Function of spinal reflex circuit for regulating volitional movement.

• Project/Area Number: 20300140
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurophysiology and muscle physiology
• Research Institution: National Center of Neurology and Psychiatry (2009-2010); National Institute for Physiological Sciences (2008)
• Principal Investigator: SEKI Kazuhiko 独立行政法人国立精神・神経医療研究センター, 神経研究所モデル動物開発研究部, 部長 (00226630)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000); Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2009: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2008: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
• Keywords: 反射 / 脊髄 / 随意運動 / 霊長類 / 電機生理 / サル / 脊髄反射

Research Abstract

By recording the activity of first-order spinal interneuron from primary afferents, we found that 1) they could be used to the automatic augmentation of voluntary muscle force, 2) afferent input to them were facilitated during static phase of task, and 3) reafference signal was strong enough to drive these interneurons.

Research Products

• [Journal Article] Spinal interneurons facilitate coactivation of hand muscles during a precision grip task in monkeys. (2010)
  • Author(s): Takei T, Seki K
  • Journal Title: The Journal of Neuroscience 30(50) Pages: 17041-50
  • Peer Reviewed
• [Journal Article] Spinal interneurons facilitate coactivation of hand muscles during a precision grip task in monkeys (2010)
  • Author(s): Takei T, Seki K
  • Journal Title: The Journal of Neuroscience Volume: 30巻(50号) Pages: 17041-17050
  • Peer Reviewed
• [Journal Article] Task-dependent modulation of primary afferent depolarization in cervical spinal cord of monkeys performing an instructed delay task (2009)
  • Author(s): Seki K., Perlmutter S.I., Fetz E.E.
  • Journal Title: J.Neurophysiol 102 Pages: 85-99
  • Peer Reviewed
• [Journal Article] Task-dependent modulation of primary afferent depolarization in cervical spinal cord of monkeys performing an instructed delay task (2009)
  • Author(s): Seki K, Perlmutter SI, Fetz EE
  • Journal Title: Journal of neurophysiology 102 Pages: 85-99
  • Peer Reviewed
• [Journal Article] Task-dependent modulation of primary afferent depolarization in cervical spinal cord of monkeys performing an instructed delay task (2009)
  • Author(s): Seki, K.Perlmutter SI, Fetz, EE
  • Journal Title: Journal of Neurophysiology 102 Pages: 85-99
  • Peer Reviewed
• [Journal Article] Spinomuscular coherence in monkeys performing a precision grip task (2008)
  • Author(s): Takei T., Seki K.
  • Journal Title: J.Neurophysiol 99(4) Pages: 2012-20
  • Peer Reviewed
• [Journal Article] Spinomuscular coherence in monkey performing a precision grip task (2008)
  • Author(s): Tomohiko Takei, Kazuhiko Seki
  • Journal Title: Journal of Neurophysiology 99 Pages: 2012-2020
  • Peer Reviewed
• [Presentation] Modulation of sensory responses at spinal and cortical levels during preparation and execution of voluntary movement (2010)
  • Author(s): Seki K, E.E.Fetz
  • Organizer: The 40th annual meeting of the Society for the Neuroscience
  • Place of Presentation: Sandiego, USA
  • Year and Date: 2010-11-15
• [Presentation] Modulation of sensory responses at spinal and cortical levels during preparation and execution of voluntary movement (2010)
  • Author(s): Seki K, E.E.Fetz
  • Organizer: The 40th annual meeting of the Society for the Neuroscience
  • Place of Presentation: Sandiego Convention Center, Sandiego, USA
  • Year and Date: 2010-11-15
• [Presentation] How motion is encoded by sensory afferent ensembles in monkeys? (2010)
  • Author(s): Umeda T, Sakatani T, Yamashita O, Saitoh M, Morimoto J, Seki K, Kawato M, Isa T
  • Organizer: The 40th annual meeting of the Society for the Neuroscience
  • Place of Presentation: Sandiego, USA
  • Year and Date: 2010-11-14
• [Presentation] How motion is encoded by sensory afferent ensembles in monkeys? (2010)
  • Author(s): Umeda.T, Sakatani.T, Yamashita.O, Saitoh.M, Morimoto.J, Seki K., Kawato.M, Isa.T
  • Organizer: The 40th annual meeting of the Society for the Neuroscience
  • Place of Presentation: Sandiego Convention Center, Sandiego, USA
  • Year and Date: 2010-11-14
• [Presentation] 随意運動の制御における脊髄の役割:反射や歩行を越えて (2010)
  • Author(s): 関和彦
  • Organizer: 第176回つくばブレインサイエンス・セミナー
  • Place of Presentation: 筑波大学
  • Year and Date: 2010-10-12
• [Presentation] 随意運動の制御における脊髄の役割:反射や歩行を越えて (2010)
  • Author(s): 関和彦
  • Organizer: 第176回つくばブレインサイエンス・セミナー
  • Place of Presentation: 茨城県つくば市筑波大学
  • Year and Date: 2010-10-12
• [Presentation] 随意運動と脊髄機能 (2010)
  • Author(s): 関和彦
  • Organizer: 第65回日本体力医学会大会
  • Place of Presentation: 千葉商科大学
