Role of mechanical load in human myocardial excitation contraction coupling

• Project/Area Number: 20300159
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Okayama University
• Principal Investigator: IRIBE Gentarou Okayama University, 大学院・医歯薬学総合研究科, 助教 (90284885)
• Co-Investigator(Renkei-kenkyūsha): NARUSE Keiji 岡山大学, 医歯(薬)学総合研究科, 教授 (40252233) ; MOURI Satoshi 川崎医科大学, 医学部, 教授 (00294413) ; KATANOSAKA Yuki 岡山大学, 医歯(薬)学総合研究科, 助教 (60432639) ; SANO Shunji 岡山大学, 医歯(薬)学総合研究科, 教授 (50235438) ; OOSHIMA Yuu 岡山大学, 医歯(薬)学総合研究科, 助教 (80364347)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
• Keywords: 生体システム・フィジオーム / 数理モデル / 機械刺激 / 興奮収縮連関 / SAKCAチャネル / 機械電気帰還現象 / 機械電気相互作用 / 心筋細胞モデル / カルシムハンドリング / カルシウムスパーク / カルシウムハンドリング / 国際研究者交流 / イギリス

Research Abstract

The normal heartbeat is the results of complex interactions of individual cardiomyocytes in the heart. Any mechanical disturbance in their interaction could be the risk of heart rhythm disturbances. In the present study, we revealed the underlying mechanisms that cause mechanically-induced arrhythmic beat by investigating mechanically-induced influx and efflux of ions via mechano-sensitive channels.

Research Products

• [Journal Article] Effects of axial stretch on sarcolemmal BKCa channels in post-hatch chick ventricular myocytes. (2010)
  • Author(s): Iribe G, Jin H, Kaihara K, Naruse K.
  • Journal Title: Exp Physiol. 95(6) Pages: 699-711
  • Peer Reviewed
• [Journal Article] Effects of axial stretch on sarcolemmal BKCa channels in post-hatch chick ventricular myocytes (2010)
  • Author(s): Iribe, G
  • Journal Title: Experimental Physiology Volume: 95 Pages: 699-711
  • Peer Reviewed
• [Journal Article] Axial stretch of rat single ventricular cardiomyocytes causes an acute and transient increase in Ca2+ spark rate. (2009)
  • Author(s): Iribe G, Ward CW, Camelliti P, Bollensdorff C, Mason F, Burton RA, Garny A, Morphew MK, Hoenger A, Lederer WJ, Kohl P.
  • Journal Title: Circ Res. 104(6) Pages: 787-795
  • Peer Reviewed
• [Journal Article] Axial stretch of rat single ventricular cardiomyocytes causes an acute andtransient increase in Ca^<2+> spark rate (2009)
  • Author(s): Iribe, G
  • Journal Title: Circulation Research 104 Pages: 787-795
  • Peer Reviewed
• [Presentation] Integrative modelling study of stretch-induced arrhythmia (2010)
  • Author(s): Iribe, G
  • Organizer: The 4th Shanghai International Conference on Biophysics and Molecular Biology
  • Place of Presentation: 上海
  • Year and Date: 2010-08-10
• [Presentation] Integrative modelling study of stretch-induced arrhythmia (2010)
  • Author(s): 入部玄太郎
  • Organizer: 第49回日本生体医工学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-06-26
• [Presentation] Stretch-sensitivity of stretch-activated BKCa channels in post-hatch chick ventricular myocytes (2010)
  • Author(s): Iribe, G
  • Organizer: Biophysical Society 54th Annual Meeting
  • Place of Presentation: サンフランシスコ
  • Year and Date: 2010-02-22
• [Presentation] Role of stretch-activated BKCa channels on stretch-induced arrhythmias in isolated chick ventricle (2009)
  • Author(s): Iribe, G
  • Organizer: Venice Arrhythmia 2009
  • Place of Presentation: ベネチア
  • Year and Date: 2009-10-05
• [Presentation] Reverse excitation-contraction coupling : the role of the sarcomere (2009)
  • Author(s): Iribe, G
  • Organizer: European Society of Cardiology Congress 2009
  • Place of Presentation: バルセロナ
  • Year and Date: 2009-08-31
• [Presentation] Effects of bepridil on stretch-induced arrhythmia in isolated chick ventricles (2009)
  • Author(s): Iribe, G
  • Organizer: European Society of Cardiology Congress 2009
  • Place of Presentation: バルセロナ
  • Year and Date: 2009-08-30
• [Presentation] Mechano-electric interaction via calcium handling (2009)
  • Author(s): Iribe, G
  • Organizer: The 36th Congress of the International Union of Physiological Sciences Satellite Symposium #8
  • Place of Presentation: 香川県直島
  • Year and Date: 2009-08-03
• [Presentation] Mechanical modulation of cardiac calcium handling (2009)
  • Author(s): Iribe, G
  • Organizer: The 36th Congress of the International Union of Physiological Sciences
  • Place of Presentation: 京都
  • Year and Date: 2009-07-30
• [Presentation] Stretch-sensitivity of chick SAKCA channel after hatching (2009)
  • Author(s): 入部玄太郎
  • Organizer: 第48回日本生体医工学会
  • Place of Presentation: 東京
  • Year and Date: 2009-04-25
• [Presentation] Effects of bepridil on stretch-induced arrhythmia in isolated chick ventricles. (2009)
  • Author(s): Iribe G, Jin H, Naruse K.
  • Organizer: European Society of Cardiology Congress 2009
  • Place of Presentation: Barcelona, Spain.
• [Presentation] Mechanical modulation of cardiac calcium handling. (2009)
  • Author(s): Iribe G.
  • Organizer: 36th International Congrss of Physiological Sciences
  • Place of Presentation: Kyoto, Japan.
• [Presentation] Mechano-electric interaction via calcium handling. (2009)
  • Author(s): Iribe G.
  • Organizer: 36th International Congrss of Physiological Sciences Satellite symposium #8
  • Place of Presentation: Kyoto, Japan.
• [Presentation] New Insight into Acute Stretch Effects on Cardiac Calcium Handling (2008)
  • Author(s): Iribe, G
  • Organizer: European Society of Cardiology Congress 2008
  • Place of Presentation: ミュンヘン(ドイツ)
  • Year and Date: 2008-09-01
• [Presentation] New Insight into Acute Stretch Effects on Cardiac Calcium Handling. (2008)
  • Author(s): Iribe G.
  • Organizer: European Society of Cardiology Congress 2008
  • Place of Presentation: Munich, Germany.
• [Book] 第5章 心血管系細胞への機械刺激負荷技術、バイオテクノロジーシリーズ 細胞分離・操作技術の最前線 (2008)
  • Author(s): 片野坂友紀、入部玄太郎、山田章、成瀬恵治
  • Publisher: (株)シーエムシー出版
• [Book] Chapter 5 "Non-Sarcolemmal Stretch-Activated Channels" in "Cardiac Mechano-Electric Coupling & Arrhythmias 2^<nd> edition"
  • Author(s): Iribe G, Kohl P.
  • Publisher: in press