Rat research resource for biomedical science generated by Sleeping Beauty transposon system
| Project/Area Number |
20300142
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Hokkaido University |
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Principal Investigator |
KITADA Kazuhiro Hokkaido University, 大学院・理学研究院, 准教授 (70263093)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2009: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2008: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Keywords | トランスポゾン / ラット / 疾患モデル / リソース / ミュータジェネシス / 挿入突然変異 / 遺伝子ノックアウトラット / Sleeping Beauty |
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| Research Abstract |
Sleeping Beauty (SB) transpson is known to be functional in mammalian species. Aim of this study is obtaining fundamental information of SB transposon system for future random-insertional-mutagenesis in the rat. We established the optimized protocol for generation of insertional mutant rat resource. SB transposon system established in this study would lead to activation of variety fields of biomedical science, based on advantages of the rat as an excellent experimental animal.
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Report
(4 results)
Research Products
(18 results)