  • Year and Date: 2010-09-17
• [Presentation] 随意運動と脊髄機能 (2010)
  • Author(s): 関和彦
  • Organizer: 第65回日本体力医学会大会
  • Place of Presentation: 千葉県市川市 千葉商科大学
  • Year and Date: 2010-09-17
• [Presentation] 随意運動の制御における脊髄ニューロン系の役割とその臨床的意義 (2010)
  • Author(s): 関和彦
  • Organizer: 第87回日本生理学会大
  • Place of Presentation: いわて県民情報交流センター
  • Year and Date: 2010-05-19
• [Presentation] 随意運動の制御における脊髄ニューロン系の役割とその臨床的意義 (2010)
  • Author(s): 関和彦
  • Organizer: 第65第87回日本生理学会大会
  • Place of Presentation: 岩手県盛岡市 盛岡市民文化ホール
  • Year and Date: 2010-05-19
• [Presentation] Spinal control of voluntary movement (2010)
  • Author(s): 関和彦
  • Organizer: Newcastle University, Motor control seminar
  • Place of Presentation: Newcastle University, Newcastle, UK
  • Year and Date: 2010-02-26
• [Presentation] Spinomuscular coherence in monkey performing a precision grip task. (2009)
  • Author(s): Takei T, Seki K
  • Organizer: The 3rd International Symposium on Mobiligence
  • Place of Presentation: Awaji, Hyogo
  • Year and Date: 2009-11-20
• [Presentation] Spinomuscular coherence in monkey performing a precision grip task (2009)
  • Author(s): 武井智彦, 関和彦
  • Organizer: The3rd International Symposium Mobiligence
  • Place of Presentation: The Awaji Yumebutai Int.Conf.Center, Hyogo
  • Year and Date: 2009-11-20
• [Presentation] Spinal interneurons : A new role for controlling voluntary movements. (2009)
  • Author(s): 関和彦
  • Organizer: International Symposium, New Perspectives on Neural Mechanisms of Cognition and Action
  • Place of Presentation: Tamagawa University, Machida
  • Year and Date: 2009-11-13
• [Presentation] Spinal interneurons : A new role for controlling voluntary movements (2009)
  • Author(s): 関和彦
  • Organizer: International Symposium, New Perspectives on Neural Mechanisms of Cognition and Action
  • Place of Presentation: Tamagawa University, Machida
  • Year and Date: 2009-11-13
• [Presentation] Post-spike effects of spinal interneurons on hand muscles in monkeys performing a precision grip. (2009)
  • Author(s): Takei T, Seki K
  • Organizer: The 39th annual meeting of the Society for the Neuroscience
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-10-19
• [Presentation] Post-spike effects of spinal interneurons on hand muscles in monkeys performing a precision grip (2009)
  • Author(s): 武井智彦, 関和彦
  • Organizer: The 39th annual meeting of the Society for the Neuroscience
  • Place of Presentation: McCormick Place, Chicago, USA
  • Year and Date: 2009-10-19
• [Presentation] Function of spinal interneurons for controlling voluntary movements (2009)
  • Author(s): 関和彦
  • Organizer: Queen's University, Centre for Neuroscience studies, 2009 seminar series
  • Place of Presentation: Queen's University, Kingston, Canada
  • Year and Date: 2009-10-14
• [Presentation] 把握運動制御における脊髄介在ニューロンの役割 (2009)
  • Author(s): 武井智彦、関和彦
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場、名古屋
  • Year and Date: 2009-09-17
• [Presentation] A new role of spinal interneuronal networks for controlling volitional movement. (2009)
  • Author(s): 関和彦
  • Organizer: The 19th Society for the neural control of movement
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2009-05-01
• [Presentation] A new role of spinal interneuronal networks for controlling volitional movements (2009)
  • Author(s): 関和彦
  • Organizer: The 19^<th> Society for the neural control of movement
  • Place of Presentation: Waikoloa Beach Marriott Resort & Spa, Hawaii, USA
  • Year and Date: 2009-05-01
• [Presentation] Activity of spinal interneurons mediationg afferent inputs from forearm muscles in monkeys performing volunary wrist movement (2008)
  • Author(s): 関和彦, 武井智彦
  • Organizer: The 38th annual meeting of the Society for the Neuroscience
  • Place of Presentation: 米国ワシントンDC
  • Year and Date: 2008-11-19
• [Presentation] Motor networks in the primate cervical spinal cord explored using intraspinal microstimulation (2008)
  • Author(s): Jackson, A., Baker, SN., Isa, T., Seki, K.
  • Organizer: The 38th annual meeting of the Society for the Neuroscience
  • Place of Presentation: 米国ワシントンDC
  • Year and Date: 2008-11-19
• [Presentation] Spinomuscular coherence in monkey performing a precision grip task (2008)
  • Author(s): 武井智彦 , 関和彦
  • Organizer: The 38th annual meeting of the Society for the Neuroscience
  • Place of Presentation: 米国ワシントンDC
  • Year and Date: 2008-11-15
• [Presentation] 随意運動時における脊髄ニューロンの活動と末梢感覚入力様式の相関 (2008)
  • Author(s): 関和彦、武井智彦
  • Organizer: 日本神経科学学会大会
  • Place of Presentation: 東京ビッグサイト・東京
  • Year and Date: 2008-07-10
• [Remarks] ホームページ等
  • URL: http://www.ncnp.go.jp/nin/guide/r_model/index.html