] Neural correlates of task performance of the visually guided saccade tasks in the primate pedunculopontine tegmental nucleus2008

    • Author(s)
      Ken-ichi Okada, Yasushi Kobayashi
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Walter E. Washington Convention Center(Washington, DC., USA)
    • Year and Date
      2008-11-15
    • Related Report
      2011 Final Research Report
  • [Presentation] Effects of relative and absolute magnitudes of reward on dorsal raphe neuronal activity in monkeys.2008

    • Author(s)
      Nakamura, K., Matsumoto, M., Hikosaka, O.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Walter E.Washington Convention Center, Washington, DC., USA
    • Year and Date
      2008-11-15
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Neural correlates of task performance of the visually guided saccade tasks in the primate pedunculopontine tegmental nucleus.2008

    • Author(s)
      Ken-ichi Okada, Yasushi Kobayashi
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Walter E.Washington Convention Center, Washington, DC., USA
    • Year and Date
      2008-11-15
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Effects of relative and absolute magnitudes of reward on dorsal raphe neuronal activity in monkeys2008

    • Author(s)
      Nakamura, K., Matsumoto, M. Hikosaka, O.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington DC., U. S. A.
    • Year and Date
      2008-11-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] Neural correlates of task performance of the visually guided sacoade tasks in the primate pedunculopontine tegmental nucleus2008

    • Author(s)
      Ken-ichi Okada, Yasushi Kobayashi
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington DC., U. S. A.
    • Year and Date
      2008-11-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] Neural correlates of task performance in the primate pedunculopontine tegmental nucleus2008

    • Author(s)
      Ken-ichi Okada, Yasushi Kobayashi
    • Organizer
      日本神経科学会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2008-07-10
    • Related Report
      2011 Final Research Report
  • [Presentation] Neural correlates of task performance in the primate pedunculo pontine tegmental nucleus.2008

    • Author(s)
      Ken-ichi Okada, Yasushi Kobayashi
    • Organizer
      Japan Neuroscience Society
    • Place of Presentation
      Tokyo, JAPAN
    • Year and Date
      2008-07-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Pedunculopontine Tegmental Nucleus Neurons Signal Predicted and Actual Reward for Reinforcement Learning2008

    • Author(s)
      Yasushi Kobayashi
    • Organizer
      ASSC12
    • Place of Presentation
      Gis Convention Center, National Taiwan University(Taipei, Taiwan)
    • Year and Date
      2008-06-19
    • Related Report
      2011 Final Research Report
  • [Presentation] Pedunculopontine Tegmental Nucleus Neurons Signal Predicted and Actual Reward for Reinforcement Learning.2008

    • Author(s)
      Yasushi Kobayashi
    • Organizer
      ASSC12
    • Place of Presentation
      Taipei, TAIWAN
    • Year and Date
      2008-06-19
    • Related Report
      2008 Annual Research Report
  • [Book] Advances in Reinforcement Learning Chapter Title : Reward prediction error computation in the pedunculopontine tegmental nucleus neurons2011

    • Author(s)
      Yasushi Kobayashi and Ken-ichi Okada
    • Publisher
      INTECH
    • Related Report
      2011 Final Research Report
  • [Book] Advances in Reinforcement Learning. Chapter Title : Reward prediction error computation in the pedunculopontine tegmental nucleus neurons2011

    • Author(s)
      Yasushi Kobayashi, Ken-ichi Okada
    • Publisher
      Publisher Open Access Publisher INTECH
    • Related Report
      2010 Self-evaluation Report
  • [Book] Advances in Reinforcement Learning Chapter Title : Reward prediction error computation in the pedunculopontine tegmental nucleus neurons2011

    • Author(s)
      Yasushi Kobayashi, Ken-ichi Okada
    • Publisher
      Publisher Open Access Publisher INTECH
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.kmu.ac.jp/depts/intro/physiol2.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.kmu.ac.jp/depts/intro/physiol2.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www7.bpe.es.osaka-u.ac.jp/~yasushi/gyoseki.htm

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.kmu.ac.jp/depts/intro/physiol

    • Related Report
      2010 Self-evaluation Report
  • [Remarks]

    • URL

      http://www7.bpe.es.osaka-u.ac.jp/~yasushi/gyoseki.htm

    • Related Report
      2010 Self-evaluation Report
  • [Remarks]

    • URL

      http://www.kmu.ac.jp/depts/intro/physiol2.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www7.bpe.es.osaka-u.ac.jp/~yasushi/gyoseki.htm

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.kmu.ac.jp/depts/intro/physiol2.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www7.bpe.es.osaka-u.ae.jp/~yasushi/gyoseki.htm

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.kmu.ac.jp/depts/intro/physiol2.html

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www7.bpe.es.osaka-u.ac.jp/~yasushi/gyoseki.htm

    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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